5 Results for "

osteogenic marker genes

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "osteogenic marker genes" in MCE Product Catalog:

Mucic acid
Mucic acid
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Cat. No.: HY-W014410
CAS No.: 526-99-8
Category:  

Microorganisms Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

RUNX

Mucic acid is an aldonic acid that can be prepared from pectin. Mucic acid increases the expression level of Runx2, promotes osteoblast differentiation, and upregulates osteogenic differentiation marker genes. Mucic acid can be used to prepare platform compounds, polymers, polymer materials and metal-organic frameworks. Mucic acid is applicable to the research of bone-related defects .
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2-Aminoacetamide hydrochloride
2-Aminoacetamide hydrochloride
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Cat. No.: HY-Y1123
CAS No.: 1668-10-6
Synonyms: Glycinamide hydrochloride
2-Aminoacetamide hydrochloride (Glycinamide hydrochloride) is a derivative of Glycine (HY-Y0966). 2-Aminoacetamide hydrochloride forms cell-absorbable nanocomplexes with proteins (such as bovine serum albumin) through strong electrostatic interactions, promoting cellular uptake of related proteins. 2-Aminoacetamide hydrochloride synergizes with BMP2 to upregulate the expression of osteogenic marker genes (such as Col1a1, Alp, Runx2) and proteins (such as COL1, BSP), enhancing collagen synthesis. 2-Aminoacetamide hydrochloride synergizes with BMP2 to promote osteoblast differentiation in vitro and bone regeneration in vivo .
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Nocardamine
Nocardamine
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Cat. No.: HY-124452
CAS No.: 26605-16-3
Purity:  95.00%
Synonyms: Desferrioxamine E; Nocardamin
Nocardamine (Desferrioxamine E; Nocardamin) is a cyclic trihydroxamate siderophore with iron ion chelation, antioxidant, antibacterial and other activities. Nocardamine is synthesized by Pseudomonas stutzeri under iron-deficient conditions, and excessive iron ions significantly inhibit its biosynthesis process. Nocardamine increases the level of phosphorylated ERK protein, promotes nuclear translocation of β-catenin, and restores the downregulated expression of SIRT1 protein. Nocardamine alleviates cellular oxidative stress, reduces ROS content, and simultaneously repairs the ability to form mineralized nodules and the expression of osteogenic markers. Nocardamine induces FoxA gene transcription and protein expression to assist Pseudomonas aeruginosa in iron ion uptake; it also selectively inhibits the proliferation of mycobacteria. Nocardamine induces spindle-shaped morphological changes in BM-N4 insect cells, and sufficient iron ions inhibit this cellular morphological change. Nocardamine is suitable for research related to bacterial infections .
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Largazole
Largazole
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Cat. No.: HY-13906
CAS No.: 1009815-87-5
Synonyms: (+)-Largazole
Category:  

Natural Products Microorganisms

Target:  

HDAC RUNX Bcl-2 Family CDK Apoptosis

Largazole ((+)-Largazole) is an orally active, blood-brain barrier-permeable class I histone deacetylase (HDAC) inhibitor with in vivo anticancer activity and osteogenic efficacy. As a prodrug, Largazole hydrolyzes to Largazole thiol (HY-170890), which has a Ki value of 0.07 nM against human HDAC2. Largazole regulates the cell cycle, induces apoptosis, upregulates tumor suppressors and osteoblast differentiation markers, inhibits osteoclast formation, and upregulates neuroprotection-related genes. Largazole can be used in the research of various cancers including colorectal cancer, as well as neurodegenerative diseases .
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Mucic acid (Standard)
Mucic acid (Standard)
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Cat. No.: HY-W014410R
CAS No.: 526-99-8
Category:  

Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite

Target:  

Reference Standards RUNX

Mucic acid (Standard) is the analytical standard of Mucic acid (HY-W014410). This product is intended for research and analytical applications. Mucic acid is an aldonic acid that can be prepared from pectin. Mucic acid increases the expression level of Runx2, promotes osteoblast differentiation, and upregulates osteogenic differentiation marker genes. Mucic acid can be used to prepare platform compounds, polymers, polymer materials and metal-organic frameworks. Mucic acid is applicable to the research of bone-related defects .
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