63 Results for "

malate

" in MedChemExpress (MCE) Product Catalog:
Products (63)

63 Results for "malate" in MCE Product Catalog:

96
Sunitinib Malate
Sunitinib Malate
0 Images
96 Publications Verification
Art. -Nr.: HY-10255
CAS. Nr.: 341031-54-7
Reinheit:  99.86%
Synonyms: SU 11248 malate
Target:  

PDGFR VEGFR IRE1 Mitophagy Autophagy Apoptosis

Forschungsgebiete:  

Infection Inflammation/Immunology Cancer

Sunitinib (SU 11248) Malat is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively . Sunitinib Malat, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation .
57
Cabozantinib S-malate
Cabozantinib S-malate
0 Images
57 Cited Publications
Art. -Nr.: HY-12044
CAS. Nr.: 1140909-48-3
Reinheit:  99.90%
Synonyms: XL184 S-malate; BMS-907351 S-malate
Target:  

VEGFR Apoptosis

Forschungsgebiete:  

Cancer

Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.
27
Nicotinamide riboside malate
Nicotinamide riboside malate
0 Images
27 Cited Publications
Art. -Nr.: HY-123033C
CAS. Nr.: 2415659-01-5
Reinheit:  98.04%
Category:  

Natural Products Neurological Disease Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Sirtuin Endogenous Metabolite

Nicotinamide riboside malate, an orally active NAD + precursor, increases NAD + levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .
24
Aminooxyacetic acid hemihydrochloride
Aminooxyacetic acid hemihydrochloride
0 Images
24 Cited Publications
Art. -Nr.: HY-107994
CAS. Nr.: 2921-14-4
Reinheit:  ≥98.0%
Synonyms: Carboxymethoxylamine hemihydrochloride; Aminooxyacetate hemihydrochloride
Target:  

GABA Receptor

Forschungsgebiete:  

Cancer

Aminooxyacetic acid (Carboxymethoxylamine) hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T.
24
Aminoxyacetic acid
Aminoxyacetic acid
0 Images
24 Cited Publications
Art. -Nr.: HY-107994A
CAS. Nr.: 645-88-5
Synonyms: Carboxymethoxylamine; Aminooxyacetate
Target:  

GABA Receptor

Forschungsgebiete:  

Cancer

Aminooxyacetic acid (Carboxymethoxylamine) is a malate-aspartate shuttle (MAS) inhibitor. Aminooxyacetic acid also inhibits the GABA degradating enzyme GABA-T.
6
L-Citrulline DL-malate
L-Citrulline DL-malate
0 Images
6 Cited Publications
Art. -Nr.: HY-N0391A
CAS. Nr.: 70796-17-7
Category:  

Ketones, Aldehydes, Acids Endogenous metabolite

Target:  

Endogenous Metabolite

L-Citrulline (DL-malate) is an organic compound commonly used as a nutritional supplement. It boosts the body's production of nitrogen oxides, improves circulation and athletic performance, and reduces muscle fatigue. In addition, L-Citrulline DL-malate also plays an important role in some industrial fields, for example, it is used in the field of agriculture to enhance plant immunity.
4
Malic acid disodium salt
Malic acid disodium salt
0 Images
4 Cited Publications
Art. -Nr.: HY-W250303
CAS. Nr.: 676-46-0
Synonyms: Hydroxybutanedioic acid disodium salt; E 296 disodium salt
Sodium DL-Malate is an organic compound commonly used as a food additive, buffer and nutritional supplement. It contains sodium and malic acid. Malic acid disodium salt has several properties suitable for these applications, including the ability to enhance food flavor, improve texture and regulate acidity. Additionally, it can be used as a dietary supplement due to its potential health benefits, including improved energy production, reduced fatigue, and enhanced athletic performance.
4
Malic acid disodium hydrate
Malic acid disodium hydrate
0 Images
4 Cited Publications
Art. -Nr.: HY-W250303A
CAS. Nr.: 63474-37-3
Synonyms: Hydroxybutanedioic acid disodium hydrate; Disodium DL-malate hydrate; E 296 disodium hydrate
Malic acid disodium hydrate is an organic compound that is commonly used as a food additive, buffering agent, and nutritional supplement. It contains sodium and malic acid. Malic acid disodium hydrate has a variety of properties that make it suitable for these applications, including the ability to enhance food flavor, improve texture, and regulate acidity. In addition, due to its potential health benefits, including improved energy production, reduced fatigue, and enhanced athletic performance, Malic acid disodium hydrate can be used as a dietary supplement .
2
Pizotifen malate
Pizotifen malate
0 Images
2 Cited Publications
Art. -Nr.: HY-B0115A
CAS. Nr.: 5189-11-7
Synonyms: Pizotyline malate; BC-105 malate
Target:  

5-HT Receptor

Forschungsgebiete:  

Neurological Disease

Pizotifen malate (Pizotyline malate) is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site.
1
Nemonoxacin malate
Nemonoxacin malate
0 Images
1 Cited Publications
Art. -Nr.: HY-111023
CAS. Nr.: 951163-60-3
Reinheit:  99.43%
Synonyms: TG-873870 malate
Target:  

Antibiotic Bacterial

Forschungsgebiete:  

Infection

Nemonoxacin (TG-873870) malate is a nonfluorinated quinolone antibiotic. Nemonoxacin malate has broad-spectrum activity against Gram-positive, Gram-negative and atypical pathogens. Nemonoxacin malate can inhibit drug-resistant Streptococcus pneumoniae and Methicillin-resistant Staphylococcus aureus. Nemonoxacin malate can be used for the research of community-acquired pneumonia .
1
Clebopride malate
Clebopride malate
0 Images
1 Cited Publications
Art. -Nr.: HY-B1613A
CAS. Nr.: 57645-91-7
Target:  

Dopamine Receptor Adrenergic Receptor

Forschungsgebiete:  

Metabolic Disease

Clebopride malate is an orally active dopamine Receptor antagonist. Clebopride malate acts on dopamine D2 receptors and has antiemetic and prokinetic effects. Clebopride malate can be used in the study of functional gastrointestinal disorders .
1
Malic dehydrogenase, microorganism
Malic dehydrogenase, microorganism
0 Images
1 Cited Publications
Art. -Nr.: HY-P2809
CAS. Nr.: 9001-64-3
Synonyms: MDH; EC 1.1.1.37
Target:  

Endogenous Metabolite

Forschungsgebiete:  

Metabolic Disease

Malate dehydrogenase (EC 1.1.1.37) (MDH) catalyzes the mutual conversion of oxaloacetate and malate, and is associated with the oxidation/reduction of dinucleotide coenzymes .
Phenoxyethanol
Phenoxyethanol
0 Images
Art. -Nr.: HY-B1729
CAS. Nr.: 122-99-6
Category:  

Natural Products

Target:  

Environmental Pollutants Bacterial Fungal Oxidative Phosphorylation

Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al .
Almotriptan malate
Almotriptan malate
0 Images
Art. -Nr.: HY-B0383
CAS. Nr.: 181183-52-8
Synonyms: PNU180638
Target:  

5-HT Receptor

Forschungsgebiete:  

Neurological Disease

Almotriptan malate (PNU180638) is an orally active, highly selective agonist of the 5-HT1B/1D receptor (5-HT1B/1D receptor), with EC50 values of 1.6 nM and 3.1 nM, respectively. Almotriptan malate shows moderate affinity for the 5-HT1F receptor, and weak affinity for the 5-HT1A, 5-HT6 and 5-HT7 receptors. Almotriptan malate induces intracranial vasoconstriction, inhibits nociceptive neurotransmission in the trigeminocervical complex, and suppresses the release of vasoactive peptides from trigeminal nerve endings. Almotriptan malate can be used in research related to migraine .
Phenoxyethanol (Standard)
Phenoxyethanol (Standard)
0 Images
Art. -Nr.: HY-B1729R
CAS. Nr.: 122-99-6
Category:  

Microorganisms

Target:  

Oxidative Phosphorylation Reference Standards Bacterial Fungal

Phenoxyethanol (Standard) is the analytical standard of Phenoxyethanol. This product is intended for research and analytical applications. Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al .
Sunitinib Malate (Standard)
Sunitinib Malate (Standard)
0 Images
Art. -Nr.: HY-10255R
CAS. Nr.: 341031-54-7
Synonyms: SU 11248 malate (Standard)
Target:  

Reference Standards PDGFR VEGFR IRE1 Mitophagy Autophagy Apoptosis

Forschungsgebiete:  

Cancer

Sunitinib (Malate) (Standard) is the analytical standard of Sunitinib (Malate). This product is intended for research and analytical applications. Sunitinib Malate (SU 11248 Malate) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively . Sunitinib Malate, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation .
β-Benzamide adenine dinucleotide
β-Benzamide adenine dinucleotide
0 Images
Art. -Nr.: HY-147342
CAS. Nr.: 156724-91-3
Target:  

Drug Metabolite IMPDH

Forschungsgebiete:  

Cancer

β-Benzamide adenine dinucleotide is a biologically active metabolite of benzamide riboside. β-Benzamide adenine dinucleotide is a competitive inhibitor of human NAD kinase with a Ki value of 90 μM, and inhibits human IMPDH with IC50 values of 0.787 μM and 0.884 μM for type I and type II, respectively. β-Benzamide adenine dinucleotide exhibits inhibitory activities against lactate dehydrogenase, glutamate dehydrogenase, and malate dehydrogenase. β-Benzamide adenine dinucleotide can be used for the study of chronic myelogenous leukemia .
Caffeoylmalic acid
Caffeoylmalic acid
0 Images
Art. -Nr.: HY-Z15849
CAS. Nr.: 39015-77-5
Category:  

Nasturtium officinale R.Br. ex W.T.Aiton Ketones, Aldehydes, Acids Plants Brassicaceae

Target:  

Others

Caffeoylmalic acid is an orally active hydroxycinnamoyl-malate ester found in stinging nettle (Urtica dioica). Caffeoylmalic acid exhibits anti-diabetic, anti-inflammation and anti-oxidant effects. Caffeoylmalic acid shows cytotoxicity to cancer cells. Caffeoylmalic acid can be used for the researches of cancer, inflammation and metabolic disease, such as colon cancer and diabetes .
Famitinib malate
Famitinib malate
0 Images
Art. -Nr.: HY-108713A
CAS. Nr.: 1256377-67-9
Synonyms: SHR1020 malate
Target:  

VEGFR PDGFR Apoptosis

Forschungsgebiete:  

Cancer

Famitinib (SHR1020) malate, an orally active multi-targeted kinase inhibitor, inhibits the activity of c-kit, VEGFR-2 and PDGFRβ with IC50 values of 2.3 nM, 4.7 nM and 6.6 nM, respectively. Famitinib malate induces cell apoptosis. Famitinib malate exerts powerful antitumor activity in human gastric cancer cells and xenografts, it can be used for the research of cancer .
K-252c
K-252c
0 Images
Art. -Nr.: HY-N6736
CAS. Nr.: 85753-43-1
Category:  

Infection Alkaloids Microorganisms Disease Research Fields Indole Alkaloids

Target:  

Beta-lactamase PKC Bacterial Apoptosis

K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase .
Assay Types