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lysyl-tRNA synthetase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminoacyl-tRNA Synthetase (4) Bacterial (1) Parasite (2) Ras (1)
By Research Areas:	Cancer (1) Infection (5) Inflammation/Immunology (1)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Targets Recommended: Aminoacyl-tRNA Synthetase Acetyl-CoA synthetase Carbamoyl Phosphate Synthetase (CPS) Methionine Adenosyltransferase (MAT)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126130

LysRs-IN-2 1 Publications Verification	Aminoacyl-tRNA Synthetase	Infection
LysRs-IN-2 is a lysyl-tRNA synthetase (KRS) inhibitor with IC₅₀s of 0.015 μM and 0.13 μM for Plasmodium falciparum lysyl-tRNA synthetase (PfKRS) and Cryptosporidium parvum lysyl-tRNA synthetase (CpKRS), respectively .

HY-103280

LysRs-IN-1	Aminoacyl-tRNA Synthetase	Others
LysRs-IN-1 is a Lysyl-tRNA synthetase (LysRs) inhibitor.

HY-15782

YH16899	Aminoacyl-tRNA Synthetase	Cancer
YH16899 binds Lysyl-tRNA synthetase (KRS), and inhibits membrane translocation of KRS. YH16899 impares the interaction of KRS with 67LR. YH16899 inhibits tumor metastasis in mouse models .

HY-168569

DDD489	Aminoacyl-tRNA Synthetase	Infection
DDD489 is a potent and selective Cryptosporidium lysyl-tRNA synthetase (CpKRS) inhibitor with IC₅₀ values of 0.85 uM.DDD489 shows anti-cryptosporidials activity in vitro and in vivo .

HY-175503

LysRs-IN-4	Bacterial	Infection
LysRS-IN-4 (Compound 49) is an orally active Mycobacterium tuberculosis LysRS (lysyl-tRNA *synthetase*) inhibitor. LysRS-IN-4 is promising for research of tuberculosis .

HY-175305

DMU759	Parasite	Infection
DMU759 is a Lysyl-tRNA synthetase 1 (KRS1) inhibitor. DMU759 has potent anti-kinetoplastid activity against Trypanosoma cruzi , Trypanosoma brucei and Leishmania donovani. DMU759 significantly reduces parasitemia in acute Chagas disease mice model. DMU759 can be used for parasitic infection like Chagas disease research .

HY-175304

DMU371	Parasite	Infection
DMU371 is a Trypanosoma cruzi lysyl-tRNA synthetase 1 (KRS1) inhibitor (IC₅₀=185 nM). DMU371 is promising for research of infectious diseases .

HY-P991156

Rapaprutug	Ras	Inflammation/Immunology
Rapaprutug is a monoclonal antibody targeting human KARS1 (lysyl-tRNA synthetase 1). Rapaprutug blocks the relevant inflammatory signaling pathways in which KARS1 is involved, reducing the production and release of inflammatory factors. Rapaprutug is promising for research of inflammatory diseases .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991156

Rapaprutug	Ras	Inflammation/Immunology
Rapaprutug is a monoclonal antibody targeting human KARS1 (lysyl-tRNA synthetase 1). Rapaprutug blocks the relevant inflammatory signaling pathways in which KARS1 is involved, reducing the production and release of inflammatory factors. Rapaprutug is promising for research of inflammatory diseases .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70840

	KARS Protein, Human (HEK293, His) Lysine--tRNA Ligase; lysyl-tRNA synthetase; LysRS; KARS; KIAA0070	Human	HEK293
	The KARS protein promotes attachment of amino acids to its cognate tRNA through a two-step reaction, inducing immune responses through monocyte/macrophage activation. In microbial infections, it interacts with the HIV-1 GAG protein to enable selective tRNA(3)(Lys) packaging to initiate reverse transcription. KARS Protein, Human (HEK293, His) is the recombinant human-derived KARS protein, expressed by HEK293 , with C-6*His labeled tag.

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HY-P85266

	KARS Antibody (YA4958) KARS; KIAA0070; Lysine--tRNA ligase; lysyl-tRNA synthetase; LysRS	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, IP	Human, Mouse
	KARS Antibody (YA4958) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to KARS.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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