1716 Results for "

kappa

" in MedChemExpress (MCE) Product Catalog:
Products (1716)

1716 Results for "kappa" in MCE Product Catalog:

20
20 Publications Verification
Cat. No.: HY-P99001

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology Cancer

Human IgG1 kappa, Isotype Control is a human monoclonal antibody that is the isotype control of human IgG1 kappa antibody .
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19
19 Cited Publications
Cat. No.: HY-N0164
CAS No.: 519-02-8
Synonyms: Matridin-15-one; Vegard; α-Matrine
Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI) .
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17
17 Cited Publications
Cat. No.: HY-P7425
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF11; Tumor Necrosis Factor (Ligand) Superfamily, Member 11; TNF Superfamily Member 11; Receptor Activator Of Nuclear Factor kappa-B Ligand; TRANCE; TNLG6B; RANKL; Receptor Activator Of Nuclear Factor kappa B Ligand; OPGL; Tumor Necrosis Factor Ligand
Species:  
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13
13 Cited Publications
Cat. No.: HY-156131
CAS No.: 53179-11-6
Synonyms: ADL 2-1294
Loperamide (ADL 2-1294) is selective and orally active μ opioid receptor agonist with Ki valuess of 3, 48 and 1156 nM against μ, δ and κ opioid receptor, respectively. Loperamide produces antinociception and antihyperalgesia. Loperamide exhibits peripheral selectivity, enhancing fluid, electrolyte, and glucose absorption, reversing PGE2 (HY-101952)- and Cholera toxin (HY-P1446)-induced intestinal secretion, and reducing intestinal motility. Loperamide can be used for the researches of inflammatory pain and protracted diarrhoea .
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11
11 Cited Publications
Cat. No.: HY-P99003

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Human IgG4 (S228P) kappa, Isotype Control, a human-derived monoclonal antibody, is an isotype control for human IgG4κ antibody.
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10
10 Cited Publications
Cat. No.: HY-101718
CAS No.: 1174130-61-0
Purity:  99.87%
Synonyms: CERC-501; LY-2456302
Target:  

Opioid Receptor

Research Areas:  

Neurological Disease

Aticaprant (CERC-501) is a potent and centrally-penetrant kappa opioid receptor antagonist with a Ki of 0.807 nM.
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10
10 Cited Publications
Cat. No.: HY-P7424
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF11; Tumor Necrosis Factor (Ligand) Superfamily, Member 11; TNF Superfamily Member 11; Receptor Activator Of Nuclear Factor kappa-B Ligand; TRANCE; TNLG6B; RANKL; Receptor Activator Of Nuclear Factor kappa B Ligand; OPGL; Tumor Necrosis Factor Ligand
Species:  
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8
8 Cited Publications
Cat. No.: HY-P99977

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Mouse IgG1 kappa, Isotype Control is a negative control reagent/isotype control for mouse-derived IgG1κ antibodies. Mouse IgG1 kappa, Isotype Control, by maintaining the same immunoglobulin structure (including isotype, light chain, etc.) as the specific mouse IgG1κ subtype primary antibody, eliminates false positive signals caused by non-specific binding in immunological experiments, thus playing a core role in verifying the specificity of the experiment. Mouse IgG1 kappa, Isotype Control can be applied to immunolocalization experiments in the field of cell biology, such as immunofluorescence staining and immunohistochemistry, assisting in research on protein subcellular localization and cell structure analysis, ensuring the reliability of experimental results .
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8
8 Cited Publications
Cat. No.: HY-100903
CAS No.: 113158-34-2
Purity:  98.91%
Synonyms: nor-Binaltorphimine dihydrochloride; nor-BNI dihydrochloride
Target:  

Opioid Receptor

Research Areas:  

Neurological Disease

Norbinaltorphimine dihydrochloride (nor-Binaltorphimine dihydrochloride; nor-BNI dihydrochloride) is a selective, long-acting competitive antagonist of the κ-opioid receptor. Norbinaltorphimine dihydrochloride blocks κ-opioid receptor-mediated analgesic effects, and inhibits butorphanol-induced changes in κ-opioid receptor binding kinetics, desensitization and down-regulation. Norbinaltorphimine dihydrochloride suppresses specific opioid withdrawal symptoms, precipitates withdrawal behaviors in butorphanol-dependent rats, and serves as a molecular probe for studying κ-opioid receptor-agonist interactions. Norbinaltorphimine dihydrochloride is applicable to research related to neurological disorders such as pain .
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8
8 Cited Publications
Cat. No.: HY-117040
CAS No.: 105618-26-6
Purity:  98.70%
Synonyms: Norbinaltorphimine; NorBNI
Target:  

Opioid Receptor

Research Areas:  

Neurological Disease

nor-Binaltorphimine (Norbinaltorphimine; NorBNI) is a selective, long-acting competitive antagonist of the κ-opioid receptor. nor-Binaltorphimine blocks κ-opioid receptor-mediated analgesic effects, and inhibits butorphanol-induced changes in κ-opioid receptor binding kinetics, desensitization and down-regulation. nor-Binaltorphimine suppresses specific opioid withdrawal symptoms, precipitates withdrawal behaviors in butorphanol-dependent rats, and serves as a molecular probe for studying κ-opioid receptor-agonist interactions. nor-Binaltorphimine is applicable to research related to neurological disorders such as pain .
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6
6 Cited Publications
Cat. No.: HY-P73388
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF11; Tumor Necrosis Factor (Ligand) Superfamily, Member 11; TNF Superfamily Member 11; Receptor Activator Of Nuclear Factor kappa-B Ligand; TRANCE; TNLG6B; RANKL; Receptor Activator Of Nuclear Factor kappa B Ligand; OPGL; Tumor Necrosis Factor Ligand
Species:  
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6
6 Cited Publications
Cat. No.: HY-N0405
CAS No.: 28608-75-5
Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases IL-10 level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain .
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6
6 Cited Publications
Cat. No.: HY-P99340
CAS No.: 2423014-07-5
Synonyms: VIR 7831; GSK-4182136

Target:  

SARS-CoV

Research Areas:  

Infection Cancer

Sotrovimab (VIR 7831) is a human IgG1κ pan-sarbecovirus monoclonal antibody (mAb), neutralizes SARS-CoV-2, SARS-CoV-1, and multiple other sarbecoviruses. Sotrovimab is developed based on S309, exhibits a long half-life and great bioavailability in the respiratory mucosa. Sotrovimab could result in immune-mediated viral clearance and prevent progression of Covid-19 early in the course of disease .
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5
5 Cited Publications
Cat. No.: HY-P990679

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology Cancer

Rat IgG2a kappa, Isotype Control is a monoclonal antibody derived from rats, representing the immunoglobulin G2a (IgG2a) subclass with a kappa light chain. Rat IgG2a kappa, Isotype Control exhibits high efficiency in inducing K cell mediated cytotoxicity. Rat IgG2a kappa, Isotype Control is utilized in research investigating the roles of different immunoglobulin subclasses in tumor immunology. Rat IgG2a kappa, an isotype control, can be used as an isotype control for Anti-Mouse PD-1 Antibody (RMP1-14) (HY-P99144), Anti-Mouse CD11a/LFA-1α Antibody (M17/4) (HY-P990801), and Anti-Mouse IL-2 Antibody (S4B6-1) (HY-P990796) .
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5
5 Cited Publications
Cat. No.: HY-P9901
CAS No.: 477202-00-9
Synonyms: MDX-010; BMS-734016

Target:  

CTLA-4

Research Areas:  

Cancer

Ipilimumab is a fully human monoclonal antibody IgG1κ that blocks the inhibitory receptor cytotoxic T lymphocyte antigen 4 (CTLA-4) on T cells. Ipilimumab can be used in unresectable or metastatic melanoma (MM) studies .
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5
5 Cited Publications
Cat. No.: HY-P990545
CAS No.: 2065212-40-8
Synonyms: ANX005

Target:  

Complement System

Research Areas:  

Neurological Disease

Tanruprubart (ANX005) is a C1q inhibitor and C1q depleter. Tanruprubart is a human antibody expressed in CHO cells, with huIgG1 heavy chains and huκ light chains, and its predicted molecular weight (MW) is 145 kDa. For the isotype control of Tanruprubart, refer to Human IgG4 kappa, Isotype Control (HY-P99003). The IC50 of Tanruprubart is 346 ng/mL for humans and 259 ng/mL for rats; its EC50 is 3.8 ng/mL for humans, 5.2 ng/mL for rats, and 9.9 ng/mL for mice. Tanruprubart is applicable to the research of Guillain-Barré syndrome and Alzheimer's disease .
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5
5 Cited Publications
Cat. No.: HY-P99137

Target:  

IFNAR

Research Areas:  

Inflammation/Immunology

Anti-Mouse IFNAR1 Antibody (MAR1-5A3) is a neutralizing antibody of IFNAR1. Anti-Mouse IFNAR1 Antibody (MAR1-5A3) reacts with IFNAR1 and inhibits IFNAR1 signaling in vitro and in vivo. Mouse IgG1 kappa, Isotype Control (HY-P99977) is the isotype control of Anti-Mouse IFNAR1 Antibody (MAR1-5A3) .
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4
4 Cited Publications
Cat. No.: HY-P9909
CAS No.: 815610-63-0
Synonyms: CNTO-1275; L04AC05; TT-20

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Ustekinumab is an anti-IL-12/IL-23 IgG1κ human monoclonal antibody.
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4
4 Cited Publications
Cat. No.: HY-N6769
CAS No.: 12772-57-5
Synonyms: Monorden
Radicicol is an inhibitor of Hsp90 with an IC50 value < 1 μM, and leads to proteasomal degradation . Radicicol exhibits inhibition on PDK with IC50s of 230 μM (PDK1) and 400 μM (PDK3). Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB . Radicicol is also an inhibitor of fat mass and obesity-associated protein (FTO), with an IC50 value of 16.04 μM .
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4
4 Cited Publications
Cat. No.: HY-P9971
CAS No.: 1798286-48-2
Synonyms: SHR-1210; INCSHR1210

Target:  

PD-1/PD-L1

Research Areas:  

Cancer

Camrelizumab (SHR-1210) is a potent humanied high-affinity IgG4-κ monoclonal antibody (mAb) to PD-1. Camrelizumab binds PD-1 at a high affinity of 3 nM and inhibits the binding interaction of PD-1 and PD-L1 with an IC50 of 0.70 nM. Camrelizumab acts as anti-PD-1/PD-L1 agent and can be used for cancer research, including NSCLC, ESCC, Hodgkin lymphoma, and advanced HCC et,al .
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