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Cat. No.: HY-184406

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Antimalarial agent 65

Antimalarial agent 65 is an inhibitor of Plasmodium falciparum lysyl-tRNA synthetase (PfKRS1), with a pIC₅₀ value of 6.9 against Plasmodium falciparum. Antimalarial agent 65 inhibits the growth of Plasmodium falciparum strains. Antimalarial agent 65 exhibits activity across multiple life cycle stages of the malaria parasite, including transmission-blocking activity. Antimalarial agent 65 can be used in malaria-related research.

For research use only. We do not sell to patients.

Formula: C₂₄H₃₂F₆N₆O
Molecular Weight:534.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antimalarial agent 65 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

All Parasite Isoforms :

In Vitro

Antimalarial agent 65 (Compound 30) (40-47 h) inhibits the asexual blood-stage growth of P. falciparum strain 3D7 with an EC₅₀ of 6 nM, and retains activity against drug-resistant strains with EC₅₀ values of 3-5 nM^[1].
Antimalarial agent 65 (40-47 h) inhibits the in vitro growth of field isolates of Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae, with EC₅₀ values ranging from 2 to 6 nM^[1].
Antimalarial agent 65 inhibits the growth of Plasmodium falciparum liver schizonts with an EC₅₀ of 734 nM, but shows no activity against the liver-stage forms and hypnozoites of P. vivax^[1].
Antimalarial agent 6 (24-48 h) inhibits the sexual stage of P. falciparum and mosquito oocyst development, with an EC₅₀ value of 3-15 nM, demonstrating potential for blocking transmission^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	V_dss	CL_blood	CL_unbound
Mice^[1]	3 mg/kg	i.v.	7 h	12 L/kg	67 mL/min/kg	114 mL/min/kg
Rat^[1]	1 mg/kg	i.v.	21 h	7 L/kg	5 mL/min/kg	8 mL/min/kg
Dog^[1]	0.3 mg/kg	i.v.	37 h	14 L/kg	19 mL/min/kg	105 mL/min/kg

Chemical Information

Molecular Weight 534.54
Formula C₂₄H₃₂F₆N₆O
SMILES

O=C1N(CC2(CCN(CC3)CCC43CCN4)CC(C(F)(F)F)CCC2)CC5=NC(N)=NC(C(F)(F)F)=C51
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Forte B, et al. Structure-Guided Optimization of Novel Inhibitors of Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites. Journal of medicinal chemistry. 2026 Jun 11;69(11):13820-13855. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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Antimalarial agent 65

All Parasite Isoforms