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indicator

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462

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Screening Libraries

159

Fluorescent Dye

164

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1055

MitoSOX Red Maximum Cited Publications 263 Publications Verification	Fluorescent Dye Reactive Oxygen Species (ROS) Mitochondrial Metabolism	Cancer
MitoSOX Red is a live cell fluorescent probe that specifically targets mitochondria and is cell membrane permeable. MitoSOX Red enters mitochondria and is oxidized by superoxide but not by other ROS or RNS generating systems. The oxidized MitoSOX Red then binds to nucleic acids in mitochondria/nucleus, producing strong red fluorescence. MitoSOX Red can be used as a fluorescent indicator to specifically detect superoxide. In addition, superoxide dismutase (SOD) can prevent the oxidation of MitoSOX Red. Excitation/emission wavelength: 510/580 nm.

HY-D0169

Phenol Red 1 Publications Verification Phenolsulfonephthalein	Environmental Pollutants Fluorescent Dye	Others
Phenol red (Phenolsulfonephthalein) is a pH indicator dye, relying on a distinct color change from pink to yellow in case of a positive reaction .

HY-111391A

Resazurin sodium, indicator Diazoresorcinol sodium, indicator	Bacterial Fluorescent Dye	Others
Resazurin (Diazoresorcinol) sodium, indicator is a non-toxic, stable, membrane-permeable blue non-fluorescent dye (faintly fluorescent). Resazurin sodium, indicator is used as a redox indicator, can be reduced to pink, highly fluorescent Resorufin (Ex=530-560 nm, Em=590 nm) in living cells. Resazurin sodium, indicator can be used for the detection of cell viability, toxicity, proliferation, migration and invasion in cells (human, plant and animal, bacterial and fungal) .

HY-113409

3-Hydroxyisovaleric acid 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
3-Hydroxyisovaleric acid is a normal endogenous metabolite excreted in the urine. The urinary excretion of 3-hydroxyisovaleric acid is early and sensitive indicator of biotin deficiency .

HY-B1571

Bromophenol blue	Environmental Pollutants Fluorescent Dye	Others
Bromophenol blue is an acid phthalein dye, and it is used as a tracking dye for electrophoresis. Bromophenol blue is also used as a pH indicator, with a transition range of pH 3 to 4.6. Bromophenol blue is used as a sensor for the determination of several compounds including ammonia, drugs, proteins and amino acids. The binding of Bromophenol blue to proteins is accompanied by the appearance of a strong absorbance at 610 nm .

HY-B1359A

Methylene blue indicator 1 Publications Verification	Biochemical Assay Reagents	Others
Methylene blue indicator is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-D0023

Pyranine 2 Publications Verification HPTS; Solvent Green 7	Environmental Pollutants Fluorescent Dye	Others
Pyranine (HPTS; Solvent Green 7) is a cell-impermeant pH-sensitive fluorescent indicator. Pyranine acts as a class of fluorescent chemosensor for the Cu ⁺ ion. Pyranine is used as a coloring agent, biological stain, optical detecting reagent, and pH indicator (Ex/Em = 450/510 nm) .

HY-D0155

Zinpyr-1 4 Publications Verification	Fluorescent Dye	Others
Zinpyr-1 is a zinc-responsive fluorescent indicator and a membrane-permeable metal-binding probe. Zinpyr-1 forms a complex with Mn ²⁺ ions and generates a fluorescence turn-on signal. Zinpyr-1 binds to free zinc ions in serum, enabling quantitative detection of free zinc concentration. Zinpyr-1 produces fluorescence signals reflecting the relative zinc concentration in plant root cells, localizes to specific layers of plant root cells, and can be used to support analyses related to plant zinc transporter mutations and homeostasis .

HY-W110798

*Bromophenol blue indicator* (3.0-4.6)** 1 Publications Verification	Environmental Pollutants Biochemical Assay Reagents	Others
Bromophenol blue indicator (3.0-4.6) is a synthetic dye commonly used as an acid-base indicator with a transition range of pH 3.0-4.6. Bromophenol blue indicator (3.0-4.6) is water soluble and changes color from yellow to blue as the pH of the solution changes from acidic to basic. Its unique chemical properties make it an important ingredient in a variety of scientific applications, especially in biochemistry and molecular biology. In addition, it can be used as a stain in microbiology and histology. However, Bromophenol blue indicator (3.0-4.6) has potential irritating and staining properties.

HY-W110927

*Alizarin Red S Indicator* (4.3-6.3), IND**	Biochemical Assay Reagents Fluorescent Dye	Others
Alizarin red S indicator (C.I. 58005) is a reductively active (quinone-based) anthraquinone dye that forms complexes with metal ions (such as zirconium, calcium) or boric acid to label calcium deposition and perform electrochemical sensing functions. Alizarin Red S undergoes reversible redox reactions (for electrochemical detection) and irreversible chelation (for bone staining). Alizarin Red S is mainly used in bone metabolism research (labeling mineralized tissue), sugar detection (boric acid-sugar competition system) and metal ion sensing (such as zirconium ion detection)， and can be used in osteoporosis and metabolic disease research .

HY-D0215

Safranin Safranine T	Fluorescent Dye Bacterial	Infection Metabolic Disease
Safranin (Safranin T) is an important and classical phenazinium dye. Safranin has been extensively used in the academic field as a spectroscopic probe and indicator. Safranin possesses a planar structure and cationic charge. Safranin can readily intercalate into biological macromolecules, including DNA and proteins. Safranin has antibacterial effects against gram-positive bacteria (S. aureus). Safranin can be used as a redox indicator in the determination of metal ion concentration .

HY-W129633

2,6-Dichlorophenolindophenol sodium hydrate 1 Publications Verification DCIP sodium hydrate; DPIP sodium hydrate	Biochemical Assay Reagents	Others
2,6-Dichlorophenolindophenol (DCIP; DPIP) sodium hydrate is a redox chromogenic indicator with a redox potential of +217 mV relative to SHE, and it acts as a substrate for reduction reactions. During the metabolic process of nutrient consumption by Saccharomyces cerevisiae, 2,6-Dichlorophenolindophenol sodium hydrate is reduced from dark blue to colorless, resulting in a decrease in absorbance. 2,6-Dichlorophenolindophenol sodium hydrate is widely used in spectrophotometric biochemical oxygen demand determination and preclinical colorimetric toxicity analysis for heavy metal ion detection based on Saccharomyces cerevisiae .

HY-W040144

Bromocresol green	Fluorescent Dye	Others
Bromocresol green is a pH-sensitive triphenylmethane dye commonly used for the determination of protein and albumin in serum. Bromocresol green is a bio-based dye with a yellow-green to blue-green color. Bromocresol green turns yellow (λmax=435 nm, protonated form) when placed in acidic solution (e.g. pH=4.15), and turns blue in basic solution (λmax=615 nm, deprotonated form). Bromocresol green is widely used as a pH indicator in the field of biochemical analysis. In addition, Bromocresol green is also used to detect the concentration of molecules such as creatinine, and to judge the viability of cells .

HY-W110910

Eriochrome black T, Indicator	Biochemical Assay Reagents	Infection
Eriochrome black T, Indicator is a complexing agent for metal ions (e.g., Ca ²⁺, Mg ²⁺) and is used as an indicator in complexometric titrations. Eriochrome black T, Indicator forms colored complexes with metal ions through covalent coordination bonds, and indicates the endpoint of the titration by color change. Eriochrome black T, Indicator can be used as an anionic azo dye in photocatalytic degradation studies to evaluate the performance of photocatalysts. The reaction solution of Eriochrome black T, Indicator combined with Mg ²⁺ is initially purple. During loop-mediated isothermal amplification (LAMP), the color changes from purple to sky blue due to the consumption of Mg ²⁺ by the formation of magnesium pyrophosphate, indicating a positive reaction. The optimal concentration of Eriochrome black T, Indicator in LAMP is 60 μM, and the detection limit for Mycobacterium tuberculosis is 1 pg DNA/reaction .

HY-Y0699

Methyl red	Environmental Pollutants Fluorescent Dye	Others
Methyl red is a pH-sensitive acid-base indicator and colorimetric reagent with a pKa of 5.1. Methyl red achieves visual judgment of the titration endpoint through reversible structural changes of protonation (red, pH <4.4) and deprotonation (yellow, pH >6.2). Methyl red is widely used in acid-base titration in chemical analysis and buffer pH monitoring in biochemistry .

HY-101883A

BCECF Acetoxymethyl ester 5+ Cited Publications	Fluorescent Dye	Others
BCECF Acetoxymethyl ester is a cell membrane permeable compound widely-used as a fluorescent indicator for intracellular pH. BCECF Acetoxymethyl ester could diffuse through the cell membrane and intracellular esterase cleave the ester bond releasing BCECF (HY-101882). BCECF allows measurements in the physiological pH range 6.0-8.0. Excitation ratio: 490/440 nm; Emission intensity: 535 nm .

HY-D0219

Thymol blue Thymolsulphonephthalein	Fluorescent Dye	Others
Thymol blue is a reversible pH indicator that responds to the pH of the solution through structural changes of protonation and deprotonation. Thymol blue is red (HI ^- form) under acidic conditions and blue (I ^2- form) under alkaline conditions. Quantitative detection is achieved through the absorption peak shift (435 nm/596 nm) of the UV-visible spectrum. Thymol blue selectively responds to pH changes, changing from red to yellow at pH 1.2-2.8 and from yellow to blue at pH 8.0-9.6. Thymol blue can be fixed in a silica gel matrix through sol-gel technology to form a solid-state sensor for in-situ pH measurement in the marine environment and acid-base monitoring in the biomedical field[1][2].

HY-W012982

3-Amino-2-oxazolidinone 1 Publications Verification AOZ	Drug Metabolite Monoamine Oxidase	Cardiovascular Disease Metabolic Disease
3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone (HY-B1336). 3-Amino-2-oxazolidinone is always be detected as a indicator of furazolidone residues in vivo. 3-Amino-2-oxazolidinone is orally active .

HY-D0169A

Phenol Red sodium salt 1 Publications Verification Phenolsulfonephthalein sodium salt	Fluorescent Dye Glutathione Peroxidase	Others
Phenol red (Phenolsulfonephthalein) sodium salt is a pH indicator dye. Phenol Red sodium salt is also an antagonist of rat P2X1R. Phenol Red sodium salt enhances the halogenating activity of myeloperoxidase. Phenol Red sodium salt shows a distinct color change from pink to yellow in a positive pH reaction .

HY-W110794

Crystal violet, IND (0.0-2.0)	Environmental Pollutants Biochemical Assay Reagents	Others
Crystal violet, IND (0.0-2.0) is a specialized indicator suitable for strongly acidic systems, which reflects changes in pH within the range of 0.0-2.0 through color changes. Crystal violet, IND (0.0-2.0) is widely used in acid-base titration, chemical analysis, and industrial testing fields .

HY-W087928

Bromocresol purple	Biochemical Assay Reagents	Others
Bromocresol purple is a pH indicator, whose color changes from yellow to purple when the pH increases from 5.2 to 6.8. Bromocresol purple can be used for detecting yeast cells with plasma membrane damage and measuring serum albumin concentrations .

HY-125929

Murexide Ammonium purpurate	Biochemical Assay Reagents	Others
Murexide (Ammonium purpurate) can be used as an indicator in complexometric titrations to determine water hardness.

HY-Y1125

6-Methyluracil Pseudothymine	Endogenous Metabolite	Metabolic Disease
6-Methyluracil (Pseudothymine), a metabolite of Uracil, can be used as an indicator of acetoacetyl-CoA (AACoA) accumulation. 6-Methyluracil exhibits antiradiation effect in vivo .

HY-125457

α-Naphtholbenzein p-Naphtolbenzein	Biochemical Assay Reagents	Others
α-Naphtholbenzein (p-Naphtolbenzein) is a dye. α-Naphtholbenzein can be used as a pH indicator. α-Naphtholbenzein is commonly used in experiments such as acid-base neutralization reactions, titration, and pH measurement .

HY-D1435

Oxonol VI	Na+/K+ ATPase Fluorescent Dye	Metabolic Disease
Oxonol VI is an optical indicator of membrane potential in lipid vesicles (excitation/emission wavelengths: 614/646 nm). Oxonol VI can be used to detect changes in membrane potential associated with (Na ⁺ + K ⁺)-ATPase activity in reconstituted vesicles .

HY-112624F

CY7-Dextran (MW 4000)	Fluorescent Dye	Others
CY7-Dextran (MW 4000) is a fluorescent dye that consists of CY7 (HY-D0825) and Dextran (HY-112624) (Ex=740 nm; Em=770 nm). CY7-Dextran (MW 4000) can be used as a cell volume indicator and delineates the thin peripheral edges of the cells .

HY-W110793

Dithizone Diphenylthiocarbazone	Biochemical Assay Reagents	Metabolic Disease
Dithizone can be toxic to pancreatic islet cells and cause experimental diabetes. Dithizone can be used for in vitro in vivo staining of transplanted islets and cytoplasmic granules of bone marrow cells. Dithizone can be used as a chelating agent and colorimetric indicator for the detection and extraction of various heavy metals, including lead and mercury, in analytical and biochemical applications. Dithizone forms stable colored complexes with metal ions and can be quantitatively analyzed by methods such as spectrophotometry .

HY-D0800

Mordant Blue 29	Biochemical Assay Reagents	Others
Chromeazurol S is a compound belonging to the class of azo dyes. It is often used as an indicator in analytical chemistry to detect metal ions such as copper, nickel, and cobalt. Chromeazurol S turns from yellow to blue in the presence of metal ions, allowing them to be detected and quantified. It can be applied to a test strip or added directly to a solution for analysis.

HY-129491

O-Desmethyl Midostaurin CGP62221; O-Desmethyl PKC412	PKC	Cancer
O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo . Midostaurin is a multi-targeted protein kinase inhibitor with IC₅₀ ranging from 22-500 nM.

HY-D0142

Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium	Environmental Pollutants Fluorescent Dye	Others
Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium is a fluorescent dye and pH indicator, also as a ligand of multifunctional metal-organic framework. Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium has been used to detect CO₂ release .

HY-109116

Hydromethylthionine Leukomethylene blue	Biochemical Assay Reagents	Others
Hydromethylthionine (Leukomethylene blue) has a very active photochemically active reagent, especially in its interaction with dissolved oxygen. The photochemical activity of Hydromethylthionine is mainly regulated by the reaction of its triplet state with dissolved oxygen, which reacts with dissolved oxygen to form Methylene Blue (HY-14536) and hydronium ions under ultraviolet light. Hydromethylthionine can be used for the photodegradation of model pollutants in semiconductor photocatalysis and for the study of indicators in chemical analysis .

HY-D0798

Catechol violet	Fluorescent Dye	Others
Catechol violet is an efficient and versatile ligand for Cu(I)-catalyzed C-S coupling reactions. Catechol violet is also a complexometric indicator dye .

HY-128545

Nitrazine yellow Nitrazine paper; Phenaphthazine	Biochemical Assay Reagents	Others
Nitrazine yellow (Nitrazine paper; Phenaphthazine) is a pH indicator. The color of Nitrazine yellow changes from yellow to blue in the pH range from 6.0 to 7.0. Nitrazine yellow is a kind of biological materials or organic compounds that are widely used in life science research .

HY-124493

Aluminon 3 Publications Verification ATA; Ammonium aurintricarboxylate; Aurintricarboxylic acid ammonium	Biochemical Assay Reagents	Others
Aluminon (ATA; Ammonium aurintricarboxylate; Aurintricarboxylic acid ammonium) is a complexometric titration indicator and can also be used as a nuclease inhibitor affecting transfection. Aluminon is a kind of biological materials or organic compounds that are widely used in life science research .

HY-D0265

Thymolphthalein	Environmental Pollutants Fluorescent Dye	Others
Thymolphthalein is an electrochemically active dye due to the presence of thymol fragments. Thymolphthalein is a Phthalein dye used as an acid-base indicator. It is colourless in acid pH and is blue in basic pH .

HY-D1436

PBFI	Fluorescent Dye	Neurological Disease
PBFI is the cell-impermeant fluorescent indicator that is widely used for the determination of concentrations of K ⁺ (Ex/Em = 340,380/500 nm) .

HY-D1091

DiSBAC2(3)	Fluorescent Dye	Neurological Disease
DiSBAC2(3) is an anionic membrane-potential-sensitive dye. DiSBAC2(3) is a plasma membrane potential indicator .

HY-D0228

4-(4-Nitrophenylazo)resorcinol Azo Violet; Magneson I	Fluorescent Dye	Others
4-(4-Nitrophenylazo)resorcinol (Azo Violet) is an azo purple dye used experimentally as a pH indicator, showing yellow when the pH value is lower than 11 and purple when the pH value is higher than 13. In slightly alkaline or alkaline environments, it also turns dark blue in the presence of magnesium salts. Azo Violet can also be used to test for the presence of ammonium ions. The color of the ammonium chloride or ammonium hydroxide solution will change depending on the concentration of azo violet used .

HY-D1677

5(6)-Carboxynaphthofluorescein	Fluorescent Dye	Others
5(6)-Carboxynaphthofluorescein is a pH-dependent fluorophore. 5(6)-Carboxynaphthofluorescein shows good sensitivity in an alkaline pH range and it can be exploited in the construction of fiber-optic pH sensors. 5(6)-Carboxynaphthofluorescein can be used as a fluorescent pH indicator (Ex/Em=593/668 nm) .

HY-W012982S

3-Amino-2-oxazolidinone-d4 AOZ-d₄	Isotope-Labeled Compounds Monoamine Oxidase Drug Metabolite	Cardiovascular Disease Metabolic Disease
3-Amino-2-oxazolidinone-d₄ (AOZ-d₄) is a deuterium labeled 3-Amino-2-oxazolidinone (HY-W012982). 3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone (HY-B1336). 3-Amino-2-oxazolidinone is always be detected as a indicator of furazolidone residues in vivo. 3-Amino-2-oxazolidinone is orally active .

HY-131490

Tetrazolium violet Violet tetrazolium	Biochemical Assay Reagents	Others
Tetrazolium violet is a redox indicator commonly used in various biochemical assays to measure cell viability and metabolic activity. Tetrazolium Violet has unique chemical properties that allow it to be reduced by cellular enzymes such as dehydrogenases to form a purple formazan product that can be detected spectrophotometrically. This makes it a useful tool for assessing cell health and growth in culture or tissue samples.

HY-W141392

2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite	Nucleoside Antimetabolite/Analog Xanthine Oxidase Phosphoramidites	Cancer
2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

HY-D2482

Asante potassium green-1 AM APG-1 AM	Fluorescent Dye	Neurological Disease
Asante potassium green-1 AM (APG-1 AM) is a cell-permeable K ⁺-sensitive fluorescent indicator and potassium ion indicator that exhibits minimal interference from Na ⁺ and pH at physiologically relevant intracellular levels. Asante potassium green-1 AM enables non-invasive monitoring and quantitative analysis of intracellular potassium ion concentration (ᵢ) . Its excitation/emission maxima are 525/545 nm, respectively.

HY-D0948

Celestine Blue	Fluorescent Dye	Infection
Celestine Blue is a electroactive indicator in DNA biosensors. Celestine Blue is strongly adsorbed on the spinel phases and CNT (carbon nanotubes), facilitates dispersion, acts as a capping agent and allows for the fabrication of spinel decorated CNT. Celestine Blue is an efficient charge transfer mediator, which allows for significant improvement of capacitive behavior. TiO₂ nanoparticles doped with Celestine Blue can be used as a label in a sandwich immunoassay for the hepatitis C virus (HCV) core antigen .

HY-D0252

m-Cresol purple	Fluorescent Dye	Others
m-Cresol purple is a pH indicator dye with large cross section and halochromic property in neutral pH range .

HY-136884

DAR-4M	Fluorescent Dye	Others
DAR-4M is a fluorescent indicator for nitric oxide (NO) based on the rhodamine chromophore (Ex/Em= 550/572 nm) .

HY-32349S

Ercalcidiol-d3 25-Hydroxy Vitamin D2-d₃	Isotope-Labeled Compounds Endogenous Metabolite VD/VDR	Metabolic Disease
Ercalcidiol-d₃ is the deuterium labeled Ercalcidiol. Ercalcidiol is a metabolite of Vitamins D2. Ercalcidiol can be used as an indicator of vitamins D status .

HY-D0219A

Thymol Blue sodium	Fluorescent Dye	Others
Thymol Blue sodium is an acid-base indicator used to indicate changes in pH. Thymol Blue sodium fades from red to yellow at pH 1.2 to 2.8 and from yellow to blue at pH 8.0 to 9.6. Quantitative detection is achieved through the absorption peak shift (435 nm/596 nm) of the UV-visible spectrum. Thymol blue sodium can be fixed in a silica gel matrix through sol-gel technology to form a solid-state sensor for in-situ pH measurement in the marine environment and acid-base monitoring in the biomedical field .

HY-N8502

Urdamycin A	Fluorescent Dye	Cancer
Urdamycin A (Compound 3b) is an angucycline antibiotic that can be isolated from Streptomyces fradiae. Urdamycin A is an orange indicator with a change of the color to ultramarine blue at pH 7.7. Urdamycin A has anticancer activity with IC₅₀s of 2.4 and 0.55 μg/mL in proliferation and stem cell assays, respectively .

HY-W760733

2,4-Decadienal	Biochemical Assay Reagents	Metabolic Disease
2,4-Decadienal is a toxic aldehyde produced by the oxidation of linoleic acid-rich oils. 2,4-decadienal can be used as an alternative oxidation indicator for linoleic acid-rich oils .

Cat. No.	Product Name

HY-L204

Lactic Acid Metabolic Compound Library

529 compounds

Lactic acid metabolism is one of the key metabolic pathways within living organisms. It plays a crucial role not only in cellular energy conversion but is also closely related to a variety of physiological and pathological processes. The production and clearance of lactic acid are important indicators of cellular metabolic balance, and its abnormal regulation may lead to conditions such as lactic acidosis, muscle fatigue, and hereditary metabolic diseases. Moreover, lactic acid is closely related to the malignancy of tumors and is considered a biomarker for malignant tumors and poor prognosis. Lactic acid can serve as a metabolic substrate to support the metabolic needs of tumor cells under hypoxic conditions, and it can also cause acidification of the tumor microenvironment, suppress immune cell function to promote immune evasion, and induce drug resistance in tumor cells. Currently, targeting lactic acid-lactylation and its related metabolic pathways has become a new research avenue for cancer treatment. In-depth exploration of the molecular mechanisms of lactic acid metabolism can help in screening lead compounds that regulate the lactic acid metabolism.

MCE contains 529 small molecule compounds targeting enzymes involved in lactic acid metabolism. This library is of significant value for researching the role of lactate metabolism in the mechanisms of diseases.

Cat. No.	Product Name	Target	Research Area

HY-P10638

TAT-CN21	CaMK	Cardiovascular Disease Neurological Disease
TAT-CN21 is a potent CaMKII inhibitor with an IC₅₀ of 77.2 nM. TAT-CN21 inhibits both calcium/calmodulin-dependent and autonomously activated CaMKII, blocks glutamate-induced translocation of CaMK IIα, and reverses the enhanced phosphorylation of CaMKII at Thr286 following excitotoxic injury. TAT-CN21 shows application potential in studies related to ischemic stroke by reducing neuronal excitotoxicity and exacerbating pre-existing long-term neuronal death prior to injury. TAT-CN21 improves definitive behaviors in rats with residual nerve injury without altering indicators such as mechanical/thermal hyperalgesia or spatial memory. TAT-CN21 can also be used in studies related to neuropathic pain .

HY-P0267A

Melanotan (MT)-II acetate	Melanocortin Receptor	Neurological Disease Metabolic Disease Endocrinology
Melanotan (MT)-II acetate is a melanocortin receptor agonist that crosses the blood-brain barrier. Melanotan (MT)-II acetate activates melanocortin receptor 3 and melanocortin receptor 4, and stimulates the release of central endogenous oxytocin. Melanotan (MT)-II acetate reverses recognition memory impairment, increased anxiety levels and reduced exploratory tendency in zebrafish exposed to short-term high-fat diet. Melanotan (MT)-II acetate improves impaired social behavior indicators in mouse models of autism spectrum disorder. Melanotan (MT)-II acetate induces weight loss, reduces food intake and exerts anorectic effects. Melanotan (MT)-II acetate increases intracavernous pressure and erectile activity in brown rats. Melanotan (MT)-II acetate can be used in studies related to memory impairment, anxiety, reduced exploratory behavior, autism spectrum disorder, obesity and erectile dysfunction .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0091

Hypoxanthine Maximum Cited Publications 15 Publications Verification Purin-6-ol; Sarcine	Natural Products Microorganisms Classification of Application Fields Disease markers Other Diseases Endogenous metabolite Disease Research Fields Cancer Source Classification	Endogenous Metabolite
Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

HY-103395

Methylmalonic acid 3 Publications Verification Methylpropanedioic acid; Methylmalonate	Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer.

HY-N0321

Caftaric acid trans-Caftaric acid	Microorganisms other families Classification of Application Fields Simple Phenylpropanols Other Diseases Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification	Others
Caftaric acid (trans-Caftaric acid) is a polyphenolic antidiuretic, antioxidant and anti-apoptotic agent that can be hydrolyzed by intestinal microbial esterases. Caftaric acid exerts its antioxidant and potential anti-inflammatory effects mainly through intestinal microbial metabolism. Caftaric acid can reduce renal damage, restore electrolyte balance, renal function indicators and antioxidant enzyme activities in a rat albinism model, and further exert anti-oxidative stress and anti-inflammatory activities .

HY-113409

3-Hydroxyisovaleric acid 1 Publications Verification	Immune System Disorder Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Cardiovascular System Disorder Cancer Source Classification	Endogenous Metabolite
3-Hydroxyisovaleric acid is a normal endogenous metabolite excreted in the urine. The urinary excretion of 3-hydroxyisovaleric acid is early and sensitive indicator of biotin deficiency .

HY-118103

Coprostanol 5β-Cholestan-3β-ol	Structural Classification Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Coprostanol (5β-Cholestan-3β-ol) is a fecal sterol formed by microbial reduction of cholesterol in the intestines of man and higher animals. Coprostanol can be used as an indicator sterol of fecal pollution. Coprostanol has been recognized as a good indicator of pollution of water resources by sewage discharges. Coprostanol can serve as a potential biological indicator for cerebral chondrodystrophy (CTX) .

HY-113168

Butyrylcarnitine 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Butyrylcarnitine is an endogenous metabolite found in plasma. Elevated levels of Butyrylcarnitine are closely associated with abnormalities in lipid and energy metabolism. Butyrylcarnitine can serve as a diagnostic and prognostic indicator for certain diseases, such as heart failure and head and neck cancer .

HY-32349

Ercalcidiol 2 Publications Verification 25-Hydroxy Vitamin D2	Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	VD/VDR Endogenous Metabolite
Ercalcidiol is a metabolite of vitamin D₂, is regarded as an indicator of vitamin D nutritional status.

HY-W017006

1-Methyl-L-histidine 2 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Cardiovascular System Disorder Source Classification	Endogenous Metabolite
1-Methyl-L-histidine is an objective indicator of meat ingestion and exogenous 3-methylhistidine (3MH) intake.

HY-D0168

Orcinol 3,5-Dihydroxytoluene	Microorganisms Classification of Application Fields Other Diseases Phenols Polyphenols Ericaceae Plants Disease Research Fields Source Classification	Fluorescent Dye Tyrosinase p38 MAPK ERK
Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of MITF, tyrosinase (TYR), TRP1, and DCT. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases .

HY-129380

Fructosyl-lysine 1 Publications Verification Fructoselysine	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Fructosyl-lysine (Fructoselysine) is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes?detection .

HY-W008820

Glutaric acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification	MOFs Endogenous Metabolite
Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I .

HY-113323

3-Methoxy-4-hydroxyphenylglycol 2 Publications Verification HMPG; MHPG; MOPEG	Monophenols Neurological Disease Classification of Application Fields Phenols Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
3-Methoxy-4-hydroxyphenylglycol (HMPG) is a metabolite of norepinephrine degradation in the brain. 3-Methoxy-4-hydroxyphenylglycol is an indicators of central nervous system noradrenergic activity. 3-Methoxy-4-hydroxyphenylglycol can be used for research of depression, chronic schizophrenia, etc .

HY-129912

N1,N8-Diacetylspermidine	Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
N1,N8-Diacetylspermidine is a polyamines in the human urine . N1,N8-Diacetylspermidine is useful as prognostic indicators after treatment and during follow-up examination of cancer patients .

HY-N0772

Isomangiferin 4 Publications Verification	Infection Structural Classification Liliaceae Xanthones Classification of Application Fields Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Disease Research Fields Source Classification	VEGFR NOD-like Receptor (NLR) NF-κB Bacterial AMPK Acetyl-CoA Carboxylase Apoptosis Reactive Oxygen Species (ROS) HSV Drug Derivative
Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing .

HY-Y1125

6-Methyluracil Pseudothymine	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
6-Methyluracil (Pseudothymine), a metabolite of Uracil, can be used as an indicator of acetoacetyl-CoA (AACoA) accumulation. 6-Methyluracil exhibits antiradiation effect in vivo .

HY-129380A

Fructosyl-lysine dihydrochloride 1 Publications Verification Fructoselysine dihydrochloride	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection .

HY-108398A

Mead acid 1 Publications Verification 5,8,11-Eicosatrienoic acid	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Mead acid (5,8,11-Eicosatrienoic acid), an unsaturated (Omega-9) fatty acid, is an indicator of essential fatty acid deficiency .

HY-N9945

3-Oxo-7-hydroxychol-4-enoic acid	Classification of Application Fields Endogenous metabolite Disease Research Fields Inflammation/Immunology Steroids Source Classification	Endogenous Metabolite
3-Oxo-7-hydroxychol-4-enoic acid is an endogenous metabolite. 3-Oxo-7-hydroxychol-4-enoic acid may be an important indicator of a poor prognosis in hepatobiliary disease .

HY-W004874

2,6-Dimethylhydroquinone M-Xylohydroquinone	Classification of Application Fields Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
2,6-Dimethylhydroquinone is a key metabolic intermediate for the Mycobacterium strain DM1 during the degradation of 2,6-dimethylphenol (2,6-xylenol). 2,6-Dimethylhydroquinone can serve as an indicator for early failures in biological treatment systems .

HY-112948

2-Methylbutyrylcarnitine	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
2-Methylbutyrylcarnitine is a fatty acid metabolite. 2-Methylbutyrylcarnitine is found mainly in the blood and urine of humans and animals and is produced through the pyruvate carboxylation pathway. 2-Methylbutyrylcarnitine exhibits high level in the plasma of subjects with steatohepatitis (NASH) and can be used as an indicator for the diagnosis of metabolic diseases .

HY-113465

Leukotriene E4 1 Publications Verification LTE4	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4. Leukotriene E4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A). Leukotriene E4 accumulates in both plasma and urine and urinary excretion of Leukotriene E4 is most often used as an indicator of asthma.

HY-Y1097

Monomethyl phthalate 2-(Methoxycarbonyl)benzoic acid	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite Reactive Oxygen Species (ROS)
Monomethyl phthalate is an orally active metabolite of phthalic acid. Monomethyl phthalate, as a urine biomarker after exposure to phthalate, can be used as a detection indicator for thyroid cancer and benign nodules. Monomethyl phthalate reduces the survival rate of young frogs. Monomethyl phthalate induces oxidative damage to red blood cells in rats .

HY-103395R

Methylmalonic acid (Standard) Methylpropanedioic acid (Standard); Methylmalonate (Standard)	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Endocrine diseases Endogenous metabolite	Reference Standards Endogenous Metabolite
Methylmalonic acid (Standard) is the analytical standard of Methylmalonic acid. This product is intended for research and analytical applications. Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer.

HY-N0091R

Hypoxanthine (Standard) Purin-6-ol (Standard); Sarcine (Standard)	Structural Classification Natural Products Microorganisms Disease markers Endogenous metabolite Cancer Source Classification	Reference Standards Endogenous Metabolite
Hypoxanthine (Standard) is the analytical standard of Hypoxanthine. This product is intended for research and analytical applications. Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

HY-129912A

N1,N8-Diacetylspermidine hydrochloride	Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
N1,N8-Diacetylspermidine hydrochloride is a polyamines in the human urine . N1,N8-Diacetylspermidine hydrochloride is useful as prognostic indicators after treatment and during follow-up examination of cancer patients .

HY-N8502

Urdamycin A	Microorganisms Antibiotics Source Classification	Fluorescent Dye
Urdamycin A (Compound 3b) is an angucycline antibiotic that can be isolated from Streptomyces fradiae. Urdamycin A is an orange indicator with a change of the color to ultramarine blue at pH 7.7. Urdamycin A has anticancer activity with IC₅₀s of 2.4 and 0.55 μg/mL in proliferation and stem cell assays, respectively .

HY-32349R

Ercalcidiol (Standard) 25-Hydroxy Vitamin D2 (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Reference Standards VD/VDR Endogenous Metabolite
Ercalcidiol (Standard) is the analytical standard of Ercalcidiol. This product is intended for research and analytical applications. Ercalcidiol is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status.

HY-113406

(±)-Hexanoylcarnitine DL-Hexanoylcarnitine	Natural Products Animals Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Others
(±)-Hexanoylcarnitine exists in human urine and plasma. (±)-Hexanoylcarnitine can be used as a plasma detection indicator in patients with methylmalonic aciduria, propionic acidemia, and medium-chain acyl-CoA dehydrogenase deficiency .

HY-W008820R

Glutaric acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Glutaric acid (Standard) is the analytical standard of Glutaric acid. This product is intended for research and analytical applications. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I . In Vitro: Glutaric acid (GA) at concentrations of 1 and 2 mM is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM .

HY-115773

NMTCA NMTPRO; N-Nitroso-2-methylthiazolidine 4-carboxylic acid; N-nitrosomethylthioproline	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
NMTCA (NMTPRO) is a sulfur-containing N-nitrosamino acid. NMTCA can be used as an indicator of endogenous nitrosation by gas chromatography-thermalenergyanalysis .

HY-113457

11-Oxo etiocholanolone 11-Ketoetiocholanolone	Endogenous metabolite Steroids Source Classification	Endogenous Metabolite Biochemical Assay Reagents
11-Oxo etiocholanolone (11-Ketoetiocholanolone) is a steroid. 11-Oxo etiocholanolone is a key indicator for detecting cortisol metabolites in feces and urine. 11-Oxo etiocholanolone has the potential to be a pheromone .

HY-W017006R

1-Methyl-L-histidine (Standard)	Structural Classification Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Source Classification	Reference Standards Endogenous Metabolite
1-Methyl-L-histidine (Standard) is the analytical standard of 1-Methyl-L-histidine. This product is intended for research and analytical applications. 1-Methyl-L-histidine is an objective indicator of meat ingestion and exogenous 3-methylhistidine (3MH) intake.

HY-113245

3-Indolyl-β-D-glucuronide	Alkaloids Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Indole Alkaloids Source Classification	Endogenous Metabolite
3-Indolyl-β-D-glucuronide, a chromogenic substrate for β-D-glucuronidase, employs in the detection and enumeration of E. coli, yielding a blue precipitate upon cleavage. 3-Indolyl-β-D-glucuronide in? patients' plasma act as a new indicator of renal failure .

HY-148851

Bacteriochlorophyll a, from Rhodopseudomonas sphaeroides (under argon) BChl a, from Rhodopseudomonas sphaeroides (under argon)	Natural Products Microorganisms Source Classification	Bacterial
Bacteriochlorophyll a, from Rhodopseudomonas sphaeroides (under argon) (BChl a, from Rhodopseudomonas sphaeroides (under argon)) is a chlorophyll analog found in some bacteria that participates in the light absorption and energy transfer processes of photosynthesis .

HY-Y1125R

6-Methyluracil (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
6-Methyluracil (Pseudothymine), a metabolite of Uracil, can be used as an indicator of acetoacetyl-CoA (AACoA) accumulation. 6-Methyluracil exhibits antiradiation effect in vivo .

HY-118103R

Coprostanol (Standard) 5β-Cholestan-3β-ol (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Reference Standards Endogenous Metabolite
Coprostanol (5β-Cholestan-3β-ol) (Standard) is the analytical standard of Coprostanol. This product is used for research and analytical applications. Coprostanol is a fecal sterol formed by the reduction of cholesterol by microorganisms in the human and higher animal intestines. Coprostanol can be used as an indicator sterol for fecal contamination. Coprostanol has been recognized as a good indicator of water resource pollution caused by sewage discharge. Coprostanol can serve as a potential biological indicator for cerebral chondrodystrophy (CTX).

HY-B1178R

Cotinine (Standard) (-)-Cotinine (Standard); (S)-Cotinine (Standard); NIH-10498 (Standard)	Alkaloids Structural Classification Pyrrole Alkaloids Nicotiana tabacum L. Pyridine Alkaloids Solanaceae Plants Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite nAChR
Cotinine (Standard) is the analytical standard of Cotinine. This product is intended for research and analytical applications. Cotinine ((-)-Cotinine), an alkaloid in tobacco and a major metabolite of nicotine, is used as a biological indicator to measure the composition of tobacco smoke

HY-N10681

Evonimine Euonine	Sesquiterpenes Celastraceae Pyridine Alkaloids Tripterygium wilfordii Hook. f. Plants Source Classification	Others
Evonimine (Euonine) is an alkaloid isolated from Tripterygium wilfordii Hook. Evonimine exhibits significant inhibition of humoral-mediated immunity using the haemolytic response as an indicator, and shows good anti-feeding activity against the lepidopteran Spodoptera littoralis .

HY-N4241

Kauran-18-oic acid, 16,17,19-trihydroxy-, (4α)-	other families Classification of Application Fields Terpenoids Other Diseases Diterpenoids Plants Disease Research Fields Source Classification	Others
Kauran-18-oic acid, 16,17,19-trihydroxy-, (4α)- (compound 5) is a endogenous ent-kaurane diterpene compound in green coffee beans, providing direct chemical indicators of low-quality coffee .

HY-129380AR

Fructosyl-lysine dihydrochloride (Standard) Fructoselysine dihydrochloride (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
Fructosyl-lysine (dihydrochloride) (Standard) is the analytical standard of Fructosyl-lysine (dihydrochloride). This product is intended for research and analytical applications. Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine-arginine protein cross-link that can be an indicator in diabetes detection .

HY-113168R

Butyrylcarnitine (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Butyrylcarnitine (Standard) is the analytical standard of Butyrylcarnitine (HY-113168). This product is intended for research and analytical applications. Butyrylcarnitine is an endogenous metabolite found in plasma. Elevated levels of Butyrylcarnitine are closely associated with abnormalities in lipid and energy metabolism. Butyrylcarnitine can serve as a diagnostic and prognostic indicator for certain diseases, such as heart failure and head and neck cancer .

HY-Y1097R

Monomethyl phthalate (Standard) 2-(Methoxycarbonyl)benzoic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Monomethyl phthalate (Standard) is the analytical standard of Monomethyl phthalate. This product is intended for research and analytical applications. Monomethyl phthalate is an orally active metabolite of phthalic acid. Monomethyl phthalate, as a urine biomarker after exposure to phthalate, can be used as a detection indicator for thyroid cancer and benign nodules. Monomethyl phthalate reduces the survival rate of young frogs. Monomethyl phthalate induces oxidative damage to red blood cells in rats.

HY-N0772R

Isomangiferin (Standard)	Structural Classification Liliaceae Xanthones Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Source Classification	Reference Standards VEGFR NF-κB NOD-like Receptor (NLR) AMPK Acetyl-CoA Carboxylase Apoptosis Reactive Oxygen Species (ROS) HSV Drug Derivative
Isomangiferin (Standard) is the analytical standard of Isomangiferin (HY-N0772). This product is intended for research and analytical applications. Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing.

HY-N9945R

3-Oxo-7-hydroxychol-4-enoic acid (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Reference Standards Endogenous Metabolite
3-Oxo-7-hydroxychol-4-enoic acid is an endogenous metabolite. 3-Oxo-7-hydroxychol-4-enoic acid may be an important indicator of a poor prognosis in hepatobiliary disease .

HY-W004874R

2,6-Dimethylhydroquinone (Standard) M-Xylohydroquinone (Standard)	Structural Classification Phenols Polyphenols Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
2,6-Dimethylhydroquinone (Standard) is an analytical standard for 2,6-Dimethylhydroquinone (HY-W004874). This product is intended for research and analytical applications. 2,6-Dimethylhydroquinone is a key metabolic intermediate in the degradation of 2,6-xylenol by Mycobacterium strain DM1. 2,6-Dimethylhydroquinone can be used as an early indicator of failure in biological treatment systems.

HY-129912AR

N1,N8-Diacetylspermidine hydrochloride (Standard)	Alkaloids Other Alkaloids Endogenous metabolite Source Classification	Endogenous Metabolite
N1,N8-Diacetylspermidine (hydrochloride) (Standard) is the analytical standard of N1,N8-Diacetylspermidine (hydrochloride). This product is intended for research and analytical applications. N1,N8-Diacetylspermidine hydrochloride is a polyamines in the human urine . N1,N8-Diacetylspermidine hydrochloride is useful as prognostic indicators after treatment and during follow-up examination of cancer patients .

HY-N18192

Kuwanon L	Structural Classification Flavonoids Flavonones Morus alba L. Plants Moraceae Source Classification	HIV HIV Integrase
Kuwanon L is an HIV-1 integrase (HIV-1 integrase) inhibitor, with IC₅₀ values of 42 μM and 34 μM for LEDGF-dependent and LEDGF-independent integrase, respectively. Kuwanon L blocks the interaction between HIV-1 integrase and LEDGF/p75, with an IC₅₀ of 22 μM. Kuwanon L inhibits HIV-1 replication in immune cells. Kuwanon L is applicable to research related to HIV-1 infection .

Cat. No.	Product Name	Chemical Structure

HY-B1727S

Phenanthrene-d10
Phenanthrene-d₁₀ is the deuterium labeled Phenanthrene. Phenanthrene is a polycyclic aromatic hydrocarbon (PAH) and has been frequently used as an indicator for monitoring PAH contaminated matrices . Phenanthrene induces oxidative stress and inflammation .

HY-N0091S5

Hypoxanthine-d4
Hypoxanthine-d₄ is the deuterium labeled Hypoxanthine . Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia .

HY-W008820S

Glutaric acid-d6 1 Publications Verification
Glutaric acid-d₆ is the deuterium labeled Glutaric acid. Glutaric acid is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I .

HY-103395S1

Methylmalonic acid-13C4
Methylmalonic acid- ¹³C₄ is the ¹³C labeled Methylmalonic acid . Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer .

HY-N0091S6

Hypoxanthine-d2 1 Publications Verification
Hypoxanthine-d₂ is the deuterium labeled Hypoxanthine . Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia .

HY-N0091S7

Hypoxanthine-15N4 2 Publications Verification
Hypoxanthine- ¹⁵N₄ is the ¹⁵N labeled Hypoxanthine . Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia .

HY-W012982S

3-Amino-2-oxazolidinone-d4
3-Amino-2-oxazolidinone-d₄ (AOZ-d₄) is a deuterium labeled 3-Amino-2-oxazolidinone (HY-W012982). 3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone (HY-B1336). 3-Amino-2-oxazolidinone is always be detected as a indicator of furazolidone residues in vivo. 3-Amino-2-oxazolidinone is orally active .

HY-118103S

Coprostanol-d5

Coprostanol-d₅ (5β-Cholestan-3β-ol-d₅) is the deuterium labeled Coprostanol. Coprostanol (5β-Cholestan-3β-ol) is a fecal sterol formed by microbial reduction of cholesterol in the intestines of man and higher animals. Coprostanol can be used as an indicator sterol of fecal pollution. Coprostanol has been recognized as a good indicator of pollution of water resources by sewage discharges. Coprostanol can serve as a potential biological indicator for cerebral chondrodystrophy (CTX).

HY-103395S

Methylmalonic acid-d3
Methylmalonic acid-d₃ is the deuterium labeled Methylmalonic acid. Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer .

HY-N0091S2

Hypoxanthine-13C5
Hypoxanthine- ¹³C₅ is a ¹³C-labeled Hypoxanthine (HY-N0091). Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

HY-W017006S

1-Methyl-L-histidine-d3
1-Methyl-L-histidine-d₃ is the deuterium labeled 1-Methyl-L-histidine. 1-Methyl-L-histidine is an objective indicator of meat ingestion and exogenous 3-methylhistidine (3MH) intake.

HY-113323S

3-Methoxy-4-hydroxyphenylglycol-d3

3-Methoxy-4-hydroxyphenylglycol-d₃ (HMPG-d₃) is the deuterium labeled 3-Methoxy-4-hydroxyphenylglycol. 3-Methoxy-4-hydroxyphenylglycol is a metabolite of norepinephrine degradation in the brain. 3-Methoxy-4-hydroxyphenylglycol (HMPG) serves as an indicator of noradrenergic activity in the central nervous system. 3-Methoxy-4-hydroxyphenylglycol (HMPG) can be used for research on diseases such as depression and chronic schizophrenia.

HY-32349S

Ercalcidiol-d3
Ercalcidiol-d₃ is the deuterium labeled Ercalcidiol. Ercalcidiol is a metabolite of Vitamins D2. Ercalcidiol can be used as an indicator of vitamins D status .

HY-113465S

Leukotriene E4-d5
Leukotriene E4-d₅ is the deuterium labeled Leukotriene E4. Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4. Leukotriene E4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A). Leukotriene E4 accumulates in both plasma and urine and urinary excretion of Leukotriene E4 is most often used as an indicator of asthma.

HY-113457S

11-Oxo etiocholanolone-d5
11-Oxo etiocholanolone-d₅ (11-Ketoetiocholanolone-d₅) is the deuterium labeled 11-Oxo etiocholanolone (HY-113457). 11-Oxo etiocholanolone (11-Ketoetiocholanolone) is a steroid. 11-Oxo etiocholanolone is a key indicator for detecting cortisol metabolites in feces and urine. 11-Oxo etiocholanolone has the potential to be a pheromone .

HY-W008820S1

Glutaric acid-d4
Glutaric acid-d₄ is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I .

HY-136457S

2-NP-AHD-13C3
2-NP-AHD- ¹³C₃ is the ¹³C labled 2-NP-AHD (HY-136457) . 2-NP-AHD is a 2-nitrophenyl derivative of AHD (a metabolite of nitrofurans type of antibiotics), can be used as indicator of the illegal usage of nitrofuran agents .

HY-135035S

Decanoyl-L-carnitine-d3
Decanoyl-L-carnitine ((-)-Decanoylcarnitine)-d₃ is deuterium labeled Decanoyl-L-carnitine (HY-135035). Decanoyl-L-carnitine is an endogenous metabolite. Decanoyl-L-carnitine can be used as a serum metabolic biomarkers as indicators in the progression of intravenous leiomyomatosis .

HY-113486S

(S)-Lathosterol-d4
(S)-Lathosterol-d₄ is the deuterium labeled (S)-Lathosterol. Lathosterol is a cholesterol-like molecule. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis .

HY-108398AS

Mead acid-d6
Mead acid-d₆ is the deuterium labeled Mead acid. Mead acid (5,8,11-Eicosatrienoic acid), an unsaturated (Omega-9) fatty acid, is an indicator of essential fatty acid deficiency .

HY-N0091S3

Hypoxanthine-13C2,15N
Hypoxanthine- ¹³C₂, ¹⁵N is a ¹⁵N-labeled and ¹³C-labled Hypoxanthine (HY-N0091). Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

HY-N0091S1

Hypoxanthine-13C,15N2
Hypoxanthine- ¹³C, ¹⁵N₂ is a ¹⁵N-labeled and ¹³C-labled Hypoxanthine (HY-N0091). Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

HY-N0091S

Hypoxanthine-13C5,15N4
Hypoxanthine- ¹³C₅, ¹⁵N4 is a ¹⁵N-labeled and ¹³C-labled Hypoxanthine (HY-N0091). Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

HY-N0091S4

Hypoxanthine-13C2,15N-1
Hypoxanthine- ¹³C₂, ¹⁵N-1 is a ¹⁵N-labeled and ¹³C-labled Hypoxanthine (HY-N0091). Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

HY-152007S

Butyrylcarnitine-d3 hydrochloride
Butyrylcarnitine-d₃ hydrochloride is deuterium labeled Butyrylcarnitine (HY-113168). Butyrylcarnitine is an endogenous metabolite found in plasma. Elevated levels of Butyrylcarnitine are closely associated with abnormalities in lipid and energy metabolism. Butyrylcarnitine can serve as a diagnostic and prognostic indicator for certain diseases, such as heart failure and head and neck cancer .

HY-129912S

N1,N8-Diacetylspermidine-d6
N1,N8-Diacetylspermidine-d₆ is the deuterium labeled N1,N8-Diacetylspermidine (HY-129912). N1,N8-Diacetylspermidine is a polyamines in the human urine . N1,N8-Diacetylspermidine is useful as prognostic indicators after treatment and during follow-up examination of cancer patients .

HY-W751181

O-Desmethyl midostaurin-13C6

O-Desmethyl midostaurin- ¹³C₆ (CGP62221- ¹³C₆; O-Desmethyl PKC412- ¹³C₆) is the ¹³C-labeled O-Desmethyl Midostaurin (HY-129491). O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo . Midostaurin is a multi-targeted protein kinase inhibitor?with?IC₅₀?ranging from 22-500 nM.

HY-B1422S

9-Aminoacridine-13C6

9-Aminoacridine-13C6 is the ¹³C-labeled 9-Aminoacridine(HY-B1422). 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .

HY-32349S2

Ercalcidiol-d9
Ercalcidiol-d₉ (25-Hydroxy Vitamin D2-d₉) is the deuterium labeled Ercalcidiol (HY-32349). Ercalcidiol is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status.

HY-W008820S2

Glutaric acid-d2
Glutaric acid-d₂ is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I .

HY-32349S3

Ercalcidiol-13C3
Ercalcidiol- ¹³C₃ (25-Hydroxy Vitamin D2- ¹³C3) is the ¹³C-labeled Ercalcidiol (HY-32349). Ercalcidiol is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status.

HY-135035S1

Decanoyl-L-carnitine-d19
Decanoyl-L-carnitine-d₁₉ ((-)-Decanoylcarnitine-d₁₉> is the deuterium labeled Decanoyl-L-carnitine (HY-135035). Decanoyl-L-carnitine ((-)-Decanoylcarnitine) is an endogenous metabolite. Decanoyl-L-carnitine can be used as a serum metabolic biomarkers as indicators in the progression of intravenous leiomyomatosis.

HY-W025785S1

Methyl yellow-d6
Methyl yellow-d₆ (Solvent Yellow 2-d₆) is the deuterium labeled Methyl yellow (HY-W025785). Methyl yellow (Solvent Yellow 2) is a pH indicator. Methyl yellow appears red at low pH, and becomes yellow above pH 4.0 .

HY-W245806S1

1-Methylnaphthalene-13C

1-Methylnaphthalene- ¹³C is the ¹³C-labeled 1-Methylnaphthalene (HY-166872). 1-Methylnaphthalene is an organic compound with antibacterial and antioxidant activities. 1-Methylnaphthalene is used as a pollutant indicator in environmental monitoring. 1-Methylnaphthalene can also be used as an intermediate for petrochemical products, helping to improve reaction efficiency during the synthesis process.

Cat. No.	Product Name		Classification

HY-W674039

6-Azido-6-deoxy-D-glucose, 95%		Azide
6-Azido-6-deoxy-D-glucose, 95% is used for visualizing protein-specific glycosylation in living cells.

HY-119578

Imiprothrin		Alkynes
Imiprothrin is an inducer that induces CYP1A2 and metallothionein 1a, with significant genotoxicity and cytotoxicity. In rat hepatocytes, Imiprothrin initiates detoxification responses by triggering the overexpression of these two genes. Imiprothrin induces chromosomal aberrations and micronucleus formation in rat bone marrow cells, and causes DNA damage in hepatocytes. Imiprothrin triggers oxidative stress in rats, leading to lipid peroxidation, excessive reactive oxygen species production and redox imbalance, which in turn impairs liver and kidney functions and causes tissue damage. Imiprothrin inhibits weight gain in mice, and even causes high mortality in female mice at high doses. However, it shows no carcinogenicity in rat experiments; among relevant indicators, aspartate aminotransferase and total protein are identified as sensitive toxicity biomarkers .

Cat. No.	Product Name		Classification

HY-W141392

2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite		Phosphoramidites Hypoxanthine
2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

HY-152696

6-O-Methylinosine		Nucleoside Analogs Inosine
6-O-Methylinosine is a hypoxanthine analogue. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

HY-157695

1-(1Z-Octadecenyl)-2-docosahexaenoyl-sn-glycero-3-phosphocholine C18(Plasm)-22:6-PC; PC(P-18:0/22:6); 18:0p/22:6-PC		Phospholipids
1-(1Z-Octadecenyl)-2-docosahexaenoyl-sn-glycero-3-phosphocholine (C18(Plasm)-22:6-PC) is a phospholipid identified in fish viscera by lipidomics strategy. It has different content and distribution in different fish species and can be used as an indicator of fish species differentiation.

HY-W392836

2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite		Phosphoramidites Hypoxanthine
2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

HY-154017

2′-C-Methyl-6-O-methylinosine		Nucleoside Analogs Inosine
2′-C-Methyl-6-O-methylinosine is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

HY-154393

2-Chloro-2'-deoxy-6-O-methylinosine		Nucleoside Analogs Inosine
2-Chloro-2'-deoxy-6-O-methylinosine is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

HY-152678

6-Methoxypurine-9-β-D-5’(R)-C-methylriboside		Nucleoside Analogs
6-Methoxypurine-9-β-D-5’(R)-C-methylriboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

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