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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
interstitial renal fibrosis
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "interstitial renal fibrosis" in MCE Product Catalog:
18
18 Publications Verification
Cat. No.: HY-P0299
CAS No.: 283609-79-0
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Research Areas:
18
18 Publications Verification
Cat. No.: HY-P0299A
CAS No.: 2828433-17-4
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Research Areas:
1
Category:
other families Metabolic Disease Lipids Plants Endogenous metabolite Disease Research Fields
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Cat. No.: HY-N2013R
CAS No.: 13395-02-3
Synonyms: Aristololactam (Standard); Aristolactam (Standard)
Category:
Target:
Cat. No.: HY-189141
Target:
Research Areas:
HIPK2-IN-2 is an orally active and selective HIPK2 inhibitor with an IC50 of 0.36 μM against HIPK2. HIPK2-IN-2 reduces HIPK2 protein expression levels. HIPK2-IN-2 inhibits the proliferation and migration of renal interstitial fibroblasts, alleviates renal tubular injury and collagen deposition, and suppresses TGF-β/Smad3-mediated profibrotic signaling pathways as well as TNF-α/NF-κB-mediated inflammatory signaling pathways in renal cells. HIPK2-IN-2 is used for the study of chronic kidney disease-associated renal fibrosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
