92-31-9
Chemical Structure
Toluidine Blue
Synonym(s): Toluidine Blue O
- CAS No.: 92-31-9
- Formula:C15H16ClN3S
- Molecular Weight:305.83
IUPAC Name: 3-amino-7-(dimethylamino)-2-methylphenothiazin-5-ium chloride
InChIKey: HNONEKILPDHFOL-UHFFFAOYSA-M
SMILES: CC1=CC2=C([S+]=C3C=C(N(C)C)C=CC3=N2)C=C1N.[Cl-]
Biological Activity: Toluidine Blue (Toluidine Blue O) is an alkaline quinonimine dye (vivo dye) with high affinity for acidic tissue components, staining nuclei blue and polysaccharides purple. Toluidine Blue shows heterostaining properties for mast cells, mucins and chondrocytes. Toluidine Blue can stain different components of plant tissues and cells in different colours. Toluidine Blue is also used as a diagnostic aid to identify malignant lesions, such as cancer[1][2][3].
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Toluidine Blue | Toluidine Blue (Toluidine Blue O) is an alkaline quinonimine dye (vivo dye) with high affinity for acidic tissue components, staining nuclei blue and polysaccharides purple. Toluidine Blue shows heterostaining properties for mast cells, mucins and chondrocytes. Toluidine Blue can stain different components of plant tissues and cells in different colours. Toluidine Blue is also used as a diagnostic aid to identify malignant lesions, such as cancer. | |||||||||||||||||||||
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- [1]. Puebla-Osorio N, et al. Detection of Infiltrating Mast Cells Using a Modified Toluidine Blue Staining. Methods Mol Biol. 2017;1627:213-222. [Content Brief]
- [2]. Sridharan G, et al. Toluidine blue: A review of its chemistry and clinical utility. J Oral Maxillofac Pathol. 2012;16(2):251-255. [Content Brief]
- [3]. O'Brien T P, et al. Polychromatic staining of plant cell walls by toluidine blue O. Protoplasma, 1964, 59(2): 368-373.
Keywords