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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
92 Results for "
leukocyte adhesion
" in MedChemExpress (MCE) Product Catalog:
Products (92)
92 Results for "leukocyte adhesion" in MCE Product Catalog:
6
6 Publications Verification
Target:
Research Areas:
Leukadherin-1, a specific agonist of the leukocyte surface integrin CD11b/CD18, increases CD11b/CD18-dependent cell adhesion to fibrinogen with an EC50 of 4 μM. Leukadherin-1 enhances leukocyte adhesion to ligands (such as ICAM-1) and vascular endothelium and thus reduces leukocyte transendothelial migration and influx to the injury sites. Leukadherin-1 suppresses innate inflammatory signaling .
2
2 Cited Publications
Cat. No.: HY-160109
Target:
Research Areas:
Ac5GalNTGc is a potent, peracetylated C-2 thioglycolyl-substituted GalNAc analog that efficiently inhibits mucin-type O-glycan biosynthesis. Ac5GalNTGc reduces leukocyte sialyl-Lewis-X expression and inhibits L-/P-selectin mediated rolling under flow, as well as P-selectin dependent leukocyte-platelet adhesion. Ac5GalNTGc exhibits anti-inflammatory activity in a thioglycollate-induced acute peritonitis model. Ac5GalNTGc can be used for studies of O-glycan/mucin biology, inflammation, and related translational research .
1
1 Cited Publications
Synonyms: 6-Desoxygalactose (Standard); L-(-)-Fucose (Standard); L-Galactomethylose (Standard)
1
1 Cited Publications
Cat. No.: HY-P73042
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SELE; ESEL; Prev. ELAM1; Endothelial adhesion Molecule 1; Prev. ELAM; ELAM-1; Endothelial leukocyte adhesion Molecule 1; LECAM2; CD62 Antigen-Like Family Member E; leukocyte Endothelial Cell adhesion Molecule 2; E-Selectin; CD62E Antigen; CD62E; Selectin-
Species:
Mouse
Source:
HEK293
1
1
1 Cited Publications
Cat. No.: HY-P70803
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SELP; Selectin P (Granule Membrane Protein 140kDa, Antigen CD62); Prev. GRMP; LECAM3; P-Selectin; Selectin P (Granule Membrane Protein 140kD, Antigen CD62); PADGEM; leukocyte-Endothelial Cell adhesion Molecule 2; Platelet Activation Dependent Granule-Exte
Species:
Human
Source:
HEK293
Category:
Human Gut Microbiota Metabolites Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Monosaccharides
Target:
Cat. No.: HY-P99336
CAS No.: 142864-19-5
Synonyms: BI-RR 0001; Anti-Human IL6 Recombinant Antibody
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Research Areas:
Synonyms: CP-66248
Target:
Research Areas:
Tenidap (CP-66248) is an orally active dual inhibitor of 5-LOX and COX with anti-inflammatory and immunomodulatory properties. Tenidap downregulates the expression of IL-1 receptors in chondrocytes, reduces the release of pro-inflammatory cytokines such as IL-1, IL-6 and TNF-α, and inhibits MMP production and cartilage degradation. Tenidap also blocks bone resorption and leukocyte adhesion to vascular endothelium, interferes with ion and pH changes associated with mouse sperm capacitation, and selectively enhances the activity of hKir2.3 channels (EC50=1.3 μM). Tenidap is applicable to research related to rheumatoid arthritis .
Cat. No.: HY-W032970
CAS No.: 534-73-6
Isomaltitol is a sugar alcohol sweet tastant. Isomaltitol affects adhesion between leukocytes and activated endothelium .
Cat. No.: HY-19151
CAS No.: 141283-87-6
Synonyms: IS-741
Target:
Research Areas:
Fuzapladib (IS-741), an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site .
Cat. No.: HY-P99788
CAS No.: 2145109-70-0
Synonyms: CX-191; CX-2009 Antibody
Target:
Research Areas:
Cat. No.: HY-145728B
Purity: 97.08%
Synonyms: (R/S)-ISIS-2302
Target:
Research Areas:
(R/S)-Alicaforsen is the racemate of Alicaforsen composed of R and S configurations. Alicaforsen is a 20-base antisense oligonucleotide inhibiting ICAM-1 production, which is an important adhesion molecule involved in leukocyte migration and trafficking to the site of inflammation.
Cat. No.: HY-19151A
CAS No.: 141284-73-3
Synonyms: IS-741 sodium
Target:
Research Areas:
Fuzapladib (IS-741) sodium, an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib sodium is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib sodium exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site .
Cat. No.: HY-P991532
Synonyms: MEMD; EJ212/007-Cl2-5
Target:
Research Areas:
Cat. No.: HY-169138
CAS No.: 140841-32-3
Target:
Research Areas:
ZD 2138 is a selective 5-lipoxygenase (5-lipoxygenase) inhibitor with an IC50 of 20-50 nM. ZD 2138 inhibits cytokine-induced rolling and adhesion of leukocytes on bovine aortic endothelial cells. ZD 2138 is applicable to research related to inflammatory diseases such as acute asthma .
Synonyms: RG7774
Target:
Vicasinabin (RG7774) is an orally active, selective, and full CB2R agonist, with EC50 values of 2.81 nM and 2.60 nM for human CB2R and mouse CB2R, respectively. Vicasinabin inhibits inflammation, reduces leukocyte adhesion and decreases vascular permeability by selectively activating CB2R. Vicasinabin can be used in the researches for diabetic retinopathy, uveitis and laser-induced choroidal neovascularization .
Cat. No.: HY-N1480S1
CAS No.: 83379-37-7
Synonyms: 6-Desoxygalactose-13C-1; L-(-)-Fucose-13C-1; L-Galactomethylose-13C-1
Cat. No.: HY-142444
CAS No.: 2647975-06-0
Target:
Research Areas:
SSAO/VAP-1 inhibitor 1 is a potent inhibitor of SSAO/VAP-1. SSAO/VAP-1 promotes the transfer of Glucose transport 4 (GLUT 4) from adipocytes to the cell membrane, thereby regulating glucose transport. In endothelial cells, SSAO/VAP-1 can mediate the adhesion and exudation of leukocytes and endothelial cells, and participate in inflammatory responses. SSAO/VAP-1 inhibitor 1 has the potential for the research of inflammation and/or inflammation-related disease or diabetes and/or diabetes-related disease (extracted from patent WO2021102774A1, compound E3) .
Cat. No.: HY-15701R
CAS No.: 344897-95-6
Target:
Research Areas:
Leukadherin-1 (Standard) is the analytical standard of Leukadherin-1. This product is intended for research and analytical applications. Leukadherin-1, a specific agonist of the leukocyte surface integrin CD11b/CD18, increases CD11b/CD18-dependent cell adhesion to fibrinogen with an EC50 of 4 μM. Leukadherin-1 enhances leukocyte adhesion to ligands (such as ICAM-1) and vascular endothelium and thus reduces leukocyte transendothelial migration and influx to the injury sites. Leukadherin-1 suppresses innate inflammatory signaling .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
