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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

mast cell

" in MedChemExpress (MCE) Product Catalog:

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226

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Targets Recommended: Microtubule‐associated serine/threonine kinase (MAST) Programmed Cell Death 4 (PDCD4) Itk TOPK NAMPT ALCAM/CD166 GDNF Receptor BCL6 Tim3 VISTA BMI1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115768

Compound 48/80 5 Publications Verification Poly-p-methoxyphenethylmethylamine	Phospholipase	Neurological Disease Cancer
Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" **mast cell** activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways .

HY-B0320A

Cromolyn disodium 5+ Cited Publications Cromoglycate disodium; Cromoglicic acid disodium; FPL-670	GSK-3 NF-κB Amyloid-β	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cromolyn (Cromoglycate) disodium is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn disodium is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn disodium can be used in the research of bronchial asthma. In addition, Cromolyn disodium has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

HY-131166

Curdlan 2 Publications Verification	Bacterial Toll-like Receptor (TLR) NO Synthase C-type Lectin-like Receptors (CTLRs) Reactive Oxygen Species (ROS)	Inflammation/Immunology
Curdlan is a polysaccharide found in bacteria, consisting of a glucose homopolymer with β-1,3-glycosidic linkages . Curdlan can be recognized by Dectin-1 (a C-type lectin receptor), inducing immune responses in tissue mast cells and enhancing dendritic cell effects in tumor immunity. Curdlan holds potential for research in cancer and immune-inflammatory diseases .

HY-B0157

Ketotifen 3 Publications Verification HC 20-511	Endogenous Metabolite Histamine Receptor SARS-CoV Influenza Virus	Infection Inflammation/Immunology Endocrinology Cancer
Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-B0157A

Ketotifen fumarate 3 Publications Verification HC 20511 fumarate	Histamine Receptor Endogenous Metabolite SARS-CoV Influenza Virus	Inflammation/Immunology Endocrinology Cancer
Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-P99462

Barzolvolimab	c-Kit	Inflammation/Immunology
Barzolvolimab is a humanized anti-KIT IgG1 monoclonal antibody. Barzolvolimab specificity and potently inhibits KIT activation by SCF. Barzolvolimab can reduce skin mast cells and disease activity in chronic inducible urticaria .

HY-13508

JNJ-7777120 1 Publications Verification	Histamine Receptor	Inflammation/Immunology
JNJ-7777120 is a potent and selective histamine H₄ receptor antagonist (K_i=4.5 nM). JNJ-7777120 effectively blocks histamine-induced migration of mouse tracheal mast cells from connective tissue to epithelial cells. JNJ-7777120 also significantly blocks neutrophil infiltration in a mouse Zymosan-induced peritonitis model. JNJ-7777120 has a good potential to study antipruritic and anti-inflammatory .

HY-B0640

Epinastine WAL801	Histamine Receptor Transmembrane Glycoprotein Interleukin Related	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Epinastine (WAL801) is a selective and orally active histamine H1 receptor antagonist, CD96/PVR inhibitor and mast cell stabilizer. Epinastine has high affinity for neuronal octopamine receptors in locusts (K_i = 2 nM) and honeybees (K_i = 1.1 nM). Epinastine hydrochloride inhibits TARC, IL-8, and IL-4. Epinastine activates anti-colon cancer immunity and inhibits Substance P (HY-P0201)-induced scratching behavior and increased vascular permeability. Epinastine can be used in the research of allergic diseases .

HY-156619

Labuxtinib EVT-8565072; THB335	c-Kit PDGFR	Metabolic Disease Inflammation/Immunology
Labuxtinib (EVT-8565072; THB335) is a potent dual inhibitor of c-Kit and PDGFR. Labuxtinib exhibits potent inhibitory activity against wild-type c-Kit (IC₅₀ = 0.005 μM). Labuxtinib inhibits SCF-dependent and PDGF-dependent cell proliferation, and blocks the proliferation of cells dependent on c-Kit or PDGFR signaling pathways. In animal models of skin allergy, Labuxtinib depletes skin mast cells and significantly alleviates anaphylactic shock responses. Labuxtinib can be used in research on mast cell-related diseases, respiratory diseases, inflammatory diseases, fibrotic diseases, metabolic diseases, and other related conditions .

HY-B1619

Cromolyn 5+ Cited Publications Cromoglycate; Cromoglicic acid; FPL-670 free acid	GSK-3 NF-κB Amyloid-β	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

HY-P99371

Lirentelimab AK002; Antolimab	Apoptosis	Inflammation/Immunology
Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis .

HY-D1425

DCVJ 9-(2,2-Dicyanovinyl)julolidine	Fluorescent Dye	Others
DCVJ (9-(2,2-Dicyanovinyl)julolidine), a molecular rotor and unique fluorescent dye, binds to tubulin and actin, and increases its fluorescence intensity drastically upon polymerization. DCVJ also binds to phospholipid bilayers and increases its fluorescence intensity. DCVJ can detect the kinetic process of degranulation of mast cells (Absorption/emission=489/505 nm) .

HY-P991636

AK006	Transmembrane Glycoprotein	Inflammation/Immunology
AK006 is a humanized IgG1 monoclonal antibody agonist targeting Sialic acid-binding immunoglobulin-like lectin6 (Siglec-6). AK006 potently inhibits IgE-mediated human mast cell activation. AK006 can be used for inflammatory diseases like chronic urticaria (CU) and asthma research .

HY-43521

Ibrutinib-MPEA	Target Protein Ligand-Linker Conjugates Btk STAT	Inflammation/Immunology Cancer
Ibrutinib-MPEA is an orally active, blood-brain barrier permeable inhibitor of BTK and STAT5. As a derivative of Ibrutinib (HY-10997) conjugated with a PROTAC linker, Ibrutinib-MPEA allows the synthesis of a series of PROTAC molecules. Ibrutinib-MPEA significantly reduces the proliferation of neoplastic mast cells and primary mastocytoma cells by inducing apoptosis and inhibiting IgE-dependent histamine release. Ibrutinib-MPEA is applicable to the research of canine mast cell tumors, cerebral ischemia/reperfusion injury in diabetic mice, and neuroinflammation-related diseases .

HY-B0640A

Epinastine hydrochloride WAL801 hydrochloride	Histamine Receptor Transmembrane Glycoprotein Interleukin Related	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Epinastine hydrochloride (WAL801 hydrochloride) is a selective and orally active histamine H1 receptor antagonist, CD96/PVR inhibitor and mast cell stabilizer. Epinastine hydrochloride has high affinity for neuronal octopamine receptors in locusts (K_i = 2 nM) and honeybees (K_i = 1.1 nM). Epinastine hydrochloride inhibits TARC, IL-8, and IL-4. Epinastine hydrochloride activates anti-colon cancer immunity and inhibits Substance P (HY-P0201)-induced scratching behavior and increased vascular permeability. Epinastine hydrochloride can be used in the research of allergic diseases .

HY-B0426A

Olopatadine hydrochloride ALO4943A; KW4679	Histamine Receptor CXCR	Infection Neurological Disease Metabolic Disease Inflammation/Immunology
Olopatadine hydrochloride (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine hydrochloride exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine hydrochloride inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine hydrochloride also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine hydrochloride inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine hydrochloride simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of ErbB3A/HER3A. Olopatadine hydrochloride can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis .

HY-14270

Lodoxamide 2 Publications Verification U-42585E free acid	Histamine Receptor	Inflammation/Immunology Endocrinology
Lodoxamide (U-42585E free acid) is an antiallergic compound acting as a mast-cell stabilizer for the treatment of asthma and allergic conjunctivitis.

HY-W159754

Chavicol p-Hydroxyallylbenzene	Cholinesterase (ChE)	Inflammation/Immunology
Chavicol (p-Hydroxyallylbenzene) is a phenylpropane compound. Chavicol can be isolated from the bark of Sassafras tzumu. Chavicol exhibits Acetylcholinesterase inhibitory activity (IC₅₀ = 7.42 μM). Chavicol produces a 3% inhibitory effect on antigen-IgE-mediated degranulation in mast cells .

HY-168532

ST2-IN-1	Interleukin Related	Inflammation/Immunology
ST2-IN-1 is a ST2 inhibitor. ST2-IN-1 blocks the binding interaction between ST2 and IL-33, thereby attenuating the downstream ST2/IL-33 signaling pathway. ST2-IN-1 reduces IL-1β release from mast cells and alleviates ST2 upregulation in cells. ST2-IN-1 can be used for research on inflammatory and immune-related diseases .

HY-D0220A

Toluidine Blue (purity 36%) 3 Publications Verification Toluidine Blue O (purity 36%)	Fluorescent Dye	Others Cancer
Toluidine Blue (Toluidine Blue O) purity 36% is an alkaline quinonimine dye (vivo dye) with high affinity for acidic tissue components, staining nuclei blue and polysaccharides purple. Toluidine Blue purity 36% shows heterostaining properties for mast cells, mucins and chondrocytes. Toluidine Blue purity 36% can stain different components of plant tissues and cells in different colours. Toluidine Blue purity 36% is also used as a diagnostic aid to identify malignant lesions, such as cancer .

HY-135490

Reproterol	Adrenergic Receptor Phosphodiesterase (PDE)	Inflammation/Immunology
Reproterol is a selective β2-adrenoceptor agonist and cAMP phosphodiesterase (PDE) inhibitor. Reproterol inhibits adenylate cyclase-induced phosphodiesterase activity. Reproterol inhibits histamine release from mast cells. Reproterol is applicable to research related to asthma .

HY-115822

α-Fluoromethylhistidine dihydrochloride	Amino Acid Decarboxylase	Neurological Disease Metabolic Disease
α-Fluoromethylhistidine dihydrochloride is an orally active histidine decarboxylase inhibitor. α-Fluoromethylhistidine dihydrochloride depletes histamine in enterochromaffin-like (ECL) cells, reduces the number and volume density of secretory vesicles in ECL cells, and does not affect histamine storage in mast cells. α-Fluoromethylhistidine dihydrochloride abolishes Omeprazole (HY-B0113)-induced vacuolization of ECL cells and decreases gastrin-induced histamine efflux from ECL cells. α-Fluoromethylhistidine dihydrochloride does not alter the granular characteristics of ECL cells, omeprazole-induced hypertrophy of ECL cells, gastrin-induced pancreastatin-like immunoreactivity efflux, nor does it affect gastric acid secretion induced by histamine or vagal stimulation. α-Fluoromethylhistidine dihydrochloride inhibits basal and gastrin-stimulated gastric acid secretion, reduces acid output induced by gastrin+IBMX (HY-12318), but does not directly affect acid generation in isolated parietal cells .

HY-105999

APC 366	Ser/Thr Protease	Inflammation/Immunology
APC 366 is a selective inhibitor of mast cell tryptase (K_i=7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma .

HY-P99193

Enokizumab MEDI-528	Interleukin Related	Inflammation/Immunology
Enokizumab (MEDI-528) is a monoclonal antibody targeting to interleukin (IL)-9. IL-9 regulates the development of airway inflammation, mucus production, airway hyperresponsiveness, and airway fibrosis largely by increasing mast cell numbers and activity in the airways .

HY-W015515

L-Citronellol (S)-3,7-Dimethyloct-6-en-1-ol	Environmental Pollutants TNF Receptor Beta-secretase γ-secretase ERK Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
L-Citronellol ((S)-3,7-Dimethyloct-6-en-1-ol) is a natural product with anti-allergic and neuroprotective effects. L-Citronellol inhibits mast cell activation and the release of inflammatory factors by inhibiting the ERK pathway. L-Citronellol inhibits BACE1/PSEN1 and AChE, reduces TNF-α expression and lipid peroxidation, demonstrating the potential of multi-target anti-Alzheimer's disease (AD) .

HY-123532

JNJ10191584 VUF6002	Histamine Receptor	Neurological Disease
JNJ10191584 (VUF6002) is an orally active and selective histamine H₄ receptor antagonist with a K_i value of 26 nM. JNJ10191584 shows 540-fold selectivity to H₄ receptor over H₃ receptor with a K_i value of 14.1 μM. JNJ10191584 inhibits chemotaxis of eosinophils and mast cells with IC₅₀ values of 530 nM and 138 nM, respectively .

HY-172458

Z-3578 1 Publications Verification	Mas-related G-protein-coupled Receptor (MRGPR) TNF Receptor	Inflammation/Immunology
Z-3578 is an orally active small-molecule antagonist of MrgX2 with potent antipseudoallergic activity, exhibiting a K_D value of 729 nM. Z-3578 effectively inhibits mast cell degranulation induced by substance P (SP) and C48/80, suppresses the release of β-hexosaminidase, significantly reduces the release of histamine and TNF-α, and decreases intracellular calcium flux. In a mouse pseudoallergy model, Z-3578 significantly alleviates paw swelling and dye extravasation, and reduces serum histamine levels. Z-3578 can be used for the study of pseudoallergic reactions .

HY-W062109

Olopatadine	Histamine Receptor CXCR	Inflammation/Immunology
Olopatadine (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of ErbB3A/HER3A. Olopatadine can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis .

HY-101810

Tazanolast TO 188; Tazalest; Tazanol	Calcium Channel PKC	Inflammation/Immunology
Tazanolast is a selective mast-cell-stabilizing agent, on ozone-induced airway hyperresponsiveness in guinea pigs.

HY-16289

Lodoxamide tromethamine 2 Publications Verification U-42585E	Histamine Receptor	Inflammation/Immunology Endocrinology
Lodoxamide tromethamine (U-42585E) is a medication for the treatment of prophylaxis of mast cell-mediated allergic disease.

HY-148244

MS47134 1 Publications Verification	Mas-related G-protein-coupled Receptor (MRGPR)	Others
MS47134 is a potent and selective MRGPRX4 agonist with an EC₅₀ value of 149 nM. MS47134 can be used for research of pain, itch and mast cell-mediated hypersensitivity .

HY-12537

Peptide 401	Histamine Receptor 5-HT Receptor	Inflammation/Immunology Endocrinology
Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).

HY-101005

N-Methylhistamine dihydrochloride Nα-Methylhistamine dihydrochloride	Histamine Receptor	Inflammation/Immunology
N-Methylhistamine (Nα-Methylhistamine) dihydrochloride is a potent agonist of the histamine H3 receptor, exhibiting significant implications in the diagnosis and management of mastocytosis. N-Methylhistamine (dihydrochloride) also serves as a biomarker for assessing mast cell accumulation in clinical evaluations.

HY-122295

Dehydroleucodine	Apoptosis	Inflammation/Immunology Cancer
Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana. Dehydroleucodine is a mast cell stabilizer that inhibits tmast cell degranulation induced by compound 48/80. Dehydroleucodine inudces cells apoptosis, and has gastric ulcer inhibition and antileukemic effects .

HY-N3007A

(E)-Naringenin chalcone	Others	Inflammation/Immunology
(E)-Naringenin chalcone is an orally active anti-allergic agent. (E)-Naringenin chalcone also has antioxidant, anti-inflammatory activities. (E)-Naringenin chalcone can improve adipocyte functions. (E)-Naringenin chalcone inhibits histamine release from rat peritoneal mast cell .

HY-P2922

Cathepsin C	Cathepsin	Cancer
Cathepsin C is a lysosomal cysteine protease essential for catalytic activation of many serine proteases, including proteinase 3 (PR3), neutrophil elastase (NE), cathepsin G (CTSG), granzyme A/B/C, and mast cell chymase .

HY-124252

5,8,11-Eicosatriynoic acid ETI	Lipoxygenase	Cancer
5,8,11-Eicosatriynoic acid (ETI) is a lipoxygenase inhibitor that blocks LTC4 biosynthesis in mast cell tumor cells .

HY-N12254

Natsudaidain	p38 MAPK	Others
Natsudaidain is a kind of polymethoxyflavone. Natsudaidain can be isolated from Citrus plants. Natsudaidain inhibits tumor necrosis factor-α and cyclooxygenase-2 production n by suppressing p38 MAPK phosphorylation on mast cells .

HY-N7885

(25R)-Spirost-4-ene-3,12-dione (-)-(25R)-Spirost-4-ene-3,12-dione	Others	Inflammation/Immunology
(25R)-Spirost-4-ene-3,12-dione ((-)-(25R)-Spirost-4-ene-3,12-dione) is a natural product that has an inhibitory effect on neutrophil superoxide anion production and histamine release from mast cells .

HY-N4207

Cnidicin	Others	Others
Cnidicin, a coumarin, inhibits the degranulation of mast cell and the nitric oxide (NO) generation in RAW 264.7 cells .

HY-122161

JNJ-10311795 RWJ-355871	Cathepsin	Inflammation/Immunology
JNJ-10311795 (RWJ-355871), a potent dual inhibitor of neutrophil cathepsin G (K_i = 38 nM) and mast cell chymase (K_i = 2.3 nM), exhibits noteworthy antiinflammatory activity .

HY-P2706

Granuliberin R	Histamine Receptor	Endocrinology
Granuliberin R is a new mast cell degranulating peptide comes from amphibian, can be isolated from the skin of frog Rana rugosa. Granuliberin R is a dodecapeptide, can act on rat peritoneal mast cell to liberate granules and release histamine .

HY-P4580

Suc-Ala-Ala-Pro-Phe-SBzl	Proteasome	Others
Suc-Ala-Ala-Pro-Phe-SBzl can be used as the substrate of rat intestinal mast cell protease (RMCP I), rat skeletal muscle mast cell protease (RMCP II) and Chymotrypsin (HY-108910). Suc-Ala-Ala-Pro-Phe-SBzl can be hydrolyzed by glycine (R208G) .

HY-100269

Chymase-IN-1	Proteasome	Inflammation/Immunology
Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC₅₀ of 29 nM.

HY-12521

GSK-5498A 3 Publications Verification	CRAC Channel	Inflammation/Immunology
GSK-5498A is a selective CARC channel inhibitor (IC₅₀: 1 μM). GSK-5498A inhibits mediators release from mast cells and pro-inflammatory cytokines release from T cells. GSK-5498A can be used in the research of inflammatory disorders .

HY-131162

Chymase	Angiotensin Receptor	Cardiovascular Disease
Chymase is a protein-digester enzyme found primarily in mast cells (MC), fibroblasts, and vascular endothelial cells. Chymase is released into the extracellular stroma in the context of inflammatory signals, tissue injury and cellular stress. Chymase is also involved in angiotensin II (Ang II) production, which is used in cardiovascular disease studies .

HY-B1619R

Cromolyn (Standard) Cromoglycate (Standard); Cromoglicic acid (Standard); FPL-670 free acid (Standard)	GSK-3 NF-κB Amyloid-β Reference Standards	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cromolyn (Standard) is the analytical standard of Cromolyn. This product is intended for research and analytical applications. Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC50 of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

HY-138961

ER-27319 1 Publications Verification	Syk	Inflammation/Immunology
ER-27319, an acridone derivative, is a potent and selective SYK inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC₅₀ of 10 μM and can be used for study in allergic diseases .

HY-B0157AR

Ketotifen fumarate (Standard) HC 20511 fumarate (Standard)	Reference Standards Histamine Receptor Endogenous Metabolite SARS-CoV Influenza Virus	Inflammation/Immunology Endocrinology Cancer
Ketotifen (fumarate) (Standard) is the analytical standard of Ketotifen (fumarate). This product is intended for research and analytical applications. Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-107558

JNJ10191584 maleate VUF6002 maleate	Histamine Receptor	Neurological Disease
JNJ10191584 (VUF6002) maleate (compound 40) is an orally active and selective histamine H₄ receptor antagonist with a K_i value of 26 nM. JNJ10191584 maleate shows 540-fold selectivity to H₄ receptor over the H₃ receptor with a K_i value of 14.1 μM. JNJ10191584 maleate inhibits chemotaxis of eosinophils and mast cells with IC₅₀ values of 530 nM and 138 nM, respectively .

Cat. No.	Product Name	Type

HY-D0220A

Toluidine Blue (purity 36%)

3 Publications Verification

Toluidine Blue O (purity 36%)

Fluorescent Dyes

Toluidine Blue (Toluidine Blue O) purity 36% is an alkaline quinonimine dye (vivo dye) with high affinity for acidic tissue components, staining nuclei blue and polysaccharides purple. Toluidine Blue purity 36% shows heterostaining properties for mast cells, mucins and chondrocytes. Toluidine Blue purity 36% can stain different components of plant tissues and cells in different colours. Toluidine Blue purity 36% is also used as a diagnostic aid to identify malignant lesions, such as cancer .

HY-W250143

Toluidine blue (ZnCl2)

Fluorescent Dyes

Toluidine blue (ZnCl2) is a basic thiazine dye commonly used as a biological stain for microscopy. It has a deep bluish-purple color and is commonly used to stain nucleic acids such as DNA and RNA, as well as to stain mast cells, cartilage, and other connective tissues. Toluidine blue (ZnCl2) stains the acidic components of these tissues, such as sulfated or carboxylated mucopolysaccharides. It is frequently used in histology, cytology, and pathology applications to aid in the diagnosis of various diseases and conditions. The dye is usually applied to tissue sections prior to microscopic examination and can be differentiated using an acidic alcohol solution. Toluidine blue (ZnCl2) is a relatively simple and inexpensive stain with good reproducibility, making it a popular choice for many laboratories.

Cat. No.	Product Name	Type

HY-Y0320C

Dimethyl sulfoxide

30+ Cited Publications

DMSO

Biochemical Assay Reagents

Dimethyl sulfoxide (DMSO) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity .
Low endotoxin, can be used in various biochemical experiments such as drug dissolution.

HY-Y0320

Dimethyl sulfoxide, meets analytical specification of Ch.P.

340+ Cited Publications

DMSO, meets analytical specification of Ch.P.

Biochemical Assay Reagents

Dimethyl sulfoxide (DMSO), meets analytical specification of Ch.P. is an aprotic solvent that dissolves polar and non-polar compounds, including water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties .
MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch.P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition). Amicrobic, low endotoxin, can be used in various biochemical experiments such as drug dissolution.

HY-Y0320GL

Dimethyl sulfoxide (GMP Like)

DMSO (GMP Like)

Biochemical Assay Reagents

Dimethyl sulfoxide (DMSO) (GMP Like) is the GMP Like class Dimethyl sulfoxide (HY-Y0320C). Dimethyl sulfoxide is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity .

HY-B0926B

Diatrizoate meglumine N-Methyl-D-glucamine diatrizoate	Biochemical Assay Reagents
Diatrizoate meglumine (N-Methyl-D-glucamine diatrizoate) is an orally active, water-soluble, poorly absorbable iodinated contrast agent. Diatrizoate meglumine is widely used as an adjuvant for radiological diagnosis and can also be applied to studies of small bowel obstruction in non-malignant conditions .

HY-Y0320E

Dimethyl sulfoxide (suitable for HPLC)

Biochemical Assay Reagents

Dimethyl sulfoxide (suitable for HPLC) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide (suitable for HPLC) is suitable for HPLC .

HY-E70177

N-Deacetylase/N-Sulfotransferase 2 EC:2.8.2.8; NDST2; N-HSST 2	Biochemical Assay Reagents
N-Deacetylase/N-Sulfotransferase 2 is a sulfotransferase. N-Deacetylase/N-Sulfotransferase 2 synthesizes serglycin-bound heparin chains in mast cells .

Cat. No.	Product Name	Target	Research Area

HY-106178

PMX-53 Maximum Cited Publications 8 Publications Verification 3D53	Complement System	Cardiovascular Disease Inflammation/Immunology Cancer
PMX-53 (3D53) is a synthetic peptidic and a potent and orally active complement C5a receptor (CD88) antagonist with an IC₅₀ of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to C5aR1 and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects .

HY-P1732

Transportan	Biochemical Assay Reagents	Cancer
Transportan is an amphipathic cell-penetrating peptide containing 12 functional amino acids from the amino terminus of the neuropeptide galanin and mastoparan in the carboxyl terminus, connected via a lysine. Transportan interacts with galanin receptors and G-proteins, modulates GTPase activity, enters cells via direct translocation and endocytic pathways, accumulates in cytoplasmic, nuclear, and membranous structures, and delivers cargo including peptides, PNAs, proteins, siRNA, and liposomes ^[12].

HY-P4476

Suc-AAPA-pNA 1 Publications Verification	Ser/Thr Protease	Others
Suc-AAPA-pNA is a substrate for chymotrypsin A and elastase. Suc-AAPA-pNA can be used for enzyme activity assay .

HY-12537

Peptide 401	Histamine Receptor 5-HT Receptor	Inflammation/Immunology Endocrinology
Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).

HY-P1793

α-Casein (90-95)	Opioid Receptor Biochemical Assay Reagents	Neurological Disease Inflammation/Immunology Cancer
α-Casein (90-95) is a partial agonist of opioid receptors and a copper ion ligand, with opioid activity. α-Casein (90-95) inhibits the secretion of β-hexosaminidase by rat peritoneal mast cells (PMC) with IC₅₀= 0.1 μM. α-Casein (90-95) inhibits the proliferation of prostate cancer cells LNCaP, DU145, and PC3 with IC₅₀ of 0.94 nM, 137 nM, and 6.92 nM, respectively. α-Casein (90-95) activates G_i-like proteins through a membrane-assisted, receptor-independent pathway, or reversibly binds to opioid receptors, inducing intracellular calcium release and conformational changes, and exerts the activity of promoting mast cell secretion and inhibiting tumor cell proliferation. α-Casein (90-95) can be used in the study of the mechanisms of allergic diseases and prostate cancer .

HY-P5641

Pleurocidin 1 Publications Verification	Bacterial p38 MAPK NF-κB NADH Dehydrogenase Antibiotic	Infection Inflammation/Immunology
Pleurocidin is an Antimicrobial peptide. Pleurocidin is derived from the skin mucosa or intestinal secretions of Pseudopleuronectes americanus. Pleurocidin inhibits the expression of key proteins in the MAPK and NF-κB inflammatory signaling pathways. Pleurocidin alters serum inflammatory and immune cytokine levels, regulates the down-regulation of tight junction proteins, and modulates the intestinal flora. Pleurocidin exerts antibacterial activity by inducing bacterial membrane damage, hydroxyl radical formation, and NADH depletion, and also produces a synergistic effect with Antibiotics. Pleurocidin alleviates DSS-induced ulcerative colitis. Pleurocidin can be used for research on ulcerative colitis, bacterial infections, and bacterial biofilm-related infections .

HY-P2706

Granuliberin R	Histamine Receptor	Endocrinology
Granuliberin R is a new mast cell degranulating peptide comes from amphibian, can be isolated from the skin of frog Rana rugosa. Granuliberin R is a dodecapeptide, can act on rat peritoneal mast cell to liberate granules and release histamine .

HY-P4580

Suc-Ala-Ala-Pro-Phe-SBzl	Proteasome	Others
Suc-Ala-Ala-Pro-Phe-SBzl can be used as the substrate of rat intestinal mast cell protease (RMCP I), rat skeletal muscle mast cell protease (RMCP II) and Chymotrypsin (HY-108910). Suc-Ala-Ala-Pro-Phe-SBzl can be hydrolyzed by glycine (R208G) .

HY-P3837

Xenopsin-Related Peptide 2 XP-2	Peptides	Metabolic Disease
Xenopsin-Related Peptide 2 (XP-2) is an avian counterpart to amphibian Xenopsin (HY-P0253). Xenopsin-Related Peptide 2 displays abilities to release histamine from isolated rat mast cells and is as effective as syntheticBradykinin (HY-P0206) .

HY-P5727

HR1	Bacterial	Infection
HR1 is a mastoid protease. HR1 can increase the permeability of human erythrocyte membrane. HR1 can induce cytoplasmic membrane permeation in bacteria and mast cells .

HY-P1793A

α-Casein (90-95) TFA	Opioid Receptor Biochemical Assay Reagents	Neurological Disease Inflammation/Immunology Cancer
α-Casein (90-95) TFA is a partial agonist of opioid receptors and a copper ion ligand, with opioid activity. α-Casein (90-95) TFA inhibits the secretion of β-hexosaminidase by rat peritoneal mast cells (PMC) with IC₅₀= 0.1 μM. α-Casein (90-95) TFA inhibits the proliferation of prostate cancer cells LNCaP, DU145, and PC3 with IC₅₀ of 0.94 nM, 137 nM, and 6.92 nM, respectively. α-Casein (90-95) TFA activates G_i-like proteins through a membrane-assisted, receptor-independent pathway, or reversibly binds to opioid receptors, inducing intracellular calcium release and conformational changes, and exerts the activity of promoting mast cell secretion and inhibiting tumor cell proliferation. α-Casein (90-95) TFA can be used in the study of the mechanisms of allergic diseases and prostate cancer .

HY-P1807

Mast Cell Degranulating Peptide HR-2	Histamine Receptor	Inflammation/Immunology
Mast Cell Degranulating Peptide HR-2, a 14-membered linear peptide isolated from the venom of the giant hornet Vespa orientalis, is capable of degranulating mast cells and thus initiating histamine release .

HY-P1987

Mast cell degranulating peptide (28-49)	Calcium Channel	Neurological Disease
Mast cell degranulating peptide (28-49) is a depolarizing agent from bee venom, it can raise the content of cGMP level in mouse cerebellar slices .

HY-P5717

Peptide 12d	Peptides	Infection
Peptide 12d is an antimicrobial peptide isolated from the venom of wasp. Peptide 12d mediates antimicrobial response by stimulating mast cell degranulation .

HY-P2442

Bombolitin V	Bacterial	Others
Bombolitin V is a potent antimicrobial peptide with an ED ⁵⁰ value of 2 micrograms/ml in causing mast cell degranulation .

HY-P11128

Mastoparan-V1	Peptides	Others
Mastoparan-V1 is a peptide belonging to the Mastoparan family. Mastoparan-V1 exhibits modest mast cell degranulation activity, with EC₅₀ of 130.24 μM in RBL-2H3 cells. Mastoparan-V1 can be used for the study of allergic reactions induced by wasp stings .

HY-P3006

Des-Leu10-angiotensin I	Drug Metabolite	Cardiovascular Disease
Des-Leu10-angiotensin I is a nonapeptide that inhibits rabbit lung angiotensin-converting enzyme peptidyl-dipeptide hydrolase with a K_i value of 31 μM, which is generated from angiotensin I by the action of carboxypeptidase-like activities residing in the human platelet and mast cell .

HY-P11163

Eumenitin	Bacterial Glycosidase	Infection
Eumenitin is an antibacterial peptide with strong membrane activity, broad-spectrum antibacterial activity, and almost no hemolytic toxicity. Eumenitin has inhibitory effects on various Gram positive and Gram negative bacteria. Eumenitin can induce the release of β-hexosaminidase from rat peritoneal mast cells and RBL-2H3 cells. Eumenitin can be used in the research of infectious conditions .

HY-P5357

SFNGGP-NH2	Protease Activated Receptor (PAR)	Others
SFNGGP-NH2 is a biological active peptide. (PAR-3 is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. Protease-Activated Receptors (PARs) have been studied for their roles in itch and their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR-4. Co-expression of PAR-3 and PAR-4 enhances thrombin action suggesting that PAR-3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR-4.)

HY-P3395A

Catestatin sCst	PERK JNK p38 MAPK	Inflammation/Immunology
Catestatin sCst is a negative control peptide with a scrambled amino acid sequence. Catestatin sCst fails to activate human mast cells and is used to verify the specificity of Catestatin action .

HY-P11646

Brazzein	COX	Metabolic Disease Inflammation/Immunology
Brazzein is a functional sweetener with antioxidant, anti-inflammatory, and anti-allergic activities. Brazzein inhibits COX-2 with an IC₅₀ of 12.62 μM. Brazzein exhibits strong antioxidant effects, showing ABTS radical scavenging activity (IC₅₀ = 12.55 μM) . Brazzein shows no antibacterial or antifungal activity. Brazzein can be used for the research of obesity, metabolic disorder, inflammation .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99462

Barzolvolimab	c-Kit	Inflammation/Immunology
Barzolvolimab is a humanized anti-KIT IgG1 monoclonal antibody. Barzolvolimab specificity and potently inhibits KIT activation by SCF. Barzolvolimab can reduce skin mast cells and disease activity in chronic inducible urticaria .

HY-P99300

Ligelizumab 1 Publications Verification QGE 031; Anti-IGHE Recombinant Antibody	Fc Receptor (FcR)	Inflammation/Immunology
Ligelizumab (QGE 031) is a humanized high-affinity anti-immunoglobulin IgE monoclonal antibody. Ligelizumab selectively inhibits the binding of IgE to the high-affinity receptor FcεRI, while the inhibitory effect on the low-affinity receptor CD23 is weak. Ligelizumab can inhibit the activation of effector cells such as mast cells and Basophil, while reducing the production of IgE by B cells, and restoring the IFN-α production and regulatory T cell (Treg) induction function of plasmacytoid dendritic cells (pDC). Ligelizumab can be used in the study of allergic diseases (such as chronic spontaneous urticaria, allergic asthma) .

HY-P99371

Lirentelimab AK002; Antolimab	Apoptosis	Inflammation/Immunology
Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis .

HY-P991636

AK006	Transmembrane Glycoprotein	Inflammation/Immunology
AK006 is a humanized IgG1 monoclonal antibody agonist targeting Sialic acid-binding immunoglobulin-like lectin6 (Siglec-6). AK006 potently inhibits IgE-mediated human mast cell activation. AK006 can be used for inflammatory diseases like chronic urticaria (CU) and asthma research .

HY-P99641

Gilvetmab	PD-1/PD-L1	Cancer
Gilvetmab is a potent caninized anti-PD-1 monoclonal antibody. Gilvetmab blocks the interaction between PD-1 and its ligand PD-L1/L2. Gilvetmab can be used in malignant melanoma and mast cell tumor research .

HY-P99193

Enokizumab MEDI-528	Interleukin Related	Inflammation/Immunology
Enokizumab (MEDI-528) is a monoclonal antibody targeting to interleukin (IL)-9. IL-9 regulates the development of airway inflammation, mucus production, airway hyperresponsiveness, and airway fibrosis largely by increasing mast cell numbers and activity in the airways .

HY-P990002

Anti-Mouse CD117/c-Kit Antibody (2B8)	c-Kit	Inflammation/Immunology Cancer
Anti-Mouse CD117/c-Kit Antibody (2B8) is an IgG2b antibody, targeting to mouse CD117/c-Kit. Anti-Mouse CD117/c-Kit Antibody (2B8) reacts with mouse c-Kit (also known as CD117), which is expressed on hematopoietic progenitor cells, mast cells, and acute myeloid leukemia (AML) cells. Anti-Mouse CD117/c-Kit Antibody (2B8) can be used for the detection of flow cytometry, immunofluorescence and immunohistochemistry in cancer and inflammation .

HY-P991467

RG-7258	Interleukin Related	Inflammation/Immunology
RG-7258 is a human monoclonal antibody (mAb) targeting CRLF2. RG-7258 blocks dendritic cell activation and mast cell cytokine release. RG-7258 reduces Th2 inflammation in a non-human primate model of allergic lung inflammation. RG-7258 can be used in asthma research .

HY-P992440

PF-06817024	Interleukin Related	Inflammation/Immunology
PF-06817024 is a high affinity, humanized antibody that binds IL-33. PF-06817024 binds to IL-33, prevents IL-33 from binding to receptor ST2, and inhibits downstream type 2 inflammatory responses. PF-06817024 can be used for the research of allergic diseases .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W004260

Arachidic acid 3 Publications Verification Eicosanoic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Arachidic acid is an orally bioavailable membrane fluidity modulator and receptor/ion channel effector. Arachidic acid does not activate arachidonic acid-sensitive K ⁺ channels in rat midbrain and hypothalamic neurons. Arachidic acid alleviates age-related spatial cognitive impairment. Arachidic acid is applicable for research related to age-related spatial cognitive impairment .

HY-B0157

Ketotifen 3 Publications Verification HC 20-511	Infection Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology Source Classification	Endogenous Metabolite Histamine Receptor SARS-CoV Influenza Virus
Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-B0157A

Ketotifen fumarate 3 Publications Verification HC 20511 fumarate	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Histamine Receptor Endogenous Metabolite SARS-CoV Influenza Virus
Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-120149

Inotodiol	Structural Classification Tetracyclic Triterpenoids Microorganisms Classification of Application Fields Terpenoids Disease Research Fields Source Classification Cancer	Toll-like Receptor (TLR) MDM-2/p53 MMP Caspase SOD p38 MAPK NF-κB Apoptosis
Inotodiol activates p53 signaling pathway, inhibits MMP-2/9, and exhibits antitumor activity in cancer cell HeLa. Inotodiol inhibits the generation of ROS and exhibits antioxidant and neuroprotective effects. Inotodiol inhibits the activation of MAPK and NF-κB signaling pathway, and exhibits anti-inflammatory activity. Inotodiol inhibits TLR-4 mediated TNF-α production (IC₅₀s in BMMC and BMDM is 0.7 μM and 3.0 μM), inhibits the degranulation in mast cell, exhibits anti-allergic activity. Inotodiol is orally active .

HY-N0631

Cornuside Maximum Cited Publications 6 Publications Verification	Structural Classification Iridoids Cornaceae Classification of Application Fields Cornus officinalis Sieb. et Zucc. Terpenoids Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	p38 MAPK NF-κB JNK Cholinesterase (ChE) Acyltransferase NO Synthase Interleukin Related TNF Receptor Prostaglandin Receptor ERK COX
Cornuside is an iridoid glycoside with anti-allergic, anti-inflammatory, and neuroprotective activities. Cornuside exerts anti-allergic activity by downregulating the p38 MAPK, JNK, and NF-κB signaling pathways, and inhibits IgE-mediated histamine release from mast cells. Cornuside improves cognitive impairment in mice by inhibiting BACE1 activity (IC₅₀ = 55.84 μg/mL) and enhancing ChAT activity. Cornuside inhibits LPS (HY-D1056)-induced inflammatory mediators, including iNOS, COX-2, PGE2, TNF-α, IL-6, and IL-1β, by suppressing NF-κB activation .

HY-124257

(R)-Citronellol D-Citronellol; (R)-(+)-β-Citronellol	Other Monoterpenes Classification of Application Fields Terpenoids Pelargonium hortorum Plants Endogenous metabolite Geraniaceae Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
(R)-Citronellol (D-Citronellol) is an alcoholic monoterpene found in geranium essential oil. (R)-Citronellol inhibits degranulation of mast cells and does not affect caffeine bitterness perception. (R)-Citronellol can be used in decorative cosmetics, toiletries as well as in non-cosmetic products .

HY-N0701

(-)-Asarinin 1 Publications Verification	Asarum sieboldii Miq. Classification of Application Fields Lignans Phenylpropanoids Plants Aristolochiaceae Disease Research Fields Source Classification Cancer	Apoptosis Reactive Oxygen Species (ROS) STAT Src Stearoyl-CoA Desaturase (SCD) Bacterial
(-)-Asarinin is a tetrahydrofurofurano lignan with various biological activities. (-)-Asarinin induces apoptosis in cancer cells. (-)-Asarinin promotes mitochondrial ROS accumulation, inhibits the STAT3 signaling pathway and induces apoptosis in precancerous cells. (-)-Asarinin is a Src family kinase inhibitor that suppresses mast cell activation. (-)-Asarinin is a non-competitive Δ5-desaturase inhibitor with a K_i of 0.28 mM. (-)-Asarinin possesses pain relief, anti-viral, anti-allergic and anti-tuberculous bacilli, and anti-tumor effects .

HY-N0762

Isobavachin 5 Publications Verification	Structural Classification Flavonoids Neurological Disease Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Source Classification	Cytochrome P450 UGT p38 MAPK NF-κB NO Synthase COX Fc Receptor (FcR) RANKL/RANK Keap1-Nrf2 Reactive Oxygen Species (ROS) Apoptosis Autophagy
Isobavachin is an orally active, blood-brain barrier-penetrating prenylated flavonoid present in Psoralea corylifolia. Isobavachin inhibits human CYP2B6, CYP2C9, CYP2C19, UGT1A1, UGT1A9, and UGT2B7. Isobavachin suppresses MAPK activation, NF-κB nuclear translocation, overexpression of iNOS/COX-2, FcεRI-mediated signaling pathways, and RANKL-induced osteoclastogenesis. Isobavachin induces autophagy, cytotoxicity, neuronal differentiation, and NRF2 activation; it alleviates oxidative damage, inflammatory responses, apoptosis, iron accumulation, mitochondrial biogenesis, and mast cell degranulation. Isobavachin is applicable to research related to liver injury, inflammatory diseases, osteoporosis, liver cancer, prostate cancer, glioma, periodontitis-induced bone loss, and Alzheimer's disease .

HY-B0426A

Olopatadine hydrochloride ALO4943A; KW4679	Structural Classification Alkaloids Classification of Application Fields Ketones, Aldehydes, Acids Other Alkaloids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Histamine Receptor CXCR
Olopatadine hydrochloride (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine hydrochloride exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine hydrochloride inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine hydrochloride also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine hydrochloride inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine hydrochloride simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of ErbB3A/HER3A. Olopatadine hydrochloride can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis .

HY-N0078

Ginkgolic Acid (C13:0) Ginkgolic acid (13:0); Ginkgoneolic Acid; 6-Tridecylsalicylic acid	Infection Monophenols Ginkgoaceae Classification of Application Fields Ketones, Aldehydes, Acids Phenols Plants Ginkgo biloba Disease Research Fields Source Classification	Bacterial PI3K Parasite
Ginkgolic Acid (C13:0) (Ginkgoneolic Acid) is an anti-cariogenic agent and a PI3Kδ inhibitor (IC₅₀: 2.49 μM). Ginkgolic Acid (C13:0) exhibits antibacterial and anti-parasitic activities. Ginkgolic Acid (C13:0) can also inhibit mast cell degranulation (IC₅₀: 2.40 μM) .

HY-116474

Viridicatol	Infection Alkaloids Structural Classification Monophenols Microorganisms Classification of Application Fields Phenols Quinoline Alkaloids Disease Research Fields Source Classification	ERK JNK MMP p38 MAPK STAT Fungal Bacterial NO Synthase PGE synthase NF-κB Wnt β-catenin
Viridicatol is a quinolone alkaloid with anti-inflammatory, antibacterial, antifungal, osteogenic and chondrogenic activities. Viridicatol reduces the phosphorylation levels of ERK, JNK, p38 and STAT6; inhibits MMP-2, MMP-9, NF-κB signaling pathway and PTP1B; downregulates genes related to mast cell activation; and binds to SHN3 to activate the Wnt/SHN3 signaling pathway. Viridicatol inhibits the expression of pro-inflammatory mediators and cytokines, and promotes osteogenic/chondrogenic differentiation. Viridicatol can be used in studies related to fibrosarcoma, allergy, bacterial infection, fungal infection and osteoporosis .

HY-N2173

Forsythoside E 1 Publications Verification	Structural Classification Oleaceae Classification of Application Fields Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Forsythia suspensa (Thunb.) Vahl Plants Inflammation/Immunology Disease Research Fields Source Classification	Others
Forsythoside E is a phenylethanoid glycoside compound. Forsythoside E can be isolated from Shuanghuanglian. Forsythoside E does not induce vascular leakage or promote histamine release in mice. Forsythoside E does not cause pseudo-allergic reactions .

HY-W015515

L-Citronellol (S)-3,7-Dimethyloct-6-en-1-ol	Zanthoxylum bungeanum Maxim. Structural Classification Other Monoterpenes Terpenoids Rutaceae Plants Source Classification	Environmental Pollutants TNF Receptor Beta-secretase γ-secretase ERK Cholinesterase (ChE)
L-Citronellol ((S)-3,7-Dimethyloct-6-en-1-ol) is a natural product with anti-allergic and neuroprotective effects. L-Citronellol inhibits mast cell activation and the release of inflammatory factors by inhibiting the ERK pathway. L-Citronellol inhibits BACE1/PSEN1 and AChE, reduces TNF-α expression and lipid peroxidation, demonstrating the potential of multi-target anti-Alzheimer's disease (AD) .

HY-W062109

Olopatadine	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Histamine Receptor CXCR
Olopatadine (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of ErbB3A/HER3A. Olopatadine can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis .

HY-N4126

6-Demethoxytangeretin 1 Publications Verification	Structural Classification Neurological Disease Classification of Application Fields Flavones Rutaceae Plants Citrus reticulata Blanco Flavonoids other families Inflammation/Immunology Disease Research Fields Source Classification Cancer	Anaplastic lymphoma kinase (ALK) p38 MAPK Interleukin Related ERK JNK JAK STAT Akt
6-Demethoxytangeretin is a flavonoid compound that can be isolated from Citrus reticulata. 6-Demethoxytangeretin has anti-inflammatory and anti-allergic activities and can inhibit the production of IL-6 and the expression of related genes in human mast cells through the ALK and MAPK pathways. 6-Demethoxytangeretin can promote CRE-mediated transcription in hippocampal neurons .

HY-114203

Eckol BE003	Eisenia bicyclis Structural Classification other families Phenols Polyphenols Plants Source Classification	Monoamine Oxidase Influenza Virus
Eckol is a potent hMAO-A (Mixed) and hMAO-B (non-competitive) inhibitor with IC₅₀s of 7.20 and 83.44 μM, respectively. Eckol shows stimulatory effects in maize and can be used as a plant biostimulant. Eckol also shows antiallergic and antiviral effects .

HY-122295

Dehydroleucodine	other families Artemisia douglasiana Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis
Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana. Dehydroleucodine is a mast cell stabilizer that inhibits tmast cell degranulation induced by compound 48/80. Dehydroleucodine inudces cells apoptosis, and has gastric ulcer inhibition and antileukemic effects .

HY-N3007A

(E)-Naringenin chalcone	Phenols Polyphenols Solanum lycopersicum L. Solanaceae Plants	Others
(E)-Naringenin chalcone is an orally active anti-allergic agent. (E)-Naringenin chalcone also has antioxidant, anti-inflammatory activities. (E)-Naringenin chalcone can improve adipocyte functions. (E)-Naringenin chalcone inhibits histamine release from rat peritoneal mast cell .

HY-N12254

Natsudaidain	Flavonols Flavonoids Rutaceae Citrus japonica Thunb. Plants Source Classification	p38 MAPK
Natsudaidain is a kind of polymethoxyflavone. Natsudaidain can be isolated from Citrus plants. Natsudaidain inhibits tumor necrosis factor-α and cyclooxygenase-2 production n by suppressing p38 MAPK phosphorylation on mast cells .

HY-N10182

Spinacetin 1 Publications Verification	Phyllodium pulchellum (L.) Desv. Flavonols Flavonoids Plants Compositae Source Classification	Histamine Receptor
Spinacetin is a natural product that can be isolated from Inula japonica. Spinacetin inhibits the release of histamine. Spinacetin has anti-inflammatory activity .

HY-103183

CV1808 2-Phenylaminoadenosine	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Adenosine Receptor Endogenous Metabolite
CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with K_is of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively .

HY-N15663

(-)-Epigallocatechin-3-O-(4-O-methyl)gallate EGCG4′′Me	Structural Classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Drug Derivative
(-)-Epigallocatechin-3-O-(4-O-methyl)gallate is an orally active catechin derivative found in Taiwanese oolong tea. (-)-Epigallocatechin-3-O-(4-O-methyl)gallate can inhibit histamine release and exhibits anti-inflammation and anti-allergic effect. (-)-Epigallocatechin-3-O-(4-O-methyl)gallate can be used for the researches of immunology and inflammation, such as type I allergic .

HY-N7885

(25R)-Spirost-4-ene-3,12-dione (-)-(25R)-Spirost-4-ene-3,12-dione	Structural Classification Polygonum chinense Linn. Polygonaceae Plants Steroids Source Classification	Others
(25R)-Spirost-4-ene-3,12-dione ((-)-(25R)-Spirost-4-ene-3,12-dione) is a natural product that has an inhibitory effect on neutrophil superoxide anion production and histamine release from mast cells .

HY-N4207

Cnidicin	Classification of Application Fields Other Diseases Coumarins Phenylpropanoids Umbelliferae Plants Disease Research Fields Echinacea angustifolia DC. Source Classification	Others
Cnidicin, a coumarin, inhibits the degranulation of mast cell and the nitric oxide (NO) generation in RAW 264.7 cells .

HY-N7292

Bakkenolide B	Other Terpenoids Structural Classification Classification of Application Fields Terpenoids Plants Compositae Piptadenia Benth. Inflammation/Immunology Disease Research Fields Source Classification	NO Synthase Keap1-Nrf2
Bakkenolide B is isolated from petasites japonicas leaves and has anti-allergic and anti-inflammatory effects. Bakkenolide B can be used for the study of asthma .

HY-W015515R

L-Citronellol (Standard) (S)-3,7-Dimethyloct-6-en-1-ol (Standard)	Zanthoxylum bungeanum Maxim. Structural Classification Other Monoterpenes Terpenoids Rutaceae Plants Source Classification	Reference Standards ERK Beta-secretase γ-secretase Cholinesterase (ChE) TNF Receptor
L-Citronellol ((S)-3,7-Dimethyloct-6-en-1-ol) is an analytical standard for L-Citronellol (HY-W015515). This product is intended for research and analytical applications. L-Citronellol is a natural product with anti-allergic and neuroprotective effects. L-Citronellol inhibits mast cell activation and the release of inflammatory factors by inhibiting the ERK pathway. L-Citronellol inhibits BACE1/PSEN1 and AChE, reduces TNF-α expression and lipid peroxidation, demonstrating the potential of multi-target anti-Alzheimer's disease (AD).

HY-N3421

Koaburaside	Eucommia ulmoides Oliver Eucommiaceae Plants Saccharides Monosaccharides Source Classification	Interleukin Related TNF Receptor Influenza Virus
Koaburaside is a cytoprotective and anti-inflammatory natural compound. Koaburaside shows antioxidant activity with an IC₅₀ of 9.0 μM for DPPH-free radical scavenging assay. Koaburaside inhibits histamine release and expressions of IL-6 and TNF-α in human mast cells. Koaburaside also effectively inhibits influenza A neuraminidase .

HY-B0157AR

Ketotifen fumarate (Standard) HC 20511 fumarate (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Histamine Receptor Endogenous Metabolite SARS-CoV Influenza Virus
Ketotifen (fumarate) (Standard) is the analytical standard of Ketotifen (fumarate). This product is intended for research and analytical applications. Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-N13148

Ganodermatriol	Triterpenes Structural Classification Microorganisms Terpenoids Source Classification	Others
Ganodermatriol is a lanostane type triterpenoid compound derived from Ganoderma lucidum. These compounds have been reported to possess various biological activities, such as inhibiting histamine release from rat mast cells and exhibiting anti-hepatoma cell activity in vitro .

HY-110013

Terreic acid	Microorganisms Source Classification	Btk Antibiotic
Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC₅₀ of approximately 100 μM .

HY-B0426AR

Olopatadine hydrochloride (Standard) ALO4943A (Standard); KW4679 (Standard)	Structural Classification Alkaloids Ketones, Aldehydes, Acids Other Alkaloids Endogenous metabolite Source Classification	Reference Standards Histamine Receptor CXCR
Olopatadine (hydrochloride) (Standard) is the analytical standard of Olopatadine (hydrochloride). This product is intended for research and analytical applications. Olopatadine hydrochloride (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine hydrochloride exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine hydrochloride inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine hydrochloride also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine hydrochloride inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine hydrochloride simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of ErbB3A/HER3A. Olopatadine hydrochloride can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis .

HY-P1987

Mast cell degranulating peptide (28-49)	Natural Products Animals Source Classification	Calcium Channel
Mast cell degranulating peptide (28-49) is a depolarizing agent from bee venom, it can raise the content of cGMP level in mouse cerebellar slices .

HY-N14978

Eurocidin D	Natural Products Microorganisms Antibiotics Source Classification	Antibiotic
Eurocidin D is a cyclic peptide antibiotic. Eurocidin D can inhibit the degranulation of rat mast cells .

HY-N16656

Ladyginoside A	Triterpenes Structural Classification Terpenoids Polyscias fruticosa (L.) Harms Plants Araliaceae Source Classification	Amylases Glycosidase
Ladyginoside A is a triterpenoid saponin found in the leaves of Polyscias fruticosa (L.) Harms. Ladyginoside A has inhibitory activities against α-amylase and α-glucosidase, and can regulate carbohydrate metabolism. Ladyginoside A also exhibits potential anti-inflammatory and mast cell stabilizing effects. Ladyginoside A can be used for the researches of inflammation and metabolic disease, such as diabetes .

HY-N16668

(3R,5S)-5'-Methoxyoctahydrocurcumin	Structural Classification Phenols Polyphenols Plants Source Classification Curcuma comosa Roxb. Zingiberaceae	Glycosidase
(3R,5S)-5'-Methoxyoctahydrocurcumin (Compound 4) is a diarylheptanoidfound in Curcuma comosa. (3R,5S)-5'-Methoxyoctahydrocurcumin exhibits strong antiallergic activity by inhibiting β-hexosaminidase release and the degranulation of mast cells. (3R,5S)-5'-Methoxyoctahydrocurcumin can be used for the research of immunology, such as asthma .

HY-B0157R

Ketotifen (Standard) HC 20-511 (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Histamine Receptor SARS-CoV Influenza Virus
Ketotifen (Standard) is the analytical standard of Ketotifen. This product is intended for research and analytical applications. Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-N11691

Thapsigargicin Thapsigargicine	Terpenoids Diterpenoids Plants Umbelliferae Bellis perennis L. Source Classification	Others
Thapsigargicin (Thapsigargicine) is a activator of mast cells and leukocytes. Thapsigargicin induces histamine release from rat peritoneal mast cells and human basophil leukocytes. Thapsigargicin increases the cytoplasmic free calcium level in intact human blood platelets .

HY-N12210

Notrilobolide	Structural Classification Terpenoids Sesquiterpenes Umbelliferae Plants Bellis perennis L. Source Classification	Histamine Receptor
Notrilobolide is a sesquiterpene lactone. Notrilobolide induces a potent histamine release from peritoneal rat mast cells .

HY-N15230

Torososide B	Quinones Structural Classification Anthraquinones Caesalpiniaceae Cassia obtusifolia (L.) H. S. Irwin & Barneby Plants Source Classification	Leukotriene Receptor
Torososide B is an antiallergic compound that inhibits calcium ionophore A-induced leukotriene release from rat peritoneal mast cells .

HY-N4207R

Cnidicin (Standard)	Structural Classification Coumarins Phenylpropanoids Umbelliferae Plants Echinacea angustifolia DC. Source Classification	Reference Standards Others
Cnidicin (Standard) is the analytical standard of Cnidicin. This product is intended for research and analytical applications. Cnidicin, a coumarin, inhibits the degranulation of mast cell and the nitric oxide (NO) generation in RAW 264.7 cells .

HY-N12295

Ciwujianoside D1	Triterpenes Structural Classification Tetracyclic Triterpenoids Terpenoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae Source Classification	Others
Ciwujianoside D1 is a natural product that can inhibit histamine release induced by anti-immunoglobulin E from rat peritoneal mast cells .

HY-N15704

Cassiaside C2	Structural Classification Monophenols Ketones, Aldehydes, Acids Phenols Caesalpiniaceae Cassia obtusifolia (L.) H. S. Irwin & Barneby Plants Source Classification	Histamine Receptor
Cassiaside C2 is a naphthopyrone with a strong antiallergic activity. Cassiaside C2 inhibits the histamine release from rat peritoneal exudate mast cells induced by antigen-antibody reaction .

HY-137787R

Cyanosafracin B (Standard)	Microorganisms Marine natural products Source Classification	Drug Intermediate Reference Standards
Nylidrin (hydrochloride) (Standard) is the analytical standard of Nylidrin (hydrochloride). This product is intended for research and analytical applications. Nylidrin hydrochloride is an inhibitor of IgE-mediated histamine release in passive sensitized rat peritoneal mast cells, and it has anti-allergic effects.

$Cyanosafracin B (Standard)$

HY-N15423

Acrophylline	Alkaloids Acronychia haplophylla Other Alkaloids Rutaceae Plants Source Classification	Others
Acrophylline is an antiallergic compound. Acrophylline inhibits mast cell degranulation. Acrophylline reduces the plasma leakage in mouse ear in a passive cutaneous anaphylactic (PCA) reaction. Acrophylline is an alkaloid can be isolated from acronychia haplophylla .

HY-N4282

8-Hydroxy-7-methoxycoumarin	Structural Classification Classification of Application Fields Alkekengi officinarum var. franchetii (Mast.) R.J.Wang Other Diseases Coumarins Phenylpropanoids Solanaceae Plants Disease Research Fields Source Classification	Others
8-Hydroxy-7-methoxycoumarin is a phenylpropanoid isolated from the calyxes of Physalis alkekengi L. var. franchetii (Mast.) Makino. 8-Hydroxy-7-methoxycoumarin shows cytotoxicity against GLC4 and COLO 320 cancer cell after continuous incubation (4 days) with IC₅₀s of 179 μM and 145 μM .

HY-N0701R

(-)-Asarinin (Standard)	Asarum sieboldii Miq. Structural Classification Lignans Phenylpropanoids Plants Aristolochiaceae Source Classification	Reference Standards Apoptosis Reactive Oxygen Species (ROS) STAT Src Stearoyl-CoA Desaturase (SCD) Bacterial
(-)-Asarinin (Standard) is the analytical standard of (-)-Asarinin (HY-N0701). This product is intended for research and analytical applications. (-)-Asarinin is a tetrahydrofurofurano lignan with various biological activities. (-)-Asarinin induces apoptosis in cancer cells. (-)-Asarinin promotes mitochondrial ROS accumulation, inhibits the STAT3 signaling pathway and induces apoptosis in precancerous cells. (-)-Asarinin is a Src family kinase inhibitor that suppresses mast cell activation. (-)-Asarinin is a non-competitive Δ5-desaturase inhibitor with a K_i of 0.28 mM. (-)-Asarinin possesses pain relief, anti-viral, anti-allergic and anti-tuberculous bacilli, and anti-tumor effects.

HY-103183R

CV1808 (Standard) 2-Phenylaminoadenosine (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Adenosine Receptor Endogenous Metabolite
CV1808 (Standard) is the analytical standard of CV1808. This product is intended for research and analytical applications. CV1808?(2-Phenylaminoadenosine) is a non-selective A2?adenosine receptor (A2 AR) agonist with Kis of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively .

HY-N0078R

Ginkgolic Acid (C13:0) (Standard) Ginkgolic acid (13:0) (Standard); Ginkgoneolic Acid (Standard); 6-Tridecylsalicylic acid (Standard)	Structural Classification Monophenols Ginkgoaceae Ketones, Aldehydes, Acids Phenols Plants Ginkgo biloba Source Classification	Reference Standards Bacterial PI3K Parasite
Ginkgolic Acid (C13:0) (Standard) is the analytical standard of Ginkgolic Acid (C13:0) (HY-N0078). This product is intended for research and analytical applications. Ginkgolic Acid (C13:0) (Ginkgoneolic Acid) is an anti-cariogenic agent and a PI3Kδ inhibitor (IC₅₀: 2.49 μM). Ginkgolic Acid (C13:0) exhibits antibacterial and anti-parasitic activities. Ginkgolic Acid (C13:0) can also inhibit mast cell degranulation (IC₅₀: 2.40 μM) .

HY-N0631R

Cornuside (Standard)	Structural Classification Iridoids Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Phenols Polyphenols Plants Source Classification	Reference Standards Prostaglandin Receptor ERK p38 MAPK Acyltransferase TNF Receptor COX Cholinesterase (ChE) Interleukin Related JNK NO Synthase NF-κB
Cornuside (Standard) is the analytical standard of Cornuside (HY-N0631). This product is intended for research and analytical applications. Cornuside is an iridoid glycoside with anti-allergic, anti-inflammatory, and neuroprotective activities. Cornuside exerts anti-allergic activity by downregulating the p38 MAPK, JNK, and NF-κB signaling pathways, and inhibits IgE-mediated histamine release from mast cells. Cornuside improves cognitive impairment in mice by inhibiting BACE1 activity (IC₅₀ = 55.84 μg/mL) and enhancing ChAT activity. Cornuside inhibits LPS (HY-D1056)-induced inflammatory mediators, including iNOS, COX-2, PGE2, TNF-α, IL-6, and IL-1β, by suppressing NF-κB activation.

HY-116474R

Viridicatol (Standard)	Alkaloids Structural Classification Monophenols Microorganisms Phenols Quinoline Alkaloids Source Classification	Reference Standards JNK β-catenin NO Synthase PGE synthase Fungal STAT ERK MMP p38 MAPK Bacterial NF-κB Wnt
Viridicatol (Standard) is the analytical standard of Viridicatol (HY-116474). This product is intended for research and analytical applications. Viridicatol is a quinolone alkaloid with anti-inflammatory, antibacterial, antifungal, osteogenic and chondrogenic activities. Viridicatol reduces the phosphorylation levels of ERK, JNK, p38 and STAT6; inhibits MMP-2, MMP-9, NF-κB signaling pathway and PTP1B; downregulates genes related to mast cell activation; and binds to SHN3 to activate the Wnt/SHN3 signaling pathway. Viridicatol inhibits the expression of pro-inflammatory mediators and cytokines, and promotes osteogenic/chondrogenic differentiation. Viridicatol can be used in studies related to fibrosarcoma, allergy, bacterial infection, fungal infection and osteoporosis .

Species:	Human (26) Rhesus Macaque (3) Rat (5) Mouse (17) Cynomolgus (1) Canine (2)
Tag:	SUMO (1) His (33) Strep (1) Tag Free (12) Avi (2) GST (4) Fc (6)
Source:	HEK293 (21) sf9 insect cells (4) CHO (1) Sf9 insect cells (1) Sf9 insect cells (4) P. pastoris (4) E. coli (18)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72290

	Chymase/CMA1 Protein, Mouse (His) Alpha-chymase; mast cell chymase 1; mast cell protease 5; mMCP-5; mast cell protease I	Mouse	E. coli
	Chymase/CMA1 Protein, a prominent secreted protease in mast cells, is implicated in various physiological processes, including the generation of vasoactive peptides, extracellular matrix degradation, and the regulation of gland secretion.Chymase/CMA1 Protein, Mouse (His) is the recombinant mouse-derived Chymase/CMA1 protein, expressed by E.coli , with N-His labeled tag.

HY-P702794

	CPA3 Protein, Human (His) carboxypeptidase A; carboxypeptidase A3 (mast cell); Carboxypeptidase A3; carboxypeptidase A3 mast cell; CBPA3_HUMAN; Cpa3; mast cell carboxypeptidase A; mast cell carboxypeptidase A3; MC CPA; MC-CPA; tissue carboxypeptidase A	Human	E. coli
	CPA3 Protein, Human (His) is the recombinant human-derived CPA3, expressed by E. coli , with N-6*His labeled tag.

HY-P702795

	CPA3 Protein, Human (P.pastoris, His) carboxypeptidase A; carboxypeptidase A3 (mast cell); Carboxypeptidase A3; carboxypeptidase A3 mast cell; CBPA3_HUMAN; Cpa3; mast cell carboxypeptidase A; mast cell carboxypeptidase A3; MC CPA; MC-CPA; tissue carboxypeptidase A	Human	P. pastoris
	CPA3 Protein, Human (P.pastoris, His) is the recombinant human-derived CPA3, expressed by P. pastoris , with N-6*His labeled tag.

HY-P77078

	Mast Cell Protease-1/MCPT-1 Protein, Mouse (HEK293, His) mast cell protease 1; mMCP-1; Mcpt1	Mouse	HEK293
	Mast Cell Protease-1 (MCPT-1) displays chymotrypsin-like enzymatic activity.Mast Cell Protease-1/MCPT-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Mast Cell Protease-1/MCPT-1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P74252

	Chymase/CMA1 Protein, Human (sf9, His) Alpha-chymase; mast cell chymase 1; mast cell protease 5; mMCP-5	Human	Sf9 insect cells
	Chymase/CMA1 Protein, a secreted protease from mast cells, plays a significant role in generating vasoactive peptides, degrading the extracellular matrix, and regulating gland secretion. Chymase/CMA1 Protein, Human (sf9, His) is the recombinant human-derived Chymase/CMA1 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P79111

	SCF Protein, Canine Kit ligand; mast cell growth factor; MGF; Stem cell Factor; SCF; c-Kit ligand; KITLG	Canine	E. coli
	SCF protein critically promotes mast cell proliferation, enhancing both myeloid and lymphoid hematopoietic progenitor proliferation in bone marrow. Additionally, SCF facilitates cell-cell adhesion and synergizes with other cytokines, potentially interleukins. As a homodimer, SCF is connected non-covalently, contributing to hematopoietic processes and immune responses. SCF Protein, Canine is the recombinant canine-derived SCF protein, expressed by E. coli , with tag free.

HY-P7216

	IL-3 Protein, Canine rCaIL-3; mast cell growth factor; MCGF; Hematopoietic growth factor	Canine	E. coli
	IL-3 Protein, Canine is a hemopoietic growth factor involved in the survival, proliferation and differentiation of multipotent hemopoietic cells.

HY-P70781

	SCF Protein, Human 5 Publications Verification Kit Ligand; mast cell Growth Factor; MGF; Stem cell Factor; SCF; c-Kit ligand; KITLG; MGF; SCF	Human	E. coli
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and regulate a variety of cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members, and PLCG1, producing diacylglycerol and inositol 1,4,5-trisphosphate. SCF Protein, Human is the recombinant human-derived SCF protein, expressed in E. coli.

HY-P70528

	SCF Protein, Mouse 2 Publications Verification Kit ligand; Hematopoietic growth factor KL; mast cell growth factor; MGF; Steel factor; Stem cell factor; SCF	Mouse	E. coli
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and are critical for multiple cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis.Binding to KIT activates multiple signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members and PLCG1, producing signaling molecules.SCF Protein, Mouse is the recombinant mouse-derived SCF protein, expressed by E.coli , with tag free.

HY-P7064

	SCF Protein, Mouse (P.pastoris) rMuSCF; Hematopoietic growth factor KL; MGF; mast cell Growth Factor	Mouse	P. pastoris
	SCF Protein, Mouse (P.pastoris) is the ligand for the receptor-type protein-tyrosine kinase KIT.It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.

HY-P7056

	SCF Protein, Human (P.pastoris) rHuSCF; Hematopoietic growth factor KL; MGF; mast cell Growth Factor	Human	P. pastoris
	SCF Protein, Human (P.pastoris), the c-kit ligand, is a two disulfide bridge-containing cytokine in the regulation of the development and function of hematopoietic cell lineages and other cells such as mast cells, germ cells, and melanocytes.

HY-P7107

	SCF Protein, Rat (P.pastoris) rRtSCF; Hematopoietic growth factor KL; MGF; mast cell Growth Factor	Rat	P. pastoris
	SCF Protein, Rat (P.pastoris) is a hematopoietic cytokine, triggered by binding to its ligand c-kit, and plays an important role in hematopoiesis, spermatogenesis, and melanogenesis.

HY-P7107A

	SCF Protein, Rat (HEK293) rRtSCF; Hematopoietic growth factor KL; MGF; mast cell Growth Factor	Rat	HEK293
	SCF Protein, Rat (HEK293) is a hematopoietic cytokine, triggered by binding to its ligand c-kit, and plays an important role in hematopoiesis, spermatogenesis, and melanogenesis.

HY-P7040

	IL-3 Protein, Human rHuIL-3; Hematopoietic growth factor; mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor	Human	E. coli
	IL-3 Protein, Human is a multilineage hematopoietic cytokine with promising effects on platelet and neutrophil counts and special usefulness in patients with secondary hematopoietic failure. IL-3 Protein, Human plays a role in neural cell proliferation and survival. IL-3 Protein, Human inhibits NF-κB nuclear translocation and activation, and inhibits osteoclast differentiation. IL-3 Protein, Human is the recombinant human-derived IL-2 Protein, expressed by E. coli.

HY-P7062

	IL-3 Protein, Mouse rMuIL-3; Hematopoietic growth factor; mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor	Mouse	E. coli
	IL-3 Protein, Mouse functions via specific cell surface receptors to stimulate the proliferation, differentiation and survival of haematopoietic cell lines.

HY-P704404

	SCF Protein, Human (HEK293) Kit Ligand; mast cell Growth Factor; MGF; Stem cell Factor; SCF; c-Kit ligand; KITLG; MGF; SCF	Human	HEK293
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and regulate a variety of cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members, and PLCG1, producing diacylglycerol and inositol 1,4,5-trisphosphate. SCF Protein, Human (HEK293) is the recombinant human-derived SCF protein, expressed by HEK293, with tag free.

HY-P70528AF

	Animal-Free SCF Protein, Mouse Kit ligand; Hematopoietic growth factor KL; mast cell growth factor; MGF; Steel factor; Stem cell factor; SCF	Mouse	E. coli
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and are critical for multiple cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates multiple signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members and PLCG1, producing signaling molecules. Animal-Free SCF Protein, Mouse is the recombinant mouse-derived Animal-Free SCF protein, expressed by E. coli, with tag free.

HY-P73410

	SCF Protein, Human (sf9, His) SCF; Hematopoietic growth factor KL; MGF; mast cell Growth Factor	Human	Sf9 insect cells
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and regulate a variety of cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members, and PLCG1, producing diacylglycerol and inositol 1,4,5-trisphosphate. SCF Protein, Human (sf9, His) is the recombinant human-derived SCF protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P73662

	SCF Protein, Mouse (sf9, His) SCF; Hematopoietic growth factor KL; MGF; mast cell Growth Factor	Mouse	Sf9 insect cells
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and are critical for multiple cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis.Binding to KIT activates multiple signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members and PLCG1, producing signaling molecules.SCF Protein, Mouse (sf9, His) is the recombinant mouse-derived SCF protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P7040A

	IL-3 Protein, Human (CHO) 1 Publications Verification rHuIL-3; Hematopoietic growth factor; mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor	Human	CHO
	IL-3 Protein, Human (CHO) is a multilineage hematopoietic cytokine with promising effects on platelet and neutrophil counts and special usefulness in patients with secondary hematopoietic failure.

HY-P7062A

	IL-3 Protein, Mouse (His) rMuIL-3; Hematopoietic growth factor; mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor	Mouse	E. coli
	IL-3 Protein, Mouse (His) is a pleiotropic cytokine containing 135 amino acids, which functions via specific cell surface receptors to stimulate the proliferation, differentiation and survival of haematopoietic cell lines.

HY-P70757

	SCF Protein, Human (HEK293, His) Kit Ligand; mast cell Growth Factor; MGF; Stem cell Factor; SCF; c-Kit ligand; KITLG; MGF; SCF	Human	HEK293
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and regulate a variety of cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members, and PLCG1, producing diacylglycerol and inositol 1,4,5-trisphosphate. SCF Protein, Human (HEK293, His) is the recombinant human-derived SCF protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P700148AF

	Animal-Free SCF Protein, Human (His) Kit Ligand; mast cell Growth Factor; MGF; Stem cell Factor; SCF; c-Kit ligand; KITLG; MGF; SCF	Human	E. coli
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and regulate a variety of cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members, and PLCG1, producing diacylglycerol and inositol 1,4,5-trisphosphate. Animal-Free SCF Protein, Human (His) is the recombinant human-derived animal-FreeSCF protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P77529

	SCF Protein, Mouse (Biotinylated, sf9, His) SCF; Hematopoietic growth factor KL; MGF; mast cell Growth Factor	Mouse	Sf9 insect cells
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and are critical for multiple cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis.Binding to KIT activates multiple signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members and PLCG1, producing signaling molecules.SCF Protein, Mouse (Biotinylated, sf9, His) is the recombinant mouse-derived SCF protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P70576AF

	Animal-Free IL-3 Protein, Human (His) rHuIL-3; Hematopoietic growth factor; mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor	Human	E. coli
	Animal-Free IL-3 Protein, Human (His) is the recombinant human-derived animal-FreeIL-3 protein, expressed by E. coli, with C-His labeled tag., has molecular weight of ~16 kDa.This product is for cell culture use only.

HY-P700205AF

	Animal-Free IL-3 Protein, Mouse (His) rMuIL-3; Hematopoietic growth factor; mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor	Mouse	E. coli
	IL-3 protein is secreted by T lymphocytes, mast cells and osteoblasts.It plays an important regulatory role in hematopoietic progenitor cells and stimulates mature basophils, eosinophils and monocytes.In addition to hematopoiesis, it supports neuronal cell proliferation, survival, and bone homeostasis by inhibiting osteoclast differentiation.Animal-Free IL-3 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-3 protein, expressed by E.coli , with C-His labeled tag.This product is for cell culture use only.

HY-P77080

	MCEMP1 Protein, Human (HEK293, Fc) mast cell-expressed membrane protein 1; C19orf59	Human	HEK293
	MCEMP1, a lung-specific surface protein, is a type II transmembran protein. MCEMP1 is primarily expressed in myeloid lineage immune cells and plays a critical in allergic and inflammatory lung diseases. MCEMP1 is an adaptor for KIT receptor to promotes stem cell factor-mediated mast cell proliferation. MCEMP1 also participates in the chemotaxis, adhesion, and migration of circulating monocytes. MCEMP1 Protein, Human (HEK293, Fc) is the recombinant human-derived MCEMP1 protein, expressed by HEK293 , with N-mFc labeled tag.

HY-P70576

	IL-3 Protein, Human (His) 3 Publications Verification Interleukin-3; IL-3; Hematopoietic Growth Factor; mast cell Growth Factor; MCGF; Multipotential Colony-Stimulating Factor; P-cell-Stimulating Factor; IL3	Human	E. coli
	IL-3 protein is mainly secreted by T lymphocytes, mast cells and osteoblasts and is critical for the generation and differentiation of hematopoietic progenitor cells. It stimulates mature basophils, eosinophils and monocytes, promoting functional activation. IL-3 Protein, Human (His) is the recombinant human-derived IL-3 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P70576G

	GMP IL-3 Protein, Human (His) Interleukin-3; IL-3; Hematopoietic Growth Factor; mast cell Growth Factor; MCGF; Multipotential Colony-Stimulating Factor; P-cell-Stimulating Factor; IL3	Human	E. coli
	IL-3 protein is mainly secreted by T lymphocytes, mast cells and osteoblasts and is critical for the generation and differentiation of hematopoietic progenitor cells. It stimulates mature basophils, eosinophils and monocytes, promoting functional activation. GMP IL-3 Protein, Human (His) is the recombinant human-derived IL-3 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P71858A

	IL-3 Protein, Rhesus macaque (His) IL3; Interleukin-3; IL-3; Hematopoietic growth factor; mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor	Rhesus Macaque	E. coli
	IL-3 protein, a hematopoietic cytokine, regulates hematopoiesis by influencing the production, differentiation, and function of various white blood cell populations. It acts as a colony-stimulating factor, promoting the development and maturation of these cell types and maintaining a functional immune system. IL-3 Protein, Rhesus macaque (His) is the recombinant Rhesus Macaque-derived IL-3 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P72752

	CD117/c-kit Protein, Human (HEK293, His) mast/stem cell growth factor receptor Kit; SCFR; PBT; CD117; KIT	Human	HEK293
	CD117/c-kit is a tyrosine protein kinase receptor for KITLG/SCF that coordinates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Upon KITLG/SCF binding, CD117 activates the pathway and phosphorylates PIK3R1, PLCG1, SH2B2/APS, and CBL. CD117/c-kit Protein, Human (HEK293, His) is the recombinant human-derived CD117/c-kit protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72879

	CD117/c-Kit Protein, Mouse (HEK293, Fc) mast/stem cell growth factor receptor Kit; SCFR; CD117; Kit; Sl	Mouse	HEK293
	CD117/c-Kit protein is a tyrosine protein kinase that acts as a cell surface receptor for KITLG/SCF and regulates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, function, and melanogenesis . CD117/c-Kit Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD117/c-Kit protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72880

	CD117/c-Kit Protein, Mouse (HEK293, His) mast/stem cell growth factor receptor Kit; SCFR; CD117; Kit; Sl	Mouse	HEK293
	CD117/c-Kit protein is a tyrosine protein kinase that acts as a cell surface receptor for KITLG/SCF and regulates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, function, and melanogenesis .CD117/c-Kit Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD117/c-Kit protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P74337

	CD117/c-kit Protein, Rat (HEK293, His) mast/stem cell growth factor receptor Kit; SCFR; CD117; Kit; Sl	Rat	HEK293
	CD117, also known as tyrosine-protein kinase KIT or mast/stem cell growth factor receptor (SCFR), is a cytokine receptor that is expressed on the surface of hematopoietic stem cells and other cell types. CD117 signaling pathway plays an important role in cell survival, proliferation and differentiation. CD117 is a proto-oncogene associated with tumor development. CD117/c-kit Protein, Rat (HEK293, His) is the recombinant rat-derived CD117/c-kit protein, expressed by HEK293 , with C-His labeled tag.

HY-P74338

	CD117/c-kit Protein, Rat (HEK293, Fc) mast/stem cell growth factor receptor Kit; SCFR; CD117; Kit; Sl	Rat	HEK293
	CD117, also known as tyrosine-protein kinase KIT or mast/stem cell growth factor receptor (SCFR), is a cytokine receptor that is expressed on the surface of hematopoietic stem cells and other cell types. CD117 signaling pathway plays an important role in cell survival, proliferation and differentiation. CD117 is a proto-oncogene associated with tumor development. CD117/c-kit Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD117/c-kit protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P70765

	IL-3 Protein, Human (HEK293, His) 1 Publications Verification Interleukin-3; IL-3; Hematopoietic Growth Factor; mast cell Growth Factor; MCGF; Multipotential Colony-Stimulating Factor; P-cell-Stimulating Factor; IL3	Human	HEK293
	IL-3 Protein, Human (HEK293, His) is a multipotent hematopoietic growth factor that can control blood formation. IL-3 Protein, Human (HEK293, His) is a recombinant human interleukin-3 (rhIL-3) expressed in HEK 293 cells with a His tag. rhIL-3 is also a weak inflammatory mediator. rhIL-3 can be used to improve states of hematopoietic failure.

HY-P74336

	CD117/c-kit Protein, Rhesus Macaque (HEK293, Fc) mast/stem cell growth factor receptor Kit; SCFR; CD117; Kit; Sl	Rhesus Macaque	HEK293
	CD117, also known as tyrosine-protein kinase KIT or mast/stem cell growth factor receptor (SCFR), is a cytokine receptor that is expressed on the surface of hematopoietic stem cells and other cell types. CD117 signaling pathway plays an important role in cell survival, proliferation and differentiation. CD117 is a proto-oncogene associated with tumor development. CD117/c-kit Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived CD117/c-kit protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P74341

	CD117/c-kit Protein, Human (141a.a, His) mast/stem cell growth factor receptor Kit; SCFR; CD117; Kit; Sl	Human	E. coli
	CD117/c-kit is a tyrosine protein kinase receptor for KITLG/SCF that coordinates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Upon KITLG/SCF binding, CD117 activates the pathway and phosphorylates PIK3R1, PLCG1, SH2B2/APS, and CBL. CD117/c-kit Protein, Human (141a.a, His) is the recombinant human-derived CD117/c-kit protein, expressed by E. coli , with N-His labeled tag.

HY-P70555

	SCF Protein, Mouse (HEK293, His) 2 Publications Verification FPH2; KIT ligand; Kitl; KITLG; KL-1; mast cell growth factor; MGF; MGFSHEP7; SCF; SCFStem cell factor; SFc-Kit ligand; SLF; steel factor	Mouse	HEK293
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and are critical for multiple cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis.Binding to KIT activates multiple signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members and PLCG1, producing signaling molecules.SCF Protein, Mouse (HEK293, His) is the recombinant mouse-derived SCF protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70685

	IL-3 Protein, Mouse (HEK293, His) 2 Publications Verification Interleukin-3; IL-3; Hematopoietic growth factor; Multipotential colony-stimulating factor; P-cell-stimulating factor; Il3; Il-3; mast cell growth factor; MCGF	Mouse	HEK293
	IL-3 Protein, Mouse (HEK293, His) is a multilineage hematopoietic cytokine with promising effects on platelet and neutrophil counts and special usefulness in patients with secondary hematopoietic failure.

HY-P71130

	SCF Protein, Rat (HEK293, His) FPH2; KIT ligand; Kitl; KITLG; KL-1; mast cell growth factor; MGF; MGFSHEP7; SCF; SCFStem cell factor; SFc-Kit ligand; SLF; steel factor	Rat	HEK293
	Stem cell factor (SCF), as a key ligand of KIT, regulates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates signaling pathways involving phosphorylation events, key kinases (AKT1, RAS, RAF1, MAPK1/ERK2, MAPK3/ERK1), STAT family members, and PLCG1. SCF Protein, Rat (HEK293, His) is the recombinant rat-derived SCF protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71131

	Tryptase beta-2 Protein, Mouse (HEK293, His) 1 Publications Verification Tryptase beta-2; Tryptase-2; mast cell protease 6; mMCP-6	Mouse	HEK293
	Tryptase beta-2, a neutral protease abundant in mast cells, plays a key role in innate immunity.As the primary proteolytic enzyme released during mast cell activation, Tryptase beta-2 contributes significantly to immune functions.Its involvement underscores its importance in mediating cellular responses linked to innate immunity, highlighting its role in the intricate defense mechanisms of the immune system.Tryptase beta-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Tryptase beta-2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P705118

	CD117/c-kit Protein, Human (Biotinylated, HEK293, His-Avi) mast/stem cell growth factor receptor Kit; SCFR; CD117; Kit; Sl	Human	HEK293

HY-P705187

	CD117/c-kit Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) mast/stem cell growth factor receptor Kit; SCFR; CD117; Kit; Sl	Cynomolgus;Rhesus Macaque	HEK293

HY-P74339

	CD117/c-kit Protein, Human (P10721-2, HEK293, Fc) mast/stem cell growth factor receptor Kit; SCFR; CD117; Kit; Sl	Human	HEK293
	CD117/c-kit is a tyrosine protein kinase receptor for KITLG/SCF that coordinates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Upon KITLG/SCF binding, CD117 activates the pathway and phosphorylates PIK3R1, PLCG1, SH2B2/APS, and CBL. CD117/c-kit Protein, Human (P10721-2, HEK293, Fc) is the recombinant human-derived CD117/c-kit protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P73495

	CD117/c-kit Protein, Human (P10721-2, HEK293, His) mast/stem cell growth factor receptor Kit; SCFR; CD117; Kit; Sl	Human	HEK293
	CD117/c-kit is a tyrosine protein kinase receptor for KITLG/SCF that coordinates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Upon KITLG/SCF binding, CD117 activates the pathway and phosphorylates PIK3R1, PLCG1, SH2B2/APS, and CBL. CD117/c-kit Protein, Human (P10721-2, HEK293, His) is the recombinant human-derived CD117/c-kit protein, expressed by HEK293 , with C-His labeled tag.

HY-P76719

	Allergin-1 Protein, Mouse (HEK293, Fc) Allergy inhibitory receptor 1; mast cell antigen 32; MCA-32; Milr1; Gm885	Mouse	HEK293
	Allergin-1 protein, an immunoglobulin-like receptor, inhibits mast cell degranulation and suppresses hypersensitivity reactions. It interacts with tyrosine-phosphorylated proteins, such as PTPN6, PTPN11, and INPP5D, to fine-tune mast cell responses. Allergin-1 plays a pivotal role in regulating allergic reactions and hypersensitivity responses. Allergin-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Allergin-1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P71598

	NLRP3 Protein, Mouse (His-SUMO) 1 Publications Verification Nlrp3; Cias1; Mmig1; Nalp3; Pypaf1; NACHT; LRR and PYD domains-containing protein 3; Cold autoinflammatory syndrome 1 protein homolog; Cryopyrin; mast cell maturation-associated-inducible protein 1; PYRIN-containing APAF1-like protein 1	Mouse	E. coli
	The NLRP3 protein acts as a sensor in the NLRP3 inflammasome, which is activated in response to membrane defects caused by pathogens or damage signals. It assembles the inflammasome complex, including NLRP3, CASP1, and PYCARD/ASC. NLRP3 Protein, Mouse (His-SUMO) is the recombinant mouse-derived NLRP3 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

HY-P702691

	CD117/c-kit Protein, Human (Active, sf9, Twin-Strep) KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; PBT, piebald trait; mast/stem cell growth factor receptor Kit; C Kit; CD117; SCFR; p145 c-kit; proto-oncogene c-Kit; piebald trait protein; soluble KIT variant 1; tyrosine-protein kinase Kit; proto-oncogene tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; PBT; C-Kit	Human	Sf9 insect cells
	CD117/c-kit is a tyrosine protein kinase receptor for KITLG/SCF that coordinates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Upon KITLG/SCF binding, CD117 activates the pathway and phosphorylates PIK3R1, PLCG1, SH2B2/APS, and CBL. CD117/c-kit Protein, Human (sf9, Twin-Strep) is the recombinant human-derived CD117/c-kit, expressed by Sf9 insect cells, with Twin-Strep tag.

HY-P705754

	CD117/c-kit Protein, Human (D816H, sf9, His-GST) KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; PBT, piebald trait; mast/stem cell growth factor receptor Kit; C Kit; CD117; SCFR; p145 c-kit; proto-oncogene c-Kit; piebald trait protein; soluble KIT variant 1; tyrosine-protein kinase Kit; proto-oncogene tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; PBT; C-Kit	Human	sf9 insect cells

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Cat. No.	Product Name	Chemical Structure

HY-10330S

Toceranib-d8
Toceranib-d₈ is the deuterium labeled Toceranib. Toceranib (SU11654) is an orally active receptor tyrosine kinase (RTK) inhibitor, and it potently inhibits PDGFR, VEGFR, and Kit with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively. Toceranib (SU11654) has antitumor and antiangiogenic activity, and used in the treatment of canine mast cell tumors .

HY-W062109S

Olopatadine-d6

Olopatadine-d₆ is the deuterium labeled Olopatadine. Olopatadine hydrochloride (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine hydrochloride exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine hydrochloride inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine hydrochloride also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine hydrochloride inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine hydrochloride simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of ErbB3A/HER3A. Olopatadine hydrochloride can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis .

HY-B0157AS

Ketotifen-d3 fumarate
Ketotifen-d₃ (fumarate) is the deuterium labeled Ketotifen fumarate. Ketotifen (HC 20511) fumarate is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer, which is used to prevent asthma attacks .

HY-B0640S

Epinastine-13C,d3 hydrobromide
Epinastine- ¹³C,d₃ (hydrobromide) is the ¹³C- and deuterium labeled Epinastine. Epinastine (WAL801) is an antihistamine and mast cell stabilizer. Epinastine is a potent, selective and orally-active histamine H1 receptor antagonist. Epinastine also inhibits IL-8 release and has an antiallergic action .

HY-B0426AS

Olopatadine-d3 hydrochloride

Olopatadine-d₃ hydrochloride (ALO4943A-d₃) is the deuterium labeled Olopatadine hydrochloride. Olopatadine hydrochloride (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine hydrochloride exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine hydrochloride inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine hydrochloride also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine hydrochloride inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine hydrochloride simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of ErbB3A/HER3A. Olopatadine hydrochloride can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis .

HY-B1619S

Cromolyn-d5

Cromolyn-d₅ (Cromoglycate-d₅) is the deuterium labeled Cromolyn (HY-B1619). Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

HY-124356AS

Alcaftadine carboxylic acid-d3 sodium

Alcaftadine carboxylic acid-d₃ (sodium) is deuterium labeled Alcaftadine carboxylic acid. Alcaftadine carboxylic acid is a broad-spectrum antihistamine compound with high affinity for histamine H1 and H2 receptors and low affinity for H4 receptors. Alcaftadine carboxylic acid has also demonstrated effects on modulating immune cell recruitment and stabilizing mast cells. Alcaftadine carboxylic acid is more effective than placebo in preventing ocular itching associated with allergic conjunctivitis and is at least as effective as olopatadine 0.01% .

HY-W755511

Lodoxamide-15N2,d2
Lodoxamide- ¹⁵N₂,d₂ (U-42585E (free acid)- ¹⁵N₂,d₂) is the deuterium and ¹⁵N-labeled Lodoxamide (HY-14270). Lodoxamide (U-42585E free acid) is an antiallergic compound acting as a mast-cell stabilizer for the treatment of asthma and allergic conjunctivitis.

HY-B0157S1

Ketotifen-d3

Ketotifen-d₃ (HC 20-511-d₃) is deuterium labeled Ketotifen. Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-W778179

Benoxaprofen-13C,d3

Benoxaprofen- ¹³C, d₃ is the ¹³C-labeled Benoxaprofen (HY-13568). Benoxaprofen (LRCL 3794) is a nonsteroidal anti-inflammatory agent that blocks the biosynthesis of inflammatory mediators such as leukotrienes and prostaglandins by inhibiting 5-LOX, PGH2 synthase and cytochrome P-450. Benoxaprofen exhibits significant toxicity: it not only alters cellular redox status, uncouples oxidative phosphorylation and disrupts calcium ion homeostasis, but also causes liver injury through the formation of covalent adducts between its active metabolites and hepatic proteins. Benoxaprofen shows strong phototoxicity under ultraviolet irradiation, and induces erythrocyte lysis, mast cell degranulation and histamine release. Benoxaprofen is widely used in studies of urticaria and related phototoxic mechanisms .

HY-B0426AS2

Olopatadine-d6 hydrochloride

Olopatadine-d₆ (ALO4943A-d₆; KW4679-d₆) hydrochloride is deuterium-labeled Olopatadine (hydrochloride) (HY-B0426A). Olopatadine hydrochloride (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine hydrochloride exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine hydrochloride inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine hydrochloride also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine hydrochloride inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine hydrochloride simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of ErbB3A/HER3A. Olopatadine hydrochloride can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis .

Host:	Mouse (8) Rabbit (7)
Reactivity:	Human (15) Rat (4) Mouse (2)
Application:	IHC-P (15) ICC/IF (8) IF-Tissue (2) IP (2) IHC-F (2) WB (9) FC (6) ELISA (8)
Isotype:	IgG (8) IgG1 (4) IgG2b (3)
Conjugation:	Non-conjugated (15) Biotin (3)
Clonality:	Monoclonal (13) Recombinant (5)
Modification:	Unmodified (13)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85998

	Mast cell tryptase Antibody (YA5690)	IHC-P, ICC/IF, ELISA	Human
	Mast cell tryptase Antibody (YA5690) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Mast cell tryptase.

HY-P86015

	Mast cell tryptase Antibody (YA5707)	IHC-P, ICC/IF, ELISA	Human
	Mast cell tryptase Antibody (YA5707) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Mast cell tryptase.

HY-P85811

	Mast cell tryptase(PT2025) Antibody (YA5503)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
	Mast cell tryptase(PT2025) Antibody (YA5503) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Mast cell tryptase(PT2025).

HY-P81788

	Mast Cell Tryptase Antibody (YA1533) TPS1; TPS2; TPSAB1; TPSB1; MCP 7; mast cell protease 7; Tryptase alpha 1	WB, IHC-P, IP	Human, Mouse, Rat
	Mast Cell Tryptase Antibody (YA1533) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Mast Cell Tryptase.

HY-P84595

	Mast Cell Tryptase Antibody (YA4292) TPS1; TPS2; TPSB1; TPSB2; Tryptase-2	IHC-P, ICC/IF, FC, ELISA	Human
	Mast Cell Tryptase Antibody (YA4292) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Mast Cell Tryptase.

HY-P84594

	Mast Cell Tryptase Antibody (YA4291) TPS1; TPS2; TPSB1; TPSB2; Tryptase-2	IHC-P, FC, ELISA	Human, Rat
	Mast Cell Tryptase Antibody (YA4291) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Mast Cell Tryptase.

HY-P84594A

	Mast Cell Tryptase Antibody (YA4291)(PBS only) TPS1; TPS2; TPSB1; TPSB2; Tryptase-2	IHC-P, FC, ELISA	Human, Rat
	Mast Cell Tryptase Antibody (YA4291) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Mast Cell Tryptase.

HY-P84595A

	Mast Cell Tryptase Antibody (YA4292)(PBS only) TPS1; TPS2; TPSB1; TPSB2; Tryptase-2	IHC-P, ICC/IF, FC, ELISA	Human
	Mast Cell Tryptase Antibody (YA4292) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Mast Cell Tryptase.

HY-P81128

	SCF Antibody (YA3538) Stem cell Factor; C kit ligand; Ckit ligand; DKFZp686F2250; KIT ligand; Kitl; KITLG; KL 1; KL1; mast cell growth factor; MGF; SF; SHEP7; Steel factor; Stem cell factor precursor; SCF_HUMAN.	WB, IHC-P, ICC/IF, FC	Human
	SCF Antibody (YA3538) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SCF.

HY-P81884

	Mast Cell Chymase Antibody (YA1629) Chymase 1; Chymase; CMA1; CYH; CYM; Mcp-5; MCP3P; Mcpt5; MCT1; MMCP-5	WB, IHC-P	Human
	Mast Cell Chymase Antibody (YA1629) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Mast Cell Chymase.

HY-P86669

	IL-4 Antibody (YA6361) Interleukin-4; IL4; IL 4; B cell growth factor 1; B cell IgG differentiation factor; B cell Stimulatory Factor 1; BCGF 1; BCGF1; Binetrakin; BSF 1; BSF1; HCGF; Hodgkin’s cell Growth Factor; IA Inducing Factor; IGG1 induction factor; Il4e12; Interleukin 4; Interleukin 4, isoform 1; Interleukin4; Lymphocyte stimulatory factor 1; Macrophage fusion factor; mast cell growth factor 2; MCGF2; MFF; MGC79402; Pitrakinra; T cell growth factor 2; TCGF2; IL4_HUMAN; B-cell stimulatory factor 1; BSF-1.	WB, IHC-P, IHC-F, IF-Tissue	Human
	IL-4 Antibody (YA6361) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IL-4.

HY-P86655

	c-Kit Antibody (YA6347) C Kit; CD 117; CD117; CD117 antigen; KIT; KIT_HUMAN; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; p145 c-kit; PBT; Piebald trait protein; Proto oncogene c Kit; Proto oncogene tyrosine protein kinase Kit; Proto-oncogene c-Kit; SCF Receptor; SCFR; soluble KIT variant 1; Stem cell factor receptor; tyrosine protein kinase Kit; Tyrosine-protein kinase Kit; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog.	WB, IHC-P, IHC-F, IF-Tissue	Human
	c-Kit Antibody (YA6347) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to c-Kit.

HY-P80619

	c-Kit Antibody (YA3501) 2 Publications Verification KIT; SCFR; mast/stem cell growth factor receptor Kit; SCFR; Piebald trait protein; PBT; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; p145 c-kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD antigen CD117	WB, IHC-P	Human
	c-Kit Antibody (YA3501) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to c-Kit.

HY-P85841

	c-Kit Antibody (YA5533) C Kit; c-Kit; c-Kit Ligand; CD117; Kit; Kit Ligand; KIT oncogene; KIT proto oncogene receptor tyrosine kinase; KIT_HUMAN; mast cell growth factor receptor; mast/stem cell growth factor receptor Kit; MGF; p145 c-kit; PBT; Piebald trait protein; Proto oncogene c Kit; Proto oncogene tyrosine protein kinase Kit; Proto-oncogene c-Kit; SCF Receptor; SCFR; soluble KIT variant 1; Steel Factor Receptor; Stem cell factor receptor; tyrosine protein kinase Kit; Tyrosine-protein kinase Kit; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	IHC-P, WB, ICC/IF, ELISA	Human
	c-Kit Antibody (YA5533) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to c-Kit.

HY-P85885

	CD63 Antibody (YA5577) Lysosomal associated membrane protein 3 antibody; CD 63 antibody; CD63 antibody; CD63 antigen; melanoma 1 antigen; antibody; CD63 antigen antibody; CD63 antigen melanoma 1 antigen antibody; CD63 molecule antibody; CD63_HUMAN antibody; gp55 antibody; Granulophysin antibody; LAMP 3 antibody; LAMP-3 antibody; LAMP3 antibody; LIMP antibody; Lysosomal-associated membrane protein 3 antibody; Lysosome associated membrane glycoprotein 3 antibody; Lysosome-associated membrane glycoprotein 3 antibody; mast cell antigen AD1 antibody; ME491 antibody; Melanoma 1 antigen antibody; Melanoma associated antigen ME491 antibody; Melanoma associated antigen MLA1 antibody; Melanoma-associated antigen ME491 antibody; MGC72893 antibody; MLA 1 antibody; MLA1 antibody; NGA antibody; Ocular melanoma associated antigen antibody; Ocular melanoma-associated antigen antibody; OMA81H antibody; PTLGP40 antibody; Tetraspanin 30 antibody; Tetraspanin-30 antibody; Tspan 30 antibody; Tspan-30 antibody; TSPAN30 antibody;	WB, IHC-P, ICC/IF, IP, FC	Human
	CD63 Antibody (YA5577) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD63.

HY-P85885A

	CD63 Antibody (YA5577)(PBS only) Lysosomal associated membrane protein 3 antibody; CD 63 antibody; CD63 antibody; CD63 antigen; melanoma 1 antigen; antibody; CD63 antigen antibody; CD63 antigen melanoma 1 antigen antibody; CD63 molecule antibody; CD63_HUMAN antibody; gp55 antibody; Granulophysin antibody; LAMP 3 antibody; LAMP-3 antibody; LAMP3 antibody; LIMP antibody; Lysosomal-associated membrane protein 3 antibody; Lysosome associated membrane glycoprotein 3 antibody; Lysosome-associated membrane glycoprotein 3 antibody; mast cell antigen AD1 antibody; ME491 antibody; Melanoma 1 antigen antibody; Melanoma associated antigen ME491 antibody; Melanoma associated antigen MLA1 antibody; Melanoma-associated antigen ME491 antibody; MGC72893 antibody; MLA 1 antibody; MLA1 antibody; NGA antibody; Ocular melanoma associated antigen antibody; Ocular melanoma-associated antigen antibody; OMA81H antibody; PTLGP40 antibody; Tetraspanin 30 antibody; Tetraspanin-30 antibody; Tspan 30 antibody; Tspan-30 antibody; TSPAN30 antibody;
	CD63 Antibody (YA5577)(PBS only) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD63.

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Cat. No.	Product Name		Classification

HY-Y0320

Dimethyl sulfoxide, meets analytical specification of Ch.P. 340+ Cited Publications DMSO, meets analytical specification of Ch.P.		Solvents
Dimethyl sulfoxide (DMSO), meets analytical specification of Ch.P. is an aprotic solvent that dissolves polar and non-polar compounds, including water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties . MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch.P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition). Amicrobic, low endotoxin, can be used in various biochemical experiments such as drug dissolution.

HY-174607

Human IL33 mRNA		mRNA Interleukin & Receptors
Human IL33 mRNA encodes the human interleukin 33 (IL33) protein, a cytokine that binds to the IL1RL1/ST2 receptor. IL33 is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells.

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