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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
microtubule organization
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "microtubule organization" in MCE Product Catalog:
3
3 Cited Publications
Synonyms: HTI-286; SPA-110
Target:
Research Areas:
Taltobulin (HTI-286), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis .
3
3 Cited Publications
Cat. No.: HY-15584A
CAS No.: 228266-41-9
Synonyms: HTI-286 trifluoroacetate; SPA-110 trifluoroacetate
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Taltobulin trifluoroacetate (HTI-286 trifluoroacetate), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin trifluoroacetate inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis .
3
3 Cited Publications
Cat. No.: HY-15584B
Purity: 99.34%
Synonyms: HTI-286 hydrochloride; SPA-110 hydrochloride
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Research Areas:
Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin hydrochloride inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis .
Cat. No.: HY-113722
CAS No.: 107401-70-7
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DAT1 is a potent antimitotic agent with anticancer effects. In HeLa cells, DAT1 blocks the spindle function by disturbing spindle microtubule and chromosome organization .
Cat. No.: HY-122228
CAS No.: 671181-94-5
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Cestrin is a plant cellulose synthase complex (CESA) trafficking inhibitor. Cestrin selectively blocks the sustained trafficking of cellulose synthase complexes (CSCs) and the interaction between CSC and POM2, which indirectly causes secondary destabilization of cortical microtubules (MTs). Cestrin reduces cellulose content, inhibits anisotropic cell growth, induces cell swelling and decreases cell elongation. Cestrin is applicable to plant cell biology research .
Cat. No.: HY-126556
CAS No.: 53760-20-6
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Target:
Cat. No.: HY-146261
CAS No.: 2411548-90-6
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HI5 is a potent tublin and IDO inhibitor, with an IC50 value of 70 nM in HeLa cells. HI5 inhibit IDO expression and decrease kynurenine production, leading to stimulating T cells activation and proliferation. HI5 can inhibit tubulin polymerization and cell migration, cause G2/M phase arrest, and induce apoptosis via the mitochondrial dependent apoptosis pathway and cause reactive oxidative stress generation in HeLa cells. HI5 can be used for researching anticancer .
Cat. No.: HY-147947
CAS No.: 2521560-46-1
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Tubulin polymerization-IN-30 (compound 6e) is a potent Tubulin polymerization inhibitor. Tubulin polymerization-IN-30 is a colchicine binding site inhibitor. Tubulin polymerization-IN-30 can disrupt intracellular microtubule organization, arrest cell cycle at the G2/M phase. Tubulin polymerization-IN-30 exhibits the high potency against the cancer cell lines including SGC-7901, A549 and HeLa, with IC50 values of 2.16, 2.21, and 0.403 μM .
Cat. No.: HY-181019
Research Areas:
iMPZ-8 is a β-tubulin polymerization inhibitor that inhibits β-tubulin protein expression, disrupts microtubule structure, impairs microtubule organization. iMPZ-8 inhibits proliferation and reduces cellular migration and colonization in cancer cells. iMPZ-8 induces G2/M phase arrestand induces apoptosis via the BAX-Caspase-3 intrinsic apoptotic signaling pathway. iMPZ-8 can be used for the research of cancer, suah as breast cancer, neuroblastoma and colon cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
