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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
37 Results for "
innate immunity genes
" in MedChemExpress (MCE) Product Catalog:
Products (37)
37 Results for "innate immunity genes" in MCE Product Catalog:
71
71 Publications Verification
Synonyms: Poly(I:C) sodium
Research Areas:
Polyinosinic-polycytidylic acid (Poly(I:C)) sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis .
70
Target:
RIG-I-like receptor (RLR) Toll-like Receptor (TLR) PKD HSP Bcl-2 Family Interleukin Related Apoptosis
Research Areas:
Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid can directly trigger cancer cells to undergo apoptosis .
64
64 Cited Publications
Cat. No.: HY-135748A
Poly (I:C):Kanamycin (1:1) sodium is an isometric complex of Poly (I:C) (HY-135748) and Kanamycin (HY-16566). Poly(I:C) sodium, a synthetic analog of double-stranded RNA, is a TLR3 and retinoic acid-inducible gene I receptor (RIG-I and MDA5) agonist. Poly(I:C) sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses and induce apoptosis in cancer cells . Kanamycin is an orally active antibacterial agent (Gram-negative/positive bacteria) that inhibits translocation and causes miscoding by binding to the 70S ribosomal subunit. Kanamycin shows good inhibitory activity against Mycobacterium tuberculosis (susceptible and drug-resistant) and Klebsiella pneumoniae, and can be used in the research of tuberculosis and pneumonia .
8
8 Cited Publications
Cat. No.: HY-107202A
Purity: 51.00%
Target:
Toll-like Receptor (TLR) RIG-I-like receptor (RLR) PKD HSP Bcl-2 Family Interleukin Related Apoptosis
Research Areas:
Poly(I:C):Kanamycin (1:1) is a mixture of Poly(I:C) (HY-107202) and Kanamycin (HY-16566). Poly(I:C) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Poly(I:C) can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Poly(I:C) can directly trigger cancer cells to undergo apoptosis. Kanamycin stabilizes Poly(I:C) .
3
3 Cited Publications
Synonyms: Abequolixron
Target:
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RGX-104 is an orally bioavailable and potent liver-X nuclear hormone receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the ApoE gene.
3
3
3 Cited Publications
Synonyms: Abequolixron hydrochloride
Target:
Research Areas:
RGX-104 hydrochloride is a small-molecule LXR agonist that modulates innate immunity via transcriptional activation of the ApoE gene.
1
1 Cited Publications
Cat. No.: HY-141567A
Purity: ≥98.0%
Synonyms: Pseudo-UTP trisodium solution (100 mM)
1
Target:
Research Areas:
5-Methylcytidine 5′-triphosphate (5-Methyl-CTP) trisodium is a modified ribonucleoside 5′-triphosphate. When incorporated into mRNA, 5-Methylcytidine 5′-triphosphate trisodium enhances the translation efficiency and stability of the mRNA, and reduces the innate immune response. 5-Methylcytidine 5′-triphosphate trisodium can be used in studies related to gene replacement and vaccination applications .
1
1 Cited Publications
Target:
Research Areas:
NaPi2b-IN-2 is a potent inhibitor of sodium-dependent phosphate transporter 2b (SLC34A2, NaPi2b), with an IC50 value of 38 nM against human NaPi2b. NaPi2b-IN-2 reduces intracellular phosphate levels and enhances innate immune gene expression. NaPi2b-IN-2 can be used in research related to hyperphosphatemia .
Cat. No.: HY-134958
CAS No.: 31852-29-6
Synonyms: Poly(I:C) potassium
Target:
Research Areas:
Polyinosinic-polycytidylic acid potassium (Poly(I:C) potassium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid potassium can directly trigger cancer cells to undergoApoptosis .
LRRK2 inhibitor 1 is a LRRK2 inhibitor. LRRK2 inhibitor 1 blocks STAT1 phosphorylation and the expression of interferon-stimulated genes, and inhibits intracellular innate immune responses. LRRK2 inhibitor 1 enhances oncolytic virus infection, replication and viral protein expression in tumor cells, promotes tumor cell apoptosis, and cooperates with oncolytic viruses to reduce tumor cell viability. LRRK2 inhibitor 1 enhances the oncolytic activity of multiple oncolytic viruses, and inhibits the growth of glioma xenografts when used in combination with oncolytic viruses. LRRK2 inhibitor 1 can be used in research related to various cancers such as lung cancer, colorectal cancer and liver cancer .
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KIN1400 is a potent IRF3 activator. KIN1400 triggers IRF3-dependent innate immune antiviral genes (RIG-I, MDA5, IFIT1, and Mx1) and IFN-β expression. KIN1400 inhibits WNV and DV, two mosquito-borne members of the Flaviviridae and the genus Flavivirus. KIN1400 also inhibits HCV replication. KIN1400 induces innate antiviral immunity through a MAVS-IRF3 axis .
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Petrolatum (white) is mainly composed of hydrocarbons, possesses strong water resistance and moisturizing properties, and is commonly used as a pharmaceutical excipient. Petrolatum (white) penetrates into stratum corneum cells, improves skin barrier function, repairs epidermal structure, and reduces transepidermal water loss and the risk of skin damage. Petrolatum (white) induces the expression of antimicrobial peptides, innate immune genes, filaggrin and loricrin. Petrolatum (white) is used in research on atopic dermatitis and post-operative skin infections .
Cat. No.: HY-107202GL
CAS No.: 24939-03-5
Synonyms: Poly(I:C) (GMP Like)
Synonyms: ORI-9020 ammonium; SB-9000 ammonium
Target:
Research Areas:
Inarigivir (ORI-9020) ammonium is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) ammonium acts as a RIG-I (Retinoic acid-inducible gene-I) agonist to activate cellular innate immune responses .
Cat. No.: HY-148420
CAS No.: 2586047-09-6
Target:
Research Areas:
CDN-A is a cyclic di-nucleotide, it can be used to synthesis antibody-drug conjugate (ADC). Cyclic di-nucleotides are potent stimulators of innate and adaptive immune responses. In humans, cyclic di-nucleotide, which are either produced endogenously in response to foreign DNA or by invading bacterial pathogens, trigger the innate immune system by activating the expression of interferon genes .
Cat. No.: HY-147338
CAS No.: 327174-86-7
Synonyms: 5-Methyl-CTP
Target:
Research Areas:
5-Methylcytidine 5′-triphosphate (5-Methyl-CTP) is a modified ribonucleoside 5′-triphosphate. When incorporated into mRNA, 5-Methylcytidine 5′-triphosphate enhances the translation efficiency and stability of the mRNA, and reduces the innate immune response. 5-Methylcytidine 5′-triphosphate can be used in studies related to gene replacement and vaccination applications .
Cat. No.: HY-P10400
CAS No.: 902781-11-7
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
