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insect antifeedant

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Bacterial (1) Carboxylesterase (CES) (1) Drug Derivative (1) Endogenous Metabolite (1) Insecticide (4) Notch (1) Parasite (1)
By Research Areas:	Cancer (2) Infection (6) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N3014

Bruceine D 4 Publications Verification	Notch Apoptosis Parasite	Infection Cancer
Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity . Bruceine D has strong anthelmintic activity against D. intermedius with an EC₅₀ value of 0.57 mg/L .

HY-N7179

7-Hydroxy-5-methoxycoumarin	Others	Others
7-Hydroxy-5-methoxycoumarin is a phloroglucinol-type furocoumarins, a potent naturally-occurring insect antifeedant .

HY-N3184

N-Methylflindersine	Others	Others
N-Methylflindersine is a compound isolated as insect antifeedants from the East African Rutaceous medicinal plants Fagara chalybea and F. holtziana .

HY-118565

Rhizocarpic acid	Endogenous Metabolite Bacterial	Infection
Rhizocarpic acid (Compound 2) is a secondary metabolite of lichen. Rhizocarpic acid effectively inhibits the growth of bacteria, such as Bacillus subtilis and Staphylococcus aureus, as well as murine myeloma NS-1 cells. Rhizocarpic acid is an antioxidant and an insect antifeedant with an ED₅₀ of 71 μmol/g dry weight against neonate larvae of the Egyptian cotton leaf worm Spodoptera littoralis .

HY-169068

Antifeedant agent 1	Carboxylesterase (CES)	Infection
Antifeedant agent 1 is a carboxylesterase inhibitor that exerts insecticidal activity by inhibiting insect feeding, with an EC₅₀ value of 0.038 mg/mL. Antifeedant agent 1 can be used in research related to pest control .

HY-N1284

Seneganolide (-)-Seneganolide	Others	Others
Seneganolide (compound 1) is isolated from the stem bark of Khaya senegalensis. Seneganolide can be used as insect antifeedant .

HY-N18061

Neoazedarachin B	Insecticide	Infection
Neoazedarachin B is an insect antifeedant present in the root bark of Melia toosendan. Neoazedarachin B reduces the feeding behavior of third-instar larvae of Spodoptera littoralis .

HY-N18148

Trichilin K	Others	Infection
Trichilin K is a insect antifeeding iimonoid found in the stem bark of Melia toosendan. Trichilin K displays antifeedant activity against Spodoptera eridania larvae .

HY-N18151

Ohchinolide C	Others	Others
Ohchinolide C is a ring C-seco limonoid and insect antifeedant. Ohchinolide C can be found in the root bark of Melia toosendan. Ohchinolide C exerts antifeedant activity against Spodoptera eridania larvae .

HY-N15634

Anticopalic acid	Insecticide	Neurological Disease
Anticopalic acid is a labdane-type diterpenoid insect antifeedant that exhibits dose-dependent antifeedant activity against the fall armyworm (Spodoptera frugiperda). Anticopalic acid can be isolated from Vitex hemsleyi. Anticopalic acid may be involved in neuroreceptor-mediated insect taste regulation and could be used to develop environmentally friendly antifeedants targeting lepidopteran pests .

HY-N18060

Nimbolinin C	Insecticide	Infection
Nimbolinin C is an insect antifeedant present in the unripe fruits of Melia toosendan. Nimbolinin C exhibits weak activity against the feeding behavior of third-instar larvae of Spodoptera exigua at a concentration of 1000 ppm .

HY-N17875

Demethylsalvicanol (+)-Demethylsalvicanol	Drug Derivative	Cancer
Demethylsalvicanol ((+)-Demethylsalvicanol), a diterpene, is a anticancer agent with an IC₅₀ of 0.71 μg/mL against P388 murine leukemia cells. Demethylsalvicanol induces cytotoxic activity against leukemia cells and insect Sf9 cells. Demethylsalvicanol acts as an antifeedant against Leptinotarsa decemlineata. Demethylsalvicanol can be used for the research of leukemia .

HY-N15281

Khellol	Insecticide	Others
Khellol is a furanochromone derivative with feeding deterrent activity against insects. Khellol induces 12.12 % feeding inhibition at 100 ppm against Spodoptma litura larvae .

Bruceine D 4 Publications Verification	Infection Simaroubaceae Classification of Application Fields Terpenoids Diterpenoids Plants Disease Research Fields Source Classification Brucea javanica (L.) Merr.	Notch Apoptosis Parasite
Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity . Bruceine D has strong anthelmintic activity against D. intermedius with an EC₅₀ value of 0.57 mg/L .

7-Hydroxy-5-methoxycoumarin	Coumarins Phenylpropanoids Plants Convolvulaceae Ipomoea batatas (Linn.) Lamarck Source Classification	Others
7-Hydroxy-5-methoxycoumarin is a phloroglucinol-type furocoumarins, a potent naturally-occurring insect antifeedant .

N-Methylflindersine	Alkaloids Rutaceae Plants Fagara chalybea Engl. Fagara holtziana Engl. Source Classification	Others
N-Methylflindersine is a compound isolated as insect antifeedants from the East African Rutaceous medicinal plants Fagara chalybea and F. holtziana .

Rhizocarpic acid	other families Ketones, Aldehydes, Acids Plants Lichen Source Classification	Endogenous Metabolite Bacterial
Rhizocarpic acid (Compound 2) is a secondary metabolite of lichen. Rhizocarpic acid effectively inhibits the growth of bacteria, such as Bacillus subtilis and Staphylococcus aureus, as well as murine myeloma NS-1 cells. Rhizocarpic acid is an antioxidant and an insect antifeedant with an ED₅₀ of 71 μmol/g dry weight against neonate larvae of the Egyptian cotton leaf worm Spodoptera littoralis .

Seneganolide (-)-Seneganolide	Natural Products Plants Meliaceae Source Classification	Others
Seneganolide (compound 1) is isolated from the stem bark of Khaya senegalensis. Seneganolide can be used as insect antifeedant .

Neoazedarachin B	Triterpenes Structural Classification Terpenoids Melia toosendan Sieb. et Zucc. Plants Meliaceae Source Classification	Insecticide
Neoazedarachin B is an insect antifeedant present in the root bark of Melia toosendan. Neoazedarachin B reduces the feeding behavior of third-instar larvae of Spodoptera littoralis .

Trichilin K	Structural Classification Natural Products Melia azedarach Linn. Plants Meliaceae Source Classification	Others
Trichilin K is a insect antifeeding iimonoid found in the stem bark of Melia toosendan. Trichilin K displays antifeedant activity against Spodoptera eridania larvae .

Ohchinolide C	Structural Classification Terpenoids Melia azedarach L. Diterpenoids Plants Meliaceae Source Classification	Others
Ohchinolide C is a ring C-seco limonoid and insect antifeedant. Ohchinolide C can be found in the root bark of Melia toosendan. Ohchinolide C exerts antifeedant activity against Spodoptera eridania larvae .

Anticopalic acid	Structural Classification Ketones, Aldehydes, Acids Labiatae Petasites hybridus (L.) G.Gaertn., B.Mey. & Schreb. Plants Source Classification	Insecticide
Anticopalic acid is a labdane-type diterpenoid insect antifeedant that exhibits dose-dependent antifeedant activity against the fall armyworm (Spodoptera frugiperda). Anticopalic acid can be isolated from Vitex hemsleyi. Anticopalic acid may be involved in neuroreceptor-mediated insect taste regulation and could be used to develop environmentally friendly antifeedants targeting lepidopteran pests .

Nimbolinin C	Triterpenes Structural Classification Terpenoids Melia toosendan Sieb. et Zucc. Plants Meliaceae Source Classification	Insecticide
Nimbolinin C is an insect antifeedant present in the unripe fruits of Melia toosendan. Nimbolinin C exhibits weak activity against the feeding behavior of third-instar larvae of Spodoptera exigua at a concentration of 1000 ppm .

Demethylsalvicanol (+)-Demethylsalvicanol	Structural Classification Labiatae Phenols Polyphenols Plants Pueraria montana (Lour.) Merr. Source Classification	Drug Derivative
Demethylsalvicanol ((+)-Demethylsalvicanol), a diterpene, is a anticancer agent with an IC₅₀ of 0.71 μg/mL against P388 murine leukemia cells. Demethylsalvicanol induces cytotoxic activity against leukemia cells and insect Sf9 cells. Demethylsalvicanol acts as an antifeedant against Leptinotarsa decemlineata. Demethylsalvicanol can be used for the research of leukemia .

Khellol	Natural Products Umbelliferae Plants Viguiera eriophora Greenm. Source Classification	Insecticide
Khellol is a furanochromone derivative with feeding deterrent activity against insects. Khellol induces 12.12 % feeding inhibition at 100 ppm against Spodoptma litura larvae .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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insect antifeedant

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