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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
iron-sulfur proteins
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "iron-sulfur proteins" in MCE Product Catalog:
1
1 Cited Publications
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Cisd2 agonist 2 (compound 6) is a Cisd2 activator (EC50=191 nM), and Cisd2 levels are associated with non-alcoholic fatty liver disease (NAFLD). Cisd2 agonist 2 has no significant in vivo toxicity in Cisd2hKO-het mice (heterozygous hepatocyte-specific Cisd2 knockout). Cisd2 (CDGSH iron sulfur domain 2) is a zinc finger protein that is mainly localized in the endoplasmic reticulum or mitochondrial membrane. Cisd2 participates in mitochondrial function by forming homodimers containing two redox-active 2Fe-2S clusters .
Cat. No.: HY-162386
CAS No.: 324530-92-9
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UM4118 is a potent copper-selective non-genotoxic copper ionophore that induces cuproptosis in acute myeloid leukemia cells. UM4118 exhibits stronger activity against SF3B1G12C mutant acute myeloid leukemia cells. UM4118 transports extracellular copper into cells, elevates intracellular and mitochondrial copper levels, and triggers lipoylated DLAT aggregation, proteotoxic stress, iron-sulfur cluster protein depletion, reduced lipoylated protein levels, and maximal mitochondrial respiratory damage. UM4118 cytotoxicity can be enhanced by supplementation with extracellular copper, abolished by copper chelation, and shows synthetic lethal effects in the absence of iron-sulfur cluster biosynthesis/transport genes. UM4118 can be used for the study of acute myeloid leukemia .
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Thiobencarb is an herbicide, can reduce growth, photosynthetic activity, and amount of rieske iron-sulfur protein in the diatom Thalassiosira pseudonana .
Cat. No.: HY-129792R
CAS No.: 28249-77-6
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Thiobencarb (Standard) is the analytical standard of Thiobencarb. This product is intended for research and analytical applications. Thiobencarb is an herbicide, can reduce growth, photosynthetic activity, and amount of rieske iron-sulfur protein in the diatom Thalassiosira pseudonana .
Cat. No.: HY-P2996D
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Nitrate Reductase, Aspergillus species (EC 1.7.1.2) is an iron-sulfur-molybdenum flavonoid protein that catalyzes the conversion of nitrite to nitrate.
Cat. No.: HY-N21828
CAS No.: 129212-94-8
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Cat. No.: HY-E71933
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5-Methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase (EC 2.1.1.245) is a transferase that can convert 5,6,7,8-tetrahydrosarcinapterin and methyl-Co(III)-[corrinoid Fe-S protein] into 5-methyltetrahydrosarcinapterin, Co(I)-[corrinoid Fe-S protein] and H +.
Cat. No.: HY-E71931
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5-Methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase (EC 2.1.1.258) is a transferase that can convert methyl-Co(III)-[corrinoid Fe-S protein] and (6S)-5,6,7,8-tetrahydrofolate into Co(I)-[corrinoid Fe-S protein], (6S)-5-methyl-5,6,7,8-tetrahydrofolate and H +.
Cat. No.: HY-L133
446 compounds
Copper is an important co-factor of all biological enzymes, but if the concentration exceeds the threshold of maintaining the homeostasis mechanism, copper will lead to cytotoxicity. This death mechanism has been named "Cuproptosis".
The mechanism of cuproptosis distinct from all other known mechanisms of regulated cell death, including apoptosis, pyroptosis, necroptosis, and ferroptosis.
Copper combine with the lipoylated components of the tricarboxylic acid cycle (TCA), leading to lipoylated protein aggregation and subsequent loss of iron-sulfur cluster proteins, ultimately resulting in protein toxicity stress and cell death. Studies have shown that the necessary factors for cuproptosis include the presence of glutathione, mitochondrial metabolism of galactose and pyruvate, and glutamine metabolism.
Targeted regulation of cuproptosis is a potential choice to treat cancer, rheumatoid arthritis, and other diseases. For example, up-regulation of LIPT1 may inhibit the occurrence and development of tumors by destroying TCA in mitochondria and then inducing cuproptosis.
MCE supplies a unique collection of 446 cuproptosis-related compounds, all of which act on the targets or signaling pathways related to cuproptosis and may have in inhibitory or activated effect on cuproptosis. MCE Cuproptosis Library is a useful tool for drug research related to cancer, rheumatoid arthritis, and other diseases.
Cat. No.: HY-W174480
CAS No.: 26908-38-3
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5-deazaflavin is a flavin analogue with redox activity. 5-deazaflavin is a photocatalyst in biological redox systems .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
