Search Result
Results for "
human IgG1 monoclonal
" in MedChemExpress (MCE) Product Catalog:
| Cat. No. |
Nom du produit |
Target |
Áreas de investigación |
Chemical Structure |
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- HY-P9905
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Cetuximab
Maximum Cited Publications
53 Publications Verification
C225; IMC-C225
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Radionuclide-Drug Conjugates (RDCs)
EGFR
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Cancer
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Cetuximab (C225) is a human IgG1 monoclonal antibody that inhibits epidermal growth factor receptor (EGFR), with a Kd of 0.201 nM for EGFR by SPR. Cetuximab has potent antitumor activity .
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- HY-P9908
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- HY-164153
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Antibody-Drug Conjugates (ADCs)
Microtubule/Tubulin
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Cancer
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ADC Control Human IgG1-vcMMAE (solution) is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-vcMMAE and can inhibit tubulin polymerization. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is vcMMAE (HY-15575) .
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- HY-164152A
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Antibody-Drug Conjugates (ADCs)
Topoisomerase
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Cancer
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ADC Control Human IgG1-Deruxtecan (DAR 8) is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-Deruxtecan and can inhibit DNA topoisomerase I. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E) .
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- HY-164152
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Antibody-Drug Conjugates (ADCs)
Topoisomerase
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Cancer
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ADC Control Human IgG1-Deruxtecan (DAR 4) is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-Deruxtecan and can inhibit DNA topoisomerase I. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E) .
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- HY-P990764
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SGN-B6A antibody
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Integrin
ADC Antibody
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Inflammation/Immunology
Cancer
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Sigvotatug (SGN-B6A antibody) is a human IgG1 κ monoclonal antibody against ITGB6.
Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
Sigvotatug can be used as an ADC antibody to synthesize ADC Sigvotatug vedotin (HY-164957) .
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- HY-P990591
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Aletekitug
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Interleukin Related
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Inflammation/Immunology
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GSK-1070806 (Aletekitug) is a humanized IgG1/κ monoclonal antibody targeting IL-18. GSK-1070806 neutralizes IL-18 activity.GSK-1070806 can be used for the research of inflammation. The isotype control for GSK-1070806 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-108852
-
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CHI 621
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Interleukin Related
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Inflammation/Immunology
Cancer
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Basiliximab (CHI 621) is a recombinant chimeric murine/human IgG1 monoclonal anti-interleukin-2 receptor antibody. Basiliximab can be used for the research of renal transplantation .
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- HY-P99262
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BAX69; Anti-human MIF Recombinant Antibody
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Macrophage migration inhibitory factor (MIF)
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Cancer
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Imalumab (BAX69) is a recombinant, human IgG1 monoclonal antibody that targets macrophage inhibitory factor (MIF). Imalumab can be used for the research of ovarian carcinoma, recurrent malignant ascites and cancer .
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- HY-P991442
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TAK-920
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TREM receptor
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Neurological Disease
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DNL-919 (TAK-920) is a human IgG1 monoclonal antibody (mAb) targeting TREM-2. DNL-919 can be used in Alzheimer's disease research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P991204
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ARX517 antibody
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PSMA
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Cancer
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Anti-PSMA Antibody (ARX517 antibody) is a humanized IgG1 monoclonal antibody that targets PSMA. Anti-PSMA Antibody is the antibody part of the ADC molecule ARX517. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P99423
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ADG 20
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SARS-CoV
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Infection
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Adintrevimab (ADG 20) is a human IgG1 monoclonal SARS-CoV (SARS-CoV) antibody. Adintrevimab inhibits SARS-CoV-2 variants and other SARS-like coronaviruses with pandemic potential .
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- HY-P991280
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Interleukin Related
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Inflammation/Immunology
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BMS-981164 is a human anti-IL31 IgG1-κ monoclonal antibody. BMS-981164 effectively inhibits the IL-31 signaling pathway. The isotype control of BMS-981164 can be referenced to Human IgG1 kappa, Isotype Control (HY-P99001). BMS-981164 is applicable to research related to atopic dermatitis .
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- HY-P990015
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VIR-3434
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HBV
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Infection
|
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Tobevibart (VIR-3434) is a human IgG1 lambda monoclonal antibody against hepatitis B virus (HBV) surface antigen (HBsAg). Tobevibart shows potent neutralization against HBsAg from all HBV genotypes in vitro and inhibits viral entry of HBV and hepatitis delta virus (HDV). Recommend Isotype Controls: Human IgG1 lambda2, Isotype Control (HY-P990096) .
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- HY-P99514
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AGEN1884
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CTLA-4
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Cancer
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Zalifrelimab (AGEN1884) is a fully human IgG1 monoclonal antibody targeting CTLA-4 (CTLA-4). Zalifrelimab antagonizes the inhibitory checkpoints of immune cell activation regulated by CTLA-4 signaling .
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- HY-P991422
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-
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- HY-164154
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Antibody-Drug Conjugates (ADCs)
Microtubule/Tubulin
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Cancer
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ADC Control Human IgG1-vcMMAF is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-vcMMAF and can inhibit tubulin polymerization. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is MC-Val-Cit-PAB-MMAF (vcMMAF; HY-112786) .
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- HY-P990756
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SARS-CoV
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Inflammation/Immunology
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Pemivibart is an anti-SARS-CoV-2 human IgG1 λ2 monoclonal antibody . Recommend Isotype Controls: Human IgG1 lambda2, Isotype Control (HY-P990096).
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- HY-P990766
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AZD3152
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SARS-CoV
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Infection
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Sipavibart (AZD3152) is a human IgG1 λ2 monoclonal antibody against SARS-CoV-2. Sipavibart is applicable to research related to COVID-19. The isotype control product for Sipavibart is Human IgG1 lambda2, Isotype Control (HY-P990096) .
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- HY-P99233
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HuMax-TAC
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ADC Antibody
Transmembrane Glycoprotein
Interleukin Related
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Cancer
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Camidanlumab (HuMax-TAC) is a humanized IgG1 monoclonal antibody against CD25. Camidanlumab can be used to synthesize the ADC molecule Camidanlumab tesirine (HY-141599). Camidanlumab can be used in the research of tumors such as lymphoma and leukemia. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P991197
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LM-305 antibody; AZD-0305 antibody
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CD3
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Cancer
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Anti-GPRC5D Antibody (LM-305 antibody) is a humanized IgG1 monoclonal antibody that targets GPRC5D. Anti-GPRC5D Antibody is the antibody part of the ADC molecule LM-305. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P9957
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ABthrax
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Bacterial
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Infection
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Raxibacumab (ABthrax) is a human IgG1 monoclonal antibody against Bacillus anthracis protective antigen (PA). Raxibacumab blocks the toxin’s deleterious effects by preventing binding of the protective antigen component of the anthrax toxin to its receptors in host cells, thereby blocking the toxin’s deleterious effects. Raxibacumab can be used for anti-anthrax research .
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- HY-P991075
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NAMPT
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Inflammation/Immunology
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ALT-100 (Human IgG1) is a humanized IgG1 monoclonal antibody that targets NAMPT. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P990734
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-
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- HY-P990767
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-
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- HY-P991164
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AZD5335 Antibody; INT-019
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Antifolate
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Inflammation/Immunology
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Torvutatug is an anti-FOLR1 human IgG1 κ monoclonal antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P99034
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-
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- HY-P99347
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-
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- HY-P99540
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PSB-205; QL1706 (iparomlimab/tuvonralimab); PBS105
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CTLA-4
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Cancer
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Tuvonralimab (PSB-205) is a humanized IgG1 monoclonal antibody against CTLA-4. Tuvonralimab can be used in the research of tumors. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P991106
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LY-3076226 antibody
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FGFR
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Cancer
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IMC-D11 (LY-3076226 antibody) is an IgG1 monoclonal antibody against FGFR3. IMC-D11 can be used for the antibody part of LY3076226. IMC-D11 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P990697
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ARX-788
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EGFR
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Inflammation/Immunology
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Anvatabart is an anti-ERBB2 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P990728
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SP-7219; STRO-001 Antibody
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CD74
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Inflammation/Immunology
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Bezetabart is an anti-CD74 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P990729
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VB-119
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CD19
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Inflammation/Immunology
|
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Budoprutug is an anti-CD19 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P990694
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TG-1801
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CD19
CD47
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Inflammation/Immunology
|
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Zeripatamig is an anti-CD19/CD47 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P991175
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-
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- HY-P991191
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-
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- HY-P9S0056
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-
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- HY-P991052
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TNF Receptor
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Cancer
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GSK-3174998 is a humanized IgG1 OX40/TNFRSF4 agonistic monoclonal antibody. GSK-3174998 has the potential for the study of advanced solid tumors. The isotype control for GSK-3174998 can refer to Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P990755
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EGFR
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Inflammation/Immunology
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Pamvatamig is an anti-EGFR/MET human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P990686
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TNF Receptor
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Inflammation/Immunology
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Ispectamab is an anti-TNFRSF17 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P990747
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CM-313
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CD38
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Inflammation/Immunology
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Lumrotatug is an anti-CD38 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P991333
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-
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- HY-P990745
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HIB210; MOR044254; MOR210; TJ-210; TJ-210001; WBP2191
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Complement System
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Inflammation/Immunology
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Izastobart is an anti-C5AR1 human IgG1 λ2 monoclonal antibody . Recommend Isotype Controls: Human IgG1 lambda2, Isotype Control (HY-P990096).
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- HY-P991374
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Tau Protein
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Neurological Disease
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PNT001 is a human IgG1 monoclonal antibody (mAb) targeting cis-pT231 Tau. PNT001 can be used in Neurodegenerative disorders and Traumatic brain injuries research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P991187
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AGX-101 Antibody
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Transmembrane Glycoprotein
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Cancer
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Anti-TM4SF1 Antibody (AGX-A07) is a humanized IgG1 monoclonal antibody that targets TM4SF1. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P991279
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Interleukin Related
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Inflammation/Immunology
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Mik-Beta-1 is a human IgG1-kappa anti-IL2RB monoclonal antibody. The isotype control of Mik-Beta-1 can be referenced to Human IgG1 kappa, Isotype Control (HY-P99001). Mik-Beta-1 can be used in research related to the prevention of allograft rejection .
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- HY-P3203A
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TNF Receptor
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Inflammation/Immunology
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DSTYSLSSTLTLSK TFA is a generic human peptide and can be used for infliximab quantitative detection . Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α.
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- HY-P991743
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Ras
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Others
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Anti-KRAS Antibody is a human-derived IgG1 kappa monoclonal antibody against KRAS.
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-
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- HY-P991341
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Cadherin
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Inflammation/Immunology
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FF-21101 is a human IgG1 monoclonal antibody (mAb) targeting CDH3/P-cadherin. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P991185
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c-Met/HGFR
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Cancer
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Anti-MST1R Antibody (MOR07692) is a humanized IgG1 monoclonal antibody that targets MST1R. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P990764B
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Integrin
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Inflammation/Immunology
Cancer
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Sigvotatug (Biotinylated) is a biotinylated derivative of Sigvotatug (HY-P990764). Sigvotatug (Biotinylated) is a humanized IgG1 κ monoclonal antibody inhibitor against ITGB6. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P991072
-
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MAPP-66
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HIV
HSV
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Infection
|
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MB-66 (MAPP-66) is a fully human IgG1 antibody that targets HSV and HIV. MB-66 is a monoclonal antibody film for vaginal application. The isotype control for MB-66 can refer to Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P99307
-
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AMG-203; Anti-human CSF2 Recombinant Antibody
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c-Fms
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Inflammation/Immunology
|
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Namilumab (AMG203) is a human IgG1 monoclonal antibody that binds with high affinity to the GM-CSF ligand, potently neutralizing GM-CSF. Namilumab can be used for the research of rheumatoid arthritis .
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- HY-P990700
-
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RO-7247669; RG-6139
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PD-1/PD-L1
LAG-3
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Inflammation/Immunology
|
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Tobemstomig is an anti-PDCD1/LAG3 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P990701
-
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RO-7121661
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PD-1/PD-L1
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Inflammation/Immunology
|
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Lomvastomig is an anti-PDCD1/HAVCR2 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P991195
-
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SIM1811-03
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TNF Receptor
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Cancer
|
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SIM-0235 is humanized immunoglobulin G1 (IgG1) monoclonal antibody that targets and inhibits TNFR2, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) [1].
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- HY-P990727
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- HY-P991300
-
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LAG-3
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Cancer
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GSK2831781 is a human IgG1 monoclonal antibody (mAb) targeting CD223/LAG3. GSK2831781 can be used in the study of ulcerative colitis Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P99324
-
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Anti-human EGFR Recombinant Antibody; CetuxiMab-GEX, GEXMab52201
|
EGFR
Apoptosis
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Cancer
|
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Tomuzotuximab (Anti-Human EGFR Recombinant Antibody) is a fully human glycoengineered IgG1 monoclonal antibody against EGFR. Tomuzotuximab has anticancer effects .
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- HY-P991495
-
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RSV
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Infection
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VIR-8190 is a human IgG1 monoclonal antibody (mAb) targeting F, Fusion glycoprotein F0. VIR-8190 can be used in respiratory syncytial virus (RSV) and metapneumovirus infections research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P991292
-
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ADC Antibody
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Cancer
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AB-3A4 is a human IgG1 monoclonal antibody (mAb) targeting KAAG1. AB-3A4 can be used in the study of ovarian cancer, triple-negative breast cancer, and prostate cancer. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P991448
-
|
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Glycoprotein VI
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Cancer
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MDX-1414 is a human IgG1 monoclonal antibody (mAb) targeting GPC3. MDX-1414 has antitumor activity in the HepG2 xenograft model. MDX-1414 can be used in liver cancer research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P991311
-
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LPL Receptor
Wnt
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Cancer
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GSK3178022 is a human IgG1 monoclonal antibody (mAb) targeting LRP6. GSK3178022 inhibits the expression of WNT target genes SP5 and AXIN2. GSK3178022 has antitumor activity in the RSPO fusion model of colorectal cancer. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P990014
-
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IMC-001; STI-3031
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PD-1/PD-L1
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Inflammation/Immunology
Cancer
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Danburstotug (IMC-001) is an IgG1-lambda anti-CD274 (PDL1, B7 homologue 1, B7H1) human monoclonal antibody. Danburstotug also is immunostimulant and antineoplastic .
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- HY-P991165
-
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KVA-12123; KVA-12.1
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Fc Receptor (FcR)
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Others
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Trovostobart is an anti-VSIR human IgG1 κ monoclonal antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P990746
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- HY-P990754
-
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M-1224
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c-Kit
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Inflammation/Immunology
|
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Opelkibart is an anti-KIT human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P990749
-
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AK-115
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Trk Receptor
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Inflammation/Immunology
|
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Luvagrobart is an anti-NGF human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P990739
-
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BA-3071
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CTLA-4
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Inflammation/Immunology
|
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Evalstotug is an anti-CTLA4 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P990775
-
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XTX101
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CTLA-4
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Inflammation/Immunology
|
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Vilastobart is an anti-CTLA4 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P990768
-
|
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SARS-CoV
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Inflammation/Immunology
|
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Timcevibart is an anti-SARS-CoV-2 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P991116
-
-
- HY-P990705
-
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REGN-15160
|
SARS-CoV
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Inflammation/Immunology
|
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Gorivitug is an anti-SARS-CoV-2 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P990725
-
|
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SARS-CoV
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Inflammation/Immunology
|
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Nisfevitug is an anti-SARS-CoV-2 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P990771
-
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INCA-00186
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CD73
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Inflammation/Immunology
|
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Uprevstobart is an anti-NT5E human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P991170
-
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SARS-CoV
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Infection
|
|
Ibramvibart is an anti-SARS-CoV-2 Spike human IgG1 κ monoclonal antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P991177
-
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RC-108 antibody
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c-Met/HGFR
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Cancer
|
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Anti-c-Met/HGFR Antibody is a humanized IgG1 monoclonal antibody that targets c-Met. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P990711
-
|
|
SARS-CoV
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Inflammation/Immunology
|
|
Canrivitug is an anti-SARS-CoV-2 human IgG1 λ2 monoclonal antibody . Recommend Isotype Controls: Human IgG1 lambda2, Isotype Control (HY-P990096).
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- HY-P991305
-
|
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Transmembrane Glycoprotein
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Cancer
|
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AGEN-1571 is a human IgG1 monoclonal antibody (mAb) targeting ILT2. AGEN-1571 promotes adaptive and innate immune responses. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001)
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- HY-P991314
-
|
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MDM-2/p53
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Cancer
|
|
NMC-001 is a human IgG1 monoclonal antibody (mAb) targeting MDM2. NMC-001 can be used in pancreatic cancer research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P991484
-
|
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Influenza Virus
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Infection
|
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ADI-65534 is a human IgG1 monoclonal antibody (mAb) targeting Envelopment polyprotein, M polyprotein. ADI-65534 can be used in Hantavirus infection research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P991483
-
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Influenza Virus
|
Infection
|
|
ADI-65533 is a human IgG1 monoclonal antibody (mAb) targeting Envelopment polyprotein, M polyprotein. ADI-65533 can be used in Hantavirus infection research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P991482
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Influenza Virus
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Infection
|
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ADI-42898 is a human IgG1 monoclonal antibody (mAb) targeting Envelopment polyprotein, M polyprotein. ADI-42898 binds to the Gn/Gc complex and blocks the cell entry of seven HCPS- and HFRS-associated hantaviruses. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P991445
-
|
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SARS-CoV
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Infection
|
|
REGN3051 is a human IgG1 monoclonal antibody (mAb) targeting MERS CoV. REGN3051 reduces viral titers in the lungs of mice expressing human DPP4. REGN3051 decreases lung disease severity and viral replication in marmosets inoculated with MERS-CoV. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P3203
-
-
- HY-P991493
-
|
|
RSV
|
Infection
|
|
AR-201 is a human IgG1 monoclonal antibody (mAb) targeting F, Fusion glycoprotein F0. AR-201 has anti-respiratory syncytial virus (RSV) activity. AR-201 can be used in lower respiratory tract illness (LRTI) research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P991173
-
|
|
Notch
|
Cancer
|
|
AMG-119 is a humanized IgG1 monoclonal antibody that targets delta-like ligand 3 (DLL3). AMG-119 can be used for the study of relapsed/refractory (R/R) small cell lung cancer (SCLC). Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P992337
-
|
|
ROR
|
Cancer
|
|
CS5001 Antibody is an IgG1 human monoclonal antibody targeting ROR1. CS5001 Antibody can be used for the synthesis of the ADC CS5001. It is applicable to research related to advanced solid tumors and lymphomas. The recommended isotype control is human IgG1 kappa (HY-P99001) .
|
-
- HY-P991903
-
|
|
CD20
|
Cancer
|
|
PSB102 is a humanized Fc-enhanced IgG1 monoclonal antibody directed against the human B-cell-specific cell surface antigen and tumor-associated antigen CD20 .
|
-
- HY-P992375
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
HuMax-IL15 is a human IgG1 monoclonal antibody against IL-15. HuMax-IL15 is applicable to the research of rheumatoid arthritis. The recommended isotype control is human IgG1 kappa (HY-P99001) .
|
-
- HY-P992443
-
-
- HY-P992148
-
|
ZL-1310 Antibody
|
Notch
|
Cancer
|
|
Zocilurtatug is a human monoclonal antibody against DLL3. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P992139
-
|
|
VEGFR
|
Others
|
|
Valancitug is a human monoclonal antibody targeting VEGFA. Its corresponding isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P992400
-
|
|
Tau Protein
|
Neurological Disease
|
|
Lu AF87908 is an IgG1 monoclonal antibody targeting the p-Ser396/404 epitope of tau protein, which mainly binds to the pSer396 region. Lu AF87908 can be used in the research of Alzheimer's disease. The recommended isotype control is human IgG1 kappa (HY-P99001) .
|
-
- HY-P992117
-
|
DCSZ-11
|
Complement System
|
Cancer
|
|
Lexucitug (DCSZ-11) is a humanized monoclonal antibody targeting CD93. The antibody isotype of Lexucitug is human IgG1κ; the recommended isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P992184
-
|
ASN004 Antibody
|
Wnt
|
Cancer
|
|
Anti-5T4 scFv-Fc Antibody (ASN004 Antibody) is a human IgG1 monoclonal antibody targeting TPBG. Anti-5T4 scFv-Fc Antibody (ASN004 Antibody) can be used in cancer research. The recommended isotype control is human IgG1 kappa (HY-P99001).
|
-
- HY-P992128
-
|
|
EGFR
|
Others
|
|
Rinumafusp alfa is a human monoclonal antibody targeting ERBB3/HER3. The corresponding isotype control is: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992412
-
|
|
Claudin
|
Cancer
|
|
MIL93 is a humanized defucosylated IgG1 monoclonal antibody targeting Claudin18.2 (CLDN18.2) with enhanced antibody-dependent cellular cytotoxicity (ADCC) activity. MIL93 can be used for research on advanced solid tumors and gastric cancer. The recommended isotype control is human IgG1 kappa (HY-P99001) .
|
-
- HY-P992118
-
|
|
TREM receptor
|
Inflammation/Immunology
|
|
Lifonebart is a humanized monoclonal antibody targeting TREM2 (triggering receptor expressed on myeloid cells 2). The antibody isotype of Lifonebart is human IgG1κ, and the recommended isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P992402
-
|
|
Transmembrane Glycoprotein
|
Cancer
|
|
MAI1738 is a human monoclonal antibody targeting PODXL. MAI1738 can be used for cancer-related research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P99807
-
|
BCD-100
|
PD-1/PD-L1
|
Cancer
|
|
Prolgolimab (BCD-100) is a human IgG1 anti-PD-1 monoclonal antibody containing the Fc-silencing 'LALA' mutation. Prolgolimab can be used for the research of advanced melanoma .
|
-
- HY-P991446
-
|
|
Influenza Virus
|
Infection
|
|
MEDI-8852 is a human IgG1 monoclonal antibody against influenza A virus hemagglutinin (HA). MEDI-8852 binds to the conserved HA stalk epitope and neutralizes viral infectivity. MEDI-8852 reduces viral titers in mouse lung tissues. MEDI-8852 is applicable to research related to pandemic influenza . Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P99337
-
|
Ansuvimab-zyk; mAb114
|
Filovirus
|
Infection
|
|
Ansuvimab (Ansuvimab-zyk) is a recombinant human monoclonal IgG1 antibody that exhibits antiviral activity against Zaire ebolavirus. Ansuvimab binds to the glycoprotein on Zaire ebolavirus to block its entry into host cells .
|
-
- HY-P99955
-
-
- HY-P991434
-
|
|
Integrin
|
Inflammation/Immunology
|
|
SAN-300 is a human IgG1 monoclonal antibody (mAb) targeting ITGA1/VLA-1. SAN-300 can be used in Rheumatoid arthritis research .
|
-
- HY-P99889
-
|
BRII-198
|
SARS-CoV
|
Infection
|
|
Romlusevimab (BRII-198) is a neutralizing recombinant human IgG1 monoclonal antibody against the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) .
|
-
- HY-P9S0008
-
|
|
Radionuclide-Drug Conjugates (RDCs)
EGFR
|
Cancer
|
|
Cetuximab (PBS) is a human IgG1 monoclonal antibody that can inhibit EGFR. The SPR method measured the Kd value of Cetuximab for EGFR to be 0.201 nM; Cetuximab has a highly effective anti-tumor effect .
|
-
- HY-P992399
-
|
|
TNF Receptor
NF-κB
|
Cancer
|
|
LBL-019 is a humanized IgG1 monoclonal antibody targeting TNFR2. LBL-019 costimulates TNFR2 and activates the NF-κB signaling pathway in an Fc crosslinking-dependent manner. LBL-019 can be used for the research of advanced malignant tumors, including hepatocellular carcinoma and melanoma. The recommended isotype control is human IgG1 kappa (HY-P99001) .
|
-
- HY-P991041
-
|
Anti-SEZ6 Antibody (SC17); ABBV-011 antibody; ABBV-706 antibody
|
ADC Antibody
|
Cancer
|
|
Turmetabart (Anti-SEZ6 Antibody (SC17)) is a humanized anti-SEZ6 IgG1 monoclonal antibody. Anti-SEZ6 Antibody (SC17) can be used to synthesize antibody-drug conjugates (ADC) product, ABBV-011. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P991174
-
|
|
TREM receptor
|
Inflammation/Immunology
|
|
Anti-TREM2 Antibody (AL2p-58) is a humanized IgG1 monoclonal antibody targeting TREM2. Anti-TREM2 Antibody (AL2p-58) can be used for the research of neuroinflammation. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P992110
-
|
DB-1311 Antibody; BNT324 Antibody
|
CD276/B7-H3
|
Cancer
|
|
Elfetabart (DB-1311 Antibody; BNT324 Antibody) is a humanized monoclonal antibody targeting CD276 with antitumor activity. The antibody isotype of Elfetabart is human IgG1κ, and the recommended isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P99322
-
|
LFG316; Anti-human C5 Recombinant Antibody
|
Complement System
|
Inflammation/Immunology
|
|
Tesidolumab (LFG316) is a fully-human IgG1/λ anti-C5 monoclonal antibody of 143 kDa (without glycosylation). Tesidolumab (LFG316) blocks cleavage of C5 and prevents subsequent formation of the membrane attack complex .
|
-
- HY-P99900
-
|
MSL-109
|
CMV
|
Infection
|
|
Sevirumab (MSL-109) is a human IgG1 neutralizing monoclonal antibody against cytomegalovirus (CMV). Sevirumab recognizes CMV gH complexes and inhibits CMV replication with an EC50 of 0.3 μg/mL .
|
-
- HY-P9922
-
|
IMC-3G3; LY3012207
|
PDGFR
|
Cancer
|
Olaratumab (IMC-3G3; LY3012207) is an anti-platelet-derived growth factor receptor alpha (PDGFRα) human monoclonal IgG1 antibody with antitumor activity .
|
-
- HY-P992013
-
|
|
CXCR
|
Others
|
|
Anti-CXCR3 Antibody (5H7) is a mouse monoclonal antibody produced using CXCR3 as the antigen. The recommended isotype control is human IgG1 kappa (HY-P99001).
|
-
- HY-P991487
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
LASN01 is a human IgG1 monoclonal antibody (mAb) targeting IL-11RA. LASN01 inhibits IGF-1 and IL-11-induced hyaluronic acid (HA) release and TGFβ-stimulated procollagen in orbital fibroblasts. LASN01 can be used in thyroid eye disease (TED) research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P991443
-
|
|
CD73
|
Cancer
|
|
IPH5301 is a human IgG1 monoclonal antibody (mAb) targeting NT5E/CD73. IPH5301 has a functionally silent Fc domain, specifically inhibits soluble and membrane CD73 enzyme activity, and restores the proliferation of immune T cells. IPH5301 can be used in anti-tumor immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P991491
-
|
|
SARS-CoV
Influenza Virus
|
Infection
|
|
VIR-7229 is a human IgG1 monoclonal antibody (mAb) targeting Receptor-Binding Domain, RBD, Spike glycoprotein. VIR-7229 exerts antiviral activity by competing with ACE2 for binding and inducing S1 protein shedding. VIR-7229 can be used in SARS-CoV-2 infection research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P991481
-
|
|
CCR
|
Inflammation/Immunology
Cancer
|
|
S-531011 is a human IgG1 monoclonal antibody (mAb) targeting CCR8. S-531011 reduces tumor-infiltrating CCR8+ Tregs and has anti-tumor activity in CT26.WT and EMT6 tumor-bearing mouse tumor models. S-531011 can be used in the study of cancer immunity. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P991471
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
GB-0895 is a human monoclonal antibody (mAb) targeting TSLP. GB-0895 can be used in Asthma research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P992373
-
|
|
Mucin
|
Cancer
|
|
huCC49 is a human monoclonal antibody targeting TAG-72. huCC49 can be used in cancer-related research. The recommended isotype control is human IgG1 kappa, with the isotype control (HY-P99001) .
|
-
- HY-P991404
-
|
|
TNF Receptor
|
Cancer
|
|
AMG-228 is a human IgG1 monoclonal antibody (mAb) targeting TNFRSF18/GITR/CD357. AMG-228 can be used in advanced solid tumors research .
|
-
- HY-P991433
-
|
|
TNF Receptor
|
Cancer
|
|
BIIB036 is a human IgG1 monoclonal antibody (mAb) targeting TNFRSF12A/Fn14. BIIB036 inhibits the growth of patient-derived primary colorectal tumors in SCID mice .
|
-
- HY-P99895
-
|
|
PD-1/PD-L1
|
Inflammation/Immunology
Cancer
|
|
Rulonilimab is a human IgG1 monoclonal antibody against PD-1 that targets, binds and inhibits PD-1 and its downstream signalling pathways with potential immune checkpoint inhibition and anti-tumour activity .
|
-
- HY-P991334
-
|
|
Orexin Receptor (OX Receptor)
|
Cancer
|
|
INCAGN1949 is a human IgG1 monoclonal antibody (mAb) targeting TNFRSF4/OX40/CD134. INCAGN1949 selectively deplete intratumoral regulatory T cells .
|
-
- HY-P992141
-
-
- HY-P991473
-
|
|
TNF Receptor
|
Cancer
|
|
hCBE-11 is a human monoclonal antibody (mAb) targeting TNFRSF3. hCBE-11 can be used in solid tumors research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P992272
-
|
|
Lipocalin Family
|
Inflammation/Immunology
|
|
Anti-NGAL Antibody is a monoclonal antibody targeting NGAL. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-NGAL Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992296
-
|
|
PTHR
|
Inflammation/Immunology
|
|
Anti-PTHrP Antibody is a monoclonal antibody that targets PTHrP. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-PTHrP Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992294
-
|
|
Prion Protein
|
Inflammation/Immunology
|
|
Anti-PRNP Antibody is a monoclonal antibody that targets PRNP. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-PRNP Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992285
-
-
- HY-P992190
-
|
|
Apelin Receptor (APJ)
|
Inflammation/Immunology
|
|
Anti-Apelin Antibody is a monoclonal antibody that targets apelin. It can be used in ELISA, FACS, and functional assays. For isotype controls of anti-Apelin Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992234
-
|
|
Glycosidase
|
Inflammation/Immunology
|
|
Anti-Heparanase Antibody is a monoclonal antibody that targets heparanase. It can be used in ELISA, FACS, and functional assays. For isotype controls of anti-heparanase antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P991867
-
|
|
Amyloid-β
|
Neurological Disease
|
|
SHR-1707 is a humanized anti-Aβ IgG1 monoclonal antibody. SHR-1707 binds Aβ fibrils and monomers, blocking plaque formation and promoting the microglial phagocytosis of Aβ. SHR-1707 reduces brain Aβ deposition in 5xFAD transgenic mice. SHR-1707 can be used for Alzheimer’s disease research. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P992411
-
|
|
Amyloid-β
|
Neurological Disease
|
|
MEDI-8490 is a fully human monoclonal antibody targeting APP/Aβ. MEDI-8490 can be used in research related to neurodegenerative diseases. Recommended isotype control: Human IgG1 lambda1, Isotype Control (HY-P99992).
|
-
- HY-P99945
-
-
- HY-P9801
-
|
SARS-CoV-2 (2019-nCoV) Spike RBD Antibody
|
SARS-CoV
|
Infection
|
|
Anti-Spike-RBD mAb is a CHO cell derived human monoclonal IgG1 antibody. Blocking the interaction of Spike protein and ACE2. Anti-Spike-RBD mAb is a potential therapeutic approach for SARS-CoV-2 treatment .
|
-
- HY-P99328
-
|
|
Interleukin Related
|
Inflammation/Immunology
Cancer
|
|
Tucotuzumab (Anti-EPCAM Recombinant Antibody) is an antigen-specific IgG1 monoclonal antibody that targets human epithelial cell adhesion molecule (EpCAM). Tucotuzumab links two IL-2 molecules and is an immunosuppressant and anti-tumor active molecule .
|
-
- HY-P991470
-
|
Neuradiab antibody
|
Transmembrane Glycoprotein
|
Cancer
|
|
Anti-Tenascin C Antibody (Neuradiab antibody) is a human monoclonal antibody (mAb) targeting Tenascin C. Anti-Tenascin C Antibody can be used in Glioblastoma research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P9915
-
|
Anti-human CD38, human Antibody; HuMax-CD38; JNJ-54767414
|
CD38
ADC Antibody
|
Inflammation/Immunology
Cancer
|
|
Daratumumab (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition .
|
-
- HY-P992051
-
|
|
Integrin
|
Inflammation/Immunology
Cancer
|
|
Anti-CD103 Antibody (hCD103.01A) is a monoclonal antibody targeting human CD103 and can be used in cancer immunotherapy and immunological research. Recommend Isotype Controls: human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P991460
-
|
|
TNF Receptor
|
Cancer
|
|
Sym029 is a human IgG monoclonal antibody (mAb) targeting TNFRSF5/CD40. Sym029 can be used in cancer research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P991421
-
|
|
VISTA
|
Cancer
|
|
W0180 is a human IgG1 monoclonal antibody (mAb) targeting VISTA/B7-H5. W0180 has the potential to activate T cells. W0180 can be used in solid tumors research .
|
-
- HY-P991192
-
|
|
TNF Receptor
|
Cancer
|
|
BI-1808 is a human IgG1 monoclonal antibody that targets TNFR2by blocking interaction of TNFR2 with ligand TNF-α, confers FcγR-dependent depletion of Treg and mediates expansion of intratumoral CD8 + T cells .
|
-
- HY-P9807
-
|
SARS-CR3022; SARS-CoV-2 Antibody-CR3022
|
SARS-CoV
|
Infection
Inflammation/Immunology
|
|
Anti-SARS-CoV-2 Spike mAb (CR3022) is a a CHO cell derived human monoclonal IgG1 antibody. It binds to both S1 domain of SARS-CoV/SARS-CoV-2 Spike protein .
|
-
- HY-P99781
-
|
MLN-1202
|
CCR
|
Inflammation/Immunology
Cancer
|
|
Plozalizumab (MLN-1202) is a humanized anti-CCR2 IgG1 monoclonal antibody. Plozalizumab blocks the recruitment of myeloid cells to the tumor microenvironment by inhibiting the CCL2/CCR2 axis. In addition, Plozalizumab also ameliorates synovial inflammation in rheumatoid arthritis. Plozalizumab can be used in the research of malignant melanoma and bone metastasis-related cancers. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P991450
-
|
ADI-15742; MBP-134 AF
|
Filovirus
|
Infection
|
|
ADI-15878 is a human IgG monoclonal antibody (mAb) targeting Envelope glycoprotein, GP2. ADI-15878 can be used in Ebola virus infection research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P991496
-
|
|
RSV
|
Infection
|
|
IDB-002 is a human monoclonal antibody (mAb) targeting F/Fusion glycoprotein F0. IDB-002 can be used in respiratory syncytial virus infection research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992227
-
|
|
Lipase
|
Inflammation/Immunology
|
|
Anti-Endothelial Lipase Antibody is a monoclonal antibody targeting endothelial lipase. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Endothelial Lipase Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992290
-
|
|
SHP1
|
Inflammation/Immunology
|
|
Anti-PILRA Antibody is a monoclonal antibody that targets PILRA. Anti-PILRA Antibody can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-PILRA Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992288
-
|
|
Serpin
|
Inflammation/Immunology
|
|
Anti-PCI Antibody is a monoclonal antibody that targets PCI. Anti-PCI Antibody can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-PCI Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992293
-
|
|
RAR/RXR
|
Inflammation/Immunology
|
|
Anti-PRAME Antibody is a monoclonal antibody that targets the melanoma antigen preferentially/PRAME. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-PRAME Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P99415
-
|
MAA868
|
Factor Xa
|
Cardiovascular Disease
|
|
Abelacimab (MAA868) is a fully human IgG1 monoclonal antibody that binds with high affinity to the catalytic structural domain of FXI and locks it in the zymogen conformation, thereby preventing its activation by FXIIa or thrombin. Abelacimab can be used in thromboembolic disease studies .
|
-
- HY-P991282
-
|
|
Interleukin Related
|
Cancer
|
|
KHK2823 is a humanized monoclonal anti-human CD123/IL3RA antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001). KHK2823 can be used in research related to leukemia .
|
-
- HY-P991942
-
|
BAY3375968; TPP-23411
|
CCR
|
Inflammation/Immunology
Cancer
|
|
Lanerkitug (BAY3375968) is a fully human monoclonal IgG1 anti-human CCR8 antibody. Lanerkitug selectively depletes human CCR8 + Tregs via antibody dependent cellular cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP). Lanerkitug can be used in the research of solid tumors .
|
-
- HY-P99110
-
|
SHP643; DX-2930; X124-G01
|
Kallikrein
|
Inflammation/Immunology
|
|
Lanadelumab (SHP643) is a human IgG1 monoclonal antibody against plasma kallikrein (pKal) with an Ki value of 0.12 nM. Lanadelumab inhibits both free and HMWK (high molecular weight kininogen)-bound pKal. Lanadelumab has the potential for the research of hereditary angioedema .
|
-
- HY-P9915A
-
|
Anti-human CD38, human Antibody (PBS)
|
ADC Antibody
CD38
|
Cancer
|
|
Daratumumab (PBS) (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab (PBS) has anti-multiple myeloma (MM) effect. Daratumumab (PBS) impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition .
|
-
- HY-P99970
-
|
|
ADC Antibody
Sodium Phosphate Cotransporter
|
Cancer
|
|
Lifastuzumab is a humanized anti-NaPi2b IgG1 monoclonal antibody. Lifastuzumab can be coupled with monomethyl auristatin E (MMAE) (HY-15162) through ADC Linker to form an antibody-drug conjugate (ADC) Lifastuzumab vedotin (HY-P99705) with anticancer activity. Lifastuzumab vedotin can be studied in research for non-small cell lung cancer and ovarian cancer. Recommend Isotype Control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P992250
-
|
|
Kallikrein
|
Inflammation/Immunology
|
|
Anti-KLK7 Antibody is a monoclonal antibody targeting KLK7. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-KLK7 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992217
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-CDH19 Antibody is a monoclonal antibody that targets CDH19. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CDH19 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992185
-
|
|
MMP
|
Inflammation/Immunology
|
|
Anti-ADAM17 Antibody is a monoclonal antibody targeting ADAM17. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-ADAM17 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992297
-
|
|
E1/E2/E3 Enzyme
|
Inflammation/Immunology
|
|
Anti-RNF43 Antibody is a monoclonal antibody targeting RNF43. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-RNF43 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992186
-
|
|
MMP
|
Inflammation/Immunology
|
|
Anti-ADMAST4 Antibody is a monoclonal antibody targeting ADMAST4. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-ADMAST4 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992300
-
|
|
Wnt
|
Inflammation/Immunology
|
|
Anti-RSPO2 Antibody is a monoclonal antibody that targets RSPO2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-RSPO2 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992216
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-CD99 Antibody is a monoclonal antibody that targets CD99. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CD99 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P99036
-
|
|
Tie
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand Angiopoietin-2 (Ang2) with high affinity, but shows no binding to Ang1. Nesvacumab can be used in vascular researches .
|
-
- HY-P992187
-
|
|
PDI
|
Inflammation/Immunology
|
|
Anti-AGR2 Antibody is a monoclonal antibody that targets AGR2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-AGR2 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992307
-
|
|
MMP
|
Inflammation/Immunology
|
|
Anti-TIMP-1 Antibody is a monoclonal antibody that targets TIMP1. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-TIMP-1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992214
-
|
|
SHP1
|
Inflammation/Immunology
|
|
Anti-CD84 Antibody is a monoclonal antibody that targets CD84. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CD84 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992251
-
-
- HY-P992197
-
|
|
CCR
|
Inflammation/Immunology
|
|
Anti-CCL21 Antibody is a monoclonal antibody targeting CCL21. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CCL21 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992189
-
|
|
Wnt
|
Inflammation/Immunology
|
|
Anti-APCDD1 Antibody is a monoclonal antibody that targets APCDD1. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-APCDD1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992255
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-LAIR1 Antibody is a monoclonal antibody that targets LAIR1. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-LAIR1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992305
-
|
|
STAT
|
Inflammation/Immunology
|
|
Anti-STAT3 Antibody is a monoclonal antibody that targets STAT3. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-STAT3 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992299
-
|
|
Slit Proteins
|
Inflammation/Immunology
|
|
Anti-Robo4 Antibody is a monoclonal antibody targeting Robo4. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Robo4 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992199
-
|
|
CCR
|
Inflammation/Immunology
|
|
Anti-CCR9 Antibody is a monoclonal antibody targeting CCR9. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CCR9 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992309
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-TSPAN33 Antibody is a monoclonal antibody targeting TSPAN33. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-TSPAN33 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992229
-
|
|
Wnt
|
Inflammation/Immunology
|
|
Anti-FZD5 Antibody is a monoclonal antibody targeting FZD5. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-FZD5 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992226
-
|
|
Orphan GPCR
|
Inflammation/Immunology
|
|
Anti-EMR2 Antibody is a monoclonal antibody targeting ADGRE2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-EMR2 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992269
-
|
|
Monocarboxylate Transporter
|
Inflammation/Immunology
|
|
Anti-MSR1 Antibody is a monoclonal antibody that targets MSR1. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-MSR1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992222
-
|
|
CXCR
|
Inflammation/Immunology
|
|
Anti-CXCL13 Antibody is a monoclonal antibody targeting CXCL13. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CXCL13 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992263
-
|
|
Wnt
|
Inflammation/Immunology
|
|
Anti-LRP5 Antibody is a monoclonal antibody that targets LRP5. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-LRP5 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992287
-
|
|
Protein Arginine Deiminase
|
Inflammation/Immunology
|
|
Anti-PAD4 Antibody is a monoclonal antibody that targets PAD4. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-PAD4 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992278
-
|
|
Notch
|
Inflammation/Immunology
|
|
Anti-Notch2 Antibody is a monoclonal antibody targeting Notch2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Notch2 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992292
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-Plexin A1 Antibody is a monoclonal antibody targeting Plexin A1. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Plexin A1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992261
-
|
|
Lipocalin Family
|
Inflammation/Immunology
|
|
Anti-Lipocalin-2 Antibody is a monoclonal antibody targeting Lipocalin-2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Lipocalin-2 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992248
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL-32 Antibody is a monoclonal antibody that targets IL-32. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-32 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992245
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL-26 Antibody is a monoclonal antibody that targets IL-26. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-26 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992218
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-CHRDL-1 Antibody is a monoclonal antibody that targets CHRDL-1. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CHRDL-1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992243
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL-24 Antibody is a monoclonal antibody that targets IL-24. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-24 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992267
-
|
|
MMP
|
Inflammation/Immunology
|
|
Anti-MMP-16 Antibody is a monoclonal antibody targeting MMP-16. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-MMP-16 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P991310
-
|
LT3015; LT-3000
|
LPL Receptor
|
Neurological Disease
Cancer
|
|
Lpathomab (LT3015; LT-3000) is a human IgG1 monoclonal antibody (mAb) targeting LPA. Lpathomab reduces the release of IL-8 and IL-6 cytokines in SKOV3 cells and blocks LPA-triggered tumor cell migration. Lpathomab reduces neovascularization in Matrigel plug and CNV models. Lpathomab inhibits brain injury in the CCI mouse model. Lpathomab can be used in the study of brain injury, ovarian cancer, diabetic neuropathy, and spinal cord injury. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P991454
-
|
|
Wnt
|
Inflammation/Immunology
|
|
Anti-LGR5/GPR49 Antibody (18G7H6A3) is a human monoclonal antibody (mAb) targeting LGR5/GPR49. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P991453
-
|
|
C-type Lectin-like Receptors (CTLRs)
|
Cancer
|
|
Anti-CD371/CLEC12A Antibody (H6e7) is a human monoclonal antibody (mAb) targeting CD371/CLEC12A. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P991346
-
|
|
PD-1/PD-L1
|
Inflammation/Immunology
|
|
CC-90006 is a human monoclonal antibody (mAb) targeting PDCD1/PD-1/CD279. CC-90006 can be used in psoriasis research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P992252
-
|
|
Wnt
|
Inflammation/Immunology
|
|
Anti-Kremen2 Antibody is a monoclonal antibody that targets Kremen2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Kremen2 Antibody, please refer to Human IgG1 (N297A) kappa, Isotype Control (HY-P99994).
|
-
- HY-P992210
-
|
|
Transmembrane Glycoprotein
|
Cancer
|
|
Anti-CD326 Antibody (17-1A) is a human monoclonal antibody targeting CD326. Anti-CD326 Antibody (17-1A) can be used in cancer research. The recommended isotype control is Mouse IgG1 kappa (HY-P99977).
|
-
- HY-P99541
-
|
anti-hepatitis B; OST 577; SDZ-OST 577
|
HBV
|
Infection
|
|
Tuvirumab (OST 577; SDZ-OST 577) is a human IgG1 subclass monoclonal antibody directed against HBV surface antigen (HBsAg). Tuvirumab binds specifically and with high affinity (K=3.6 nM) to HBsAg. Tuvirumab has the potential for chronic hepatitis B research .
|
-
- HY-P99962
-
|
BGB-A425
|
Mucin
|
Cancer
|
|
Surzebiclimab (BGB-A425) is a humanized IgG1-variant monoclonal antibody against T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). Surzebiclimab binds to the extracellular domain of human Tim-3 with high affinity (KD=0.36 nM) and specificity. Surzebiclimab can be used in research of cancer .
|
-
- HY-P991599
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
SHR-1703 is a long-acting humanized anti-IL-5 IgG1 monoclonal antibody. SHR-1703 can selectively recognize and bind to IL-5, blocking the binding of IL-5 to the α chain of the receptor on the surface of eosinophils, thereby inhibiting the proliferation, activation, and migration of eosinophils, and ultimately reducing eosinophil-mediated inflammation and damage. SHR-1703 can be used in the research of eosinophil-related diseases, such as eosinophilic asthma. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P99191
-
|
NI-0501
|
IFNAR
|
Inflammation/Immunology
|
|
Emapalumab (NI-0501) is a human monoclonal IgG1 antibody that noncompetitively inhibits IFN-γ. Emapalumab binds with high affinity (Kd= 1.4 pM) to both free IFN-γ as well as IFN-γ bound to its receptor. Emapalumab can be used in research of hemophagocytic lymphohistiocytosis (HLH) .
|
-
- HY-P99680
-
|
SB-210396; IDEC CE9.1
|
Interleukin Related
|
Cancer
|
|
Keliximab (SB-210396) is a chimeric human/macaque IgG1 anti-CD4 monoclonal antibody with a Ki value of 1.0 nM for soluble CD4. Keliximab blocks T cell proliferation and inhibits IL-2 production. Keliximab can be used for cancer research .
|
-
- HY-P992008
-
|
|
TGF-β Receptor
|
Cardiovascular Disease
|
|
PF-07868489 is a recombinant monoclonal antibody targeting GDF2/BMP-9. PF-07868489 can be used for the research of pulmonary arterial hypertension (PAH). Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P99271
-
|
Anti-human F3 Recombinant Antibody
|
ADC Antibody
|
Cancer
|
|
Tisotumab (Anti-Human F3 Recombinant Antibody) is a human IgG1 monoclonal antibody and ADC antibody. Tisotumab targets tissue factor (TF). Tisotumab can be used to synthesize antibody-drug conjugates (ADCs) targeting tissue factor (TF), Tisotumab vedotin (HY-152963). Tisotumab can be used for the research of solid tumors .
|
-
- HY-P992354
-
|
INBRX-110
|
TNF Receptor
NF-κB
|
Cancer
|
|
FPA154 is a human monoclonal antibody against TNFRSF18/GITR/CD357. FPA154 activates NF-κB via the GITR pathway. FPA154 can be used in solid tumor research. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P990302
-
|
|
nAChR
|
Neurological Disease
|
|
Anti-Human/Rat/Fish AChR Antibody (Mab35) is an anti-human/rat/fish AChR IgG1 monoclonal antibody. Anti-Human/Rat/Fish AChR Antibody (Mab35) can attack the AChR of neuromuscular junctions. Anti-Human/Rat/Fish AChR Antibody (Mab35) can be used for the construction of myasthenia gravis models .
|
-
- HY-P992213
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-CD79 Antibody is a monoclonal antibody that targets CD79. Anti-CD79 Antibody can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CD79 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P99234
-
|
|
Interleukin Related
ADC Antibody
|
Cancer
|
|
Pivekimab is a human IgG1 monoclonal antibody that targets interleukin-3 (IL-3) and CD123. Pivekimab is used to synthesize pivekimab sunirine, a CD123-directed antibody-active molecule conjugate (ADC). Pivekimab is used in the study of blastic plasmacytoid dendritic cell neoplasm (BPDCN) .
|
-
- HY-P992310
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-UPK-1B Antibody is a monoclonal antibody targeting UPK1B. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-UPK-1B Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992208
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-CD300C Antibody is a monoclonal antibody targeting CD300C. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CD300C Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P99384
-
|
B-701; MFGR-1877S; RG-7444
|
FGFR
|
Cancer
|
|
Vofatamab (B-701) is an anti-FGFR3 monoclonal antibody (mAb). Vofatamab blocks activation of both the wildtype and genetically activated receptor. Vofatamab can be used in the research of metastatic urothelial carcinoma (mUC). Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P992274
-
|
|
Transglutaminase
|
Inflammation/Immunology
|
|
Anti-NGLY1 Antibody is a monoclonal antibody that targets NGLY1. Anti-NGLY1 Antibody can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-NGLY1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992257
-
|
|
Galectin
|
Inflammation/Immunology
|
|
Anti-LGALS3BP Antibody is a monoclonal antibody targeting LGALS3BP. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-LGALS3BP Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P9803
-
|
SARS-80R; SARS Antibody-80R
|
SARS-CoV
|
Infection
|
|
Anti-SARS-80R mAb (SARS-80R) is a human monoclonal IgG1 antibody produced in CHO cells. Anti-SARS-80R mAb can specifically bind to Spike (S1) protein to prevent SARS virus infection of susceptible cells .
|
-
- HY-P992306
-
|
|
Wnt
|
Inflammation/Immunology
|
|
Anti-TEM8 Antibody is a monoclonal antibody targeting TEM8/ANTXR1. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-TEM8 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P9805
-
|
MERS-3A1; MERS Antibody-3A1
|
SARS-CoV
|
Infection
|
|
Anti-MERS-3A1 mAb (MERS-3A1) is a human monoclonal IgG1 antibody with the high binding affinity produced in CHO cells.
Anti-MERS-3A1 mAb bocks the binding of MERS-CoV spike protein to DPP4 receptor .
|
-
- HY-P992276
-
-
- HY-P992265
-
|
|
Monocarboxylate Transporter
|
Inflammation/Immunology
|
|
Anti-MCT1 Antibody is a monoclonal antibody that targets MCT1. Anti-MCT1 Antibody can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-MCT1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992195
-
|
|
FGFR
|
Inflammation/Immunology
|
|
Anti-Beta Klotho Antibody is a monoclonal antibody targeting *Beta Klotho*. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Beta Klotho Antibody, please refer to Human IgG1 (L234A/L235A) kappa, Isotype Control (HY-P991207).
|
-
- HY-P992204
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-CD180 Antibody is a monoclonal antibody that targets CD180. Anti-CD180 Antibody can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CD180 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992268
-
|
|
MEK
|
Inflammation/Immunology
|
|
Anti-MP1 Antibody is a monoclonal antibody that targets MP1. Anti-MP1 Antibody can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-MP1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P9991
-
|
TST001
|
Gap Junction Protein
|
Cancer
|
|
Osemitamab is an IgG1 antibody targeting to human claudin-18.2. Osemitamab consists of human-Mus musculus monoclonal TST001 γ1-chain, disulfide with human-Mus musculus monoclonal TST001 κ-chain, dimer (ACI). Osemitamab in combination with Capecitabine (HY-B0016) and Oxaliplatin (HY-17371), can be used for G/GEJ cancer study .
|
-
- HY-108730
-
|
Anti-human PD-L1, human Antibody; MSB 0010718C; MSB0010718C
|
PD-1/PD-L1
|
Inflammation/Immunology
Cancer
|
|
Avelumab (Anti-Human PD-L1) a fully human IgG1 anti-PD-L1 monoclonal antibody (mAb) with potential antibody-dependent cell-mediated cytotoxicity (ADCC). Avelumab enhances ADCC on several cancer cell lines expressing PD-L1. Avelumab can be used for the study of chordoma .
|
-
- HY-P992344
-
|
|
Transmembrane Glycoprotein
|
Cancer
|
|
DNP002 is a humanized IgG1 monoclonal antibody targeting tumor-associated CEACAM6. DNP002 binds to CEACAM1, CEACAM5 and CEACAM6, and exhibits antibody-dependent cellular cytotoxicity against tumor cells overexpressing these targets. DNP002 binds to CEACAM6 on the surface of tumor-associated neutrophils (including MDSCs) to reverse the immunosuppressive effect in the tumor microenvironment. DNP002 shows anti-tumor activity in advanced solid tumors. DNP002 can be used for the research of advanced solid tumors. The recommended isotype control is human IgG1 kappa (HY-P99001) .
|
-
- HY-P990870
-
|
|
CD19
IFNAR
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-CD19 Antibody (4G7) is an anti-human CD19 IgG1 monoclonal antibody. Anti-CD19 Antibody (4G7) reduces the killing effect of CAR T cells on Raji cells. Anti-CD19 Antibody (4G7) can be used for research on immunology. Anti-CD19 Antibody (4G7) is often used in flow cytometry. The recommend isotype control of Anti-CD19 Antibody (4G7): Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
- HY-P990838
-
|
|
Interleukin Related
IFNAR
|
Inflammation/Immunology
|
|
Anti-IL-12 p70 Antibody (20C2) is an anti-human IL-12 p70 IgG1 monoclonal antibody. Anti-IL-12 p70 Antibody (20C2) can inhibit the production of IFN-γ. Anti-IL-12 p70 Antibody (20C2) can be used for research on inflammation conditions. The recommend isotype control of Anti-IL-12 p70 Antibody (20C2): Rat IgG1 kappa, Isotype Control (HY-P99979) .
|
-
- HY-P992221
-
|
|
Gap Junction Protein
|
Inflammation/Immunology
|
|
Anti-CLDN9 Antibody is a monoclonal antibody targeting CLDN9. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CLDN9 Antibody, please refer to Human IgG1 (L234A/L235A) kappa, Isotype Control (HY-P991207).
|
-
- HY-P992188
-
|
|
TGF-β Receptor
|
Inflammation/Immunology
|
|
Anti-ALK7 Antibody is a monoclonal antibody that targets ALK7. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-ALK7 Antibody, please refer to Human IgG1 (L234A/L235A) kappa, Isotype Control (HY-P991207).
|
-
- HY-P992246
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL-27RA Antibody is a monoclonal antibody that targets IL-27RA. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-27RA Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P99656
-
|
MCDS0593A
|
ADC Antibody
|
Cancer
|
|
Iladatuzumab (MCDS0593A) is a humanized IgG1 anti-human CD79B monoclonal antibody. Iladatuzumab can be used to synthesize antibody-drug conjugates (ADC) Iladatuzumab vedotin (DCDS0780A; HY-P99657), which has the potential for B-cell non-Hodgkin lymphoma (B-NHL) research .
|
-
- HY-P992264
-
|
|
Wnt
|
Inflammation/Immunology
|
|
Anti-LRP6 Antibody is a monoclonal antibody that targets LRP6. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-LRP6 Antibody, please refer to Human IgG1 (L234A/L235A) kappa, Isotype Control (HY-P991207).
|
-
- HY-P992236
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL-17F Antibody is a monoclonal antibody that targets IL-17F. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-17F Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992253
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-L1-CAM Antibody is a monoclonal antibody that targets L1-CAM. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-L1-CAM Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P99813
-
|
HER3-DXd; U3-1402
|
Antibody-Drug Conjugates (ADCs)
|
Cancer
|
|
Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab (HY-P99275) attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patritumab deruxtecan shows anticancer activity .
|
-
- HY-P991066
-
|
ARGX-119
|
nAChR
|
Neurological Disease
|
|
ARGX-119 is a first-in-class humanized agonist monoclonal antibody specific for muscle-specific kinase (MuSK). ARGX-119 can be used for the study of neuromuscular diseases. The isotype control for ARGX-119 can refer to Human IgG1 lambda1, Isotype Control (HY-P99992) .
|
-
- HY-P992242
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL-23R Antibody is a monoclonal antibody that targets IL-23R. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-23R Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992298
-
|
|
Slit Proteins
|
Inflammation/Immunology
|
|
Anti-ROBO2 Antibody is a monoclonal antibody targeting ROBO2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-ROBO2 Antibody, please refer to Human IgG1 (L234A/L235A) kappa, Isotype Control (HY-P991207).
|
-
- HY-P991636
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
AK006 is a humanized IgG1 monoclonal antibody agonist targeting Sialic acid-binding immunoglobulin-like lectin6 (Siglec-6). AK006 potently inhibits IgE-mediated human mast cell activation. AK006 can be used for inflammatory diseases like chronic urticaria (CU) and asthma research .
|
-
- HY-P992193
-
|
|
APC
|
Inflammation/Immunology
|
|
Anti-B7-H7 Antibody is a monoclonal antibody targeting HHLA2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-B7-H7 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992237
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL-17RB Antibody is a monoclonal antibody targeting IL-17RB. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-17RB Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992205
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-CD226 Antibody is a monoclonal antibody targeting CD226. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CD226 Antibody, please refer to Human IgG1 (L234A/L235A) kappa, Isotype Control (HY-P991207).
|
-
- HY-P991247
-
|
|
MHC
|
Cancer
|
|
Anti-HLA-A2 (Hu8F4) is a human monoclonal antibody (mAb) targeting HLA-A2. Anti-HLA-A2 (Hu8F4) can be used in Acute myeloid leukaemia research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P991557
-
|
|
TNF Receptor
|
Inflammation/Immunology
|
|
ABI793 is a human IgG1 anti-human CD154 (CD40 ligand) monoclonal antibody. ABI793 inhibits immune response by blocking the CD154-CD40 (IC50 = 75 nM) signaling pathway. ABI793 effectively prevents kidney transplant rejection. ABI793 can be used for research on immunological rejection .
|
-
- HY-P991196
-
|
|
Transmembrane Glycoprotein
|
Cancer
|
|
Anti-CD24 Antibody (SWA11) is a human IgG1 monoclonal antibody targeting CD24, with high affinity and specificity for CD24-expressing tumor cells. Anti-CD24 Antibody (SWA11) triggers endocytosis, alters STAT3-dependent gene expression, regulates Src phosphorylation, and blocks CD24-mediated signaling pathways. Anti-CD24 Antibody (SWA11) is applicable to cancer-related research such as lung cancer and ovarian cancer. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P9931
-
|
CNTO 1959
|
Interleukin Related
|
Inflammation/Immunology
|
|
Guselkumab is a recombinant human IgG1 monoclonal antibody against the IL-23p19 subunit. Guselkumab binds to human and cynomolgus monkey IL-23 with Kd values of 3.3 and 1.9 pmol/L, respectively. Guselkumab inhibits production of cytokines lying downstream of the IL-23 signaling pathway and can be used for psoriatic arthritis research .
|
-
- HY-P99271A
-
|
Anti-human F3 Recombinant Antibody (powder)
|
ADC Antibody
|
Cancer
|
|
Tisotumab (Anti-Human F3 Recombinant Antibody) (powder) is a human IgG1 monoclonal antibody and ADC antibody. Tisotumab (powder) targets tissue factor (TF). Tisotumab (powder) can be used to synthesize antibody-drug conjugates (ADCs) targeting tissue factor (TF), Tisotumab vedotin (HY-152963). Tisotumab (powder) can be used for the research of solid tumors .
|
-
- HY-P992239
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL-18Rα Antibody is a monoclonal antibody targeting IL-18Ra. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-18Rα Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P99230
-
|
|
Integrin
CD22
|
Cancer
|
|
Pinatuzumab is a humanized monoclonal antibody targeting cell-surface antigen CD22. Pinatuzumab can be used to synthesize antibody-drug conjugate (ADC) such as Pinatuzumab vedotin (HY-141602). Pinatuzumab can be studied in research on cancer such as non-Hodgkin lymphoma. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P9806
-
|
MERS-D12; MERS Antibody-D12
|
SARS-CoV
|
Infection
|
|
Anti-MERS-D12 mAb (MERS-D12; MERS Antibody-D12) is a human monoclonal IgG1. Anti-MERS-D12 mAb binds directly to the DPP4 interacting region of the MERS-CoV Spike receptor binding domain (RBD) and effect neutralization by directly blocking receptor binding .
|
-
- HY-P992260
-
|
|
LILRB
|
Inflammation/Immunology
|
|
Anti-LILRB3 Antibody is a monoclonal antibody targeting LILRB3/ILT5/CD85a. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-LILRB3 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P991532
-
|
MEMD; EJ212/007-Cl2-5
|
ALCAM/CD166
|
Inflammation/Immunology
Cancer
|
|
AT002 (CBAS-173, EJ212/007-Cl2-5) is a recombinant human IgG1 monoclonal antibody. AT002 targets the cell surface protein activated leukocyte adhesion molecule (ALCAM)/CD166. AT002 can be used in the research of cancer, autoimmune diseases and inflammatory diseases.
|
-
- HY-P992259
-
|
|
LILRB
|
Inflammation/Immunology
|
|
Anti-LILRB1 Antibody is a monoclonal antibody targeting LILRB1/CD85j/ILT2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-LILRB1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992286
-
|
|
P2X Receptor
|
Inflammation/Immunology
|
|
Anti-P2XR4 Antibody is a monoclonal antibody targeting P2XR4. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-P2XR4 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P992303
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-Siglec-10/CD24 Antibody is a monoclonal antibody targeting Siglec-10. It can be used in ELISA, FACS, and functional assays. Isotype controls for Anti-Siglec-10/CD24 Antibody can be found in Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P991426
-
|
|
Transmembrane Glycoprotein
IFNAR
TNF Receptor
|
Cancer
|
|
MB-314 is a human IgG1 monoclonal antibody (mAb) targeting Lewis Y. MB-314 induces enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) activity. MB-314 increases the release of IFN-γ, TNF-α, MCP-1, and IL-6. MB-314 can be used in cancer research .
|
-
- HY-P992238
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL-18RAP Antibody is a monoclonal antibody targeting IL-18RAP/IL-18RB. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-18RAP Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P99155
-
|
2F8; HUMAX-EGFR
|
EGFR
|
Cancer
|
|
Zalutumumab is a high affinity, completely human IgG1 monoclonal antibody targeting EGFR. Zalutumumab binds to domain III of the EGF receptor and acts by blocking the binding of EGF and by sterically interfering with the active conformation of the receptor. Zalutumumab binds with IgG and its Fab fragment with EC50s of 7 and 19 nM, respectively. Zalutumumab can be used for the research of cancer .
|
-
- HY-P992133
-
|
SYS6002 Antibody; CRB-701 Antibody
|
ADC Antibody
Nectin-4
|
Cancer
|
|
Sutantatug (SYS6002 Antibody) is a monoclonal antibody targeting Nectin-4, and serves as the antibody moiety of the ADC CRB-701. Sutantatug is applicable to the research of Nectin-4-positive solid tumors, urothelial carcinoma and cervical cancer. The corresponding isotype control for Sutantatug is Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P990869
-
|
|
CD1
IFNAR
Interleukin Related
|
Inflammation/Immunology
Cancer
|
|
Anti-CD1a Antibody (OKT-6) is an anti-human CD1a IgG1 monoclonal antibody. Anti-CD1a Antibody (OKT-6) blocks T cell activation by blocking CD1a function. Anti-CD1a Antibody (OKT-6) can reduce the production of IFN-γ. Anti-CD1a Antibody (OKT-6) can be used for researches on cancer and inflammation such as leukemia. The recommend isotype control of Anti-CD1a Antibody (OKT-6): Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
- HY-P991950
-
|
|
TGF-beta/Smad
|
Inflammation/Immunology
|
|
SHR-1906 is a selective fully humanized monoclonal IgG1 inhibitory antibody targeting CTGF. SHR-1906 specifically binds to CTGF, thereby blocking the interaction between CTGF and TGF-B1 with an inhibition rate of 55%. SHR-1906increases the survival rate in a pulmonary fibrosis model by reducing TGF-β1 levels and inhibiting fibrotic lesions in lung tissue in Bleomycin (HY-108345)-induced pulmonary fibrosis.SHR-1906 can be used for pulmonary fibrosis (IPF) research. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P990043
-
|
VGL101
|
Ser/Thr Kinase
TREM receptor
|
Inflammation/Immunology
|
|
Iluzanebart is a human monoclonal IgG1 antibody and is the agonist antibody for human TREM2 (hTREM2). Iluzanebart improves the survival and function of microglia by activating the TREM2 signaling pathway to compensate for the loss of CSF1R function. Iluzanebart can be used for research of adult-onset leukoencephalopathy associated with CSF1R (colony stimulating factor 1 receptor) (CSF1R-ALSP) .
|
-
- HY-P99229
-
|
XMT-1535; Upinitatug
|
ADC Antibody
|
Cancer
|
|
Upifitamab is a humanized monoclonal antibody targeting NaPi2b. Upifitamab can be used to synthesize ADC such as Upfitamab rilsodotin. Upfitamab rilsodotin can be used in research for solid tumors including high-grade serious epithelial ovarian, fallopian tube and primary peritoneal cancer (OC). Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-164957
-
|
SGN-B6A; PF-08046047
|
Antibody-Drug Conjugates (ADCs)
Integrin
|
Cancer
|
|
SGN-B6A is an ADC, which targets integrin beta-6 (ITGB6) through human IgG1 monoclonal antibody Sigvotatug (HY-P990764), and exhibits cytotoxicity against multiple integrin beta-6-positive cancer cell through mitotic inhibitor MMAE (HY-15162) .
|
-
- HY-P991214
-
|
EMD 273066; huKS-IL2
|
Interleukin Related
|
Cancer
|
|
Tucotuzumab celmoleukin (EMD 273066) is an immunocytokine. Tucotuzumab celmoleukin consists of the following components: an IgG1 monoclonal antibody targeting human EpCAM antigen, and two molecules of IL2. Tucotuzumab celmoleukin binds to EpCAM. Tucotuzumab celmoleukin exerts anti-tumor effects on colon adenocarcinoma in synergy with radiofrequency ablation. Tucotuzumab celmoleukin can be used in research related to colon adenocarcinoma and colon cancer .
|
-
- HY-P99190
-
|
BMS-936557; MDX-1100
|
CXCR
|
Inflammation/Immunology
|
|
Eldelumab (BMS-936557) is a human anti-CXCL10 (IP-10) monoclonal antibody (IgG1 type). Eldelumab selectively binds to CXCL10 and blocks CXCL10-induced calcium flux and cell migration. Eldelumab can be used in studies of autoimmune and auto-inflammatory diseases such as rheumatoid arthritis, ulcerative colitis and crohn's disease .
|
-
- HY-P99754
-
|
BCD-085
|
Interleukin Related
|
Infection
Inflammation/Immunology
|
|
Netakimab (BCD-085) is a humanized IgG1κ monoclonal anti-IL-17 antibody that binds to and blocks IL-17 and IL-17A activity, including reduction of downstream IL-6 production. Netakimab can be used for the research of moderate-to-severe plaque psoriasis, ankylosing spondylitis, and COVID-19 with cytokine release syndrome . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P990781
-
-
- HY-P991961
-
|
|
CTLA-4
|
Cancer
|
|
REGN4659 is a fully human anti-CTLA-4 monoclonal antibody and IgG1 antibody. REGN4659 binds to the extracellular domain of human and monkey CTLA-4 with high affinity and specificity. REGN4659 blocks CTLA-4 interaction with CD80 and CD86 ligands. REGN4659 significantly suppresses MC38.Ova tumor growth in CTLA-4 knock-in mice .
|
-
- HY-P992453
-
|
MTBT1466A; RG-6315
|
TGF-β Receptor
|
Neurological Disease
Inflammation/Immunology
|
|
RO-7303509 (MTBT1466A; RG-6315) is a human monoclonal antibody and TGFβ3 neutralizer. RO-7303509 targets the profibrotic mediator TGFβ3 to alleviate fibrosis. RO-7303509 can be administered via subcutaneous or intravenous routes and is used in research on systemic sclerosis . Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
- HY-P99155A
-
|
|
EGFR
|
Cancer
|
|
Zalutumumab (powder) is a high affinity, completely human IgG1 monoclonal antibody targeting EGFR. Zalutumumab (powder) binds to domain III of the EGF receptor and acts by blocking the binding of EGF and by sterically interfering with the active conformation of the receptor. Zalutumumab (powder) binds with IgG and its Fab fragment with EC50s of 7 and 19 nM, respectively. Zalutumumab (powder) can be used for the research of cancer .
|
-
- HY-P990031
-
|
M-6223
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
Cancer
|
|
Dargistotug (M-6223) is a fully human IgG1 monoclonal antibody targeting TIGIT (T cell immune receptor with Ig domain and ITIM). TIGIT is an inhibitory immune checkpoint that promotes NK cell depletion and reduces the secretion of cytokines by binding to CD155 and other antibodies. It can also directly or indirectly inhibit effector T cells and upregulate Tregs cells, thereby exerting immunosuppression. Function .
|
-
- HY-P992241
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL-21R Antibody is a monoclonal antibody targeting IL-21R. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-21R Antibody, please refer to Human IgG1 (L234A/L235A) kappa, Isotype Control (HY-P991207).
|
-
- HY-P991475
-
|
|
Transmembrane Glycoprotein
NF-κB
IFNAR
|
Cancer
|
|
MG-1131 is a human monoclonal antibody (mAb) targeting TIGIT. MG-1131 activates NF-κB signaling in T cells and enhances NK-mediated tumor killing activity in a PVR-dependent manner. MG-1131 blocks TIGIT to increase IFN-γ secretion. MG-1131 can be used in anti-tumor immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P991430
-
|
TB-403
|
VEGFR
|
Cancer
|
|
RO5323441 (TB-403) is a human IgG1 monoclonal antibody (mAb) targeting PlGF. RO5323441 inhibits the binding of human PlGF-1 or PlGF-2 to VEGFR-1 (IC50 values are 0.1 and 0.2 nM, respectively). RO5323441 blocks PlGF-induced VEGFR-1 phosphorylation in Flt-1-transfected HEK293 cells. RO5323441 has antitumor activity .
|
-
- HY-P992215
-
|
|
LILRB
|
Inflammation/Immunology
|
|
Anti-CD85a/LILRB3 Antibody (7C5) is a human monoclonal antibody targeting LILRB3/ILT5/CD85a. Anti-CD85a/LILRB3 Antibody (7C5) can be used for research on inflammatory and immune diseases. The recommended isotype control is human IgG1 kappa, isotype control (HY-P99001).
|
-
- HY-P991455
-
|
|
TNF Receptor
|
Cancer
|
|
PTX-35 is a human IgG monoclonal antibody (mAb) targeting TNFRSF25. PTX-35 reduces the suppressive activity of regulatory T cells and enhances CD4+ T cell effector responses in a mouse melanoma model. PTX-35 can be used in Islet cell transplant rejection and Solid tumours research. Recommended isotype control: Human IgG1 lambda2, Isotype Control (HY-P990096) .
|
-
- HY-P991365
-
|
|
Transmembrane Glycoprotein
|
Endocrinology
|
|
DS-1501 is a human monoclonal antibody (mAb) targeting Siglec-15/CD33L3. DS-1501 inhibits osteoclastogenesis. DS-1501 suppresses the decrease of lumbar spine bone mineral density (BMD) in ovariectomized (OVX) rats. DS-1501 can be used in Osteoporosis research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-108730A
-
|
|
PD-1/PD-L1
|
Inflammation/Immunology
Cancer
|
|
Avelumab (anti-PD-L1) a fully human IgG1 anti-PD-L1 monoclonal antibody (mAb) with potential antibody-dependent cell-mediated cytotoxicity (ADCC). Avelumab (anti-PD-L1) enhances ADCC on several cancer cell lines expressing PD-L1. Avelumab (anti-PD-L1) can be used for the study of chordoma .
|
-
- HY-P992404
-
|
|
TNF Receptor
|
Cancer
|
|
MDX-1401 is a fully human IgG1 (κ isotype) monoclonal antibody against CD30, with a Kd value of 0.83 nmol/L. MDX-1401 induces antibody-dependent cellular cytotoxicity in CD30-expressing cells and inhibits tumor growth in CD30 + lymphoma xenograft models. MDX-1401 can be used in research related to malignant lymphoma and Hodgkin lymphoma .
|
-
- HY-145644
-
|
C-135-LS; BMS-986414
|
SARS-CoV
|
Infection
Cancer
|
|
Ogalvibart (C-135-LS) is a human anti-SARS-CoV-2 monoclonal antibody (IgG1 type). Ogalvibart binds to the spike (S) glycoprotein receptor-binding domain (RBD) of SARS-CoV-2. Ogalvibart in combination with C144LS (1:1 ratio) shows good preventive activity and can effectively block the development of COVID19 in a rhesus monkey disease model .
|
-
- HY-P991465
-
|
|
TNF Receptor
|
Cancer
|
|
Anti-CD27 Antibody (M2177) is a human monoclonal antibody (mAb) targeting TNFRSF7/CD27. Anti-CD27 Antibody (M2177) inhibits the binding of sCD70 to human CD27 ECD-Fc. Anti-CD27 Antibody (M2177) can be used in the study of anti-tumor immunity. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P991466
-
|
|
TNF Receptor
|
Cancer
|
|
Anti-CD27 Antibody (M2191) is a human monoclonal antibody (mAb) targeting TNFRSF7/CD27. Anti-CD27 Antibody (M2191) inhibits the binding of sCD70 to human CD27 ECD-Fc. Anti-CD27 Antibody (M2191) can be used in the study of anti-tumor immunity. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P990867
-
|
|
Insulin Receptor
Akt
|
Cancer
|
|
Anti-CD220/Insulin Receptor Antibody (IR 83-22) is an anti-human CD220/Insulin Receptor IgG1 monoclonal antibody. Anti-CD220/Insulin Receptor Antibody (IR 83-22) can block Akt overactivation caused by Trip13 deficiency. Anti-CD220/Insulin Receptor Antibody (IR 83-22) can be used for research on cancer such as hepatocellular carcinoma (HCC). Anti-CD220/Insulin Receptor Antibody (IR 83-22) often used in western blotting. The recommend isotype control of Anti-CD220/Insulin Receptor Antibody (IR 83-22): Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
- HY-P990690
-
|
MEDI-5752
|
PD-1/PD-L1
CTLA-4
|
Cancer
|
|
Volrustomig (MEDI-5752) is a human IgG1 κ monoclonal antibody targeting CTLA4/PD1. The isotype control for Volrustomig is Human IgG1 kappa, Isotype Control (HY-P99001). Volrustomig anchors to the surface of T cells by binding PD-1, induces PD-1 internalization and degradation, and preferentially inhibits CTLA-4 on activated PD-1 + T cells. Volrustomig binds to tumor-infiltrating lymphocytes and a subset of PD-1 + B cells, enhances T cell function and IFNγ secretion. Volrustomig reduces the activation of non-tumor-infiltrating lymphocytes and exhibits manageable toxicity. Volrustomig can be used in research on various cancers, such as non-small cell lung cancer, gastric cancer, hepatobiliary cancer, and cervical cancer .
|
-
- HY-P991888
-
|
|
STAT
|
Cardiovascular Disease
Cancer
|
|
INCA033989 is a fully human IgG1 monoclonal antibody targeting mutCALR (KD = 1.75 nM for mutCALR del52; KD = 6.78 nM for mutCALR ins5). INCA033989 antagonizes mutCALR-driven signaling and proliferation. INCA033989 selectively inhibits pSTAT3/pSTAT5. INCA033989 prevents thrombocytosis and reduces the expansion of mutCALR-positive cells. INCA033989 is useful for research on myeloproliferative neoplasms .
|
-
- HY-P991458
-
|
|
Transmembrane Glycoprotein
|
Cancer
|
|
hu3S193 is a human IgG monoclonal antibody (mAb) targeting Lewis Y. hu3S193 has excellent immune effector function (complement-dependent cytotoxicity) (IC50: 1.0 μg/ml) and antibody-dependent cellular cytotoxicity (IC50: 5.0 μg/ml). hu3S193 can be used in small cell lung cancer (SCLC) research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P99315
-
|
BG 9588; Anti-human CD40L Recombinant Antibody; Hu5c8
|
TNF Receptor
|
Inflammation/Immunology
|
|
Ruplizumab (BG 9588) is a humanized anti-CD40L IgG1κ monoclonal antibody. By binding to CD40L, Ruplizumab blocks its interaction with the CD40 receptor, inhibits T-B cell costimulatory signals, and mediates the depletion of activated T cells via the Fc segment. Ruplizumab has immunosuppressive effects. Ruplizumab can be used in the study of systemic lupus erythematosus, organ transplant rejection, and autoimmune diseases. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P991883
-
|
Licartin; Metuximab; Mehuzumab
|
Apoptosis
CDK
Caspase
Bcl-2 Family
|
Cancer
|
|
Metuzumab (Licartin) is a human-mouse chimeric IgG1 monoclonal antibody targeting CD147. Metuzumab induces Apoptosis, reduces levels of Cyclin D1, full-length Caspase-3, and Bcl-2, and increases Bax expression. Metuzumab enhances the sensitivity of non-small cell lung cancer (NSCLC) cells to Gemcitabine (HY-17026). Metuzumab is applicable for research on hepatocellular carcinoma and non-small cell lung cancer [1] [2].
|
-
- HY-P991995
-
|
OMTX705 antibody
|
ADC Antibody
FAP
|
Cancer
|
|
OMTX005 (OMTX705 antibody) is a humanized anti-FAP IgG1 monoclonal antibody that specifically binds to human (EC50: 0.33 nM)/mouse (EC50: 0.14 nM) FAP proteins and FAP-positive cells. OMTX005 exhibits no cytotoxicity when used alone and fails to induce an increase in caspase 3/7 activity in relevant cells. OMTX005 can be used to synthesize the ADC molecule OMTX705 for tumor research .
|
-
- HY-P99780
-
|
BIIB033
|
Transmembrane Glycoprotein
|
Neurological Disease
Inflammation/Immunology
|
|
Opicinumab (BIIB033) is a human IgG1 monoclonal antibody targeting LINGO-1. Opicinumab binds LINGO-1 to block its negative regulatory signaling, suppress axonal degeneration, enhance axonal regeneration, promote remyelination, and exert neuroprotective effects. Opicinumab maintains axonal protective effects during co-administration with methylprednisolone. Opicinumab can be used for the research of multiple sclerosis, acute optic neuritis, and optic neuritis. .
|
-
- HY-P99111
-
|
CNTO-148
|
TNF Receptor
Apoptosis
Interleukin Related
Caspase
|
Inflammation/Immunology
Cancer
|
|
Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research .
|
-
- HY-P991425
-
|
|
Transmembrane Glycoprotein
|
Cancer
|
|
AT-1413 is a human monoclonal antibody (mAb) targeting CD43. AT-1413 induces antibody-dependent cell-mediated cytotoxicity (ADCC) in melanoma cell lines and acute myeloid leukemia (AML) cells. AT-1413 has antitumor activity in AML mouse models. AT-1413 can be used in Acute myeloid leukaemia, Breast cancer, Malignant melanoma and Myelodysplastic syndromes research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P991364
-
|
PYX-106; BSI-060T
|
Transmembrane Glycoprotein
|
Cancer
|
|
Aldastotug (PYX-106; BSI-060T) is a human monoclonal antibody (mAb) targeting Siglec-15/CD33L3. Aldastotug reverses Siglec-15-mediated immunosuppression and enhances T-cell proliferation. Aldastotug induces significantly increased levels of IFNγ and TNFα in T cells. Aldastotug can be used in cancer immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P99551
-
|
KBSA301; AR-301
|
Antibiotic
Bacterial
|
Infection
|
|
Tosatoxumab (AR-301; KBSA301) is a human immunoglobulin G1 monoclonal antibody that specifically neutralizes alpha-toxin (alpha-hemolysin; Hla) of S. aureus. Tosatoxumab binds to an N-terminal epitope of alpha-toxin, thereby preventing functional toxin pore oligomerisation. Tosatoxumab has the potential for passive immunotherapy in the S. aureus pneumonia as an adjunctive therapy to standard antibiotic agent. Recommend Isotope Control: Human IgG1 lambda1, Isotype Control (HY-P99992) .
|
-
- HY-P990239
-
|
|
HSP
Akt
Interleukin Related
|
Inflammation/Immunology
Cancer
|
|
Anti-Human/Mouse GRP78 Antibody (N88) is an anti-human/mouse GRP78 IgG1 monoclonal antibody. Anti-Human/Mouse GRP78 Antibody (N88) can activate the Akt signaling pathway. Anti-Human/Mouse GRP78 Antibody (N88) can inhibit the expression of inflammatory factors and plasminogen activator inhibitors induced by TLR agonists. Anti-Human/Mouse GRP78 Antibody (N88) can be used for research on inflammation conditions. Anti-Human/Mouse GRP78 Antibody (N88) can be used for immunoprecipitation .
|
-
- HY-P991082
-
|
SAR-428926 antibody
|
Transmembrane Glycoprotein
|
Cancer
|
|
Anti-LAMP1/CD107a Antibody (SAR-428926 antibody) is an anti-LAMP1 humanized monoclonal antibody. Anti-LAMP1/CD107a Antibody can be used for the antibody part of SAR-428926. Antibody Anti-LAMP1/CD107a Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P990661
-
|
|
c-Met/HGFR
ERK
PERK
|
Cancer
|
|
SAIT-301 is a Met-targeting monoclonal antibody. SAIT-301 inhibits Met activation, induces downregulated expression of phosphorylated Met(p-Met) and phosphorylated ERK(p-ERK), and reduces EGR-1 expression. SAIT-301 inhibits the migration and invasion of nasopharyngeal carcinoma cells. SAIT-301 is applicable to relevant research on nasopharyngeal carcinoma. For the isotype control of SAIT-301, refer to Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P991447
-
|
|
VISTA
|
Cancer
|
|
Anti-VSIR/VISTA Antibody (SG7) is a human monoclonal antibody (mAb) targeting VISTA/B7-H5. Anti-VSIR/VISTA Antibody (SG7) inhibits VISTA function and prevents PSGL-1 and VSIG3 from binding to VISTA. Anti-VSIR/VISTA Antibody (SG7) has anti-tumor activity in the mouse B16F10 melanoma model. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P991424
-
|
|
Interleukin Related
STAT
|
Inflammation/Immunology
|
|
GSK2618960 is a human monoclonal antibody (mAb) targeting IL-7Ra/CD127. GSK2618960 inhibits IL-7-induced STAT5 phosphorylation. GSK2618960 enhances CD4 T cell proliferation response and increases CD83, CD86, and CD209 expression in PBMCs. GSK2618960 can be used for the research of autoimmune and allergic inflammatory diseases. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P991595
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
HB-0017 is a humanized IgG1κ monoclonal antibody inhibitor, targeting IL-17A. HB-0017 inhibits the IL-6 secretion induced by IL-17A with an IC50 of 2.09 nM. HB-0017 significantly decreases ear thickness in Imiquimod (HY-B0180)-induced psoriasis-like mice model and alleviates inflammations in IL-17A-induced arthritis and air pouch mice model. The isotype control for the HB-0017 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P991958
-
|
|
CTLA-4
|
Cancer
|
|
GIGA-564 is a fully human anti-CTLA4 IgG1 monoclonal antibody with a Kd of 9.8 nM. GIGA-564 binds to a unique epitope of CTLA-4, mediates FcR-dependent signaling pathways, depletes CTLA-4-highly-expressing regulatory T cells within tumors, and inhibits the proliferation of peripheral regulatory T cells. GIGA-564 exhibits anti-tumor activity in mouse models. GIGA-564 can be used for tumor research .
|
-
- HY-P99646
-
|
MEDI6570
|
LOX-1
|
Metabolic Disease
Inflammation/Immunology
|
|
Gocdacimab (MEDI6570) is a fully human IgG1 monoclonal antibody inhibitor targeting the lectin-like oxidized low-density lipoprotein receptor LOX-1. By binding to LOX-1 and blocking its function, gocdacimab effectively reduces the level of free soluble LOX-1, thereby inhibiting key pathological processes such as lipid accumulation, foam cell formation, and vascular wall inflammation. Gocdacimab can interfere with atherosclerosis-related mechanisms, and it is used for research on atherosclerosis, and type 2 diabetes mellitus .
|
-
- HY-P99620
-
|
CT-P22; CT120
|
Influenza Virus
|
Infection
|
|
Firivumab (CT-P22; CT120) is a human IgG1 monoclonal influenza A virus hemagglutinin (Anti-IAV HA) antibody. Firivumab is capable of neutralizing H1N1, H5N1, H6N1, H6N2, H8N4, H8N8, H9N2 and H12N7. Firivumab shows protection against H1N1 virus in mice .
|
-
- HY-P991468
-
|
|
Interleukin Related
|
Cancer
|
|
IMM20324 is a human monoclonal antibody (mAb) targeting IL38. IMM20324 inhibits the interaction of IL-38 with human IL1RAPL1-Fc and human IL-36R-Fc with IC50 values of 1.267 nM and 1.4667 nM, respectively. IMM20324 has antitumor activity in the B16.F10 syngeneic mouse model. IMM20324 can be used in antitumor immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P991565
-
|
|
c-Met/HGFR
|
Cancer
|
|
CE-355621 is a humanized anti-c-Met IgG1 monoclonal antibody. CE-355621 can effectively bind with human c-Met (KD = 200 pM, IC50 = 466 pM) in A549 cells and cyno c-Met (KD = 610 pM) in cynomolgus kidney cells. CE-355621 inhibits the c-Met signaling pathway by blocking HGF binding. CE-355621 significantly inhibits the growth of tumors dependent on the c-Met/HGF pathway. CE-355621 can be used for research on cancer such as glioblastoma and gastric cancer .
|
-
- HY-185483
-
|
|
Antibody-Drug Conjugates (ADCs)
Transmembrane Glycoprotein
Microtubule/Tubulin
|
Cancer
|
|
AMG-172 is an antibody-drug conjugate (ADC) composed of a fully human IgG1 monoclonal anti-CD27L antibody conjugated to DM1 (HY-19792) via the non-cleavable linker MCC. AMG-172 releases the intracellular active component Lysine-MCC-DM through catabolism. Lysine-MCC-DM inhibits the assembly and disassembly dynamics of Microtubule and induces cell arrest at metaphase. AMG-172 can be used for research on relapsed/refractory clear cell renal cell carcinoma .
|
-
- HY-P991598
-
|
MOR12743; MOR03207
|
Interleukin Related
NF-κB
|
Inflammation/Immunology
|
|
MOR-106 (MOR12743) is a humanized anti-IL-17C IgG1 monoclonal antibody. MOR-106 inhibits the NF-κB signaling pathway by specifically binding to IL-17C (IC50 = 59 pM for human IL-17C, IC50 = 55 pM for mouse IL-17C). MOR-106 can effectively inhibit skin inflammation and reduce related inflammatory factors in animal models of psoriasis and atopic dermatitis .
|
-
- HY-P992450
-
|
|
TNF Receptor
|
Cancer
|
|
REGN6569 is a fully human IgG1 monoclonal antibody targeting glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) with high specificity for GITR. REGN6569 exerts stronger in vitro antibody-dependent cell-mediated cytotoxicity (ADCC) against regulatory T cells expressing GITR. REGN6569 selectively depletes regulatory T cells via antibody-dependent cell-mediated cytotoxicity and increases the proportion of proliferative natural killer (NK) cells in peripheral blood. REGN6569 is applicable for advanced solid malignancies. Isotype control: HY-P99001 .
|
-
- HY-P992381
-
|
|
Drug Derivative
|
Cancer
|
|
IBI352g4a is a humanized IgG1 monoclonal antibody targeting PVRIG (Kd = 0.53 nM) and acts as a PVRIG/PVRL2 inhibitor. The anti-tumor effect of IBI352g4a depends on the binding of its Fc region to FcγR. IBI352g4a binds to the extracellular domains of human and cynomolgus monkey PVRIG, and blocks the PVRIG-PVRL2 interaction. IBI352g4a induces NK cell activation, promotes their degranulation and tumor killing. IBI352g4a can be used in the research of gastric cancer .
|
-
- HY-P99361
-
|
PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab)
|
TNF Receptor
|
Cancer
|
|
Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .
|
-
- HY-P99390
-
|
MCLA 117
|
CD3
Interleukin Related
IFNAR
TNF Receptor
|
Inflammation/Immunology
Cancer
|
|
Tepoditamab (MCLA-117) is a full-length human IgG1 bispecific monoclonal antibody that binds to CLEC12A of myeloid cells and CD3 of cytotoxic T cells. Among others, CLEC12A is a myeloid differentiation antigen. Tepoditamab kills AML leukaemia mother cells and AML leukaemia stem cells, induces T cell-mediated proliferative lysis of AML cells. Tepoditamab induces upto 30-fold T-cell expansion. Tepoditamab results in moderate to strong cytokine (IFNγ, IL-6, IL-8, IL-10, and TNFα) and IFNγ release in human whole blood and PBMC, respectively. Tepoditamab can be used in acute myeloid leukaemia (AML) research .
|
-
- HY-P991000
-
|
AU-007; BD-8; BDG8
|
Interleukin Related
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
Imneskibart (AU-007) is a human monoclonal antibody that binds to the CD25-binding epitope of interleukin-2 (IL-2), blocking the binding of IL-2 to the trimeric IL-2 receptor while retaining the ability to bind to the dimeric IL-2 receptor. Imneskibart expands effector T cell and NK cell populations, reduces regulatory T cells, increases the effector T cell/regulatory T cell ratio, and alleviates vascular leakage. Imneskibart can be used in research related to melanoma and non-small cell lung cancer. The corresponding isotype control is: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P991381
-
|
PPMX-T003
|
Transferrin Receptor
Reactive Oxygen Species (ROS)
Ferroptosis
|
Cancer
|
|
JST‑TfR09 (PPMX‑T003) is a human monoclonal antibody (mAb) targeting transferrin receptor 1 (TfR1/CD71). JST‑TfR09 blocks the binding of transferrin to TfR1, inhibits TfR1 internalization, and suppresses cellular iron uptake. JST‑TfR09 triggers ferritin degradation via activating the autolysosomal system, promotes ROS production and lipid peroxidation, and ultimately induces ferroptosis. JST‑TfR09 exhibits cytotoxicity toward human erythroblasts differentiated from hematopoietic stem cells. JST-TfR09 can be used in leukemia research. Recommended isotype control: Human IgG1 lambda, Isotype Control (HY-P99992) .
|
-
- HY-P990132
-
|
|
CD47
|
Inflammation/Immunology
Cancer
|
|
Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) is an anti-mouse/rat/human CD47/IAP IgG1 monoclonal antibody. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) can effectively block CD47 signaling and enhance macrophage phagocytic function. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) can increase the infiltration of immune cells. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) may interfere with wound healing. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) can be used for researches on cancer and inflammation conditions such as breast cancer and intestinal mucosal repair .
|
-
- HY-P99488
-
|
JSP-191; AMG-191
|
c-Kit
|
Inflammation/Immunology
Cancer
|
|
Briquilimab (JSP-191 or AMG-191) is a humanized IgG1 monoclonal antibody that binds human CD117 (c-Kit). Briquilimab blocks the interaction between CD117 receptor and stem cell factor on various CD117 expressing tissues. Briquilimab can lead to inhibition of SCF/c-Kit signaling and MC apoptosis. Briquilimab is a non-toxic approach to target and deplete HSC, enabling blood and immune reconstitution with minimal toxicity with the other agents being used for transient immune suppression to prevent immunologic rejection. Briquilimab can be used in various disease research such as severe combined immunodeficiency (SCID), myelodyplastic syndromes (MDS), acute myeloid leukemia (AML), chronic spontaneous urticarial (CSU), chronic inducible urticarial (CIndU) and asthema .
|
-
- HY-P11084
-
|
|
MHC
|
Inflammation/Immunology
Cancer
|
|
WT1 126-134 peptide is a Wilms' tumor oncogene protein (WT1) peptide (RMFPNAPYL). WT1 126-134 peptide is presented by HLA-A0201 and induces cytotoxic CD8 T cells capable of killing WT1+ positive tumor cells. WT1 126-134 can form stable complexes with the H-2Db (mouse) or HLA-A0201 (human) molecules. WT1 126-134 peptide/HLA-A0201 complex has an extremely high affinity (Kd = 0.2 nM) with the humanized monoclonal antibody (IgG1). WT1 126-134 peptide can be used as a vaccine for T cells or as a target for antibodies .
|
-
- HY-P11084A
-
|
|
MHC
|
Inflammation/Immunology
Cancer
|
|
WT1 126-134 peptide acetate is a Wilms' tumor oncogene protein (WT1) peptide (RMFPNAPYL). WT1 126-134 peptide acetate is presented by HLA-A0201 and induces cytotoxic CD8 T cells capable of killing WT1+ positive tumor cells. WT1 126-134 can form stable complexes with the H-2Db (mouse) or HLA-A0201 (human) molecules. WT1 126-134 peptide acetate/HLA-A0201 complex has an extremely high affinity (Kd = 0.2 nM) with the humanized monoclonal antibody (IgG1). WT1 126-134 peptide acetate can be used as a vaccine for T cells or as a target for antibodies .
|
-
- HY-P992410
-
|
|
PAI-1
TGF-beta/Smad
|
Inflammation/Immunology
|
|
MEDI-579 is a fully human monoclonal antibody against PAI-1, with a KD value of 6 pM for human PAI-1 and 105 pM for rat PAI-1. MEDI-579 restores renal plasmin activity and inhibits PAI-1-mediated intracellular signal transduction. MEDI-579 reduces albuminuria, glomerulosclerosis severity, TGF-β1 expression level, and phosphorylated Smad2 level induced in diabetic mice. MEDI-579 decreases the levels of active PAI-1 in plasma and kidneys, and increases plasma plasmin level in a mouse model of lupus nephritis. MEDI-579 can be used in research related to diabetic nephropathy and lupus nephritis. The recommended isotype control is human IgG1 kappa (HY-P99001) .
|
-
- HY-P992212
-
|
|
L-Selectin
|
Inflammation/Immunology
|
|
Anti-CD62L Antibody (DREG-200) is a human monoclonal antibody targeting CD62L/L-selectin. Anti-CD62L Antibody (DREG-200) binds to residues 45, 46 and 47 of L-selectin, and blocks L-selectin-mediated interactions, neutrophil rolling, adhesion, aggregation, secondary anchoring, as well as leukocyte rolling on ligands. Anti-CD62L Antibody (DREG-200) reduces myocardial necrosis, coronary endothelial dysfunction, and neutrophil migration driven by neutrophil microparticles. Anti-CD62L Antibody (DREG-200) exerts cardioprotective effects in feline models. Anti-CD62L Antibody (DREG-200) can be used in studies related to myocardial ischemia-reperfusion injury. The recommended isotype control is Mouse IgG1 kappa (HY-P99977) .
|
-
- HY-P99447
-
|
ASN-1
|
Bacterial
|
Infection
|
|
Atidortoxumab is a human IgG1κ monoclonal antibody that targets Staph aureus alpha toxin .
|
-
- HY-P9909
-
-
- HY-P99057A
-
|
CDX-1127 (anti-CD27)
|
TNF Receptor
Transmembrane Glycoprotein
|
Inflammation/Immunology
Cancer
|
|
Varlilumab (CDX-1127) (anti-CD27) is an agonist anti-CD27 monoclonal antibody. Varlilumab (anti-CD27) can promote T cell expansion and activate the immune response. Varlilumab (anti-CD27) has anti-tumor activity and can be used in the research of hematological malignancies and solid tumors .
|
-
- HY-P99057
-
|
CDX-1127
|
TNF Receptor
Transmembrane Glycoprotein
|
Inflammation/Immunology
Cancer
|
|
Varlilumab (CDX-1127) is an agonist anti-CD27 monoclonal antibody. Varlilumab can promote T cell expansion and activate the immune response. Varlilumab has anti-tumor activity and can be used in the research of hematological malignancies and solid tumors .
|
-
- HY-P99014
-
|
ARGX-110
|
Fc Receptor (FcR)
NF-κB
|
Inflammation/Immunology
Cancer
|
|
Cusatuzumab (ARGX-110) is a selective competitive blocker targeting CD70 (with an equilibrium dissociation constant of 17 pM for binding to human CD70). Cusatuzumab also possesses enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) activity. It is a humanized IgG1 monoclonal antibody, artificially synthesized through humanization and genetic engineering modifications (CH2 region mutation to enhance effector function). Cusatuzumab has a dual mechanism of action: firstly, it competitively blocks the interaction between CD70 and CD27, inhibiting the CD27-NF-κB signaling pathway, reducing regulatory T cell (Treg) activation and tumor cell proliferation; secondly, by enhancing binding to FcγRIIIa, it mediates ADCC and antibody-dependent cellular phagocytosis (ADCP), directly lysing CD70-positive tumor cells. Cusatuzumab can efficiently eliminate leukemia stem cells (LSCs), induce tumor cell differentiation and apoptosis, restore immune surveillance, and target CD70-positive tumors. Cusatuzumab is used in the study of acute myeloid leukemia (AML) .
|
-
- HY-P9966
-
|
MGA271
|
CD276/B7-H3
|
Cancer
|
|
Enoblituzumab (MGA271) is a humanized IgG1κ monoclonal antibody recognizing human B7-H3 protein, a member of the B7 family of immune regulators .
|
-
- HY-P99040
-
|
JNJ-61610588; CI-8993; VSTB112
|
VISTA
|
Cancer
|
|
Onvatilimab (JNJ-61610588) is a human IgG1κ anti-VISTA (V-domain Ig Suppressor of T-cell Activation) monoclonal antibody. Onvatilimab can be used in colorectal cancer research .
|
-
- HY-P9901
-
|
MDX-010; BMS-734016
|
CTLA-4
|
Cancer
|
|
Ipilimumab is a fully human monoclonal antibody IgG1κ that blocks the inhibitory receptor cytotoxic T lymphocyte antigen 4 (CTLA-4) on T cells. Ipilimumab can be used in unresectable or metastatic melanoma (MM) studies .
|
-
- HY-P99424
-
|
RG 7624; RO 5553110; NI-1401
|
Interleukin Related
|
Inflammation/Immunology
|
|
Afasevikumab (RG 7624; RO 5553110; NI-1401) is a fully human monoclonal IgG1κ antibody neutralizing both IL-17A and IL-17F. Afasevikumab has anti-inflammatory activities .
|
-
- HY-P99669
-
|
MDX-060
|
TNF Receptor
|
Cancer
|
|
Iratumumab (MDX-060) a human anti-CD30 IgG1κ monoclonal antibody. Iratumumab inhibits the growth of CD30-expressing tumor cells. Iratumumab can be used for research of Hodgkin's lymphoma (HL) and anaplastic large-cell lymphoma (ALCL) .
|
-
- HY-P99039
-
|
MEDI9447
|
CD73
|
Cancer
|
|
Oleclumab (MEDI9447) is a human IgG1λ monoclonal antibody targeting CD73 and inhibits the exonuclease activity of the extracellular enzyme CD73. Oleclumab can adjust the composition of bone marrow and lymphoid infiltrating leukocyte populations in the tumor microenvironment and has anti-tumor activity .
|
-
- HY-P992330
-
|
KB312
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
CBT004 (KB312) is a human IgG1κ type monoclonal antibody against CD83. CD83 is a type I transmembrane glycoprotein and is a highly expressed marker on the surface of mature DCs. It can also be induced to be expressed on activated B cells, some activated T cells, and activated monocytes.
|
-
- HY-P992326
-
|
|
PDGFR
|
Inflammation/Immunology
Cancer
|
|
BOT1711 is a human IgG1κ monoclonal antibody targeting PDGFRB/CD140b. PDGFRB/CD140b belongs to type I receptor tyrosine kinases (RTKs), and is mainly expressed in vascular smooth muscle cells, pericytes, fibroblasts, certain mesenchymal stem cells, and tumor stromal cells.
|
-
- HY-P99313
-
|
Anti-human IGHE Recombinant Antibody
|
Apoptosis
|
Inflammation/Immunology
|
|
Quilizumab (Anti-Human IGHE Recombinant Antibody) is a humanized IgG1κ monoclonal antibody targeting immunoglobulin epsilon (also konwn as: IGHE, IgE). Quilizumab targets the M1-prime fragment of membrane-expressed IGHE/IgE, leading to IGHE/IgE switching and memory B cell depletion. Quilizumab has potential in asthma research .
|
-
- HY-P991651
-
|
|
Fc Receptor (FcR)
|
Inflammation/Immunology
|
|
MEDI4212 is a humanized IgG1λ monoclonal antibody inhibitor targeting IgE. MEDI4212 potently inhibits human IgE-mediated functional responses through its receptor FcεRI, such as calcium signaling, β-hexosaminidase release and phagocytosis. MEDI4212 prevents the binding of IgE to CD23 with an IC50 of 8 nM. MEDI4212 can be used severe asthma research .
|
-
- HY-P99583
-
|
MEDI4893
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Suvratoxumab (MEDI4893) is a long-acting, high-affinity human anti-α-toxin monoclonal antibody (IgG1κ type). Suvratoxumab potently neutralizes α-toxin, a key S. aureus virulence factor. Suvratoxumab improves survival and reduces lung injury in an immunocompromised mice model of pneumonia. Suvratoxumab also enhances the antibacterial activity of Vancomycin (HY-B0671) or Linezolid (HY-10394) .
|
-
- HY-P99340
-
|
VIR 7831; GSK-4182136
|
SARS-CoV
|
Infection
Cancer
|
|
Sotrovimab (VIR 7831) is a human IgG1κ pan-sarbecovirus monoclonal antibody (mAb), neutralizes SARS-CoV-2, SARS-CoV-1, and multiple other sarbecoviruses. Sotrovimab is developed based on S309, exhibits a long half-life and great bioavailability in the respiratory mucosa. Sotrovimab could result in immune-mediated viral clearance and prevent progression of Covid-19 early in the course of disease .
|
-
- HY-P991567
-
|
VX5/5261
|
CXCR
|
Inflammation/Immunology
Cancer
|
|
VX5 (VX5/5261) is a humanized IgG1κ monoclonal antibody inhibitor targeting BCA-1/CXCL13. VX5 significantly inhibits human CXCL13-mediated internalization of CXCR5, blocks both human and mouse CXCL13-dependent B-cells chemotaxis and migration. VX5 can be used to study autoimmune diseases like multiple sclerosis and arthritis, and cancers like gastric lymphomas and colon cancer .
|
-
- HY-P99410
-
|
AMG 714; PRV-015
|
Interleukin Related
|
Inflammation/Immunology
|
|
Ordesekimab (AMG 714; PRV-015) is a fully human IgG1κ anti-IL-15 (Interleukin Related) monoclonal antibody. The binding of Ordesekimab to IL-15 inhibits the interaction of IL-15 with the IL-2Rβ and common γ chain of the IL-15 receptor complex, but not with the IL-15Rα chain. Ordesekimab has the potential for study of nonresponsive celiac disease (NRCD) .
|
-
- HY-P99952
-
|
SCT400
|
CD20
|
Cardiovascular Disease
Inflammation/Immunology
Endocrinology
Cancer
|
|
Ripertamab (SCT400) is a recombinant human-mouse chimeric anti-CD20 IgG1κ monoclonal antibody. As an immunomodulator, ripertamab reduces the levels of pathogenic autoantibodies, alleviates immune complex deposition, and blocks the antigen-presenting function of cells. Ripertamab depletes CD20-positive cells. Ripertamab can induce infusion-related reactions, pulmonary toxicity, neutropenia and thrombocytopenia. Ripertamab is applicable to research related to non-Hodgkin's lymphoma, primary membranous nephropathy and idiopathic membranous nephropathy .
|
-
- HY-P991229
-
|
AGS-1C4D4; AGS-PSCA
|
Complement System
|
Cancer
|
|
AGS-1C4D4 is a fully human IgG1κ monoclonal antibody targeting PSCA, with a Ka value of 0.2 nM. AGS-1C4D4 mediates antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) against PSCA-expressing cells. AGS-1C4D4 can be used for the research of pancreatic cancer .
|
-
- HY-P991566
-
|
|
CTLA-4
|
Cancer
|
|
KD6001 is a humanized IgG1κ monoclonal antibody, targeting CTLA4. KD6001 significantly disrupts CTLA-4 interactions with CD80 (IC50: 16 ng/mL) and CD86. KD6001 enhances IL-2 and IFNγ expression in PHA-activated human lymphocytes and exhibits potent antitumor effects. KD6001 effectively inhibits tumor growth in MC38, B16, and Hepa1-6 tumor mice model. KD6001 can be used for cancers research, such as advanced melanoma, hepatocellular carcinoma and liver cancer .
|
-
- HY-P991223
-
|
|
Transmembrane Glycoprotein
TNF Receptor
|
Cancer
|
|
NC762 is a humanized IgG1κ monoclonal antibody that targets human B7-H4 (B7 homolog 4). NC762 has enhanced binding to CD16a (FcγRIIIa) after being Fc engineered with three point mutations (S239D/A330L/I332E; DLE) and demonstrate increased antibody-dependent cellular cytotoxicity (ADCC) activity. NC762 inhibits tumor growth in vivo through binding to tumor-expressing B7-H4. NC762 can be studies in research on cancer such as advanced or metastatic solid tumors .
|
-
| Cat. No. |
Nom du produit |
Type |
-
- HY-164153
-
|
|
Fluorescent Dyes
|
|
ADC Control Human IgG1-vcMMAE (solution) is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-vcMMAE and can inhibit tubulin polymerization. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is vcMMAE (HY-15575) .
|
-
- HY-164152A
-
|
|
Fluorescent Dyes
|
|
ADC Control Human IgG1-Deruxtecan (DAR 8) is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-Deruxtecan and can inhibit DNA topoisomerase I. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E) .
|
-
- HY-164152
-
|
|
Fluorescent Dyes
|
|
ADC Control Human IgG1-Deruxtecan (DAR 4) is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-Deruxtecan and can inhibit DNA topoisomerase I. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E) .
|
-
- HY-164154
-
|
|
Fluorescent Dyes
|
|
ADC Control Human IgG1-vcMMAF is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-vcMMAF and can inhibit tubulin polymerization. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is MC-Val-Cit-PAB-MMAF (vcMMAF; HY-112786) .
|
| Cat. No. |
Nom du produit |
Target |
Research Area |
-
- HY-P3203A
-
|
|
TNF Receptor
|
Inflammation/Immunology
|
|
DSTYSLSSTLTLSK TFA is a generic human peptide and can be used for infliximab quantitative detection . Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α.
|
-
- HY-P11084
-
|
|
MHC
|
Inflammation/Immunology
Cancer
|
|
WT1 126-134 peptide is a Wilms' tumor oncogene protein (WT1) peptide (RMFPNAPYL). WT1 126-134 peptide is presented by HLA-A0201 and induces cytotoxic CD8 T cells capable of killing WT1+ positive tumor cells. WT1 126-134 can form stable complexes with the H-2Db (mouse) or HLA-A0201 (human) molecules. WT1 126-134 peptide/HLA-A0201 complex has an extremely high affinity (Kd = 0.2 nM) with the humanized monoclonal antibody (IgG1). WT1 126-134 peptide can be used as a vaccine for T cells or as a target for antibodies .
|
-
- HY-P3203
-
-
- HY-P11084A
-
|
|
MHC
|
Inflammation/Immunology
Cancer
|
|
WT1 126-134 peptide acetate is a Wilms' tumor oncogene protein (WT1) peptide (RMFPNAPYL). WT1 126-134 peptide acetate is presented by HLA-A0201 and induces cytotoxic CD8 T cells capable of killing WT1+ positive tumor cells. WT1 126-134 can form stable complexes with the H-2Db (mouse) or HLA-A0201 (human) molecules. WT1 126-134 peptide acetate/HLA-A0201 complex has an extremely high affinity (Kd = 0.2 nM) with the humanized monoclonal antibody (IgG1). WT1 126-134 peptide acetate can be used as a vaccine for T cells or as a target for antibodies .
|
| Cat. No. |
Nom du produit |
Target |
Research Area |
Image |
-
- HY-P9908
-
-
(5)
-
- HY-P99001
-
-
(5)
-
- HY-164153
-
|
|
Antibody-Drug Conjugates (ADCs)
Microtubule/Tubulin
|
Cancer
|
|
ADC Control Human IgG1-vcMMAE (solution) is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-vcMMAE and can inhibit tubulin polymerization. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is vcMMAE (HY-15575) .
|
-
(5)
-
- HY-164152
-
|
|
Antibody-Drug Conjugates (ADCs)
Topoisomerase
|
Cancer
|
|
ADC Control Human IgG1-Deruxtecan (DAR 4) is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-Deruxtecan and can inhibit DNA topoisomerase I. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E) .
|
-
(5)
-
- HY-P990764
-
|
SGN-B6A antibody
|
Integrin
ADC Antibody
|
Inflammation/Immunology
Cancer
|
|
Sigvotatug (SGN-B6A antibody) is a human IgG1 κ monoclonal antibody against ITGB6.
Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
Sigvotatug can be used as an ADC antibody to synthesize ADC Sigvotatug vedotin (HY-164957) .
|
-
(5)
-
- HY-P990591
-
|
Aletekitug
|
Interleukin Related
|
Inflammation/Immunology
|
|
GSK-1070806 (Aletekitug) is a humanized IgG1/κ monoclonal antibody targeting IL-18. GSK-1070806 neutralizes IL-18 activity.GSK-1070806 can be used for the research of inflammation. The isotype control for GSK-1070806 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
-
- HY-P99262
-
|
BAX69; Anti-human MIF Recombinant Antibody
|
Macrophage migration inhibitory factor (MIF)
|
Cancer
|
|
Imalumab (BAX69) is a recombinant, human IgG1 monoclonal antibody that targets macrophage inhibitory factor (MIF). Imalumab can be used for the research of ovarian carcinoma, recurrent malignant ascites and cancer .
|
-
(5)
-
- HY-P991442
-
|
TAK-920
|
TREM receptor
|
Neurological Disease
|
|
DNL-919 (TAK-920) is a human IgG1 monoclonal antibody (mAb) targeting TREM-2. DNL-919 can be used in Alzheimer's disease research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
-
- HY-P991204
-
|
ARX517 antibody
|
PSMA
|
Cancer
|
|
Anti-PSMA Antibody (ARX517 antibody) is a humanized IgG1 monoclonal antibody that targets PSMA. Anti-PSMA Antibody is the antibody part of the ADC molecule ARX517. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
-
- HY-P99423
-
|
ADG 20
|
SARS-CoV
|
Infection
|
|
Adintrevimab (ADG 20) is a human IgG1 monoclonal SARS-CoV (SARS-CoV) antibody. Adintrevimab inhibits SARS-CoV-2 variants and other SARS-like coronaviruses with pandemic potential .
|
-
(5)
-
- HY-P99995
-
|
|
Inhibitory Antibodies
|
Inflammation/Immunology
|
|
Human IgG1 (K214R) kappa, Isotype Control is a human IgG1 kappa monoclonal antibody mutant with a lysine-to-arginine substitution at position 214. Human IgG1 (K214R) kappa, Isotype Control is mainly used as an isotype control in experiments such as immunoprecipitation. Human IgG1 (K214R) kappa, Isotype Control binds to proteins non-specifically, thereby helping researchers verify the interactions of specific antibodies and ensure the accuracy of experimental results .
|
-
(5)
-
- HY-P990100
-
-
(5)
-
- HY-P991280
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
BMS-981164 is a human anti-IL31 IgG1-κ monoclonal antibody. BMS-981164 effectively inhibits the IL-31 signaling pathway. The isotype control of BMS-981164 can be referenced to Human IgG1 kappa, Isotype Control (HY-P99001). BMS-981164 is applicable to research related to atopic dermatitis .
|
-
(5)
-
- HY-P99514
-
|
AGEN1884
|
CTLA-4
|
Cancer
|
|
Zalifrelimab (AGEN1884) is a fully human IgG1 monoclonal antibody targeting CTLA-4 (CTLA-4). Zalifrelimab antagonizes the inhibitory checkpoints of immune cell activation regulated by CTLA-4 signaling .
|
-
(5)
-
- HY-P991422
-
-
(5)
-
- HY-164154
-
|
|
Antibody-Drug Conjugates (ADCs)
Microtubule/Tubulin
|
Cancer
|
|
ADC Control Human IgG1-vcMMAF is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-vcMMAF and can inhibit tubulin polymerization. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is MC-Val-Cit-PAB-MMAF (vcMMAF; HY-112786) .
|
-
(5)
-
- HY-P990756
-
|
|
SARS-CoV
|
Inflammation/Immunology
|
|
Pemivibart is an anti-SARS-CoV-2 human IgG1 λ2 monoclonal antibody . Recommend Isotype Controls: Human IgG1 lambda2, Isotype Control (HY-P990096).
|
-
(5)
-
- HY-P990766
-
|
AZD3152
|
SARS-CoV
|
Infection
|
|
Sipavibart (AZD3152) is a human IgG1 λ2 monoclonal antibody against SARS-CoV-2. Sipavibart is applicable to research related to COVID-19. The isotype control product for Sipavibart is Human IgG1 lambda2, Isotype Control (HY-P990096) .
|
-
(5)
-
- HY-P99233
-
|
HuMax-TAC
|
ADC Antibody
Transmembrane Glycoprotein
Interleukin Related
|
Cancer
|
|
Camidanlumab (HuMax-TAC) is a humanized IgG1 monoclonal antibody against CD25. Camidanlumab can be used to synthesize the ADC molecule Camidanlumab tesirine (HY-141599). Camidanlumab can be used in the research of tumors such as lymphoma and leukemia. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
-
- HY-P99603
-
|
SEA-CD40
|
Inhibitory Antibodies
|
Cancer
|
|
Cifurtilimab (SEA-CD40) is an agonistic nonfucosylated, human IgG1 monoclonal antibody directed against CD40. Cifurtilimab shows antitumor activities .
|
-
(5)
-
- HY-P9957
-
|
ABthrax
|
Bacterial
|
Infection
|
|
Raxibacumab (ABthrax) is a human IgG1 monoclonal antibody against Bacillus anthracis protective antigen (PA). Raxibacumab blocks the toxin’s deleterious effects by preventing binding of the protective antigen component of the anthrax toxin to its receptors in host cells, thereby blocking the toxin’s deleterious effects. Raxibacumab can be used for anti-anthrax research .
|
-
(5)
-
- HY-P991075
-
|
|
NAMPT
|
Inflammation/Immunology
|
|
ALT-100 (Human IgG1) is a humanized IgG1 monoclonal antibody that targets NAMPT. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
-
- HY-P990734
-
-
(5)
-
- HY-P990767
-
-
(5)
-
- HY-P991164
-
|
AZD5335 Antibody; INT-019
|
Antifolate
|
Inflammation/Immunology
|
|
Torvutatug is an anti-FOLR1 human IgG1 κ monoclonal antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
-
- HY-P99034
-
-
(5)
-
- HY-P991207
-
-
(5)
-
- HY-P99347
-
-
(5)
-
- HY-P99540
-
|
PSB-205; QL1706 (iparomlimab/tuvonralimab); PBS105
|
CTLA-4
|
Cancer
|
|
Tuvonralimab (PSB-205) is a humanized IgG1 monoclonal antibody against CTLA-4. Tuvonralimab can be used in the research of tumors. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
-
- HY-P991106
-
|
LY-3076226 antibody
|
FGFR
|
Cancer
|
|
IMC-D11 (LY-3076226 antibody) is an IgG1 monoclonal antibody against FGFR3. IMC-D11 can be used for the antibody part of LY3076226. IMC-D11 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
-
- HY-P990697
-
|
ARX-788
|
EGFR
|
Inflammation/Immunology
|
|
Anvatabart is an anti-ERBB2 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
-
- HY-P990728
-
|
SP-7219; STRO-001 Antibody
|
CD74
|
Inflammation/Immunology
|
|
Bezetabart is an anti-CD74 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
-
- HY-P990729
-
|
VB-119
|
CD19
|
Inflammation/Immunology
|
|
Budoprutug is an anti-CD19 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
-
- HY-P990687
-
-
(5)
-
- HY-P990694
-
|
TG-1801
|
CD19
CD47
|
Inflammation/Immunology
|
|
Zeripatamig is an anti-CD19/CD47 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
-
- HY-P991175
-
-
(5)
-
- HY-P991191
-
-
(5)
-
- HY-P991052
-
|
|
TNF Receptor
|
Cancer
|
|
GSK-3174998 is a humanized IgG1 OX40/TNFRSF4 agonistic monoclonal antibody. GSK-3174998 has the potential for the study of advanced solid tumors. The isotype control for GSK-3174998 can refer to Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
-
- HY-P990755
-
|
|
EGFR
|
Inflammation/Immunology
|
|
Pamvatamig is an anti-EGFR/MET human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
-
- HY-P990686
-
|
|
TNF Receptor
|
Inflammation/Immunology
|
|
Ispectamab is an anti-TNFRSF17 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
-
- HY-P990760
-
-
(5)
-
- HY-P990747
-
|
CM-313
|
CD38
|
Inflammation/Immunology
|
|
Lumrotatug is an anti-CD38 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
-
- HY-P991333
-
-
(5)
-
- HY-P990745
-
|
HIB210; MOR044254; MOR210; TJ-210; TJ-210001; WBP2191
|
Complement System
|
Inflammation/Immunology
|
|
Izastobart is an anti-C5AR1 human IgG1 λ2 monoclonal antibody . Recommend Isotype Controls: Human IgG1 lambda2, Isotype Control (HY-P990096).
|
-
(5)
-
- HY-P991374
-
|
|
Tau Protein
|
Neurological Disease
|
|
PNT001 is a human IgG1 monoclonal antibody (mAb) targeting cis-pT231 Tau. PNT001 can be used in Neurodegenerative disorders and Traumatic brain injuries research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
-
- HY-P991187
-
|
AGX-101 Antibody
|
Transmembrane Glycoprotein
|
Cancer
|
|
Anti-TM4SF1 Antibody (AGX-A07) is a humanized IgG1 monoclonal antibody that targets TM4SF1. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
-
- HY-P991279
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Mik-Beta-1 is a human IgG1-kappa anti-IL2RB monoclonal antibody. The isotype control of Mik-Beta-1 can be referenced to Human IgG1 kappa, Isotype Control (HY-P99001). Mik-Beta-1 can be used in research related to the prevention of allograft rejection .
|
-
(5)
-
- HY-P991743
-
|
|
Ras
|
Others
|
|
Anti-KRAS Antibody is a human-derived IgG1 kappa monoclonal antibody against KRAS.
|
-
(5)
-
- HY-P991341
-
|
|
Cadherin
|
Inflammation/Immunology
|
|
FF-21101 is a human IgG1 monoclonal antibody (mAb) targeting CDH3/P-cadherin. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
-
- HY-P991185
-
|
|
c-Met/HGFR
|
Cancer
|
|
Anti-MST1R Antibody (MOR07692) is a humanized IgG1 monoclonal antibody that targets MST1R. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P990764B
-
|
|
Integrin
|
Inflammation/Immunology
Cancer
|
|
Sigvotatug (Biotinylated) is a biotinylated derivative of Sigvotatug (HY-P990764). Sigvotatug (Biotinylated) is a humanized IgG1 κ monoclonal antibody inhibitor against ITGB6. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991072
-
|
MAPP-66
|
HIV
HSV
|
Infection
|
|
MB-66 (MAPP-66) is a fully human IgG1 antibody that targets HSV and HIV. MB-66 is a monoclonal antibody film for vaginal application. The isotype control for MB-66 can refer to Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P990700
-
|
RO-7247669; RG-6139
|
PD-1/PD-L1
LAG-3
|
Inflammation/Immunology
|
|
Tobemstomig is an anti-PDCD1/LAG3 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P990701
-
|
RO-7121661
|
PD-1/PD-L1
|
Inflammation/Immunology
|
|
Lomvastomig is an anti-PDCD1/HAVCR2 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P991195
-
|
SIM1811-03
|
TNF Receptor
|
Cancer
|
|
SIM-0235 is humanized immunoglobulin G1 (IgG1) monoclonal antibody that targets and inhibits TNFR2, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) [1].
|
-
(5)
- HY-P990727
-
-
(5)
- HY-P991300
-
|
|
LAG-3
|
Cancer
|
|
GSK2831781 is a human IgG1 monoclonal antibody (mAb) targeting CD223/LAG3. GSK2831781 can be used in the study of ulcerative colitis Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P99324
-
|
Anti-human EGFR Recombinant Antibody; CetuxiMab-GEX, GEXMab52201
|
EGFR
Apoptosis
|
Cancer
|
|
Tomuzotuximab (Anti-Human EGFR Recombinant Antibody) is a fully human glycoengineered IgG1 monoclonal antibody against EGFR. Tomuzotuximab has anticancer effects .
|
-
(5)
- HY-P991495
-
|
|
RSV
|
Infection
|
|
VIR-8190 is a human IgG1 monoclonal antibody (mAb) targeting F, Fusion glycoprotein F0. VIR-8190 can be used in respiratory syncytial virus (RSV) and metapneumovirus infections research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P991292
-
|
|
ADC Antibody
|
Cancer
|
|
AB-3A4 is a human IgG1 monoclonal antibody (mAb) targeting KAAG1. AB-3A4 can be used in the study of ovarian cancer, triple-negative breast cancer, and prostate cancer. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991448
-
|
|
Glycoprotein VI
|
Cancer
|
|
MDX-1414 is a human IgG1 monoclonal antibody (mAb) targeting GPC3. MDX-1414 has antitumor activity in the HepG2 xenograft model. MDX-1414 can be used in liver cancer research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991311
-
|
|
LPL Receptor
Wnt
|
Cancer
|
|
GSK3178022 is a human IgG1 monoclonal antibody (mAb) targeting LRP6. GSK3178022 inhibits the expression of WNT target genes SP5 and AXIN2. GSK3178022 has antitumor activity in the RSPO fusion model of colorectal cancer. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991165
-
|
KVA-12123; KVA-12.1
|
Fc Receptor (FcR)
|
Others
|
|
Trovostobart is an anti-VSIR human IgG1 κ monoclonal antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P990746
-
-
(5)
- HY-P990754
-
|
M-1224
|
c-Kit
|
Inflammation/Immunology
|
|
Opelkibart is an anti-KIT human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P990749
-
|
AK-115
|
Trk Receptor
|
Inflammation/Immunology
|
|
Luvagrobart is an anti-NGF human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P990739
-
|
BA-3071
|
CTLA-4
|
Inflammation/Immunology
|
|
Evalstotug is an anti-CTLA4 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P990775
-
|
XTX101
|
CTLA-4
|
Inflammation/Immunology
|
|
Vilastobart is an anti-CTLA4 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P990768
-
|
|
SARS-CoV
|
Inflammation/Immunology
|
|
Timcevibart is an anti-SARS-CoV-2 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P991116
-
-
(5)
- HY-P990705
-
|
REGN-15160
|
SARS-CoV
|
Inflammation/Immunology
|
|
Gorivitug is an anti-SARS-CoV-2 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P990725
-
|
|
SARS-CoV
|
Inflammation/Immunology
|
|
Nisfevitug is an anti-SARS-CoV-2 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P990771
-
|
INCA-00186
|
CD73
|
Inflammation/Immunology
|
|
Uprevstobart is an anti-NT5E human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P991170
-
|
|
SARS-CoV
|
Infection
|
|
Ibramvibart is an anti-SARS-CoV-2 Spike human IgG1 κ monoclonal antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991177
-
|
RC-108 antibody
|
c-Met/HGFR
|
Cancer
|
|
Anti-c-Met/HGFR Antibody is a humanized IgG1 monoclonal antibody that targets c-Met. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P990711
-
|
|
SARS-CoV
|
Inflammation/Immunology
|
|
Canrivitug is an anti-SARS-CoV-2 human IgG1 λ2 monoclonal antibody . Recommend Isotype Controls: Human IgG1 lambda2, Isotype Control (HY-P990096).
|
-
(5)
- HY-P991304
-
|
|
Inhibitory Antibodies
|
Cancer
|
|
IO-106 is a human IgG1 monoclonal antibody (mAb) targeting LAIR1/CD305. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991305
-
|
|
Transmembrane Glycoprotein
|
Cancer
|
|
AGEN-1571 is a human IgG1 monoclonal antibody (mAb) targeting ILT2. AGEN-1571 promotes adaptive and innate immune responses. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001)
|
-
(5)
- HY-P991314
-
|
|
MDM-2/p53
|
Cancer
|
|
NMC-001 is a human IgG1 monoclonal antibody (mAb) targeting MDM2. NMC-001 can be used in pancreatic cancer research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991484
-
|
|
Influenza Virus
|
Infection
|
|
ADI-65534 is a human IgG1 monoclonal antibody (mAb) targeting Envelopment polyprotein, M polyprotein. ADI-65534 can be used in Hantavirus infection research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991483
-
|
|
Influenza Virus
|
Infection
|
|
ADI-65533 is a human IgG1 monoclonal antibody (mAb) targeting Envelopment polyprotein, M polyprotein. ADI-65533 can be used in Hantavirus infection research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991482
-
|
|
Influenza Virus
|
Infection
|
|
ADI-42898 is a human IgG1 monoclonal antibody (mAb) targeting Envelopment polyprotein, M polyprotein. ADI-42898 binds to the Gn/Gc complex and blocks the cell entry of seven HCPS- and HFRS-associated hantaviruses. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991184
-
|
|
Inhibitory Antibodies
|
Cancer
|
|
Anti-LY6G6D Antibody (1G4) is a humanized IgG1 monoclonal antibody that targets LY6G6D. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P991445
-
|
|
SARS-CoV
|
Infection
|
|
REGN3051 is a human IgG1 monoclonal antibody (mAb) targeting MERS CoV. REGN3051 reduces viral titers in the lungs of mice expressing human DPP4. REGN3051 decreases lung disease severity and viral replication in marmosets inoculated with MERS-CoV. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991493
-
|
|
RSV
|
Infection
|
|
AR-201 is a human IgG1 monoclonal antibody (mAb) targeting F, Fusion glycoprotein F0. AR-201 has anti-respiratory syncytial virus (RSV) activity. AR-201 can be used in lower respiratory tract illness (LRTI) research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P991173
-
|
|
Notch
|
Cancer
|
|
AMG-119 is a humanized IgG1 monoclonal antibody that targets delta-like ligand 3 (DLL3). AMG-119 can be used for the study of relapsed/refractory (R/R) small cell lung cancer (SCLC). Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P992337
-
|
|
ROR
|
Cancer
|
|
CS5001 Antibody is an IgG1 human monoclonal antibody targeting ROR1. CS5001 Antibody can be used for the synthesis of the ADC CS5001. It is applicable to research related to advanced solid tumors and lymphomas. The recommended isotype control is human IgG1 kappa (HY-P99001) .
|
-
(5)
- HY-P991903
-
|
|
CD20
|
Cancer
|
|
PSB102 is a humanized Fc-enhanced IgG1 monoclonal antibody directed against the human B-cell-specific cell surface antigen and tumor-associated antigen CD20 .
|
-
(5)
- HY-P990772
-
-
(5)
- HY-P990744
-
-
(5)
- HY-P990684
-
-
(5)
- HY-P990769
-
-
(5)
- HY-P992375
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
HuMax-IL15 is a human IgG1 monoclonal antibody against IL-15. HuMax-IL15 is applicable to the research of rheumatoid arthritis. The recommended isotype control is human IgG1 kappa (HY-P99001) .
|
-
(5)
- HY-P992443
-
-
(5)
- HY-P992148
-
|
ZL-1310 Antibody
|
Notch
|
Cancer
|
|
Zocilurtatug is a human monoclonal antibody against DLL3. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P992139
-
|
|
VEGFR
|
Others
|
|
Valancitug is a human monoclonal antibody targeting VEGFA. Its corresponding isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P99745
-
-
(5)
- HY-P992400
-
|
|
Tau Protein
|
Neurological Disease
|
|
Lu AF87908 is an IgG1 monoclonal antibody targeting the p-Ser396/404 epitope of tau protein, which mainly binds to the pSer396 region. Lu AF87908 can be used in the research of Alzheimer's disease. The recommended isotype control is human IgG1 kappa (HY-P99001) .
|
-
(5)
- HY-P992117
-
|
DCSZ-11
|
Complement System
|
Cancer
|
|
Lexucitug (DCSZ-11) is a humanized monoclonal antibody targeting CD93. The antibody isotype of Lexucitug is human IgG1κ; the recommended isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P992184
-
|
ASN004 Antibody
|
Wnt
|
Cancer
|
|
Anti-5T4 scFv-Fc Antibody (ASN004 Antibody) is a human IgG1 monoclonal antibody targeting TPBG. Anti-5T4 scFv-Fc Antibody (ASN004 Antibody) can be used in cancer research. The recommended isotype control is human IgG1 kappa (HY-P99001).
|
-
(5)
- HY-108852
-
|
CHI 621
|
Interleukin Related
|
Inflammation/Immunology
Cancer
|
|
Basiliximab (CHI 621) is a recombinant chimeric murine/human IgG1 monoclonal anti-interleukin-2 receptor antibody. Basiliximab can be used for the research of renal transplantation .
|
-
(5)
- HY-P992128
-
|
|
EGFR
|
Others
|
|
Rinumafusp alfa is a human monoclonal antibody targeting ERBB3/HER3. The corresponding isotype control is: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P990096
-
|
|
Inhibitory Antibodies
|
Inflammation/Immunology
|
|
Human IgG1 lambda2, Isotype Control is a human monoclonal antibody that is the isotype control of human IgG1λ antibody. Isotype control antibodies can help remove non-specific signals from experimental results and assess the accuracy and reliability of the experiment .
|
-
(5)
- HY-P9905
-
Cetuximab
Maximum Cited Publications
53 Publications Verification
C225; IMC-C225
|
Radionuclide-Drug Conjugates (RDCs)
EGFR
|
Cancer
|
|
Cetuximab (C225) is a human IgG1 monoclonal antibody that inhibits epidermal growth factor receptor (EGFR), with a Kd of 0.201 nM for EGFR by SPR. Cetuximab has potent antitumor activity .
|
-
(5)
- HY-P991197
-
|
LM-305 antibody; AZD-0305 antibody
|
CD3
|
Cancer
|
|
Anti-GPRC5D Antibody (LM-305 antibody) is a humanized IgG1 monoclonal antibody that targets GPRC5D. Anti-GPRC5D Antibody is the antibody part of the ADC molecule LM-305. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992412
-
|
|
Claudin
|
Cancer
|
|
MIL93 is a humanized defucosylated IgG1 monoclonal antibody targeting Claudin18.2 (CLDN18.2) with enhanced antibody-dependent cellular cytotoxicity (ADCC) activity. MIL93 can be used for research on advanced solid tumors and gastric cancer. The recommended isotype control is human IgG1 kappa (HY-P99001) .
|
-
(5)
- HY-P992118
-
|
|
TREM receptor
|
Inflammation/Immunology
|
|
Lifonebart is a humanized monoclonal antibody targeting TREM2 (triggering receptor expressed on myeloid cells 2). The antibody isotype of Lifonebart is human IgG1κ, and the recommended isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P990014
-
|
IMC-001; STI-3031
|
PD-1/PD-L1
|
Inflammation/Immunology
Cancer
|
|
Danburstotug (IMC-001) is an IgG1-lambda anti-CD274 (PDL1, B7 homologue 1, B7H1) human monoclonal antibody. Danburstotug also is immunostimulant and antineoplastic .
|
-
(5)
- HY-P992402
-
|
|
Transmembrane Glycoprotein
|
Cancer
|
|
MAI1738 is a human monoclonal antibody targeting PODXL. MAI1738 can be used for cancer-related research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P990015
-
|
VIR-3434
|
HBV
|
Infection
|
|
Tobevibart (VIR-3434) is a human IgG1 lambda monoclonal antibody against hepatitis B virus (HBV) surface antigen (HBsAg). Tobevibart shows potent neutralization against HBsAg from all HBV genotypes in vitro and inhibits viral entry of HBV and hepatitis delta virus (HDV). Recommend Isotype Controls: Human IgG1 lambda2, Isotype Control (HY-P990096) .
|
-
(5)
- HY-P99307
-
|
AMG-203; Anti-human CSF2 Recombinant Antibody
|
c-Fms
|
Inflammation/Immunology
|
|
Namilumab (AMG203) is a human IgG1 monoclonal antibody that binds with high affinity to the GM-CSF ligand, potently neutralizing GM-CSF. Namilumab can be used for the research of rheumatoid arthritis .
|
-
(5)
- HY-P99807
-
|
BCD-100
|
PD-1/PD-L1
|
Cancer
|
|
Prolgolimab (BCD-100) is a human IgG1 anti-PD-1 monoclonal antibody containing the Fc-silencing 'LALA' mutation. Prolgolimab can be used for the research of advanced melanoma .
|
-
(5)
- HY-P991446
-
|
|
Influenza Virus
|
Infection
|
|
MEDI-8852 is a human IgG1 monoclonal antibody against influenza A virus hemagglutinin (HA). MEDI-8852 binds to the conserved HA stalk epitope and neutralizes viral infectivity. MEDI-8852 reduces viral titers in mouse lung tissues. MEDI-8852 is applicable to research related to pandemic influenza . Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P99337
-
|
Ansuvimab-zyk; mAb114
|
Filovirus
|
Infection
|
|
Ansuvimab (Ansuvimab-zyk) is a recombinant human monoclonal IgG1 antibody that exhibits antiviral activity against Zaire ebolavirus. Ansuvimab binds to the glycoprotein on Zaire ebolavirus to block its entry into host cells .
|
-
(5)
- HY-P99955
-
-
(5)
- HY-P991434
-
|
|
Integrin
|
Inflammation/Immunology
|
|
SAN-300 is a human IgG1 monoclonal antibody (mAb) targeting ITGA1/VLA-1. SAN-300 can be used in Rheumatoid arthritis research .
|
-
(5)
- HY-P99889
-
|
BRII-198
|
SARS-CoV
|
Infection
|
|
Romlusevimab (BRII-198) is a neutralizing recombinant human IgG1 monoclonal antibody against the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) .
|
-
(5)
- HY-P9S0008
-
|
|
Radionuclide-Drug Conjugates (RDCs)
EGFR
|
Cancer
|
|
Cetuximab (PBS) is a human IgG1 monoclonal antibody that can inhibit EGFR. The SPR method measured the Kd value of Cetuximab for EGFR to be 0.201 nM; Cetuximab has a highly effective anti-tumor effect .
|
-
(5)
- HY-P992399
-
|
|
TNF Receptor
NF-κB
|
Cancer
|
|
LBL-019 is a humanized IgG1 monoclonal antibody targeting TNFR2. LBL-019 costimulates TNFR2 and activates the NF-κB signaling pathway in an Fc crosslinking-dependent manner. LBL-019 can be used for the research of advanced malignant tumors, including hepatocellular carcinoma and melanoma. The recommended isotype control is human IgG1 kappa (HY-P99001) .
|
-
(5)
- HY-P991041
-
|
Anti-SEZ6 Antibody (SC17); ABBV-011 antibody; ABBV-706 antibody
|
ADC Antibody
|
Cancer
|
|
Turmetabart (Anti-SEZ6 Antibody (SC17)) is a humanized anti-SEZ6 IgG1 monoclonal antibody. Anti-SEZ6 Antibody (SC17) can be used to synthesize antibody-drug conjugates (ADC) product, ABBV-011. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991174
-
|
|
TREM receptor
|
Inflammation/Immunology
|
|
Anti-TREM2 Antibody (AL2p-58) is a humanized IgG1 monoclonal antibody targeting TREM2. Anti-TREM2 Antibody (AL2p-58) can be used for the research of neuroinflammation. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P992110
-
|
DB-1311 Antibody; BNT324 Antibody
|
CD276/B7-H3
|
Cancer
|
|
Elfetabart (DB-1311 Antibody; BNT324 Antibody) is a humanized monoclonal antibody targeting CD276 with antitumor activity. The antibody isotype of Elfetabart is human IgG1κ, and the recommended isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P99278
-
|
MT 201; Anti-human EPCAM Recombinant Antibody
|
Inhibitory Antibodies
|
Cancer
|
|
Adecatumumab (Anti-Human EPCAM Recombinant Antibody; MT201) is a full human monoclonal antibody of the IgG1 isotype, targeting human EpCAM. Adecatumumab is expressed in almost all adenocarcinomas, and its activity is not dependent of K-Ras status .
|
-
(5)
- HY-P99322
-
|
LFG316; Anti-human C5 Recombinant Antibody
|
Complement System
|
Inflammation/Immunology
|
|
Tesidolumab (LFG316) is a fully-human IgG1/λ anti-C5 monoclonal antibody of 143 kDa (without glycosylation). Tesidolumab (LFG316) blocks cleavage of C5 and prevents subsequent formation of the membrane attack complex .
|
-
(5)
- HY-P99900
-
|
MSL-109
|
CMV
|
Infection
|
|
Sevirumab (MSL-109) is a human IgG1 neutralizing monoclonal antibody against cytomegalovirus (CMV). Sevirumab recognizes CMV gH complexes and inhibits CMV replication with an EC50 of 0.3 μg/mL .
|
-
(5)
- HY-P9922
-
|
IMC-3G3; LY3012207
|
PDGFR
|
Cancer
|
Olaratumab (IMC-3G3; LY3012207) is an anti-platelet-derived growth factor receptor alpha (PDGFRα) human monoclonal IgG1 antibody with antitumor activity .
|
-
(5)
- HY-P992013
-
|
|
CXCR
|
Others
|
|
Anti-CXCR3 Antibody (5H7) is a mouse monoclonal antibody produced using CXCR3 as the antigen. The recommended isotype control is human IgG1 kappa (HY-P99001).
|
-
(5)
- HY-P991487
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
LASN01 is a human IgG1 monoclonal antibody (mAb) targeting IL-11RA. LASN01 inhibits IGF-1 and IL-11-induced hyaluronic acid (HA) release and TGFβ-stimulated procollagen in orbital fibroblasts. LASN01 can be used in thyroid eye disease (TED) research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991443
-
|
|
CD73
|
Cancer
|
|
IPH5301 is a human IgG1 monoclonal antibody (mAb) targeting NT5E/CD73. IPH5301 has a functionally silent Fc domain, specifically inhibits soluble and membrane CD73 enzyme activity, and restores the proliferation of immune T cells. IPH5301 can be used in anti-tumor immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991491
-
|
|
SARS-CoV
Influenza Virus
|
Infection
|
|
VIR-7229 is a human IgG1 monoclonal antibody (mAb) targeting Receptor-Binding Domain, RBD, Spike glycoprotein. VIR-7229 exerts antiviral activity by competing with ACE2 for binding and inducing S1 protein shedding. VIR-7229 can be used in SARS-CoV-2 infection research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991481
-
|
|
CCR
|
Inflammation/Immunology
Cancer
|
|
S-531011 is a human IgG1 monoclonal antibody (mAb) targeting CCR8. S-531011 reduces tumor-infiltrating CCR8+ Tregs and has anti-tumor activity in CT26.WT and EMT6 tumor-bearing mouse tumor models. S-531011 can be used in the study of cancer immunity. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991471
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
GB-0895 is a human monoclonal antibody (mAb) targeting TSLP. GB-0895 can be used in Asthma research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P992373
-
|
|
Mucin
|
Cancer
|
|
huCC49 is a human monoclonal antibody targeting TAG-72. huCC49 can be used in cancer-related research. The recommended isotype control is human IgG1 kappa, with the isotype control (HY-P99001) .
|
-
(5)
- HY-P991404
-
|
|
TNF Receptor
|
Cancer
|
|
AMG-228 is a human IgG1 monoclonal antibody (mAb) targeting TNFRSF18/GITR/CD357. AMG-228 can be used in advanced solid tumors research .
|
-
(5)
- HY-P991433
-
|
|
TNF Receptor
|
Cancer
|
|
BIIB036 is a human IgG1 monoclonal antibody (mAb) targeting TNFRSF12A/Fn14. BIIB036 inhibits the growth of patient-derived primary colorectal tumors in SCID mice .
|
-
(5)
- HY-P99895
-
|
|
PD-1/PD-L1
|
Inflammation/Immunology
Cancer
|
|
Rulonilimab is a human IgG1 monoclonal antibody against PD-1 that targets, binds and inhibits PD-1 and its downstream signalling pathways with potential immune checkpoint inhibition and anti-tumour activity .
|
-
(5)
- HY-P991334
-
|
|
Orexin Receptor (OX Receptor)
|
Cancer
|
|
INCAGN1949 is a human IgG1 monoclonal antibody (mAb) targeting TNFRSF4/OX40/CD134. INCAGN1949 selectively deplete intratumoral regulatory T cells .
|
-
(5)
- HY-P992141
-
-
(5)
- HY-P991473
-
|
|
TNF Receptor
|
Cancer
|
|
hCBE-11 is a human monoclonal antibody (mAb) targeting TNFRSF3. hCBE-11 can be used in solid tumors research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P992272
-
|
|
Lipocalin Family
|
Inflammation/Immunology
|
|
Anti-NGAL Antibody is a monoclonal antibody targeting NGAL. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-NGAL Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992296
-
|
|
PTHR
|
Inflammation/Immunology
|
|
Anti-PTHrP Antibody is a monoclonal antibody that targets PTHrP. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-PTHrP Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992294
-
|
|
Prion Protein
|
Inflammation/Immunology
|
|
Anti-PRNP Antibody is a monoclonal antibody that targets PRNP. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-PRNP Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992285
-
-
(5)
- HY-P992190
-
|
|
Apelin Receptor (APJ)
|
Inflammation/Immunology
|
|
Anti-Apelin Antibody is a monoclonal antibody that targets apelin. It can be used in ELISA, FACS, and functional assays. For isotype controls of anti-Apelin Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992234
-
|
|
Glycosidase
|
Inflammation/Immunology
|
|
Anti-Heparanase Antibody is a monoclonal antibody that targets heparanase. It can be used in ELISA, FACS, and functional assays. For isotype controls of anti-heparanase antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P991867
-
|
|
Amyloid-β
|
Neurological Disease
|
|
SHR-1707 is a humanized anti-Aβ IgG1 monoclonal antibody. SHR-1707 binds Aβ fibrils and monomers, blocking plaque formation and promoting the microglial phagocytosis of Aβ. SHR-1707 reduces brain Aβ deposition in 5xFAD transgenic mice. SHR-1707 can be used for Alzheimer’s disease research. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P992411
-
|
|
Amyloid-β
|
Neurological Disease
|
|
MEDI-8490 is a fully human monoclonal antibody targeting APP/Aβ. MEDI-8490 can be used in research related to neurodegenerative diseases. Recommended isotype control: Human IgG1 lambda1, Isotype Control (HY-P99992).
|
-
(5)
- HY-P99945
-
-
(5)
- HY-P9801
-
|
SARS-CoV-2 (2019-nCoV) Spike RBD Antibody
|
SARS-CoV
|
Infection
|
|
Anti-Spike-RBD mAb is a CHO cell derived human monoclonal IgG1 antibody. Blocking the interaction of Spike protein and ACE2. Anti-Spike-RBD mAb is a potential therapeutic approach for SARS-CoV-2 treatment .
|
-
(5)
- HY-P99328
-
|
|
Interleukin Related
|
Inflammation/Immunology
Cancer
|
|
Tucotuzumab (Anti-EPCAM Recombinant Antibody) is an antigen-specific IgG1 monoclonal antibody that targets human epithelial cell adhesion molecule (EpCAM). Tucotuzumab links two IL-2 molecules and is an immunosuppressant and anti-tumor active molecule .
|
-
(5)
- HY-P991470
-
|
Neuradiab antibody
|
Transmembrane Glycoprotein
|
Cancer
|
|
Anti-Tenascin C Antibody (Neuradiab antibody) is a human monoclonal antibody (mAb) targeting Tenascin C. Anti-Tenascin C Antibody can be used in Glioblastoma research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P9915
-
|
Anti-human CD38, human Antibody; HuMax-CD38; JNJ-54767414
|
CD38
ADC Antibody
|
Inflammation/Immunology
Cancer
|
|
Daratumumab (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition .
|
-
(5)
- HY-P992051
-
|
|
Integrin
|
Inflammation/Immunology
Cancer
|
|
Anti-CD103 Antibody (hCD103.01A) is a monoclonal antibody targeting human CD103 and can be used in cancer immunotherapy and immunological research. Recommend Isotype Controls: human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P991460
-
|
|
TNF Receptor
|
Cancer
|
|
Sym029 is a human IgG monoclonal antibody (mAb) targeting TNFRSF5/CD40. Sym029 can be used in cancer research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991421
-
|
|
VISTA
|
Cancer
|
|
W0180 is a human IgG1 monoclonal antibody (mAb) targeting VISTA/B7-H5. W0180 has the potential to activate T cells. W0180 can be used in solid tumors research .
|
-
(5)
- HY-P99265
-
|
HGS-ETR1; Anti-human TNFRSF10A Recombinant Antibody
|
Inhibitory Antibodies
|
Cancer
|
|
Mapatumumab (HGS-ETR1) is a fully human IgG1 agonistic monoclonal antibody that targets tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1). Mapatumumab can be used for the research of cancer .
|
-
(5)
- HY-P991192
-
|
|
TNF Receptor
|
Cancer
|
|
BI-1808 is a human IgG1 monoclonal antibody that targets TNFR2by blocking interaction of TNFR2 with ligand TNF-α, confers FcγR-dependent depletion of Treg and mediates expansion of intratumoral CD8 + T cells .
|
-
(5)
- HY-P9807
-
|
SARS-CR3022; SARS-CoV-2 Antibody-CR3022
|
SARS-CoV
|
Infection
Inflammation/Immunology
|
|
Anti-SARS-CoV-2 Spike mAb (CR3022) is a a CHO cell derived human monoclonal IgG1 antibody. It binds to both S1 domain of SARS-CoV/SARS-CoV-2 Spike protein .
|
-
(5)
- HY-P99781
-
|
MLN-1202
|
CCR
|
Inflammation/Immunology
Cancer
|
|
Plozalizumab (MLN-1202) is a humanized anti-CCR2 IgG1 monoclonal antibody. Plozalizumab blocks the recruitment of myeloid cells to the tumor microenvironment by inhibiting the CCL2/CCR2 axis. In addition, Plozalizumab also ameliorates synovial inflammation in rheumatoid arthritis. Plozalizumab can be used in the research of malignant melanoma and bone metastasis-related cancers. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991450
-
|
ADI-15742; MBP-134 AF
|
Filovirus
|
Infection
|
|
ADI-15878 is a human IgG monoclonal antibody (mAb) targeting Envelope glycoprotein, GP2. ADI-15878 can be used in Ebola virus infection research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991496
-
|
|
RSV
|
Infection
|
|
IDB-002 is a human monoclonal antibody (mAb) targeting F/Fusion glycoprotein F0. IDB-002 can be used in respiratory syncytial virus infection research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992227
-
|
|
Lipase
|
Inflammation/Immunology
|
|
Anti-Endothelial Lipase Antibody is a monoclonal antibody targeting endothelial lipase. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Endothelial Lipase Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992290
-
|
|
SHP1
|
Inflammation/Immunology
|
|
Anti-PILRA Antibody is a monoclonal antibody that targets PILRA. Anti-PILRA Antibody can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-PILRA Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992288
-
|
|
Serpin
|
Inflammation/Immunology
|
|
Anti-PCI Antibody is a monoclonal antibody that targets PCI. Anti-PCI Antibody can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-PCI Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992293
-
|
|
RAR/RXR
|
Inflammation/Immunology
|
|
Anti-PRAME Antibody is a monoclonal antibody that targets the melanoma antigen preferentially/PRAME. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-PRAME Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P99415
-
|
MAA868
|
Factor Xa
|
Cardiovascular Disease
|
|
Abelacimab (MAA868) is a fully human IgG1 monoclonal antibody that binds with high affinity to the catalytic structural domain of FXI and locks it in the zymogen conformation, thereby preventing its activation by FXIIa or thrombin. Abelacimab can be used in thromboembolic disease studies .
|
-
(5)
- HY-P991282
-
|
|
Interleukin Related
|
Cancer
|
|
KHK2823 is a humanized monoclonal anti-human CD123/IL3RA antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001). KHK2823 can be used in research related to leukemia .
|
-
(5)
- HY-P991942
-
|
BAY3375968; TPP-23411
|
CCR
|
Inflammation/Immunology
Cancer
|
|
Lanerkitug (BAY3375968) is a fully human monoclonal IgG1 anti-human CCR8 antibody. Lanerkitug selectively depletes human CCR8 + Tregs via antibody dependent cellular cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP). Lanerkitug can be used in the research of solid tumors .
|
-
(5)
- HY-P99110
-
|
SHP643; DX-2930; X124-G01
|
Kallikrein
|
Inflammation/Immunology
|
|
Lanadelumab (SHP643) is a human IgG1 monoclonal antibody against plasma kallikrein (pKal) with an Ki value of 0.12 nM. Lanadelumab inhibits both free and HMWK (high molecular weight kininogen)-bound pKal. Lanadelumab has the potential for the research of hereditary angioedema .
|
-
(5)
- HY-P9915A
-
|
Anti-human CD38, human Antibody (PBS)
|
ADC Antibody
CD38
|
Cancer
|
|
Daratumumab (PBS) (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab (PBS) has anti-multiple myeloma (MM) effect. Daratumumab (PBS) impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition .
|
-
(5)
- HY-P99970
-
|
|
ADC Antibody
Sodium Phosphate Cotransporter
|
Cancer
|
|
Lifastuzumab is a humanized anti-NaPi2b IgG1 monoclonal antibody. Lifastuzumab can be coupled with monomethyl auristatin E (MMAE) (HY-15162) through ADC Linker to form an antibody-drug conjugate (ADC) Lifastuzumab vedotin (HY-P99705) with anticancer activity. Lifastuzumab vedotin can be studied in research for non-small cell lung cancer and ovarian cancer. Recommend Isotype Control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P992250
-
|
|
Kallikrein
|
Inflammation/Immunology
|
|
Anti-KLK7 Antibody is a monoclonal antibody targeting KLK7. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-KLK7 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992217
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-CDH19 Antibody is a monoclonal antibody that targets CDH19. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CDH19 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992185
-
|
|
MMP
|
Inflammation/Immunology
|
|
Anti-ADAM17 Antibody is a monoclonal antibody targeting ADAM17. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-ADAM17 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992297
-
|
|
E1/E2/E3 Enzyme
|
Inflammation/Immunology
|
|
Anti-RNF43 Antibody is a monoclonal antibody targeting RNF43. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-RNF43 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992186
-
|
|
MMP
|
Inflammation/Immunology
|
|
Anti-ADMAST4 Antibody is a monoclonal antibody targeting ADMAST4. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-ADMAST4 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992300
-
|
|
Wnt
|
Inflammation/Immunology
|
|
Anti-RSPO2 Antibody is a monoclonal antibody that targets RSPO2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-RSPO2 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992216
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-CD99 Antibody is a monoclonal antibody that targets CD99. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CD99 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P99036
-
|
|
Tie
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand Angiopoietin-2 (Ang2) with high affinity, but shows no binding to Ang1. Nesvacumab can be used in vascular researches .
|
-
(5)
- HY-P992187
-
|
|
PDI
|
Inflammation/Immunology
|
|
Anti-AGR2 Antibody is a monoclonal antibody that targets AGR2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-AGR2 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992307
-
|
|
MMP
|
Inflammation/Immunology
|
|
Anti-TIMP-1 Antibody is a monoclonal antibody that targets TIMP1. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-TIMP-1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992214
-
|
|
SHP1
|
Inflammation/Immunology
|
|
Anti-CD84 Antibody is a monoclonal antibody that targets CD84. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CD84 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992251
-
-
(5)
- HY-P992197
-
|
|
CCR
|
Inflammation/Immunology
|
|
Anti-CCL21 Antibody is a monoclonal antibody targeting CCL21. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CCL21 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992189
-
|
|
Wnt
|
Inflammation/Immunology
|
|
Anti-APCDD1 Antibody is a monoclonal antibody that targets APCDD1. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-APCDD1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992255
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-LAIR1 Antibody is a monoclonal antibody that targets LAIR1. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-LAIR1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992305
-
|
|
STAT
|
Inflammation/Immunology
|
|
Anti-STAT3 Antibody is a monoclonal antibody that targets STAT3. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-STAT3 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992299
-
|
|
Slit Proteins
|
Inflammation/Immunology
|
|
Anti-Robo4 Antibody is a monoclonal antibody targeting Robo4. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Robo4 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992199
-
|
|
CCR
|
Inflammation/Immunology
|
|
Anti-CCR9 Antibody is a monoclonal antibody targeting CCR9. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CCR9 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992309
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-TSPAN33 Antibody is a monoclonal antibody targeting TSPAN33. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-TSPAN33 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992229
-
|
|
Wnt
|
Inflammation/Immunology
|
|
Anti-FZD5 Antibody is a monoclonal antibody targeting FZD5. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-FZD5 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992226
-
|
|
Orphan GPCR
|
Inflammation/Immunology
|
|
Anti-EMR2 Antibody is a monoclonal antibody targeting ADGRE2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-EMR2 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992269
-
|
|
Monocarboxylate Transporter
|
Inflammation/Immunology
|
|
Anti-MSR1 Antibody is a monoclonal antibody that targets MSR1. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-MSR1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P99327
-
|
BT-061
|
Inhibitory Antibodies
|
Inflammation/Immunology
|
|
Tregalizumab is a humanized anti-human CD4 monoclonal antibody (IgG1 type) that selectively activates the suppressive properties of regulatory T cells (Tregs) in vitro. Tregalizumab can be used in the research of autoimmune diseases (resulting from insufficient Treg activity) and allergies .
|
-
(5)
- HY-P992222
-
|
|
CXCR
|
Inflammation/Immunology
|
|
Anti-CXCL13 Antibody is a monoclonal antibody targeting CXCL13. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CXCL13 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992263
-
|
|
Wnt
|
Inflammation/Immunology
|
|
Anti-LRP5 Antibody is a monoclonal antibody that targets LRP5. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-LRP5 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992287
-
|
|
Protein Arginine Deiminase
|
Inflammation/Immunology
|
|
Anti-PAD4 Antibody is a monoclonal antibody that targets PAD4. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-PAD4 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992278
-
|
|
Notch
|
Inflammation/Immunology
|
|
Anti-Notch2 Antibody is a monoclonal antibody targeting Notch2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Notch2 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992292
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-Plexin A1 Antibody is a monoclonal antibody targeting Plexin A1. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Plexin A1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992261
-
|
|
Lipocalin Family
|
Inflammation/Immunology
|
|
Anti-Lipocalin-2 Antibody is a monoclonal antibody targeting Lipocalin-2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Lipocalin-2 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992248
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL-32 Antibody is a monoclonal antibody that targets IL-32. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-32 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992245
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL-26 Antibody is a monoclonal antibody that targets IL-26. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-26 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992218
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-CHRDL-1 Antibody is a monoclonal antibody that targets CHRDL-1. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CHRDL-1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992243
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL-24 Antibody is a monoclonal antibody that targets IL-24. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-24 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992267
-
|
|
MMP
|
Inflammation/Immunology
|
|
Anti-MMP-16 Antibody is a monoclonal antibody targeting MMP-16. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-MMP-16 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P991310
-
|
LT3015; LT-3000
|
LPL Receptor
|
Neurological Disease
Cancer
|
|
Lpathomab (LT3015; LT-3000) is a human IgG1 monoclonal antibody (mAb) targeting LPA. Lpathomab reduces the release of IL-8 and IL-6 cytokines in SKOV3 cells and blocks LPA-triggered tumor cell migration. Lpathomab reduces neovascularization in Matrigel plug and CNV models. Lpathomab inhibits brain injury in the CCI mouse model. Lpathomab can be used in the study of brain injury, ovarian cancer, diabetic neuropathy, and spinal cord injury. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991454
-
|
|
Wnt
|
Inflammation/Immunology
|
|
Anti-LGR5/GPR49 Antibody (18G7H6A3) is a human monoclonal antibody (mAb) targeting LGR5/GPR49. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P991453
-
|
|
C-type Lectin-like Receptors (CTLRs)
|
Cancer
|
|
Anti-CD371/CLEC12A Antibody (H6e7) is a human monoclonal antibody (mAb) targeting CD371/CLEC12A. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991346
-
|
|
PD-1/PD-L1
|
Inflammation/Immunology
|
|
CC-90006 is a human monoclonal antibody (mAb) targeting PDCD1/PD-1/CD279. CC-90006 can be used in psoriasis research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P992252
-
|
|
Wnt
|
Inflammation/Immunology
|
|
Anti-Kremen2 Antibody is a monoclonal antibody that targets Kremen2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Kremen2 Antibody, please refer to Human IgG1 (N297A) kappa, Isotype Control (HY-P99994).
|
-
(5)
- HY-P992210
-
|
|
Transmembrane Glycoprotein
|
Cancer
|
|
Anti-CD326 Antibody (17-1A) is a human monoclonal antibody targeting CD326. Anti-CD326 Antibody (17-1A) can be used in cancer research. The recommended isotype control is Mouse IgG1 kappa (HY-P99977).
|
-
(5)
- HY-P99541
-
|
anti-hepatitis B; OST 577; SDZ-OST 577
|
HBV
|
Infection
|
|
Tuvirumab (OST 577; SDZ-OST 577) is a human IgG1 subclass monoclonal antibody directed against HBV surface antigen (HBsAg). Tuvirumab binds specifically and with high affinity (K=3.6 nM) to HBsAg. Tuvirumab has the potential for chronic hepatitis B research .
|
-
(5)
- HY-P99962
-
|
BGB-A425
|
Mucin
|
Cancer
|
|
Surzebiclimab (BGB-A425) is a humanized IgG1-variant monoclonal antibody against T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). Surzebiclimab binds to the extracellular domain of human Tim-3 with high affinity (KD=0.36 nM) and specificity. Surzebiclimab can be used in research of cancer .
|
-
(5)
- HY-P991599
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
SHR-1703 is a long-acting humanized anti-IL-5 IgG1 monoclonal antibody. SHR-1703 can selectively recognize and bind to IL-5, blocking the binding of IL-5 to the α chain of the receptor on the surface of eosinophils, thereby inhibiting the proliferation, activation, and migration of eosinophils, and ultimately reducing eosinophil-mediated inflammation and damage. SHR-1703 can be used in the research of eosinophil-related diseases, such as eosinophilic asthma. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P99191
-
|
NI-0501
|
IFNAR
|
Inflammation/Immunology
|
|
Emapalumab (NI-0501) is a human monoclonal IgG1 antibody that noncompetitively inhibits IFN-γ. Emapalumab binds with high affinity (Kd= 1.4 pM) to both free IFN-γ as well as IFN-γ bound to its receptor. Emapalumab can be used in research of hemophagocytic lymphohistiocytosis (HLH) .
|
-
(5)
- HY-P99680
-
|
SB-210396; IDEC CE9.1
|
Interleukin Related
|
Cancer
|
|
Keliximab (SB-210396) is a chimeric human/macaque IgG1 anti-CD4 monoclonal antibody with a Ki value of 1.0 nM for soluble CD4. Keliximab blocks T cell proliferation and inhibits IL-2 production. Keliximab can be used for cancer research .
|
-
(5)
- HY-P992008
-
|
|
TGF-β Receptor
|
Cardiovascular Disease
|
|
PF-07868489 is a recombinant monoclonal antibody targeting GDF2/BMP-9. PF-07868489 can be used for the research of pulmonary arterial hypertension (PAH). Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P99271
-
|
Anti-human F3 Recombinant Antibody
|
ADC Antibody
|
Cancer
|
|
Tisotumab (Anti-Human F3 Recombinant Antibody) is a human IgG1 monoclonal antibody and ADC antibody. Tisotumab targets tissue factor (TF). Tisotumab can be used to synthesize antibody-drug conjugates (ADCs) targeting tissue factor (TF), Tisotumab vedotin (HY-152963). Tisotumab can be used for the research of solid tumors .
|
-
(5)
- HY-P992354
-
|
INBRX-110
|
TNF Receptor
NF-κB
|
Cancer
|
|
FPA154 is a human monoclonal antibody against TNFRSF18/GITR/CD357. FPA154 activates NF-κB via the GITR pathway. FPA154 can be used in solid tumor research. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P990302
-
|
|
nAChR
|
Neurological Disease
|
|
Anti-Human/Rat/Fish AChR Antibody (Mab35) is an anti-human/rat/fish AChR IgG1 monoclonal antibody. Anti-Human/Rat/Fish AChR Antibody (Mab35) can attack the AChR of neuromuscular junctions. Anti-Human/Rat/Fish AChR Antibody (Mab35) can be used for the construction of myasthenia gravis models .
|
-
(5)
- HY-P992213
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-CD79 Antibody is a monoclonal antibody that targets CD79. Anti-CD79 Antibody can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CD79 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P99234
-
|
|
Interleukin Related
ADC Antibody
|
Cancer
|
|
Pivekimab is a human IgG1 monoclonal antibody that targets interleukin-3 (IL-3) and CD123. Pivekimab is used to synthesize pivekimab sunirine, a CD123-directed antibody-active molecule conjugate (ADC). Pivekimab is used in the study of blastic plasmacytoid dendritic cell neoplasm (BPDCN) .
|
-
(5)
- HY-P992310
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-UPK-1B Antibody is a monoclonal antibody targeting UPK1B. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-UPK-1B Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992208
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-CD300C Antibody is a monoclonal antibody targeting CD300C. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CD300C Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P99384
-
|
B-701; MFGR-1877S; RG-7444
|
FGFR
|
Cancer
|
|
Vofatamab (B-701) is an anti-FGFR3 monoclonal antibody (mAb). Vofatamab blocks activation of both the wildtype and genetically activated receptor. Vofatamab can be used in the research of metastatic urothelial carcinoma (mUC). Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P992274
-
|
|
Transglutaminase
|
Inflammation/Immunology
|
|
Anti-NGLY1 Antibody is a monoclonal antibody that targets NGLY1. Anti-NGLY1 Antibody can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-NGLY1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992257
-
|
|
Galectin
|
Inflammation/Immunology
|
|
Anti-LGALS3BP Antibody is a monoclonal antibody targeting LGALS3BP. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-LGALS3BP Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P9803
-
|
SARS-80R; SARS Antibody-80R
|
SARS-CoV
|
Infection
|
|
Anti-SARS-80R mAb (SARS-80R) is a human monoclonal IgG1 antibody produced in CHO cells. Anti-SARS-80R mAb can specifically bind to Spike (S1) protein to prevent SARS virus infection of susceptible cells .
|
-
(5)
- HY-P992306
-
|
|
Wnt
|
Inflammation/Immunology
|
|
Anti-TEM8 Antibody is a monoclonal antibody targeting TEM8/ANTXR1. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-TEM8 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P9805
-
|
MERS-3A1; MERS Antibody-3A1
|
SARS-CoV
|
Infection
|
|
Anti-MERS-3A1 mAb (MERS-3A1) is a human monoclonal IgG1 antibody with the high binding affinity produced in CHO cells.
Anti-MERS-3A1 mAb bocks the binding of MERS-CoV spike protein to DPP4 receptor .
|
-
(5)
- HY-P992276
-
-
(5)
- HY-P992265
-
|
|
Monocarboxylate Transporter
|
Inflammation/Immunology
|
|
Anti-MCT1 Antibody is a monoclonal antibody that targets MCT1. Anti-MCT1 Antibody can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-MCT1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992195
-
|
|
FGFR
|
Inflammation/Immunology
|
|
Anti-Beta Klotho Antibody is a monoclonal antibody targeting *Beta Klotho*. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Beta Klotho Antibody, please refer to Human IgG1 (L234A/L235A) kappa, Isotype Control (HY-P991207).
|
-
(5)
- HY-P992204
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-CD180 Antibody is a monoclonal antibody that targets CD180. Anti-CD180 Antibody can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CD180 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992268
-
|
|
MEK
|
Inflammation/Immunology
|
|
Anti-MP1 Antibody is a monoclonal antibody that targets MP1. Anti-MP1 Antibody can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-MP1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P9991
-
|
TST001
|
Gap Junction Protein
|
Cancer
|
|
Osemitamab is an IgG1 antibody targeting to human claudin-18.2. Osemitamab consists of human-Mus musculus monoclonal TST001 γ1-chain, disulfide with human-Mus musculus monoclonal TST001 κ-chain, dimer (ACI). Osemitamab in combination with Capecitabine (HY-B0016) and Oxaliplatin (HY-17371), can be used for G/GEJ cancer study .
|
-
(5)
- HY-108730
-
|
Anti-human PD-L1, human Antibody; MSB 0010718C; MSB0010718C
|
PD-1/PD-L1
|
Inflammation/Immunology
Cancer
|
|
Avelumab (Anti-Human PD-L1) a fully human IgG1 anti-PD-L1 monoclonal antibody (mAb) with potential antibody-dependent cell-mediated cytotoxicity (ADCC). Avelumab enhances ADCC on several cancer cell lines expressing PD-L1. Avelumab can be used for the study of chordoma .
|
-
(5)
- HY-P992344
-
|
|
Transmembrane Glycoprotein
|
Cancer
|
|
DNP002 is a humanized IgG1 monoclonal antibody targeting tumor-associated CEACAM6. DNP002 binds to CEACAM1, CEACAM5 and CEACAM6, and exhibits antibody-dependent cellular cytotoxicity against tumor cells overexpressing these targets. DNP002 binds to CEACAM6 on the surface of tumor-associated neutrophils (including MDSCs) to reverse the immunosuppressive effect in the tumor microenvironment. DNP002 shows anti-tumor activity in advanced solid tumors. DNP002 can be used for the research of advanced solid tumors. The recommended isotype control is human IgG1 kappa (HY-P99001) .
|
-
(5)
- HY-P990870
-
|
|
CD19
IFNAR
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-CD19 Antibody (4G7) is an anti-human CD19 IgG1 monoclonal antibody. Anti-CD19 Antibody (4G7) reduces the killing effect of CAR T cells on Raji cells. Anti-CD19 Antibody (4G7) can be used for research on immunology. Anti-CD19 Antibody (4G7) is often used in flow cytometry. The recommend isotype control of Anti-CD19 Antibody (4G7): Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P990838
-
|
|
Interleukin Related
IFNAR
|
Inflammation/Immunology
|
|
Anti-IL-12 p70 Antibody (20C2) is an anti-human IL-12 p70 IgG1 monoclonal antibody. Anti-IL-12 p70 Antibody (20C2) can inhibit the production of IFN-γ. Anti-IL-12 p70 Antibody (20C2) can be used for research on inflammation conditions. The recommend isotype control of Anti-IL-12 p70 Antibody (20C2): Rat IgG1 kappa, Isotype Control (HY-P99979) .
|
-
(5)
- HY-P992221
-
|
|
Gap Junction Protein
|
Inflammation/Immunology
|
|
Anti-CLDN9 Antibody is a monoclonal antibody targeting CLDN9. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CLDN9 Antibody, please refer to Human IgG1 (L234A/L235A) kappa, Isotype Control (HY-P991207).
|
-
(5)
- HY-P992188
-
|
|
TGF-β Receptor
|
Inflammation/Immunology
|
|
Anti-ALK7 Antibody is a monoclonal antibody that targets ALK7. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-ALK7 Antibody, please refer to Human IgG1 (L234A/L235A) kappa, Isotype Control (HY-P991207).
|
-
(5)
- HY-P992246
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL-27RA Antibody is a monoclonal antibody that targets IL-27RA. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-27RA Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P99656
-
|
MCDS0593A
|
ADC Antibody
|
Cancer
|
|
Iladatuzumab (MCDS0593A) is a humanized IgG1 anti-human CD79B monoclonal antibody. Iladatuzumab can be used to synthesize antibody-drug conjugates (ADC) Iladatuzumab vedotin (DCDS0780A; HY-P99657), which has the potential for B-cell non-Hodgkin lymphoma (B-NHL) research .
|
-
(5)
- HY-P992264
-
|
|
Wnt
|
Inflammation/Immunology
|
|
Anti-LRP6 Antibody is a monoclonal antibody that targets LRP6. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-LRP6 Antibody, please refer to Human IgG1 (L234A/L235A) kappa, Isotype Control (HY-P991207).
|
-
(5)
- HY-P992236
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL-17F Antibody is a monoclonal antibody that targets IL-17F. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-17F Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992253
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-L1-CAM Antibody is a monoclonal antibody that targets L1-CAM. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-L1-CAM Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P991066
-
|
ARGX-119
|
nAChR
|
Neurological Disease
|
|
ARGX-119 is a first-in-class humanized agonist monoclonal antibody specific for muscle-specific kinase (MuSK). ARGX-119 can be used for the study of neuromuscular diseases. The isotype control for ARGX-119 can refer to Human IgG1 lambda1, Isotype Control (HY-P99992) .
|
-
(5)
- HY-P992242
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL-23R Antibody is a monoclonal antibody that targets IL-23R. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-23R Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992298
-
|
|
Slit Proteins
|
Inflammation/Immunology
|
|
Anti-ROBO2 Antibody is a monoclonal antibody targeting ROBO2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-ROBO2 Antibody, please refer to Human IgG1 (L234A/L235A) kappa, Isotype Control (HY-P991207).
|
-
(5)
- HY-P991636
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
AK006 is a humanized IgG1 monoclonal antibody agonist targeting Sialic acid-binding immunoglobulin-like lectin6 (Siglec-6). AK006 potently inhibits IgE-mediated human mast cell activation. AK006 can be used for inflammatory diseases like chronic urticaria (CU) and asthma research .
|
-
(5)
- HY-P992193
-
|
|
APC
|
Inflammation/Immunology
|
|
Anti-B7-H7 Antibody is a monoclonal antibody targeting HHLA2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-B7-H7 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992237
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL-17RB Antibody is a monoclonal antibody targeting IL-17RB. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-17RB Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992205
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-CD226 Antibody is a monoclonal antibody targeting CD226. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CD226 Antibody, please refer to Human IgG1 (L234A/L235A) kappa, Isotype Control (HY-P991207).
|
-
(5)
- HY-P991247
-
|
|
MHC
|
Cancer
|
|
Anti-HLA-A2 (Hu8F4) is a human monoclonal antibody (mAb) targeting HLA-A2. Anti-HLA-A2 (Hu8F4) can be used in Acute myeloid leukaemia research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991557
-
|
|
TNF Receptor
|
Inflammation/Immunology
|
|
ABI793 is a human IgG1 anti-human CD154 (CD40 ligand) monoclonal antibody. ABI793 inhibits immune response by blocking the CD154-CD40 (IC50 = 75 nM) signaling pathway. ABI793 effectively prevents kidney transplant rejection. ABI793 can be used for research on immunological rejection .
|
-
(5)
- HY-P991196
-
|
|
Transmembrane Glycoprotein
|
Cancer
|
|
Anti-CD24 Antibody (SWA11) is a human IgG1 monoclonal antibody targeting CD24, with high affinity and specificity for CD24-expressing tumor cells. Anti-CD24 Antibody (SWA11) triggers endocytosis, alters STAT3-dependent gene expression, regulates Src phosphorylation, and blocks CD24-mediated signaling pathways. Anti-CD24 Antibody (SWA11) is applicable to cancer-related research such as lung cancer and ovarian cancer. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P9931
-
|
CNTO 1959
|
Interleukin Related
|
Inflammation/Immunology
|
|
Guselkumab is a recombinant human IgG1 monoclonal antibody against the IL-23p19 subunit. Guselkumab binds to human and cynomolgus monkey IL-23 with Kd values of 3.3 and 1.9 pmol/L, respectively. Guselkumab inhibits production of cytokines lying downstream of the IL-23 signaling pathway and can be used for psoriatic arthritis research .
|
-
(5)
- HY-P990558
-
|
BMS-986148 antibody
|
Inhibitory Antibodies
|
Inflammation/Immunology
|
|
BMS-986021 (BMS-986148 antibody) is a human monoclonal antibody expressed in CHO, targeting Mesothelin. BMS-986021 has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 144.46 kDa. For the isotype control of BMS-986021, refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P99271A
-
|
Anti-human F3 Recombinant Antibody (powder)
|
ADC Antibody
|
Cancer
|
|
Tisotumab (Anti-Human F3 Recombinant Antibody) (powder) is a human IgG1 monoclonal antibody and ADC antibody. Tisotumab (powder) targets tissue factor (TF). Tisotumab (powder) can be used to synthesize antibody-drug conjugates (ADCs) targeting tissue factor (TF), Tisotumab vedotin (HY-152963). Tisotumab (powder) can be used for the research of solid tumors .
|
-
(5)
- HY-P992239
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL-18Rα Antibody is a monoclonal antibody targeting IL-18Ra. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-18Rα Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P99230
-
|
|
Integrin
CD22
|
Cancer
|
|
Pinatuzumab is a humanized monoclonal antibody targeting cell-surface antigen CD22. Pinatuzumab can be used to synthesize antibody-drug conjugate (ADC) such as Pinatuzumab vedotin (HY-141602). Pinatuzumab can be studied in research on cancer such as non-Hodgkin lymphoma. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P9806
-
|
MERS-D12; MERS Antibody-D12
|
SARS-CoV
|
Infection
|
|
Anti-MERS-D12 mAb (MERS-D12; MERS Antibody-D12) is a human monoclonal IgG1. Anti-MERS-D12 mAb binds directly to the DPP4 interacting region of the MERS-CoV Spike receptor binding domain (RBD) and effect neutralization by directly blocking receptor binding .
|
-
(5)
- HY-P992260
-
|
|
LILRB
|
Inflammation/Immunology
|
|
Anti-LILRB3 Antibody is a monoclonal antibody targeting LILRB3/ILT5/CD85a. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-LILRB3 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P991532
-
|
MEMD; EJ212/007-Cl2-5
|
ALCAM/CD166
|
Inflammation/Immunology
Cancer
|
|
AT002 (CBAS-173, EJ212/007-Cl2-5) is a recombinant human IgG1 monoclonal antibody. AT002 targets the cell surface protein activated leukocyte adhesion molecule (ALCAM)/CD166. AT002 can be used in the research of cancer, autoimmune diseases and inflammatory diseases.
|
-
(5)
- HY-P992259
-
|
|
LILRB
|
Inflammation/Immunology
|
|
Anti-LILRB1 Antibody is a monoclonal antibody targeting LILRB1/CD85j/ILT2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-LILRB1 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992286
-
|
|
P2X Receptor
|
Inflammation/Immunology
|
|
Anti-P2XR4 Antibody is a monoclonal antibody targeting P2XR4. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-P2XR4 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P992303
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-Siglec-10/CD24 Antibody is a monoclonal antibody targeting Siglec-10. It can be used in ELISA, FACS, and functional assays. Isotype controls for Anti-Siglec-10/CD24 Antibody can be found in Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P991426
-
|
|
Transmembrane Glycoprotein
IFNAR
TNF Receptor
|
Cancer
|
|
MB-314 is a human IgG1 monoclonal antibody (mAb) targeting Lewis Y. MB-314 induces enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) activity. MB-314 increases the release of IFN-γ, TNF-α, MCP-1, and IL-6. MB-314 can be used in cancer research .
|
-
(5)
- HY-P992238
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL-18RAP Antibody is a monoclonal antibody targeting IL-18RAP/IL-18RB. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-18RAP Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P99155
-
|
2F8; HUMAX-EGFR
|
EGFR
|
Cancer
|
|
Zalutumumab is a high affinity, completely human IgG1 monoclonal antibody targeting EGFR. Zalutumumab binds to domain III of the EGF receptor and acts by blocking the binding of EGF and by sterically interfering with the active conformation of the receptor. Zalutumumab binds with IgG and its Fab fragment with EC50s of 7 and 19 nM, respectively. Zalutumumab can be used for the research of cancer .
|
-
(5)
- HY-P992133
-
|
SYS6002 Antibody; CRB-701 Antibody
|
ADC Antibody
Nectin-4
|
Cancer
|
|
Sutantatug (SYS6002 Antibody) is a monoclonal antibody targeting Nectin-4, and serves as the antibody moiety of the ADC CRB-701. Sutantatug is applicable to the research of Nectin-4-positive solid tumors, urothelial carcinoma and cervical cancer. The corresponding isotype control for Sutantatug is Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P990869
-
|
|
CD1
IFNAR
Interleukin Related
|
Inflammation/Immunology
Cancer
|
|
Anti-CD1a Antibody (OKT-6) is an anti-human CD1a IgG1 monoclonal antibody. Anti-CD1a Antibody (OKT-6) blocks T cell activation by blocking CD1a function. Anti-CD1a Antibody (OKT-6) can reduce the production of IFN-γ. Anti-CD1a Antibody (OKT-6) can be used for researches on cancer and inflammation such as leukemia. The recommend isotype control of Anti-CD1a Antibody (OKT-6): Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P991950
-
|
|
TGF-beta/Smad
|
Inflammation/Immunology
|
|
SHR-1906 is a selective fully humanized monoclonal IgG1 inhibitory antibody targeting CTGF. SHR-1906 specifically binds to CTGF, thereby blocking the interaction between CTGF and TGF-B1 with an inhibition rate of 55%. SHR-1906increases the survival rate in a pulmonary fibrosis model by reducing TGF-β1 levels and inhibiting fibrotic lesions in lung tissue in Bleomycin (HY-108345)-induced pulmonary fibrosis.SHR-1906 can be used for pulmonary fibrosis (IPF) research. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P990043
-
|
VGL101
|
Ser/Thr Kinase
TREM receptor
|
Inflammation/Immunology
|
|
Iluzanebart is a human monoclonal IgG1 antibody and is the agonist antibody for human TREM2 (hTREM2). Iluzanebart improves the survival and function of microglia by activating the TREM2 signaling pathway to compensate for the loss of CSF1R function. Iluzanebart can be used for research of adult-onset leukoencephalopathy associated with CSF1R (colony stimulating factor 1 receptor) (CSF1R-ALSP) .
|
-
(5)
- HY-P99229
-
|
XMT-1535; Upinitatug
|
ADC Antibody
|
Cancer
|
|
Upifitamab is a humanized monoclonal antibody targeting NaPi2b. Upifitamab can be used to synthesize ADC such as Upfitamab rilsodotin. Upfitamab rilsodotin can be used in research for solid tumors including high-grade serious epithelial ovarian, fallopian tube and primary peritoneal cancer (OC). Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991214
-
|
EMD 273066; huKS-IL2
|
Interleukin Related
|
Cancer
|
|
Tucotuzumab celmoleukin (EMD 273066) is an immunocytokine. Tucotuzumab celmoleukin consists of the following components: an IgG1 monoclonal antibody targeting human EpCAM antigen, and two molecules of IL2. Tucotuzumab celmoleukin binds to EpCAM. Tucotuzumab celmoleukin exerts anti-tumor effects on colon adenocarcinoma in synergy with radiofrequency ablation. Tucotuzumab celmoleukin can be used in research related to colon adenocarcinoma and colon cancer .
|
-
(5)
- HY-P99190
-
|
BMS-936557; MDX-1100
|
CXCR
|
Inflammation/Immunology
|
|
Eldelumab (BMS-936557) is a human anti-CXCL10 (IP-10) monoclonal antibody (IgG1 type). Eldelumab selectively binds to CXCL10 and blocks CXCL10-induced calcium flux and cell migration. Eldelumab can be used in studies of autoimmune and auto-inflammatory diseases such as rheumatoid arthritis, ulcerative colitis and crohn's disease .
|
-
(5)
- HY-P99754
-
|
BCD-085
|
Interleukin Related
|
Infection
Inflammation/Immunology
|
|
Netakimab (BCD-085) is a humanized IgG1κ monoclonal anti-IL-17 antibody that binds to and blocks IL-17 and IL-17A activity, including reduction of downstream IL-6 production. Netakimab can be used for the research of moderate-to-severe plaque psoriasis, ankylosing spondylitis, and COVID-19 with cytokine release syndrome . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P990781
-
-
(5)
- HY-P991961
-
|
|
CTLA-4
|
Cancer
|
|
REGN4659 is a fully human anti-CTLA-4 monoclonal antibody and IgG1 antibody. REGN4659 binds to the extracellular domain of human and monkey CTLA-4 with high affinity and specificity. REGN4659 blocks CTLA-4 interaction with CD80 and CD86 ligands. REGN4659 significantly suppresses MC38.Ova tumor growth in CTLA-4 knock-in mice .
|
-
(5)
- HY-P992453
-
|
MTBT1466A; RG-6315
|
TGF-β Receptor
|
Neurological Disease
Inflammation/Immunology
|
|
RO-7303509 (MTBT1466A; RG-6315) is a human monoclonal antibody and TGFβ3 neutralizer. RO-7303509 targets the profibrotic mediator TGFβ3 to alleviate fibrosis. RO-7303509 can be administered via subcutaneous or intravenous routes and is used in research on systemic sclerosis . Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
- HY-P99155A
-
|
|
EGFR
|
Cancer
|
|
Zalutumumab (powder) is a high affinity, completely human IgG1 monoclonal antibody targeting EGFR. Zalutumumab (powder) binds to domain III of the EGF receptor and acts by blocking the binding of EGF and by sterically interfering with the active conformation of the receptor. Zalutumumab (powder) binds with IgG and its Fab fragment with EC50s of 7 and 19 nM, respectively. Zalutumumab (powder) can be used for the research of cancer .
|
-
(5)
- HY-P990031
-
|
M-6223
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
Cancer
|
|
Dargistotug (M-6223) is a fully human IgG1 monoclonal antibody targeting TIGIT (T cell immune receptor with Ig domain and ITIM). TIGIT is an inhibitory immune checkpoint that promotes NK cell depletion and reduces the secretion of cytokines by binding to CD155 and other antibodies. It can also directly or indirectly inhibit effector T cells and upregulate Tregs cells, thereby exerting immunosuppression. Function .
|
-
(5)
- HY-P992241
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL-21R Antibody is a monoclonal antibody targeting IL-21R. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-21R Antibody, please refer to Human IgG1 (L234A/L235A) kappa, Isotype Control (HY-P991207).
|
-
(5)
- HY-P991475
-
|
|
Transmembrane Glycoprotein
NF-κB
IFNAR
|
Cancer
|
|
MG-1131 is a human monoclonal antibody (mAb) targeting TIGIT. MG-1131 activates NF-κB signaling in T cells and enhances NK-mediated tumor killing activity in a PVR-dependent manner. MG-1131 blocks TIGIT to increase IFN-γ secretion. MG-1131 can be used in anti-tumor immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991430
-
|
TB-403
|
VEGFR
|
Cancer
|
|
RO5323441 (TB-403) is a human IgG1 monoclonal antibody (mAb) targeting PlGF. RO5323441 inhibits the binding of human PlGF-1 or PlGF-2 to VEGFR-1 (IC50 values are 0.1 and 0.2 nM, respectively). RO5323441 blocks PlGF-induced VEGFR-1 phosphorylation in Flt-1-transfected HEK293 cells. RO5323441 has antitumor activity .
|
-
(5)
- HY-P992215
-
|
|
LILRB
|
Inflammation/Immunology
|
|
Anti-CD85a/LILRB3 Antibody (7C5) is a human monoclonal antibody targeting LILRB3/ILT5/CD85a. Anti-CD85a/LILRB3 Antibody (7C5) can be used for research on inflammatory and immune diseases. The recommended isotype control is human IgG1 kappa, isotype control (HY-P99001).
|
-
(5)
- HY-P991455
-
|
|
TNF Receptor
|
Cancer
|
|
PTX-35 is a human IgG monoclonal antibody (mAb) targeting TNFRSF25. PTX-35 reduces the suppressive activity of regulatory T cells and enhances CD4+ T cell effector responses in a mouse melanoma model. PTX-35 can be used in Islet cell transplant rejection and Solid tumours research. Recommended isotype control: Human IgG1 lambda2, Isotype Control (HY-P990096) .
|
-
(5)
- HY-P991365
-
|
|
Transmembrane Glycoprotein
|
Endocrinology
|
|
DS-1501 is a human monoclonal antibody (mAb) targeting Siglec-15/CD33L3. DS-1501 inhibits osteoclastogenesis. DS-1501 suppresses the decrease of lumbar spine bone mineral density (BMD) in ovariectomized (OVX) rats. DS-1501 can be used in Osteoporosis research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-108730A
-
|
|
PD-1/PD-L1
|
Inflammation/Immunology
Cancer
|
|
Avelumab (anti-PD-L1) a fully human IgG1 anti-PD-L1 monoclonal antibody (mAb) with potential antibody-dependent cell-mediated cytotoxicity (ADCC). Avelumab (anti-PD-L1) enhances ADCC on several cancer cell lines expressing PD-L1. Avelumab (anti-PD-L1) can be used for the study of chordoma .
|
-
(5)
- HY-P992404
-
|
|
TNF Receptor
|
Cancer
|
|
MDX-1401 is a fully human IgG1 (κ isotype) monoclonal antibody against CD30, with a Kd value of 0.83 nmol/L. MDX-1401 induces antibody-dependent cellular cytotoxicity in CD30-expressing cells and inhibits tumor growth in CD30 + lymphoma xenograft models. MDX-1401 can be used in research related to malignant lymphoma and Hodgkin lymphoma .
|
-
(5)
- HY-145644
-
|
C-135-LS; BMS-986414
|
SARS-CoV
|
Infection
Cancer
|
|
Ogalvibart (C-135-LS) is a human anti-SARS-CoV-2 monoclonal antibody (IgG1 type). Ogalvibart binds to the spike (S) glycoprotein receptor-binding domain (RBD) of SARS-CoV-2. Ogalvibart in combination with C144LS (1:1 ratio) shows good preventive activity and can effectively block the development of COVID19 in a rhesus monkey disease model .
|
-
(5)
- HY-P991465
-
|
|
TNF Receptor
|
Cancer
|
|
Anti-CD27 Antibody (M2177) is a human monoclonal antibody (mAb) targeting TNFRSF7/CD27. Anti-CD27 Antibody (M2177) inhibits the binding of sCD70 to human CD27 ECD-Fc. Anti-CD27 Antibody (M2177) can be used in the study of anti-tumor immunity. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991466
-
|
|
TNF Receptor
|
Cancer
|
|
Anti-CD27 Antibody (M2191) is a human monoclonal antibody (mAb) targeting TNFRSF7/CD27. Anti-CD27 Antibody (M2191) inhibits the binding of sCD70 to human CD27 ECD-Fc. Anti-CD27 Antibody (M2191) can be used in the study of anti-tumor immunity. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P990867
-
|
|
Insulin Receptor
Akt
|
Cancer
|
|
Anti-CD220/Insulin Receptor Antibody (IR 83-22) is an anti-human CD220/Insulin Receptor IgG1 monoclonal antibody. Anti-CD220/Insulin Receptor Antibody (IR 83-22) can block Akt overactivation caused by Trip13 deficiency. Anti-CD220/Insulin Receptor Antibody (IR 83-22) can be used for research on cancer such as hepatocellular carcinoma (HCC). Anti-CD220/Insulin Receptor Antibody (IR 83-22) often used in western blotting. The recommend isotype control of Anti-CD220/Insulin Receptor Antibody (IR 83-22): Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P990690
-
|
MEDI-5752
|
PD-1/PD-L1
CTLA-4
|
Cancer
|
|
Volrustomig (MEDI-5752) is a human IgG1 κ monoclonal antibody targeting CTLA4/PD1. The isotype control for Volrustomig is Human IgG1 kappa, Isotype Control (HY-P99001). Volrustomig anchors to the surface of T cells by binding PD-1, induces PD-1 internalization and degradation, and preferentially inhibits CTLA-4 on activated PD-1 + T cells. Volrustomig binds to tumor-infiltrating lymphocytes and a subset of PD-1 + B cells, enhances T cell function and IFNγ secretion. Volrustomig reduces the activation of non-tumor-infiltrating lymphocytes and exhibits manageable toxicity. Volrustomig can be used in research on various cancers, such as non-small cell lung cancer, gastric cancer, hepatobiliary cancer, and cervical cancer .
|
-
(5)
- HY-P991888
-
|
|
STAT
|
Cardiovascular Disease
Cancer
|
|
INCA033989 is a fully human IgG1 monoclonal antibody targeting mutCALR (KD = 1.75 nM for mutCALR del52; KD = 6.78 nM for mutCALR ins5). INCA033989 antagonizes mutCALR-driven signaling and proliferation. INCA033989 selectively inhibits pSTAT3/pSTAT5. INCA033989 prevents thrombocytosis and reduces the expansion of mutCALR-positive cells. INCA033989 is useful for research on myeloproliferative neoplasms .
|
-
(5)
- HY-P991458
-
|
|
Transmembrane Glycoprotein
|
Cancer
|
|
hu3S193 is a human IgG monoclonal antibody (mAb) targeting Lewis Y. hu3S193 has excellent immune effector function (complement-dependent cytotoxicity) (IC50: 1.0 μg/ml) and antibody-dependent cellular cytotoxicity (IC50: 5.0 μg/ml). hu3S193 can be used in small cell lung cancer (SCLC) research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P99315
-
|
BG 9588; Anti-human CD40L Recombinant Antibody; Hu5c8
|
TNF Receptor
|
Inflammation/Immunology
|
|
Ruplizumab (BG 9588) is a humanized anti-CD40L IgG1κ monoclonal antibody. By binding to CD40L, Ruplizumab blocks its interaction with the CD40 receptor, inhibits T-B cell costimulatory signals, and mediates the depletion of activated T cells via the Fc segment. Ruplizumab has immunosuppressive effects. Ruplizumab can be used in the study of systemic lupus erythematosus, organ transplant rejection, and autoimmune diseases. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991883
-
|
Licartin; Metuximab; Mehuzumab
|
Apoptosis
CDK
Caspase
Bcl-2 Family
|
Cancer
|
|
Metuzumab (Licartin) is a human-mouse chimeric IgG1 monoclonal antibody targeting CD147. Metuzumab induces Apoptosis, reduces levels of Cyclin D1, full-length Caspase-3, and Bcl-2, and increases Bax expression. Metuzumab enhances the sensitivity of non-small cell lung cancer (NSCLC) cells to Gemcitabine (HY-17026). Metuzumab is applicable for research on hepatocellular carcinoma and non-small cell lung cancer [1] [2].
|
-
(5)
- HY-P991995
-
|
OMTX705 antibody
|
ADC Antibody
FAP
|
Cancer
|
|
OMTX005 (OMTX705 antibody) is a humanized anti-FAP IgG1 monoclonal antibody that specifically binds to human (EC50: 0.33 nM)/mouse (EC50: 0.14 nM) FAP proteins and FAP-positive cells. OMTX005 exhibits no cytotoxicity when used alone and fails to induce an increase in caspase 3/7 activity in relevant cells. OMTX005 can be used to synthesize the ADC molecule OMTX705 for tumor research .
|
-
(5)
- HY-P991319
-
|
|
Inhibitory Antibodies
|
Cancer
|
|
TAB-004 is a murine IgG1 monoclonal antibody that specifically binds to the tumor-associated hypoglycosylated mucin 1 (tMUC1), with high selectivity for human tMUC1. TAB-004 can be conjugated with Indocyanine green (ICG) (HY-D0711) for in vivo targeted imaging. TAB-004 can be used for the research of early detection, tumor progression monitoring and cancer stem cell targeting in breast cancer and pancreatic cancer.
|
-
(5)
- HY-P99780
-
|
BIIB033
|
Transmembrane Glycoprotein
|
Neurological Disease
Inflammation/Immunology
|
|
Opicinumab (BIIB033) is a human IgG1 monoclonal antibody targeting LINGO-1. Opicinumab binds LINGO-1 to block its negative regulatory signaling, suppress axonal degeneration, enhance axonal regeneration, promote remyelination, and exert neuroprotective effects. Opicinumab maintains axonal protective effects during co-administration with methylprednisolone. Opicinumab can be used for the research of multiple sclerosis, acute optic neuritis, and optic neuritis. .
|
-
(5)
- HY-P99111
-
|
CNTO-148
|
TNF Receptor
Apoptosis
Interleukin Related
Caspase
|
Inflammation/Immunology
Cancer
|
|
Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research .
|
-
(5)
- HY-P991425
-
|
|
Transmembrane Glycoprotein
|
Cancer
|
|
AT-1413 is a human monoclonal antibody (mAb) targeting CD43. AT-1413 induces antibody-dependent cell-mediated cytotoxicity (ADCC) in melanoma cell lines and acute myeloid leukemia (AML) cells. AT-1413 has antitumor activity in AML mouse models. AT-1413 can be used in Acute myeloid leukaemia, Breast cancer, Malignant melanoma and Myelodysplastic syndromes research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991364
-
|
PYX-106; BSI-060T
|
Transmembrane Glycoprotein
|
Cancer
|
|
Aldastotug (PYX-106; BSI-060T) is a human monoclonal antibody (mAb) targeting Siglec-15/CD33L3. Aldastotug reverses Siglec-15-mediated immunosuppression and enhances T-cell proliferation. Aldastotug induces significantly increased levels of IFNγ and TNFα in T cells. Aldastotug can be used in cancer immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P99551
-
|
KBSA301; AR-301
|
Antibiotic
Bacterial
|
Infection
|
|
Tosatoxumab (AR-301; KBSA301) is a human immunoglobulin G1 monoclonal antibody that specifically neutralizes alpha-toxin (alpha-hemolysin; Hla) of S. aureus. Tosatoxumab binds to an N-terminal epitope of alpha-toxin, thereby preventing functional toxin pore oligomerisation. Tosatoxumab has the potential for passive immunotherapy in the S. aureus pneumonia as an adjunctive therapy to standard antibiotic agent. Recommend Isotope Control: Human IgG1 lambda1, Isotype Control (HY-P99992) .
|
-
(5)
- HY-P990239
-
|
|
HSP
Akt
Interleukin Related
|
Inflammation/Immunology
Cancer
|
|
Anti-Human/Mouse GRP78 Antibody (N88) is an anti-human/mouse GRP78 IgG1 monoclonal antibody. Anti-Human/Mouse GRP78 Antibody (N88) can activate the Akt signaling pathway. Anti-Human/Mouse GRP78 Antibody (N88) can inhibit the expression of inflammatory factors and plasminogen activator inhibitors induced by TLR agonists. Anti-Human/Mouse GRP78 Antibody (N88) can be used for research on inflammation conditions. Anti-Human/Mouse GRP78 Antibody (N88) can be used for immunoprecipitation .
|
-
(5)
- HY-P991592
-
|
|
Inhibitory Antibodies
|
Inflammation/Immunology
|
|
UB-221 is a humanized IgG1 monoclonal antibody inhibitor targeting IgE. UB-221 significantly decreases IgE synthesis by stabilization of membrane-bound CD23 on B lymphocytes and inhibits FcԑRI-mediated basophil activation and degranulation. UB-221 reduces IgE level in cynomolgus macaques and human IgE (ε, κ)-transgenic (hIGHE-knockin) mice. UB-221 can be used for asthma and chronic spontaneous urticaria (CSU) research .
|
-
(5)
- HY-P991082
-
|
SAR-428926 antibody
|
Transmembrane Glycoprotein
|
Cancer
|
|
Anti-LAMP1/CD107a Antibody (SAR-428926 antibody) is an anti-LAMP1 humanized monoclonal antibody. Anti-LAMP1/CD107a Antibody can be used for the antibody part of SAR-428926. Antibody Anti-LAMP1/CD107a Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P990661
-
|
|
c-Met/HGFR
ERK
PERK
|
Cancer
|
|
SAIT-301 is a Met-targeting monoclonal antibody. SAIT-301 inhibits Met activation, induces downregulated expression of phosphorylated Met(p-Met) and phosphorylated ERK(p-ERK), and reduces EGR-1 expression. SAIT-301 inhibits the migration and invasion of nasopharyngeal carcinoma cells. SAIT-301 is applicable to relevant research on nasopharyngeal carcinoma. For the isotype control of SAIT-301, refer to Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991447
-
|
|
VISTA
|
Cancer
|
|
Anti-VSIR/VISTA Antibody (SG7) is a human monoclonal antibody (mAb) targeting VISTA/B7-H5. Anti-VSIR/VISTA Antibody (SG7) inhibits VISTA function and prevents PSGL-1 and VSIG3 from binding to VISTA. Anti-VSIR/VISTA Antibody (SG7) has anti-tumor activity in the mouse B16F10 melanoma model. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991424
-
|
|
Interleukin Related
STAT
|
Inflammation/Immunology
|
|
GSK2618960 is a human monoclonal antibody (mAb) targeting IL-7Ra/CD127. GSK2618960 inhibits IL-7-induced STAT5 phosphorylation. GSK2618960 enhances CD4 T cell proliferation response and increases CD83, CD86, and CD209 expression in PBMCs. GSK2618960 can be used for the research of autoimmune and allergic inflammatory diseases. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991595
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
HB-0017 is a humanized IgG1κ monoclonal antibody inhibitor, targeting IL-17A. HB-0017 inhibits the IL-6 secretion induced by IL-17A with an IC50 of 2.09 nM. HB-0017 significantly decreases ear thickness in Imiquimod (HY-B0180)-induced psoriasis-like mice model and alleviates inflammations in IL-17A-induced arthritis and air pouch mice model. The isotype control for the HB-0017 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991958
-
|
|
CTLA-4
|
Cancer
|
|
GIGA-564 is a fully human anti-CTLA4 IgG1 monoclonal antibody with a Kd of 9.8 nM. GIGA-564 binds to a unique epitope of CTLA-4, mediates FcR-dependent signaling pathways, depletes CTLA-4-highly-expressing regulatory T cells within tumors, and inhibits the proliferation of peripheral regulatory T cells. GIGA-564 exhibits anti-tumor activity in mouse models. GIGA-564 can be used for tumor research .
|
-
(5)
- HY-P99646
-
|
MEDI6570
|
LOX-1
|
Metabolic Disease
Inflammation/Immunology
|
|
Gocdacimab (MEDI6570) is a fully human IgG1 monoclonal antibody inhibitor targeting the lectin-like oxidized low-density lipoprotein receptor LOX-1. By binding to LOX-1 and blocking its function, gocdacimab effectively reduces the level of free soluble LOX-1, thereby inhibiting key pathological processes such as lipid accumulation, foam cell formation, and vascular wall inflammation. Gocdacimab can interfere with atherosclerosis-related mechanisms, and it is used for research on atherosclerosis, and type 2 diabetes mellitus .
|
-
(5)
- HY-P99620
-
|
CT-P22; CT120
|
Influenza Virus
|
Infection
|
|
Firivumab (CT-P22; CT120) is a human IgG1 monoclonal influenza A virus hemagglutinin (Anti-IAV HA) antibody. Firivumab is capable of neutralizing H1N1, H5N1, H6N1, H6N2, H8N4, H8N8, H9N2 and H12N7. Firivumab shows protection against H1N1 virus in mice .
|
-
(5)
- HY-P991468
-
|
|
Interleukin Related
|
Cancer
|
|
IMM20324 is a human monoclonal antibody (mAb) targeting IL38. IMM20324 inhibits the interaction of IL-38 with human IL1RAPL1-Fc and human IL-36R-Fc with IC50 values of 1.267 nM and 1.4667 nM, respectively. IMM20324 has antitumor activity in the B16.F10 syngeneic mouse model. IMM20324 can be used in antitumor immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991565
-
|
|
c-Met/HGFR
|
Cancer
|
|
CE-355621 is a humanized anti-c-Met IgG1 monoclonal antibody. CE-355621 can effectively bind with human c-Met (KD = 200 pM, IC50 = 466 pM) in A549 cells and cyno c-Met (KD = 610 pM) in cynomolgus kidney cells. CE-355621 inhibits the c-Met signaling pathway by blocking HGF binding. CE-355621 significantly inhibits the growth of tumors dependent on the c-Met/HGF pathway. CE-355621 can be used for research on cancer such as glioblastoma and gastric cancer .
|
-
(5)
- HY-P991598
-
|
MOR12743; MOR03207
|
Interleukin Related
NF-κB
|
Inflammation/Immunology
|
|
MOR-106 (MOR12743) is a humanized anti-IL-17C IgG1 monoclonal antibody. MOR-106 inhibits the NF-κB signaling pathway by specifically binding to IL-17C (IC50 = 59 pM for human IL-17C, IC50 = 55 pM for mouse IL-17C). MOR-106 can effectively inhibit skin inflammation and reduce related inflammatory factors in animal models of psoriasis and atopic dermatitis .
|
-
(5)
- HY-P992450
-
|
|
TNF Receptor
|
Cancer
|
|
REGN6569 is a fully human IgG1 monoclonal antibody targeting glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) with high specificity for GITR. REGN6569 exerts stronger in vitro antibody-dependent cell-mediated cytotoxicity (ADCC) against regulatory T cells expressing GITR. REGN6569 selectively depletes regulatory T cells via antibody-dependent cell-mediated cytotoxicity and increases the proportion of proliferative natural killer (NK) cells in peripheral blood. REGN6569 is applicable for advanced solid malignancies. Isotype control: HY-P99001 .
|
-
(5)
- HY-P992381
-
|
|
Drug Derivative
|
Cancer
|
|
IBI352g4a is a humanized IgG1 monoclonal antibody targeting PVRIG (Kd = 0.53 nM) and acts as a PVRIG/PVRL2 inhibitor. The anti-tumor effect of IBI352g4a depends on the binding of its Fc region to FcγR. IBI352g4a binds to the extracellular domains of human and cynomolgus monkey PVRIG, and blocks the PVRIG-PVRL2 interaction. IBI352g4a induces NK cell activation, promotes their degranulation and tumor killing. IBI352g4a can be used in the research of gastric cancer .
|
-
(5)
- HY-P99361
-
|
PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab)
|
TNF Receptor
|
Cancer
|
|
Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .
|
-
(5)
- HY-P99390
-
|
MCLA 117
|
CD3
Interleukin Related
IFNAR
TNF Receptor
|
Inflammation/Immunology
Cancer
|
|
Tepoditamab (MCLA-117) is a full-length human IgG1 bispecific monoclonal antibody that binds to CLEC12A of myeloid cells and CD3 of cytotoxic T cells. Among others, CLEC12A is a myeloid differentiation antigen. Tepoditamab kills AML leukaemia mother cells and AML leukaemia stem cells, induces T cell-mediated proliferative lysis of AML cells. Tepoditamab induces upto 30-fold T-cell expansion. Tepoditamab results in moderate to strong cytokine (IFNγ, IL-6, IL-8, IL-10, and TNFα) and IFNγ release in human whole blood and PBMC, respectively. Tepoditamab can be used in acute myeloid leukaemia (AML) research .
|
-
(5)
- HY-P991000
-
|
AU-007; BD-8; BDG8
|
Interleukin Related
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
Imneskibart (AU-007) is a human monoclonal antibody that binds to the CD25-binding epitope of interleukin-2 (IL-2), blocking the binding of IL-2 to the trimeric IL-2 receptor while retaining the ability to bind to the dimeric IL-2 receptor. Imneskibart expands effector T cell and NK cell populations, reduces regulatory T cells, increases the effector T cell/regulatory T cell ratio, and alleviates vascular leakage. Imneskibart can be used in research related to melanoma and non-small cell lung cancer. The corresponding isotype control is: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991381
-
|
PPMX-T003
|
Transferrin Receptor
Reactive Oxygen Species (ROS)
Ferroptosis
|
Cancer
|
|
JST‑TfR09 (PPMX‑T003) is a human monoclonal antibody (mAb) targeting transferrin receptor 1 (TfR1/CD71). JST‑TfR09 blocks the binding of transferrin to TfR1, inhibits TfR1 internalization, and suppresses cellular iron uptake. JST‑TfR09 triggers ferritin degradation via activating the autolysosomal system, promotes ROS production and lipid peroxidation, and ultimately induces ferroptosis. JST‑TfR09 exhibits cytotoxicity toward human erythroblasts differentiated from hematopoietic stem cells. JST-TfR09 can be used in leukemia research. Recommended isotype control: Human IgG1 lambda, Isotype Control (HY-P99992) .
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(5)
- HY-P990132
-
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CD47
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Inflammation/Immunology
Cancer
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Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) is an anti-mouse/rat/human CD47/IAP IgG1 monoclonal antibody. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) can effectively block CD47 signaling and enhance macrophage phagocytic function. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) can increase the infiltration of immune cells. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) may interfere with wound healing. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) can be used for researches on cancer and inflammation conditions such as breast cancer and intestinal mucosal repair .
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(5)
- HY-P99488
-
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JSP-191; AMG-191
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c-Kit
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Inflammation/Immunology
Cancer
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Briquilimab (JSP-191 or AMG-191) is a humanized IgG1 monoclonal antibody that binds human CD117 (c-Kit). Briquilimab blocks the interaction between CD117 receptor and stem cell factor on various CD117 expressing tissues. Briquilimab can lead to inhibition of SCF/c-Kit signaling and MC apoptosis. Briquilimab is a non-toxic approach to target and deplete HSC, enabling blood and immune reconstitution with minimal toxicity with the other agents being used for transient immune suppression to prevent immunologic rejection. Briquilimab can be used in various disease research such as severe combined immunodeficiency (SCID), myelodyplastic syndromes (MDS), acute myeloid leukemia (AML), chronic spontaneous urticarial (CSU), chronic inducible urticarial (CIndU) and asthema .
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(5)
- HY-P992410
-
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PAI-1
TGF-beta/Smad
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Inflammation/Immunology
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MEDI-579 is a fully human monoclonal antibody against PAI-1, with a KD value of 6 pM for human PAI-1 and 105 pM for rat PAI-1. MEDI-579 restores renal plasmin activity and inhibits PAI-1-mediated intracellular signal transduction. MEDI-579 reduces albuminuria, glomerulosclerosis severity, TGF-β1 expression level, and phosphorylated Smad2 level induced in diabetic mice. MEDI-579 decreases the levels of active PAI-1 in plasma and kidneys, and increases plasma plasmin level in a mouse model of lupus nephritis. MEDI-579 can be used in research related to diabetic nephropathy and lupus nephritis. The recommended isotype control is human IgG1 kappa (HY-P99001) .
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(5)
- HY-P992212
-
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L-Selectin
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Inflammation/Immunology
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Anti-CD62L Antibody (DREG-200) is a human monoclonal antibody targeting CD62L/L-selectin. Anti-CD62L Antibody (DREG-200) binds to residues 45, 46 and 47 of L-selectin, and blocks L-selectin-mediated interactions, neutrophil rolling, adhesion, aggregation, secondary anchoring, as well as leukocyte rolling on ligands. Anti-CD62L Antibody (DREG-200) reduces myocardial necrosis, coronary endothelial dysfunction, and neutrophil migration driven by neutrophil microparticles. Anti-CD62L Antibody (DREG-200) exerts cardioprotective effects in feline models. Anti-CD62L Antibody (DREG-200) can be used in studies related to myocardial ischemia-reperfusion injury. The recommended isotype control is Mouse IgG1 kappa (HY-P99977) .
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(5)
- HY-P99447
-
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ASN-1
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Bacterial
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Infection
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Atidortoxumab is a human IgG1κ monoclonal antibody that targets Staph aureus alpha toxin .
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(5)
- HY-P9909
-
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(5)
- HY-P99057A
-
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CDX-1127 (anti-CD27)
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TNF Receptor
Transmembrane Glycoprotein
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Inflammation/Immunology
Cancer
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Varlilumab (CDX-1127) (anti-CD27) is an agonist anti-CD27 monoclonal antibody. Varlilumab (anti-CD27) can promote T cell expansion and activate the immune response. Varlilumab (anti-CD27) has anti-tumor activity and can be used in the research of hematological malignancies and solid tumors .
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(5)
- HY-P99057
-
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CDX-1127
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TNF Receptor
Transmembrane Glycoprotein
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Inflammation/Immunology
Cancer
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Varlilumab (CDX-1127) is an agonist anti-CD27 monoclonal antibody. Varlilumab can promote T cell expansion and activate the immune response. Varlilumab has anti-tumor activity and can be used in the research of hematological malignancies and solid tumors .
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(5)
- HY-P99014
-
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ARGX-110
|
Fc Receptor (FcR)
NF-κB
|
Inflammation/Immunology
Cancer
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|
Cusatuzumab (ARGX-110) is a selective competitive blocker targeting CD70 (with an equilibrium dissociation constant of 17 pM for binding to human CD70). Cusatuzumab also possesses enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) activity. It is a humanized IgG1 monoclonal antibody, artificially synthesized through humanization and genetic engineering modifications (CH2 region mutation to enhance effector function). Cusatuzumab has a dual mechanism of action: firstly, it competitively blocks the interaction between CD70 and CD27, inhibiting the CD27-NF-κB signaling pathway, reducing regulatory T cell (Treg) activation and tumor cell proliferation; secondly, by enhancing binding to FcγRIIIa, it mediates ADCC and antibody-dependent cellular phagocytosis (ADCP), directly lysing CD70-positive tumor cells. Cusatuzumab can efficiently eliminate leukemia stem cells (LSCs), induce tumor cell differentiation and apoptosis, restore immune surveillance, and target CD70-positive tumors. Cusatuzumab is used in the study of acute myeloid leukemia (AML) .
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(5)
- HY-P9966
-
|
MGA271
|
CD276/B7-H3
|
Cancer
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|
Enoblituzumab (MGA271) is a humanized IgG1κ monoclonal antibody recognizing human B7-H3 protein, a member of the B7 family of immune regulators .
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(5)
- HY-P99040
-
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JNJ-61610588; CI-8993; VSTB112
|
VISTA
|
Cancer
|
|
Onvatilimab (JNJ-61610588) is a human IgG1κ anti-VISTA (V-domain Ig Suppressor of T-cell Activation) monoclonal antibody. Onvatilimab can be used in colorectal cancer research .
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(5)
- HY-P9901
-
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MDX-010; BMS-734016
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CTLA-4
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Cancer
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|
Ipilimumab is a fully human monoclonal antibody IgG1κ that blocks the inhibitory receptor cytotoxic T lymphocyte antigen 4 (CTLA-4) on T cells. Ipilimumab can be used in unresectable or metastatic melanoma (MM) studies .
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(5)
- HY-P99424
-
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RG 7624; RO 5553110; NI-1401
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Interleukin Related
|
Inflammation/Immunology
|
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Afasevikumab (RG 7624; RO 5553110; NI-1401) is a fully human monoclonal IgG1κ antibody neutralizing both IL-17A and IL-17F. Afasevikumab has anti-inflammatory activities .
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(5)
- HY-P99669
-
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MDX-060
|
TNF Receptor
|
Cancer
|
|
Iratumumab (MDX-060) a human anti-CD30 IgG1κ monoclonal antibody. Iratumumab inhibits the growth of CD30-expressing tumor cells. Iratumumab can be used for research of Hodgkin's lymphoma (HL) and anaplastic large-cell lymphoma (ALCL) .
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(5)
- HY-P99039
-
|
MEDI9447
|
CD73
|
Cancer
|
|
Oleclumab (MEDI9447) is a human IgG1λ monoclonal antibody targeting CD73 and inhibits the exonuclease activity of the extracellular enzyme CD73. Oleclumab can adjust the composition of bone marrow and lymphoid infiltrating leukocyte populations in the tumor microenvironment and has anti-tumor activity .
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-
(5)
- HY-P992330
-
|
KB312
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
CBT004 (KB312) is a human IgG1κ type monoclonal antibody against CD83. CD83 is a type I transmembrane glycoprotein and is a highly expressed marker on the surface of mature DCs. It can also be induced to be expressed on activated B cells, some activated T cells, and activated monocytes.
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(5)
- HY-P992326
-
|
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PDGFR
|
Inflammation/Immunology
Cancer
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BOT1711 is a human IgG1κ monoclonal antibody targeting PDGFRB/CD140b. PDGFRB/CD140b belongs to type I receptor tyrosine kinases (RTKs), and is mainly expressed in vascular smooth muscle cells, pericytes, fibroblasts, certain mesenchymal stem cells, and tumor stromal cells.
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(5)
- HY-P99313
-
|
Anti-human IGHE Recombinant Antibody
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Apoptosis
|
Inflammation/Immunology
|
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Quilizumab (Anti-Human IGHE Recombinant Antibody) is a humanized IgG1κ monoclonal antibody targeting immunoglobulin epsilon (also konwn as: IGHE, IgE). Quilizumab targets the M1-prime fragment of membrane-expressed IGHE/IgE, leading to IGHE/IgE switching and memory B cell depletion. Quilizumab has potential in asthma research .
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-
(5)
- HY-P991651
-
|
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Fc Receptor (FcR)
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Inflammation/Immunology
|
|
MEDI4212 is a humanized IgG1λ monoclonal antibody inhibitor targeting IgE. MEDI4212 potently inhibits human IgE-mediated functional responses through its receptor FcεRI, such as calcium signaling, β-hexosaminidase release and phagocytosis. MEDI4212 prevents the binding of IgE to CD23 with an IC50 of 8 nM. MEDI4212 can be used severe asthma research .
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-
(5)
- HY-P99583
-
|
MEDI4893
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Suvratoxumab (MEDI4893) is a long-acting, high-affinity human anti-α-toxin monoclonal antibody (IgG1κ type). Suvratoxumab potently neutralizes α-toxin, a key S. aureus virulence factor. Suvratoxumab improves survival and reduces lung injury in an immunocompromised mice model of pneumonia. Suvratoxumab also enhances the antibacterial activity of Vancomycin (HY-B0671) or Linezolid (HY-10394) .
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-
(5)
- HY-P99340
-
|
VIR 7831; GSK-4182136
|
SARS-CoV
|
Infection
Cancer
|
|
Sotrovimab (VIR 7831) is a human IgG1κ pan-sarbecovirus monoclonal antibody (mAb), neutralizes SARS-CoV-2, SARS-CoV-1, and multiple other sarbecoviruses. Sotrovimab is developed based on S309, exhibits a long half-life and great bioavailability in the respiratory mucosa. Sotrovimab could result in immune-mediated viral clearance and prevent progression of Covid-19 early in the course of disease .
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-
(5)
- HY-P991567
-
|
VX5/5261
|
CXCR
|
Inflammation/Immunology
Cancer
|
|
VX5 (VX5/5261) is a humanized IgG1κ monoclonal antibody inhibitor targeting BCA-1/CXCL13. VX5 significantly inhibits human CXCL13-mediated internalization of CXCR5, blocks both human and mouse CXCL13-dependent B-cells chemotaxis and migration. VX5 can be used to study autoimmune diseases like multiple sclerosis and arthritis, and cancers like gastric lymphomas and colon cancer .
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-
(5)
- HY-P99410
-
|
AMG 714; PRV-015
|
Interleukin Related
|
Inflammation/Immunology
|
|
Ordesekimab (AMG 714; PRV-015) is a fully human IgG1κ anti-IL-15 (Interleukin Related) monoclonal antibody. The binding of Ordesekimab to IL-15 inhibits the interaction of IL-15 with the IL-2Rβ and common γ chain of the IL-15 receptor complex, but not with the IL-15Rα chain. Ordesekimab has the potential for study of nonresponsive celiac disease (NRCD) .
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-
(5)
- HY-P99952
-
|
SCT400
|
CD20
|
Cardiovascular Disease
Inflammation/Immunology
Endocrinology
Cancer
|
|
Ripertamab (SCT400) is a recombinant human-mouse chimeric anti-CD20 IgG1κ monoclonal antibody. As an immunomodulator, ripertamab reduces the levels of pathogenic autoantibodies, alleviates immune complex deposition, and blocks the antigen-presenting function of cells. Ripertamab depletes CD20-positive cells. Ripertamab can induce infusion-related reactions, pulmonary toxicity, neutropenia and thrombocytopenia. Ripertamab is applicable to research related to non-Hodgkin's lymphoma, primary membranous nephropathy and idiopathic membranous nephropathy .
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-
(5)
- HY-P991229
-
|
AGS-1C4D4; AGS-PSCA
|
Complement System
|
Cancer
|
|
AGS-1C4D4 is a fully human IgG1κ monoclonal antibody targeting PSCA, with a Ka value of 0.2 nM. AGS-1C4D4 mediates antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) against PSCA-expressing cells. AGS-1C4D4 can be used for the research of pancreatic cancer .
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-
(5)
- HY-P991566
-
|
|
CTLA-4
|
Cancer
|
|
KD6001 is a humanized IgG1κ monoclonal antibody, targeting CTLA4. KD6001 significantly disrupts CTLA-4 interactions with CD80 (IC50: 16 ng/mL) and CD86. KD6001 enhances IL-2 and IFNγ expression in PHA-activated human lymphocytes and exhibits potent antitumor effects. KD6001 effectively inhibits tumor growth in MC38, B16, and Hepa1-6 tumor mice model. KD6001 can be used for cancers research, such as advanced melanoma, hepatocellular carcinoma and liver cancer .
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-
(5)
- HY-P991223
-
|
|
Transmembrane Glycoprotein
TNF Receptor
|
Cancer
|
|
NC762 is a humanized IgG1κ monoclonal antibody that targets human B7-H4 (B7 homolog 4). NC762 has enhanced binding to CD16a (FcγRIIIa) after being Fc engineered with three point mutations (S239D/A330L/I332E; DLE) and demonstrate increased antibody-dependent cellular cytotoxicity (ADCC) activity. NC762 inhibits tumor growth in vivo through binding to tumor-expressing B7-H4. NC762 can be studies in research on cancer such as advanced or metastatic solid tumors .
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(5)
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