2 Results for "

malignant vascular endothelial cells

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "malignant vascular endothelial cells" in MCE Product Catalog:

Clausenidin
Clausenidin
0 Images
Cat. No.: HY-N16771
CAS No.: 28384-44-3
Category:  

Rutaceae Coumarins Phenylpropanoids Plants Clausena excavata N. L. Burman

Target:  

Caspase Apoptosis Bcl-2 Family Bacterial VEGFR

Clausenidin is a selective inhibitor targeting apoptosis-related pathways, including the mitochondrial pathway and death receptor pathway, and vascular endothelial growth factor (VEGF). Clausenidin induces mitochondrial membrane depolarization by activating caspase-3, caspase-8 and caspase-9, upregulating the pro-apoptotic protein Bax and downregulating the anti-apoptotic protein Bcl-2. Clausenidin also inhibits VEGF expression and blocks angiogenesis, exerting anti-tumor activity. Clausenidin has inhibitory effects against Mycobacterium tuberculosis (MIC=200 μg/mL). Clausenidin can induce apoptosis in liver cancer cells, arrest the cell cycle in the G2/M phase, and inhibit tumor angiogenesis. Clausenidin can be used in the research of malignant tumors such as liver cancer .
loading...
    loading...
View All Sizes
Bavituximab (Mouse IgG1)
Bavituximab (Mouse IgG1)
0 Images
Cat. No.: HY-P99279A

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology Cancer

Bavituximab (Mouse IgG1) is a mouse-derived IgG1 antibody. The human-mouse chimeric Bavituximab localizes to tumor sites by crosslinking exposed PS with two β2GP1 molecules on the cell surface, activates host effector (immune) functions such as antibody-dependent cellular cytotoxicity, and ultimately leads to tumor vascular destruction .
loading...
    loading...
View All Sizes
Assay Types