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Dihydrorhodamine 123

(Synonyms: DHR 123)
20 Cited Publications
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Based on 20 publication(s) in Google Scholar

Dihydrorhodamine 123 (DHR 123) is a non-fluorescent reactive oxygen species (ROS) indicator. Dihydrorhodamine 123 is oxidized to fluorescent Rhodamine 123 (HY-D0816) within cells in the presence of reactive oxygen species and it localizes in mitochondria (Ex/Em = 515/536 nm).

For research use only. We do not sell to patients.

  • Purity: 99.83%
  • CAS No.: 109244-58-8
  • Formula: C21H18N2O3
  • Molecular Weight:346.38
  • Storage:

    -20°C, protect from light

    * The compound is unstable in solutions, freshly prepared is recommended.

  • Dihydrorhodamine 123 Chemical Structure
    Dihydrorhodamine 123 Chemical Structure
  • Experimental Validation Results for Dihydrorhodamine 123
  • Experimental Validation Results for Dihydrorhodamine 123
  • Experimental Validation Results for Dihydrorhodamine 123
  • Experimental Validation Results for Dihydrorhodamine 123
  • Experimental Validation Results for Dihydrorhodamine 123
  • Experimental Validation Results for Dihydrorhodamine 123
CAS No.: 109244-58-8
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  • Bio/Physico-chemical Assay
  • Bio/Physico-chemical Assay
  • Cell Imaging/Staining
  • Cell Imaging/Staining
  • Cell Imaging/Staining
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  • Dihydrorhodamine 123 Chemical Structure
    Dihydrorhodamine 123 Chemical Structure
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    Dihydrorhodamine 123 purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Jan 21;19(2):2822-2833. [Abstract]

    Customer Validation
     O2−·detection via DHR 123 (10 μM) in water under irradiation (660 nm, 20 mW/cm2) at an interval of 20 s.

  • 1/16

    Dihydrorhodamine 123 purchased from MedChemExpress. Usage Cited in: Food Packag Shelf Life. 2025 Sep.

    Customer Validation
     The curve of fluorescence emission intensity of BA and BBR at 1.34 × 10-4 mol/L with the change of solvent composition ⋅O2- generation of BA (1.34 ×10-4 mol/L) and BBR (1.34 ×10-4 mol/L) in different solutions under white light irradiation (60 mW/cm2) detected by DHR123 (10 μM; 5 min).

  • 1/16

    Dihydrorhodamine 123 purchased from MedChemExpress. Usage Cited in: Adv Healthc Mater. 2024 Sep 3:e2402079. [Abstract]

    Customer Validation
     Fluorescence images of MCF-7 cells treated with different-sized Fe3O4, SiO2, and Au NPs and stained with Dihydrorhodamine 123 to characterize the generated H2O2. Green fluorescence: Dihydrorhodamine 123 (DHR123, 10 μM, 30 min), an indicator of H2O2; blue fluorescence: Hoechst 33342.

  • 1/16

    Dihydrorhodamine 123 purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2023 May 1:200:73-86. [Abstract]

    Customer Validation
     The Dihydroethidium (DHE; 10 μM; 1 h), Dihydrorhodamine 123 (DHR 123, 5 μM; 1 h), FerroOrange and C11 BODIPY probes detect O2• − (red fluorescence),OONO − (green fluorescence), Fe 2+ (orange fluorescence), and lipid peroxides (red fluorescence in the unoxidized state and green fluorescence in the oxidized state), respectively, In normal lung tissue from 10 smoking patients and 10 non-smoking patients.

  • 1/16

    Dihydrorhodamine 123 purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2023 May 1:200:73-86. [Abstract]

    Customer Validation
     The Dihydroethidium (DHE; 5-20 μM; 1 h）, Dihydrorhodamine 123 (DHR 123, 5 μM, 15-60 min) probes were used to detect ROS intensities in CS-induced bronchial epithelial ferroptosis. Control, and 0.5%,1%, and 2% CSE were used to stimulate BEAS-2B cells for 48 h.

  • 1/16

    Dihydrorhodamine 123 purchased from MedChemExpress. Usage Cited in: Commun Biol. 2023 Mar 11;6(1):259. [Abstract]

    Customer Validation
     Dihydrorhodamine 123 detectes the mitochondrial ROS level in mouse tumors. Left panels: Representative histograms. Right panels: Quantification of the MFI values.

  • Dihydrorhodamine 123