2227445-31-8
Chemical Structure
NaPi2b-IN-2
- CAS No.: 2227445-31-8
- Formula:C41H47ClF3N5O5S
- Molecular Weight:814.36
IUPAC Name: N-(2-(2-(2-(3-(2-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)thiazole-4-carbonyl)phenoxy)ethoxy)ethoxy)ethyl)-4-(4-(((4-(isobutylamino)pyrimidin-2-yl)amino)methyl)thiazol-2-yl)benzamide
InChIKey: IHCQIEZWVTZYDU-UHFFFAOYSA-N
SMILES: O=C(NC1=C(C2=C(S1)CC(C)(CC2)C)C(C3=CN(C4=CC(C(F)(F)F)=C(Cl)C=C4)N=C3)=O)C5=CC(CN(C(CC)CC)CCN(C)C(CCC(O)=O)=O)=CC=C5
Biological Activity: NaPi2b-IN-2 is a potent inhibitor of sodium-dependent phosphate transporter 2b (SLC34A2, NaPi2b), with an IC50 value of 38 nM against human NaPi2b. NaPi2b-IN-2 reduces intracellular phosphate levels and enhances innate immune gene expression. NaPi2b-IN-2 can be used in research related to hyperphosphatemia[1][2].
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NaPi2b-IN-2 | 99.02% | NaPi2b-IN-2 is a potent inhibitor of sodium-dependent phosphate transporter 2b (SLC34A2, NaPi2b), with an IC50 value of 38 nM against human NaPi2b. NaPi2b-IN-2 reduces intracellular phosphate levels and enhances innate immune gene expression. NaPi2b-IN-2 can be used in research related to hyperphosphatemia. | ||||||||||||||||||||
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[1]. Yasunobu Ushiki, et al. Design, synthesis and biological evaluation of novel 1H-pyrazole-4-carbo-nyl-4,5,6,7-tetrahydrobenzo [b]thiophene derivatives as gut-selective
NaPi2b inhibitors. Bioorganic & Medicinal Chemistry Letters
Volume 59, 1 March 2022, 128572 - [2]. Gao M, et al. Human-specific activation of the DUX4-SLC34A2 axis by herpesviruses suppresses antiviral innate immunity. mBio. 2025;16(12):e0255425. [Content Brief]
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