Search Result
Results for "
metabolite precursor
" in MedChemExpress (MCE) Product Catalog:
3
Biochemical Assay Reagents
21
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-N0122
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- HY-Y0520
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Methylenesuccinic acid
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Endogenous Metabolite
Ferroptosis
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Inflammation/Immunology
Cancer
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Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid has anti-inflammatory, anti-microbial and immunomodulatory effect .
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- HY-117433
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DNA Alkylator/Crosslinker
Apoptosis
Reactive Oxygen Species (ROS)
Drug Metabolite
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Inflammation/Immunology
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4-Hydroperoxy cyclophosphamide is the active metabolite form of the precursor Cyclophosphamide. 4-Hydroperoxy cyclophosphamide cross-links DNA to induce T cell apoptosis independent of caspase receptor activation, and can activate the mitochondrial death pathway by producing reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide can be used in the study of rheumatoid arthritis and autoimmune diseases .
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- HY-W015851
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(R)-(-)-3-Hydroxybutanoic acid sodium; (R)-3-Hydroxybutyric acid sodium
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Endogenous Metabolite
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Metabolic Disease
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(R)-3-Hydroxybutanoic acid ((R)-3-Hydroxybutyric acid) sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones .
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- HY-W051723
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(R)-(-)-3-Hydroxybutanoic acid; (R)-3-Hydroxybutyric acid
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Endogenous Metabolite
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Metabolic Disease
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(R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones .
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- HY-113263
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17-OHP5
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Endogenous Metabolite
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Metabolic Disease
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17a-Hydroxypregnenolone (17-OHP5) is a metabolite of Pregnenolone (HY-B0151) and a precursor in the biosynthesis of Dehydroepiandrosterone (HY-14650). 17a-Hydroxypregnenolone is a substrate for the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD) .
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- HY-126370A
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Endogenous Metabolite
YAP
Apoptosis
Interleukin Related
STAT
ERK
Ras
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Cancer
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Geranylgeranyl pyrophosphate triammonium is a type of isoprenoid metabolic intermediate, mainly synthesized through the mevalonate pathway. Geranylgeranyl pyrophosphate triammonium is a key precursor in various biological synthesis processes, especially as a necessary substrate for post-translational modification of proteins - geranylgeranyl phosphorylation. Geranylgeranyl pyrophosphate triammonium regulates various cellular processes and disease progression through protein geranylgeranyl phosphorylation, such as activating the YAP signaling pathway, promoting cell proliferation and inhibiting apoptosis; promoting IL-2 production and STAT5 phosphorylation; and influencing metabolic homeostasis and cancer, etc .
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- HY-137808
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Succinyl-CoA sodium
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Endogenous Metabolite
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Neurological Disease
Metabolic Disease
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Succinyl CoA (Succinyl-coenzyme A) sodium is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA sodium is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA sodium acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA sodium insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA sodium can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .
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- HY-128748
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Endogenous Metabolite
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Others
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DL-Glyceraldehyde is a bioactive substance involved in cellular energy metabolism and a key intermediate in sugar metabolism pathways (such as glycolysis and gluconeogenesis). During glycolysis, DL-Glyceraldehyde is converted by enzymes into other metabolites to provide energy for cells; during gluconeogenesis, DL-Glyceraldehyde participates in the synthesis of glucose as a precursor. In the field of medical research, DL-Glyceraldehyde can be used to study diseases related to sugar metabolism, such as diabetes, tumors, etc[1][2].
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- HY-113224
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- HY-W674241
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Endogenous Metabolite
Apoptosis
Bcl-2 Family
Reactive Oxygen Species (ROS)
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Neurological Disease
Cancer
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4-Ethylphenyl sulfate is an orally active and brain-penetrant gut microbial metabolite. 4-Ethylphenyl sulfate downregulates Bcl2 expression, upregulates Bax expression, and induces cancer cell apoptosis via the endogenous apoptotic pathway. 4-Ethylphenyl sulfate induces G2/M cell cycle arrest and reactive oxygen species (ROS) production. 4-Ethylphenyl sulfate impairs oligodendrocyte maturation, reduces oligodendrocyte-neuron interactions, decreases axonal myelination levels, and shifts the oligodendrocyte population toward immature precursor cells. 4-Ethylphenyl sulfate alters brain region-specific neural activity and functional connectivity in mice, and correlates with anxiety-like behaviors in mice .
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- HY-124265
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Endogenous Metabolite
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Metabolic Disease
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4β-Hydroxycholesterol is a major Cholesterol (HY-N0322) metabolite and a precursor in the synthesis of bile acids that is found in human circulation .
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- HY-141570
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Phospholipase
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Others
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Lyso-PAF C-16 is a precursor and metabolite of 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (PAF C-16). Lyso-PAF C-16 is a substrate for either PAF C-16 formation by the remodeling pathway or selective acylation with arachidonic acid by a CoA-independent transacylase .
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- HY-N7080
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Hydroferulic acid
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Drug Metabolite
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Metabolic Disease
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Dihydroferulic acid (Hydroferulic acid) is one of the main metabolites of curcumin and antioxidant/radical-scavenging properties with an IC50 value of 19.5 μM. Dihydroferulic acid is a metabolite of human gut microflora as well as a precursor of vanillic acid .
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- HY-W002112
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Nornicotine
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Endogenous Metabolite
Drug Metabolite
nAChR
β-catenin
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Cardiovascular Disease
Neurological Disease
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(±)-Nornicotine is a major metabolite of Nicotine. (±)-Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±)-Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±)-Nornicotine supports self-administration behavior. (±)-Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia .
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- HY-119663
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Fungal
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Infection
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Averantin is the minor metabolite of the fungus Cercospora arachidicola . Averantin is an aflatoxin B1 precursor that can be used in the biosynthetic pathway .
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- HY-114297
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Endogenous Metabolite
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Others
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Zymosterol is a Cholesterol (HY-N0322) biosynthesis metabolite. Zymosterol, a precursor of Cholesterol, is found mostly in the plasma membrane. Zymosterol circulates within the cell .
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- HY-133068
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COMT
Endogenous Metabolite
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Others
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5-Hydroxyferulic acid is a hydroxycinnamic acid and is a metabolite of the phenylpropanoid pathway. 5-Hydroxyferulic acid is a precursor in the biosynthesis of sinapic acid and is also a COMT non-esterifed substrate .
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- HY-128742
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Endogenous Metabolite
Drug Derivative
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Metabolic Disease
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Thiamine monophosphate chloride dihydrate is a vitamin B1 (HY-A0100) metabolite and thiamine precursor. Thiamine monophosphate chloride dihydrate is absorbable in vivo and can be converted into thiamine. Thiamine monophosphate chloride dihydrate can be used as a food additive .
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- HY-122009
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Indoxyl-β-D-glucoside
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P-glycoprotein
OAT
Fluorescent Dye
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Others
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Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4 .
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- HY-W096638A
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(S)-Glycerolphosphocholine
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Endogenous Metabolite
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Neurological Disease
Metabolic Disease
Cancer
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Glycerophosphocholine ((S)-Glycerolphosphocholine) is an orally active metabolite that crosses the blood-brain barrier. Glycerophosphocholine acts as a precursor of acetylcholine, a specific marker for phosphatidylcholine breakdown, a major water-soluble storage form of choline, and an intermediate in phosphatidylcholine metabolism. Glycerophosphocholine is specifically elevated in the cerebrospinal fluid of Alzheimer's disease models, and it also promotes growth hormone secretion and fat oxidation. Glycerophosphocholine is also a potential biomarker for breast cancer .
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- HY-126370
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Endogenous Metabolite
YAP
Apoptosis
Interleukin Related
STAT
ERK
Ras
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Cancer
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Geranylgeranyl pyrophosphate is a type of isoprenoid metabolic intermediate, mainly synthesized through the mevalonate pathway. Geranylgeranyl pyrophosphate is a key precursor in various biological synthesis processes, especially as a necessary substrate for post-translational modification of proteins - geranylgeranyl phosphorylation. Geranylgeranyl pyrophosphate regulates various cellular processes and disease progression through protein geranylgeranyl phosphorylation, such as activating the YAP signaling pathway, promoting cell proliferation and inhibiting apoptosis; promoting IL-2 production and STAT5 phosphorylation; and influencing metabolic homeostasis and cancer, etc .
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- HY-124265S
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Endogenous Metabolite
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Metabolic Disease
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4β-Hydroxycholesterol-d7 is the deuterium labeled 4β-Hydroxycholesterol (HY-124265). 4β-Hydroxycholesterol is a major Cholesterol (HY-N0322) metabolite and a precursor in the synthesis of bile acids that is found in human circulation .
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- HY-N6660
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Tricaprin; Glyceryl tridecanoate
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Endogenous Metabolite
Androgen Receptor
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Cardiovascular Disease
Metabolic Disease
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Trisdecanoin (Tricaprin; Glyceryl tridecanoate) is an orally available precursor of decanoic acid (DA precursor) that can be hydrolyzed to decanoic acid. Trisdecanoin and its metabolite capric acid not only provide the body with a quick source of energy, but can also affect lipid metabolism. Trisdecanoin is a major component of medium chain triglycerides (MCT), which has preventive or inhibitory properties for abdominal aortic aneurysms (AAA), inhibition of cardiovascular disease, and anti-androgen (NSAA) and anti-hyperglycemic properties. Trisdecanoin can be used as an additive in food, medicine and cosmetics .
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- HY-124370
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9Z,11E-CLA; Methyl 9(Z),11(E)-octadecadienoate; (9Z,11E)-SFE 19:2
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Endogenous Metabolite
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Cardiovascular Disease
Cancer
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9 (Z),11 (E)-Conjugated linoleic acid methyl ester (9Z,11E-CLA; Methyl 9 (Z),11 (E)-octadecadienoate; (9Z,11E)-SFE 19:2) is an isomer of Linoleic acid (HY-N0729), and is a conjugated linoleic acid mainly found in meat and dairy products. Conjugated linoleic acid is a bioactive fatty acid that improves body composition, enhances immune system function, and exhibits anti-cancer and anti-atherosclerotic effects .
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- HY-113224S
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Isotope-Labeled Compounds
Endogenous Metabolite
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Metabolic Disease
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Desmosterol-d6 is the deuterium labeled Desmosterol. Desmosterol is a molecule similar to cholesterol. Desmosterol is the immediate precursor of cholesterol in the Bloch pathway of cholesterol biosynthesis. Desmosterol, as an endogenous metabolite, used to study cholesterol metabolism .
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- HY-W587960
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Histidine-betaine
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Drug Metabolite
Drug Intermediate
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Metabolic Disease
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Hercynine (Histidine-betaine) is an intermediate (precursor) and a redox metabolite of Ergothioneine (HY-N1914), which is found in the fine leaf algae, Schizosaccharomyces cerevisiae and honey bees. Hercynine has no effect on scavenging •OH radicals .
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- HY-Y0520S
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Endogenous Metabolite
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Inflammation/Immunology
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Itaconic acid- 13C5 is the 13C labeled Itaconic acid. Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors .
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- HY-W014018
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PPO; DPO; POP
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Fluorescent Dye
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Others
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2,5-Diphenyloxazole (PPO; DPO; POP) is a fluorescent dye, as well as a substrate and metabolite precursor of cytochrome P-450 (cytochrome P-448/P1-450). 2,5-Diphenyloxazole serves as a scintillator .
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- HY-124265S2
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Endogenous Metabolite
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Metabolic Disease
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4β-Hydroxycholesterol-d4 is the deuterium labeled 4β-Hydroxycholesterol (HY-124265) . 4β-Hydroxycholesterol is a major Cholesterol (HY-N0322) metabolite and a precursor in the synthesis of bile acids that is found in human circulation .
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- HY-33893
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Drug Derivative
Drug Intermediate
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Infection
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Indole-3-methanamine is an indole derivative, stress-related metabolite, and also a biosynthetic precursor of Gramine (HY-N0166). The accumulation level of Indole-3-methanamine increases in susceptible barley varieties infected with Bipolaris sorokiniana. Indole-3-methanamine can be used in studies related to barley spot blotch .
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- HY-128753
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Endogenous Metabolite
Drug Intermediate
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Metabolic Disease
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D-Lyxose is an endogenous metabolite. D-Lyxose is a rare pentose with significant potential for pharmaceutical synthesis. D-Lyxose serves as a starting material for antitumor agents (such as α-galactosylceramide-based immunostimulants). D-Lyxose acts as a precursor for L-nucleoside analogs used in the development of antiviral drugs. D-Lyxose can be used as a synthetic intermediate for other rare sugars (such as L-ribose) .
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- HY-W014504
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Endogenous Metabolite
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Metabolic Disease
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DL-Kynurenine is a key metabolite in the tryptophan metabolic pathway and can cross the blood-brain barrier. DL-Kynurenine has a bidirectional regulatory effect on neural excitability. DL-Kynurenine can enhance the convulsive and lethal effects caused by strychnine. DL-Kynurenine is the precursor of Kynurenic acid (HY-100806), which is an antagonist at the glycine site of NMDA receptors and can counteract excitatory toxins. DL-Kynurenine can be used for research on neurotoxicity .
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- HY-Y0669S
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Isotope-Labeled Compounds
Endogenous Metabolite
Ferroptosis
YAP
Glutathione Peroxidase
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Infection
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Pipecolic acid-d9 is the deuterium labeled Pipecolic acid. Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy .
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- HY-W001996
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Endogenous Metabolite
Drug Intermediate
Bacterial
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Infection
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6-Hydroxynicotinic acid is an intermediate in the oxidation of Nicotinic acid (HY-B0143) by Pseudomonas fluorescens and metabolite. 6-Hydroxynicotinic acid can be isolated from root exudates of Cucumis melo. 6-Hydroxynicotinic acid disrupts the Auxin signaling pathway. 6-Hydroxynicotinic acid inhibits haustoria precursor formation in Phlipanche aegyptiaca .
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- HY-Y0520R
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Methylenesuccinic acid (Standard)
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Reference Standards
Endogenous Metabolite
Ferroptosis
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Inflammation/Immunology
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Itaconic acid (Standard) is the analytical standard of Itaconic acid. This product is intended for research and analytical applications. Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid has anti-inflammatory, anti-microbial and immunomodulatory effect .
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- HY-W015851S2
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(R)-(-)-3-Hydroxybutanoic acid-13C4 sodium; (R)-3-Hydroxybutyric acid-13C4 sodium
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Isotope-Labeled Compounds
Endogenous Metabolite
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Metabolic Disease
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(R)-3-Hydroxybutanoic acid- 13C4 sodium is a 13C labeled (R)-3-Hydroxybutanoic acid (HY-W051723). (R)-3-Hydroxybutanoic acid is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones .
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- HY-148285
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Succinyl-coenzyme A; S-(Hydrogen succinyl)coenzyme A
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Endogenous Metabolite
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Metabolic Disease
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Succinyl CoA (Succinyl-coenzyme A) is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .
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- HY-W654002
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Isotope-Labeled Compounds
Endogenous Metabolite
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Others
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(3R)-3-Hydroxybutyric acid-1- 13C is 13C labeled (R)-3-Hydroxybutanoic acid. (R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones .
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- HY-N10479
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DNA/RNA Synthesis
Drug Intermediate
Endogenous Metabolite
Bacterial
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Infection
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Chorismic acid is a precursor for the biosynthesis of aromatic amino acids and vitamins, as well as a key metabolite in tRNA modification. Chorismic acid is a critical metabolite for the synthesis of cmo 5U. Deficiency of Chorismic acid inhibits the formation of cmo 5U and mcmo 5U. Chorismic acid can be used in studies of S. typhimurium and E. coli infections .\n
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- HY-113031
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16α-Hydroxy-DHEA; 16α-OH-DHEA; 16α-hydroxy DHEA
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Cytochrome P450
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Endocrinology
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16a-Hydroxydehydroisoandrosterone (16α-Hydroxy-DHEA) is a metabolite of the endogenous steroid hormone dehydroepiandrosterone. 16α-hydroxy Dehydroepiandrosterone is formed from dehydroepiandrosterone via 16-hydroxylation by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in adult human liver microsomes, as well as by fetal recombinant CYP3A7. It is a precursor to fetal estrogens, including estriol.
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- HY-W016203
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Sodium phenylpyruvate
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Endogenous Metabolite
PDI
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Infection
Metabolic Disease
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Phenylpyruvic acid sodium is a endogenous metabolite that participates in the synthesis of 3-phenyllactic acid (PLA) by lactate dehydrogenase. Phenylpyruvic acid is a precursor of the antifungal compound phenyllactic acid. Phenylpyruvic acid can improve the antifungal activity of eight lactic acid bacterial strains through the addition into a dedined growth medium. Phenylpyruvic acid demonstrates improved inhibitory activity against fungal bread contaminants Aspergillus niger and Penicillium roqueforti. Phenylpyruvic acid affects enzyme activity of the pentose phosphate pathway involved in the oxidative phase in rat brain homogenates. Phenylpyruvic acid can reduce glucose-6-phosphate dehydrogenase activity .
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- HY-128425A
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L-Ureidosuccinic acid
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Fungal
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Infection
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N-Carbamoyl-L-aspartic acid (L-Ureidosuccinic acid) is an important pyrimidine metabolic precursor and intermediate metabolite. N-Carbamoyl-L-aspartic acid reverses the growth inhibition of Ura + strains induced by 2-thiouracil (with growth rate increasing linearly with its concentration), but fails to support the growth of uracil-requiring Ura - strains. N-Carbamoyl-L-aspartic acid inhibits the cell growth of *Saccharomyces cerevisiae* by suppressing the purine biosynthetic pathway at a pre-step of 5-aminoimidazole nucleotide synthesis. The growth inhibitory effect of N-Carbamoyl-L-aspartic acid on yeast can be alleviated by purines, and the sensitivity of strains is closely related to the activity level of dihydroorotase .
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- HY-W674241A
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Endogenous Metabolite
Apoptosis
Bcl-2 Family
Reactive Oxygen Species (ROS)
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Neurological Disease
Cancer
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4-Ethylphenyl sulfate sodium is an orally active and brain-penetrant gut microbial metabolite. 4-Ethylphenyl sulfate sodium downregulates Bcl2 expression, upregulates Bax expression, and induces cancer cell apoptosis via the endogenous apoptotic pathway. 4-Ethylphenyl sulfate sodium induces G2/M cell cycle arrest and reactive oxygen species (ROS) production. 4-Ethylphenyl sulfate sodium impairs oligodendrocyte maturation, reduces oligodendrocyte-neuron interactions, decreases axonal myelination levels, and shifts the oligodendrocyte population toward immature precursor cells. 4-Ethylphenyl sulfate sodium alters brain region-specific neural activity and functional connectivity in mice, and correlates with anxiety-like behaviors in mice .
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- HY-101416
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- HY-113097
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Endogenous Metabolite
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Metabolic Disease
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3α,7α-Dihydroxycoprostanic acid is an endogenous metabolite. 3α,7α-Dihydroxycoprostanic acid, a bile acid, is the precursor to chenodeoxycholic acid .
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- HY-Y0669R
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- HY-W012264
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3-Methoxy-L-tyrosine monohydrate; 3-O-Methyl-L-DOPA monohydrate
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COMT
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Neurological Disease
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3-O-Methyldopa monohydrate (3-Methoxy-L-tyrosine monohydrate) is a significant metabolite of L-DOPA produced through the action of catechol O-methyltransferase (COMT). Unlike its precursor, 3-O-Methyldopa does not serve as a substrate or inhibitor of L-amino acid decarboxylase activity. Additionally, the inhibition of COMT can amplify the anti-Parkinson effects of L-DOPA.
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- HY-B0228S10
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(R)-(-)-3-Hydroxybutanoic acid-13C2 sodium; (R)-3-Hydroxybutyric acid-13C2 sodium
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Isotope-Labeled Compounds
Endogenous Metabolite
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Metabolic Disease
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(R)-3-Hydroxybutanoic acid- 13C2 sodium is the 13C labeled (R)-3-Hydroxybutanoic acid sodium (HY-W015851). (R)-3-Hydroxybutanoic acid sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones .
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- HY-W104075
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Drug Metabolite
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Others
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2-Amino-5-bromo-2’-chlorobenzophenone is a precursor in the synthesis of Phenazepam.1 2-Amino-5-bromo-2’-chlorobenzophenone is also an active metabolite of Phenazepam.
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- HY-B0167S1
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- HY-133068A
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COMT
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Metabolic Disease
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(E)-5-Hydroxyferulic acid is the E-isomer of 5-Hydroxyferulic acid (HY-133068). 5-hydroxyferulic acid is a hydroxycinnamic acid and is a metabolite of the phenylpropanoid pathway. 5-Hydroxyferulic acid is a precursor in the biosynthesis of sinapic acid and is also a COMT non-esterifed substrat .
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- HY-113263R
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17-OHP5 (Standard)
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Reference Standards
Endogenous Metabolite
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Metabolic Disease
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17a-Hydroxypregnenolone (Standard) is the analytical standard of 17a-Hydroxypregnenolone. This product is intended for research and analytical applications. 17a-Hydroxypregnenolone is a metabolite of Pregnenolone (HY-B0151) and a precursor in the biosynthesis of Dehydroepiandrosterone (HY-14650). 17a-Hydroxypregnenolone is a substrate for the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD) .
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- HY-113263S
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17-OHP5-d3
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Isotope-Labeled Compounds
Endogenous Metabolite
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Metabolic Disease
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17a-Hydroxypregnenolone-d3 (17-OHP5-d3) is the deuterium labeled 17a-Hydroxypregnenolone (HY-113263). 17a-Hydroxypregnenolone is a metabolite of Pregnenolone (HY-B0151) and a precursor in the biosynthesis of Dehydroepiandrosterone (HY-14650). 17a-Hydroxypregnenolone is a substrate for the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD) .
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- HY-W001996R
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Reference Standards
Endogenous Metabolite
Drug Intermediate
Bacterial
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Infection
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6-Hydroxynicotinic acid (Standard) is the analytical standard of 6-Hydroxynicotinic acid (HY-W001996). This product is intended for research and analytical applications. 6-Hydroxynicotinic acid is an intermediate in the oxidation of Nicotinic acid (HY-B0143) by Pseudomonas fluorescens and metabolite. 6-Hydroxynicotinic acid can be isolated from root exudates of Cucumis melo. 6-Hydroxynicotinic acid disrupts the Auxin signaling pathway. 6-Hydroxynicotinic acid inhibits haustoria precursor formation in Phlipanche aegyptiaca .
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- HY-128753S6
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|
Isotope-Labeled Compounds
Endogenous Metabolite
Drug Intermediate
|
Metabolic Disease
|
|
D-Lyxose-d is the deuterium labeled D-Lyxose. D-Lyxose is an endogenous metabolite. D-Lyxose is a rare pentose sugar with significant potential for drug synthesis. D-Lyxose can be used as a starting material for anti-tumor drugs such as alpha galactose ceramide immunostimulants. D-Lyxose can be used as a precursor for L-nucleoside analogs for the development of antiviral drugs. D-Lyxose can be used as a synthetic intermediate for other rare sugars such as L-ribose .
|
-
- HY-115127
-
|
m-Methoxytoluene; m-Methylanisole
|
Endogenous Metabolite
Bacterial
|
Infection
Others
|
|
Methylanisole (m-Methoxytoluene; m-MetHYlanisole) is a volatile metabolite produced by Penicillium strains growing on barley. 3-Methylanisole serves as a precursor for the biotechnological production of vanillin .
|
-
- HY-134520
-
|
|
Glucocorticoid Receptor
|
Inflammation/Immunology
|
|
21-Deacetoxy deflazacort is a dehydrogenated derivative of Deflazacort (HY-13609), a glucocorticoid, an inactive precursor that is rapidly converted to the active metabolite 21-Desacetyldeflazacort. Deflazacort acts as an anti-inflammatory and immunosuppressant .
|
-
- HY-124265S1
-
-
- HY-N0122R
-
-
- HY-124265R
-
|
|
Reference Standards
Endogenous Metabolite
|
Metabolic Disease
|
|
4β-hydroxy Cholesterol (Standard) is the analytical reference standard of 4β-hydroxy Cholesterol (HY-124265). This product is used for research and analytical applications. 4β-Hydroxycholesterol is a major Cholesterol (HY-N0322) metabolite and a precursor in the synthesis of bile acids that is found in human circulation .
|
-
- HY-113224R
-
|
|
Reference Standards
Endogenous Metabolite
LXR
Fatty Acid Synthase (FASN)
Interleukin Related
Reactive Oxygen Species (ROS)
NOD-like Receptor (NLR)
|
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
|
|
Desmosterol (Standard) is the analytical standard of Desmosterol. This product is intended for research and analytical applications. Desmosterol is a cholesterol-like molecule. In the Bloch pathway of cholesterol biosynthesis, Desmosterol is a direct precursor of cholesterol. As an endogenous metabolite, Desmosterol is used to study cholesterol metabolism [1]. Desmosterol is an LXR activator and SREBP inhibitor, which can suppress macrophage inflammasome activation and prevent vascular inflammation and atherosclerosis. A reduction in Desmosterol promotes the production of mitochondrial reactive oxygen species (ROS) in macrophages and pyrin domain-dependent inflammasome activation of NLRP3. Desmosterol holds potential for research in inflammation, metabolism, and cardiovascular diseases [1][2][3].
|
-
- HY-125538
-
-
- HY-101416R
-
-
- HY-114687
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
Others
|
|
5,7-Dihydroxy-11-ketotetranorprostanoic acid is a urinary metabolite of prostaglandin F2α and precursor to tetranor-PGF metabolites, exhibits hardly activity in blood pressure assay and smooth muscle stiumulation assay .
|
-
- HY-N8400
-
|
|
Endogenous Metabolite
|
Others
|
|
Roridin L2, a fungal metabolite, is a biosynthetic precursor of Satratoxin G. Roridin L2 possesses little in vitro or in vivo toxic activity .
|
-
- HY-N7080R
-
|
Hydroferulic acid (Standard)
|
Drug Metabolite
Reference Standards
|
Metabolic Disease
|
|
Dihydroferulic acid (Standard) is the analytical standard of Dihydroferulic acid. This product is intended for research and analytical applications. Dihydroferulic acid (Hydroferulic acid) is one of the main metabolites of curcumin and antioxidant/radical-scavenging properties with an IC50 value of 19.5 μM. Dihydroferulic acid is a metabolite of human gut microflora as well as a precursor of vanillic acid[1][2].
|
-
- HY-168779
-
-
- HY-N6740R
-
|
|
Reference Standards
Apoptosis
|
Metabolic Disease
|
|
(±)-Nornicotine (Standard) is the analytical standard of (±)-Nornicotine. This product is intended for research and analytical applications. (±)-Nornicotine is the primary metabolite of nicotine that is formed through demethylation of nicotine in the genus Nicotiana tabacum L. (±)-Nornicotine is a precursor of tobacco-specific nitrosamine N-nitrosonornicotine. (±)-Nornicotine has detrimental effects to human health .
|
-
- HY-W002112R
-
|
Nornicotine (Standard)
|
Reference Standards
Endogenous Metabolite
Drug Metabolite
nAChR
β-catenin
|
Cardiovascular Disease
Neurological Disease
|
|
(±)-Nornicotine (Standard) is the analytical standard of (±)-Nornicotine (HY-W002112). This product is intended for research and analytical applications. (±)-Nornicotine is a major metabolite of Nicotine. (±)-Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±)-Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±)-Nornicotine supports self-administration behavior. (±)-Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia .
|
-
- HY-W744098
-
|
1-DHC 21-acetate
|
Drug Derivative
|
Metabolic Disease
|
|
1-Dehydrocorticosterone 21-acetate is an acetylated derivative of corticosterone (HY-B1618) that is dehydrogenated at the one position. It has been used as a precursor in the synthesis of 21-hydroxypregna-1,4-diene-3,11,20-trione, which is a metabolite of 1α-hydroxycorticosterone in the skate.
|
-
- HY-170229
-
|
1-O-Heptadecyl-2-hydroxy-sn-glycero-3-phosphocholine
|
Biochemical Assay Reagents
|
Others
|
|
C17 Lyso PAF (1-O-Heptadecyl-2-hydroxy-sn-glycero-3-phosphocholine) is a precursor and metabolite of 1-O-heptadecyl-2-acetyl-sn-glycero-3-phosphocholine (C17:0 PAF) .
|
-
- HY-N9923
-
|
|
Bacterial
|
Infection
|
|
2-C-Methyl-D-erythritol 4-phosphate is a metabolite intermediate exclusive to the non-mevalonate MEP pathway, predominantly found in prokaryotes, serving as a precursor for the synthesis of isoprenoids and non-isoprenoids, including vitamins; its absence in humans makes it a promising target for the development of bacterium-specific drugs aimed at treating infectious diseases.
|
-
- HY-134520R
-
|
|
Glucocorticoid Receptor
Reference Standards
|
Inflammation/Immunology
|
|
21-Deacetoxy deflazacort (Standard) is the analytical standard of 21-Deacetoxy deflazacort. This product is intended for research and analytical applications. 21-Deacetoxy deflazacort is a dehydrogenated derivative of Deflazacort (HY-13609), a glucocorticoid, an inactive precursor that is rapidly converted to the active metabolite 21-Desacetyldeflazacort. Deflazacort acts as an anti-inflammatory and immunosuppressant .
|
-
- HY-137551R
-
|
|
Herbicide
Reference Standards
|
Others
|
|
21-Deacetoxy deflazacort (Standard) is the analytical standard of 21-Deacetoxy deflazacort. This product is intended for research and analytical applications. 21-Deacetoxy deflazacort is a dehydrogenated derivative of Deflazacort (HY-13609), a glucocorticoid, an inactive precursor that is rapidly converted to the active metabolite 21-Desacetyldeflazacort. Deflazacort acts as an anti-inflammatory and immunosuppressant .
|
-
- HY-115127S
-
|
m-Methoxytoluene-d3; m-Methylanisole-d3
|
Isotope-Labeled Compounds
Endogenous Metabolite
Bacterial
|
Infection
|
|
3-Methylanisole-d3 (m-Methoxytoluene-d3; m-MetHYlanisole-d3) is the deuterium labeled 3-Methylanisole (HY-115127) . Methylanisole is a volatile metabolite produced by Penicillium strains growing on barley. 3-Methylanisole serves as a precursor for the biotechnological production of vanillin .
|
-
- HY-N6660R
-
|
Tricaprin (Standard); Glyceryl tridecanoate (Standard)
|
Reference Standards
Endogenous Metabolite
Androgen Receptor
|
Metabolic Disease
|
|
Trisdecanoin (Standard) is the analytical standard of Trisdecanoin. This product is intended for research and analytical applications. Trisdecanoin (Tricaprin; Glyceryl tridecanoate) is an orally available precursor of decanoic acid (DA precursor) that can be hydrolyzed to decanoic acid. Trisdecanoin and its metabolite capric acid not only provide the body with a quick source of energy, but can also affect lipid metabolism. Trisdecanoin is a major component of medium chain triglycerides (MCT), which has preventive or inhibitory properties for abdominal aortic aneurysms (AAA), inhibition of cardiovascular disease, and anti-androgen (NSAA) and anti-hyperglycemic properties. Trisdecanoin can be used as an additive in food, medicine and cosmetics .
|
-
- HY-113097S1
-
-
- HY-128742R
-
|
|
Reference Standards
Endogenous Metabolite
Drug Derivative
|
Metabolic Disease
|
|
Thiamine monophosphate chloride dihydrate (Standard) is an analytical standard for Thiamine monophosphate chloride dihydrate (HY-128742). This product is intended for use in research and analytical applications. Thiamine monophosphate chloride dihydrate is a vitamin B1 (HY-A0100) metabolite and thiamine precursor. Thiamine monophosphate chloride dihydrate is absorbable in vivo and can be converted into thiamine. Thiamine monophosphate chloride dihydrate can be used as a food additive .
|
-
- HY-113097S
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
3α,7α-Dihydroxycoprostanic acid-d3 is the deuterium labeled 3α,7α-Dihydroxycoprostanic acid (HY-113097) . 3α,7α-Dihydroxycoprostanic acid is an endogenous metabolite. 3α,7α-Dihydroxycoprostanic acid, a bile acid, is the precursor to chenodeoxycholic acid .
|
-
- HY-W051723R
-
|
(R)-(-)-3-Hydroxybutanoic acid (Standard); (R)-3-Hydroxybutyric acid (Standard)
|
Reference Standards
Endogenous Metabolite
|
Metabolic Disease
|
|
(R)-3-Hydroxybutanoic acid (Standard) is the analytical standard of (R)-3-Hydroxybutanoic acid. This product is intended for research and analytical applications. (R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones[1][2].
|
-
- HY-W015851R
-
|
(R)-(-)-3-Hydroxybutanoic acid sodium (Standard); (R)-3-Hydroxybutyric acid sodium (Standard)
|
Reference Standards
Endogenous Metabolite
|
Metabolic Disease
|
|
(R)-3-Hydroxybutanoic acid (sodium) (Standard) is the analytical standard of (R)-3-Hydroxybutanoic acid (sodium). This product is intended for research and analytical applications. (R)-3-Hydroxybutanoic acid ((R)-3-Hydroxybutyric acid) sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones[1][2].
|
-
- HY-113263S1
-
|
17-OHP5-13C2,d2
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
17α-Hydroxypregnenolone- 13C2,d2 is the deuterium and 13C labeled 17α-Hydroxypregnenolone . 17a-Hydroxypregnenolone is a metabolite of Pregnenolone (HY-B0151) and a precursor in the biosynthesis of Dehydroepiandrosterone (HY-14650). 17a-Hydroxypregnenolone is a substrate for the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD) .
|
-
- HY-148285A
-
|
Succinyl-coenzyme A disodium; S-(Hydrogen succinyl)coenzyme A disodium
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Succinyl CoA (Succinyl-coenzyme A) disodium is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA disodium is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA disodium acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA disodium insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl-Coenzyme A sodium can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .
|
-
- HY-128753S7
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
Drug Intermediate
|
Metabolic Disease
|
|
D-Lyxose-d-1 is the deuterium labeled D-Lyxose. D-Lyxose is an endogenous metabolite. D-Lyxose is a rare pentose sugar with significant potential for drug synthesis. D-Lyxose can be used as a starting material for anti-tumor drugs such as alpha galactose ceramide immunostimulants. D-Lyxose can be used as a precursor for L-nucleoside analogs for the development of antiviral drugs. D-Lyxose can be used as a synthetic intermediate for other rare sugars such as L-ribose .
|
-
- HY-128748R
-
|
|
Endogenous Metabolite
Reference Standards
|
Others
|
|
DL-Glyceraldehyde (Standard) is the analytical standard of DL-Glyceraldehyde. This product is intended for research and analytical applications. DL-Glyceraldehyde is a bioactive substance involved in cellular energy metabolism and a key intermediate in sugar metabolism pathways (such as glycolysis and gluconeogenesis). During glycolysis, DL-Glyceraldehyde is converted by enzymes into other metabolites to provide energy for cells; during gluconeogenesis, DL-Glyceraldehyde participates in the synthesis of glucose as a precursor. In the field of medical research, DL-Glyceraldehyde can be used to study diseases related to sugar metabolism, such as diabetes, tumors, etc .
|
-
- HY-W014504S1
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
DL-Kynurenine-d7 is the deuterium labeled DL-Kynurenine. DL-Kynurenine is a key metabolite in the tryptophan metabolic pathway and can cross the blood-brain barrier. DL-Kynurenine has a bidirectional regulatory effect on neural excitability. DL-Kynurenine can enhance the convulsive and lethal effects caused by strychnine. DL-Kynurenine is the precursor of Kynurenic acid (HY-100806), which is an antagonist at the glycine site of NMDA receptors and can counteract excitatory toxins. DL-Kynurenine can be used for research on neurotoxicity.
|
-
- HY-128753S5
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
Drug Intermediate
|
Others
|
|
D-Lyxose- 13C-4 is the 13C labeled D-Lyxose. D-Lyxose is an endogenous metabolite. D-Lyxose is a rare pentose sugar with significant potential for drug synthesis. D-Lyxose can be used as a starting material for anti-tumor drugs such as alpha galactose ceramide immunostimulants. D-Lyxose can be used as a precursor for L-nucleoside analogs for the development of antiviral drugs. D-Lyxose can be used as a synthetic intermediate for other rare sugars such as L-ribose .
|
-
- HY-128753R
-
|
|
Reference Standards
Endogenous Metabolite
Drug Intermediate
|
Metabolic Disease
|
|
D-Lyxose (Standard) is the analytical standard of D-Lyxose. This product is intended for research and analytical applications. D-Lyxose is an endogenous metabolite. D-Lyxose is a rare pentose sugar with significant potential for drug synthesis. D-Lyxose can be used as a starting material for anti-tumor drugs such as alpha galactose ceramide immunostimulants. D-Lyxose can be used as a precursor for L-nucleoside analogs for the development of antiviral drugs. D-Lyxose can be used as a synthetic intermediate for other rare sugars such as L-ribose .
|
-
- HY-128753S3
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
Drug Intermediate
|
Others
|
|
D-Lyxose- 13C-2 is the 13C labeled D-Lyxose. D-Lyxose is an endogenous metabolite. D-Lyxose is a rare pentose sugar with significant potential for drug synthesis. D-Lyxose can be used as a starting material for anti-tumor drugs such as alpha galactose ceramide immunostimulants. D-Lyxose can be used as a precursor for L-nucleoside analogs for the development of antiviral drugs. D-Lyxose can be used as a synthetic intermediate for other rare sugars such as L-ribose .
|
-
- HY-128753S4
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
Drug Intermediate
|
Others
|
|
D-Lyxose- 13C-3 is the 13C labeled D-Lyxose. D-Lyxose is an endogenous metabolite. D-Lyxose is a rare pentose sugar with significant potential for drug synthesis. D-Lyxose can be used as a starting material for anti-tumor drugs such as alpha galactose ceramide immunostimulants. D-Lyxose can be used as a precursor for L-nucleoside analogs for the development of antiviral drugs. D-Lyxose can be used as a synthetic intermediate for other rare sugars such as L-ribose .
|
-
- HY-W014504R
-
|
|
Reference Standards
Endogenous Metabolite
|
Metabolic Disease
|
|
DL-Kynurenine (Standard) is the analytical standard of DL-Kynurenine. This product is intended for research and analytical applications. DL-Kynurenine is a key metabolite in the tryptophan metabolic pathway and can cross the blood-brain barrier. DL-Kynurenine has a bidirectional regulatory effect on neural excitability. DL-Kynurenine can enhance the convulsive and lethal effects caused by strychnine. DL-Kynurenine is the precursor of Kynurenic acid (HY-100806), which is an antagonist at the glycine site of NMDA receptors and can counteract excitatory toxins. DL-Kynurenine can be used for research on neurotoxicity.
|
-
- HY-W014277
-
|
|
Environmental Pollutants
Drug Metabolite
|
Others
|
|
2,6-Diisopropylnaphthalene is a substituted naphthalene compound and metabolite precursor. 2,6-Diisopropylnaphthalene undergoes metabolism exclusively via oxidation of its isopropyl chain in Rattus norvegicus (rats), producing five major unconjugated urinary metabolites. 2,6-Diisopropylnaphthalene forms glucuronide conjugates of these metabolites, and a small amount of unchanged compound is excreted in urine .
|
-
- HY-W740123
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
8-Hydroxy mianserin is a synthetic metabolite of Mianserin (HY-B0188). 8-Hydroxy mianserin serves as a precursor for the chemical synthesis of mianserin metabolite derivatives .
|
-
- HY-N17686
-
|
|
Drug Metabolite
|
Endocrinology
|
|
Androstenediol 3-sulfate is a metabolite DHEA sulfate (HY-113416). Androstenediol 3-sulfate is a key precursor for the synthesis of androgens in the testes and plays a significant role in the self-regulatory pathway of androgen synthesis .
|
-
- HY-171664
-
|
ent-CPP
|
Endogenous Metabolite
|
Others
|
|
ent-Copalyl diphosphate (ent-CPP) is a terpenoid precursor and metabolite involved in plant biosynthetic pathways. ent-Copalyl diphosphate participates in metabolism of natural products including phytoalexins in rice and maize, and steviol glycoside in Stevia rebaudiana .
|
-
- HY-N10619
-
|
|
Drug Intermediate
|
Metabolic Disease
|
|
Gibberellin A12 is a free C20-gibberellin, serving as a gibberellin biosynthesis intermediate and metabolite precursor. Gibberellin A12 exists in maturing Sechium edule seed testa, developing Pisum sativum seeds and Gibberella fujikuroi .
|
-
- HY-182429
-
|
|
Beta-secretase
Cathepsin
Amyloid-β
|
Neurological Disease
|
|
NB-533 is an orally active and brain-penetrant BACE-1 inhibitor with a human IC50 of 0.002 μM. NB-533 also inhibits human cathepsin D with an IC50 of 0.001 μM. NB-533 inhibits amyloidogenic amyloid precursor protein (APP) processing and reduces Aβ40 release. NB-533 reduces brain levels of APP metabolite C99 and Aβ40 in transgenic mice. NB-533 can be used for the research of Alzheimer’s disease .
|
-
- HY-134837
-
|
|
Endogenous Metabolite
|
Others
|
|
(3α,5β,7α,25R)-3,7-Dihydroxycholestan-26-oic acid (compound (25S)-3α,7α-dihydroxy-5β-cholestanoyl-CoA) is a Ursodeoxycholic Acid (HY-13771) precursor. (3α,5β,7α,25R)-3,7-Dihydroxycholestan-26-oic acid is a key intermediary metabolite in the pathway of bile acid biosynthesis .
|
-
- HY-B1686
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Menthyl salicylate is a flavor ingredient and a volatile flavor compound. Menthyl salicylate imparts a fresh mint-like aroma to black tea. Menthyl salicylate can be used in studies related to the aroma of black tea and the behavior of ingredients in cosmetic formulations [1] .
|
-
- HY-124404
-
|
|
Aryl Hydrocarbon Receptor
Na+/K+ ATPase
Prostaglandin Receptor
|
Inflammation/Immunology
|
|
12(R)-HETE is a CYP-dependent arachidonic acid metabolite that acts as a proinflammatory lipid mediator. 12 (R)-HETE widely exists in various tissues including the eye, skin and liver. In the cornea, 12(R)-HETE is metabolized via pathways such as β-oxidation into the precursor of 12(R)-HETrE. Without direct receptor binding, 12(R)-HETE indirectly activates AHR-mediated target gene transcription, while inhibiting the enzymatic activity of Na+,K+-ATPase and the intracellular calcium elevation induced by TP agonists. 12(R)-HETE also possesses multiple physiological effects such as chemotaxis, proangiogenesis, vasodilation, natriuresis, diuresis and intraocular pressure reduction, and can be widely used in studies related to psoriasis, inflammatory skin diseases and ocular inflammation .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-W014018
-
|
PPO; DPO; POP
|
Biochemical Assay Reagents
|
|
2,5-Diphenyloxazole (PPO; DPO; POP) is a fluorescent dye, as well as a substrate and metabolite precursor of cytochrome P-450 (cytochrome P-448/P1-450). 2,5-Diphenyloxazole serves as a scintillator .
|
-
- HY-Y0669R
-
|
|
Biochemical Assay Reagents
|
|
Pipecolic acid (Standard) is the analytical standard of Pipecolic acid. This product is intended for research and analytical applications. Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy .
|
-
- HY-170229
-
|
1-O-Heptadecyl-2-hydroxy-sn-glycero-3-phosphocholine
|
Biochemical Assay Reagents
|
|
C17 Lyso PAF (1-O-Heptadecyl-2-hydroxy-sn-glycero-3-phosphocholine) is a precursor and metabolite of 1-O-heptadecyl-2-acetyl-sn-glycero-3-phosphocholine (C17:0 PAF) .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-N0122
-
-
-
- HY-Y0520
-
-
-
- HY-W015851
-
|
(R)-(-)-3-Hydroxybutanoic acid sodium; (R)-3-Hydroxybutyric acid sodium
|
Ketones, Aldehydes, Acids
Endogenous metabolite
Source Classification
|
Endogenous Metabolite
|
|
(R)-3-Hydroxybutanoic acid ((R)-3-Hydroxybutyric acid) sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones .
|
-
-
- HY-W051723
-
-
-
- HY-113263
-
-
-
- HY-126370A
-
-
-
- HY-137808
-
-
-
- HY-128748
-
-
-
- HY-113224
-
-
-
- HY-124265
-
-
-
- HY-N7080
-
-
-
- HY-W002112
-
-
-
- HY-119663
-
-
-
- HY-114297
-
-
-
- HY-133068
-
-
-
- HY-128742
-
-
-
- HY-122009
-
-
-
- HY-W096638A
-
|
(S)-Glycerolphosphocholine
|
Structural Classification
Human Gut Microbiota Metabolites
Ketones, Aldehydes, Acids
Endogenous metabolite
Source Classification
|
Endogenous Metabolite
|
|
Glycerophosphocholine ((S)-Glycerolphosphocholine) is an orally active metabolite that crosses the blood-brain barrier. Glycerophosphocholine acts as a precursor of acetylcholine, a specific marker for phosphatidylcholine breakdown, a major water-soluble storage form of choline, and an intermediate in phosphatidylcholine metabolism. Glycerophosphocholine is specifically elevated in the cerebrospinal fluid of Alzheimer's disease models, and it also promotes growth hormone secretion and fat oxidation. Glycerophosphocholine is also a potential biomarker for breast cancer .
|
-
-
- HY-126370
-
-
-
- HY-N6660
-
|
Tricaprin; Glyceryl tridecanoate
|
Ketones, Aldehydes, Acids
umbellularia californica
Metabolic Disease
Plants
Lauraceae
Disease Research Fields
Source Classification
|
Endogenous Metabolite
Androgen Receptor
|
|
Trisdecanoin (Tricaprin; Glyceryl tridecanoate) is an orally available precursor of decanoic acid (DA precursor) that can be hydrolyzed to decanoic acid. Trisdecanoin and its metabolite capric acid not only provide the body with a quick source of energy, but can also affect lipid metabolism. Trisdecanoin is a major component of medium chain triglycerides (MCT), which has preventive or inhibitory properties for abdominal aortic aneurysms (AAA), inhibition of cardiovascular disease, and anti-androgen (NSAA) and anti-hyperglycemic properties. Trisdecanoin can be used as an additive in food, medicine and cosmetics .
|
-
-
- HY-33893
-
-
-
- HY-128753
-
-
-
- HY-W014504
-
-
-
- HY-W001996
-
-
-
- HY-Y0520R
-
-
-
- HY-148285
-
|
Succinyl-coenzyme A; S-(Hydrogen succinyl)coenzyme A
|
Human Gut Microbiota Metabolites
Microorganisms
Endogenous metabolite
Source Classification
|
Endogenous Metabolite
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Succinyl CoA (Succinyl-coenzyme A) is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .
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- HY-N10479
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- HY-128425A
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L-Ureidosuccinic acid
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Structural Classification
Natural Products
Classification of Application Fields
Other Diseases
Endogenous metabolite
Disease Research Fields
Source Classification
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Fungal
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N-Carbamoyl-L-aspartic acid (L-Ureidosuccinic acid) is an important pyrimidine metabolic precursor and intermediate metabolite. N-Carbamoyl-L-aspartic acid reverses the growth inhibition of Ura + strains induced by 2-thiouracil (with growth rate increasing linearly with its concentration), but fails to support the growth of uracil-requiring Ura - strains. N-Carbamoyl-L-aspartic acid inhibits the cell growth of *Saccharomyces cerevisiae* by suppressing the purine biosynthetic pathway at a pre-step of 5-aminoimidazole nucleotide synthesis. The growth inhibitory effect of N-Carbamoyl-L-aspartic acid on yeast can be alleviated by purines, and the sensitivity of strains is closely related to the activity level of dihydroorotase .
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- HY-W674241A
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- HY-101416
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- HY-113097
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- HY-W001996R
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- HY-N0122R
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- HY-124265R
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- HY-113224R
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- HY-125538
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- HY-101416R
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- HY-N8400
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- HY-N7080R
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- HY-N6740R
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- HY-W002112R
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- HY-N9923
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- HY-N6660R
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Tricaprin (Standard); Glyceryl tridecanoate (Standard)
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Ketones, Aldehydes, Acids
umbellularia californica
Plants
Lauraceae
Source Classification
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Reference Standards
Endogenous Metabolite
Androgen Receptor
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Trisdecanoin (Standard) is the analytical standard of Trisdecanoin. This product is intended for research and analytical applications. Trisdecanoin (Tricaprin; Glyceryl tridecanoate) is an orally available precursor of decanoic acid (DA precursor) that can be hydrolyzed to decanoic acid. Trisdecanoin and its metabolite capric acid not only provide the body with a quick source of energy, but can also affect lipid metabolism. Trisdecanoin is a major component of medium chain triglycerides (MCT), which has preventive or inhibitory properties for abdominal aortic aneurysms (AAA), inhibition of cardiovascular disease, and anti-androgen (NSAA) and anti-hyperglycemic properties. Trisdecanoin can be used as an additive in food, medicine and cosmetics .
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- HY-128742R
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- HY-W051723R
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- HY-W015851R
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(R)-(-)-3-Hydroxybutanoic acid sodium (Standard); (R)-3-Hydroxybutyric acid sodium (Standard)
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Structural Classification
Ketones, Aldehydes, Acids
Endogenous metabolite
Source Classification
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Reference Standards
Endogenous Metabolite
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(R)-3-Hydroxybutanoic acid (sodium) (Standard) is the analytical standard of (R)-3-Hydroxybutanoic acid (sodium). This product is intended for research and analytical applications. (R)-3-Hydroxybutanoic acid ((R)-3-Hydroxybutyric acid) sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones[1][2].
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- HY-128748R
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- HY-128753R
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- HY-W014504R
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- HY-N17686
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- HY-171664
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- HY-N10619
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- HY-134837
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- HY-B1686
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| Cat. No. |
Product Name |
Chemical Structure |
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- HY-124265S
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4β-Hydroxycholesterol-d7 is the deuterium labeled 4β-Hydroxycholesterol (HY-124265). 4β-Hydroxycholesterol is a major Cholesterol (HY-N0322) metabolite and a precursor in the synthesis of bile acids that is found in human circulation .
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- HY-113224S
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Desmosterol-d6 is the deuterium labeled Desmosterol. Desmosterol is a molecule similar to cholesterol. Desmosterol is the immediate precursor of cholesterol in the Bloch pathway of cholesterol biosynthesis. Desmosterol, as an endogenous metabolite, used to study cholesterol metabolism .
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- HY-Y0520S
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Itaconic acid- 13C5 is the 13C labeled Itaconic acid. Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors .
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- HY-124265S2
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4β-Hydroxycholesterol-d4 is the deuterium labeled 4β-Hydroxycholesterol (HY-124265) . 4β-Hydroxycholesterol is a major Cholesterol (HY-N0322) metabolite and a precursor in the synthesis of bile acids that is found in human circulation .
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- HY-Y0669S
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Pipecolic acid-d9 is the deuterium labeled Pipecolic acid. Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy .
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- HY-W015851S2
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(R)-3-Hydroxybutanoic acid- 13C4 sodium is a 13C labeled (R)-3-Hydroxybutanoic acid (HY-W051723). (R)-3-Hydroxybutanoic acid is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones .
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- HY-W654002
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(3R)-3-Hydroxybutyric acid-1- 13C is 13C labeled (R)-3-Hydroxybutanoic acid. (R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones .
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- HY-B0228S10
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(R)-3-Hydroxybutanoic acid- 13C2 sodium is the 13C labeled (R)-3-Hydroxybutanoic acid sodium (HY-W015851). (R)-3-Hydroxybutanoic acid sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones .
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- HY-B0167S1
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Salicylic acid- 13C6 is the 13C-labeled Salicylic acid (HY-B0167). Salicylic acid is a precursor to and a metabolite of Aspirin (HY-14654), can inhibit cyclo-oxygenase-2 (COX-2) activity .
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- HY-113263S
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17a-Hydroxypregnenolone-d3 (17-OHP5-d3) is the deuterium labeled 17a-Hydroxypregnenolone (HY-113263). 17a-Hydroxypregnenolone is a metabolite of Pregnenolone (HY-B0151) and a precursor in the biosynthesis of Dehydroepiandrosterone (HY-14650). 17a-Hydroxypregnenolone is a substrate for the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD) .
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- HY-128753S6
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D-Lyxose-d is the deuterium labeled D-Lyxose. D-Lyxose is an endogenous metabolite. D-Lyxose is a rare pentose sugar with significant potential for drug synthesis. D-Lyxose can be used as a starting material for anti-tumor drugs such as alpha galactose ceramide immunostimulants. D-Lyxose can be used as a precursor for L-nucleoside analogs for the development of antiviral drugs. D-Lyxose can be used as a synthetic intermediate for other rare sugars such as L-ribose .
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- HY-124265S1
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4β-Hydroxycholesterol-d5 is the deuterium labeled 4β-Hydroxycholesterol (HY-124265). 4β-Hydroxycholesterol is a major Cholesterol (HY-N0322) metabolite and a precursor in the synthesis of bile acids that is found in human circulation .
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- HY-115127S
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3-Methylanisole-d3 (m-Methoxytoluene-d3; m-MetHYlanisole-d3) is the deuterium labeled 3-Methylanisole (HY-115127) . Methylanisole is a volatile metabolite produced by Penicillium strains growing on barley. 3-Methylanisole serves as a precursor for the biotechnological production of vanillin .
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- HY-113097S1
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3α,7α-Dihydroxycoprostanic acid-d5 is deuterium labeled 3α,7α-Dihydroxycoprostanic acid. 3α,7α-Dihydroxycoprostanic acid is an endogenous metabolite. 3α,7α-Dihydroxycoprostanic acid, a bile acid, is the precursor to chenodeoxycholic acid .
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- HY-113097S
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3α,7α-Dihydroxycoprostanic acid-d3 is the deuterium labeled 3α,7α-Dihydroxycoprostanic acid (HY-113097) . 3α,7α-Dihydroxycoprostanic acid is an endogenous metabolite. 3α,7α-Dihydroxycoprostanic acid, a bile acid, is the precursor to chenodeoxycholic acid .
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- HY-113263S1
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17α-Hydroxypregnenolone- 13C2,d2 is the deuterium and 13C labeled 17α-Hydroxypregnenolone . 17a-Hydroxypregnenolone is a metabolite of Pregnenolone (HY-B0151) and a precursor in the biosynthesis of Dehydroepiandrosterone (HY-14650). 17a-Hydroxypregnenolone is a substrate for the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD) .
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- HY-128753S7
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D-Lyxose-d-1 is the deuterium labeled D-Lyxose. D-Lyxose is an endogenous metabolite. D-Lyxose is a rare pentose sugar with significant potential for drug synthesis. D-Lyxose can be used as a starting material for anti-tumor drugs such as alpha galactose ceramide immunostimulants. D-Lyxose can be used as a precursor for L-nucleoside analogs for the development of antiviral drugs. D-Lyxose can be used as a synthetic intermediate for other rare sugars such as L-ribose .
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- HY-W014504S1
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DL-Kynurenine-d7 is the deuterium labeled DL-Kynurenine. DL-Kynurenine is a key metabolite in the tryptophan metabolic pathway and can cross the blood-brain barrier. DL-Kynurenine has a bidirectional regulatory effect on neural excitability. DL-Kynurenine can enhance the convulsive and lethal effects caused by strychnine. DL-Kynurenine is the precursor of Kynurenic acid (HY-100806), which is an antagonist at the glycine site of NMDA receptors and can counteract excitatory toxins. DL-Kynurenine can be used for research on neurotoxicity.
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- HY-128753S5
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D-Lyxose- 13C-4 is the 13C labeled D-Lyxose. D-Lyxose is an endogenous metabolite. D-Lyxose is a rare pentose sugar with significant potential for drug synthesis. D-Lyxose can be used as a starting material for anti-tumor drugs such as alpha galactose ceramide immunostimulants. D-Lyxose can be used as a precursor for L-nucleoside analogs for the development of antiviral drugs. D-Lyxose can be used as a synthetic intermediate for other rare sugars such as L-ribose .
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- HY-128753S3
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D-Lyxose- 13C-2 is the 13C labeled D-Lyxose. D-Lyxose is an endogenous metabolite. D-Lyxose is a rare pentose sugar with significant potential for drug synthesis. D-Lyxose can be used as a starting material for anti-tumor drugs such as alpha galactose ceramide immunostimulants. D-Lyxose can be used as a precursor for L-nucleoside analogs for the development of antiviral drugs. D-Lyxose can be used as a synthetic intermediate for other rare sugars such as L-ribose .
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- HY-128753S4
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D-Lyxose- 13C-3 is the 13C labeled D-Lyxose. D-Lyxose is an endogenous metabolite. D-Lyxose is a rare pentose sugar with significant potential for drug synthesis. D-Lyxose can be used as a starting material for anti-tumor drugs such as alpha galactose ceramide immunostimulants. D-Lyxose can be used as a precursor for L-nucleoside analogs for the development of antiviral drugs. D-Lyxose can be used as a synthetic intermediate for other rare sugars such as L-ribose .
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| Cat. No. |
Product Name |
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Classification |
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- HY-141570
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Phospholipids
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Lyso-PAF C-16 is a precursor and metabolite of 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (PAF C-16). Lyso-PAF C-16 is a substrate for either PAF C-16 formation by the remodeling pathway or selective acylation with arachidonic acid by a CoA-independent transacylase .
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