Caffeoylmalic acid
Caffeoylmalic acid is an orally active hydroxycinnamoyl-malate ester found in stinging nettle (Urtica dioica). Caffeoylmalic acid exhibits anti-diabetic, anti-inflammation and anti-oxidant effects. Caffeoylmalic acid shows cytotoxicity to cancer cells. Caffeoylmalic acid can be used for the researches of cancer, inflammation and metabolic disease, such as colon cancer and diabetes.
For research use only. We do not sell to patients.
- CAS No.: 39015-77-5
- Formula: C13H12O8
- Molecular Weight:296.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Caffeoylmalic acid (5-80 μM) increases glucose absoption in yeast cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Alloxan-induced diabetic mice models[1]
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Dosage:0.5 mg/kg
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Administration:Orally administration, daily for 21 days
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Result:Reduced blood glucose level.
Increased body weight.
Induced the production of insulin.
Decreased total cholesterol, triglycerides and LDL as well as increased HDL.
Reduced the levels of SGOT, ALP and SGPT.
Increased RBC count and decreased WBC count.
Chemical Information
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CAS No. 39015-77-5
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Molecular Weight 296.23
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Formula C13H12O8
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SMILES
O=C(/C=C/C1=CC=C(C(O)=C1)O)OC(CC(O)=O)C(O)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Rehman G, et al. Antidiabetic Properties of Caffeoylmalic Acid, a Bioactive Natural Compound Isolated from Urtica dioica. Fitoterapia. 2024 Jul;176:106024. [Content Brief]
[2]. Delgadillo Puga C, et al. Phenolic Compounds in Organic and Aqueous Extracts from Acacia farnesiana Pods Analyzed by ULPS-ESI-Q-oa/TOF-MS. In Vitro Antioxidant Activity and Anti-Inflammatory Response in CD-1 Mice. Molecules. 2018 Sep 18;23(9):2386. [Content Brief]
[3]. Wójciak M, et al. Antioxidant and Anti-Inflammatory Effects of Nettle Polyphenolic Extract: Impact on Human Colon Cells and Cytotoxicity Against Colorectal Adenocarcinoma. Molecules. 2024 Oct 22;29(21):5000. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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