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Results for "

p38 kinase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	p38 MAPK (101) 5-HT Receptor (1) Adenosine Deaminase (1) Akt (4) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (2) Apoptosis (26) Aurora Kinase (3) Autophagy (28) Bacterial (5) Bcl-2 Family (1) Bcr-Abl (2) Btk (1) c-Kit (2) Calcium Channel (8) Casein Kinase (11) Caspase (3) CCR (1) CDK (3) Checkpoint Kinase (Chk) (1) Chemerin Receptor (1) Cholinesterase (ChE) (2) COX (1) CXCR (1) Cytochrome P450 (1) Drug Derivative (1) Drug Isomer (2) EGFR (2) Endogenous Metabolite (1) Enterovirus (2) ERK (7) Eukaryotic Initiation Factor (eIF) (3) Ferroptosis (1) Formyl Peptide Receptor (FPR) (1) Fungal (1) GCGR (1) Glutathione Peroxidase (2) Histamine Receptor (1) HIV (4) HSP (5) IKK (1) Influenza Virus (1) Integrin (1) Interleukin Related (5) Isotope-Labeled Compounds (1) Itk (1) JNK (9) Lactate Dehydrogenase (1) Lipoxygenase (1) MAP3K (2) MAPKAPK2 (MK2) (3) MEK (2) Mitochondrial Metabolism (3) MNK (2) mTOR (1) NF-κB (3) Organoid (4) P-selectin (1) PARP (2) Phosphatase (2) Phosphodiesterase (PDE) (3) PKA (5) PKC (7) PROTACs (1) Protease Activated Receptor (PAR) (1) Pyk2 (1) Raf (3) Reactive Oxygen Species (ROS) (3) Reference Standards (15) ROCK (5) ROR (1) Src (10) Syk (3) TGF-β Receptor (4) TNF Receptor (5) Toll-like Receptor (TLR) (1) Transmembrane Glycoprotein (1) Wnt (2)
By Research Areas:	Cancer (58) Cardiovascular Disease (17) Endocrinology (1) Infection (8) Inflammation/Immunology (69) Metabolic Disease (14) Neurological Disease (12)
Click Chemistry:	Alkynes (1)

146

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

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Targets Recommended: p38 MAPK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10295

SB 202190 Maximum Cited Publications 134 Publications Verification	Organoid p38 MAPK Autophagy Apoptosis	Neurological Disease Cancer
SB 202190 is a selective **p38 MAP kinase inhibitor with IC₅₀*s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 binds to the ATP pocket of the active recombinant human p38* kinase with a K_d of 38 nM. SB 202190 has anti-cancer activity and rescued memory deficits . SB202190 induces autophagy .

HY-10320

Doramapimod 50+ Cited Publications BIRB 796	p38 MAPK Raf Autophagy	Inflammation/Immunology Cancer
Doramapimod (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC₅₀ for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. Doramapimod has picomolar affinity for p38 kinase (K_d=0.1 nM). Doramapimod also inhibits B-Raf with an IC₅₀ of 83 nM .

HY-10971

Alisertib 70+ Cited Publications MLN 8237	Aurora Kinase Autophagy Apoptosis	Cancer
Alisertib (MLN 8237) is an orally active and selective Aurora A kinase inhibitor (IC₅₀=1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib (MLN 8237) induces apoptosis and autophagy through targeting the *AKT/mTOR/AMPK/p38* pathway in leukemic cells. Antitumor activity .

HY-10578

PD 169316 25+ Cited Publications	p38 MAPK Autophagy Enterovirus	Cancer
PD 169316 is a potent, cell-permeable and selective **p38 MAP kinase inhibitor, with IC₅₀** of 89 nM. PD169316 selectively inhibits the kinase activity of the phosphorylated p38 without hindering upstream kinases to phosphorylate p38. PD169316 shows antiviral activity against Enterovirus71. PD169316 shows antiviral activity against Enterovirus71.

HY-N6871

Abietic acid 3 Publications Verification	Bacterial IKK Ferroptosis	Infection Metabolic Disease Inflammation/Immunology Cancer
Abietic acid, an orally active diterpene isolated from Colophony, displays significant anti-proliferative, anti-inflammatory, anti-obesity effect, bacteriostatic, cell cycle arresting and pro-apoptotic activities. Abietic acid inhibits lipoxygenase activity for allergy. Abietic acid enhances cell migration and tube formation in HUVECs. Abietic acid induces significant angiogenic potential, which is associated with upregulation of extracellular signal-regulated kinase (ERK) and p38 expression. Abietic acid attenuates sepsis-induced lung injury by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to inhibit M1 macrophage polarization. Abietic acid exhibits a positive effect against liver injury by attenuating inflammation and ferroptosis. Abietic acid shows accelerated wound closure in a mouse model of cutaneous wounds. Abietic acid significantly reduces the proliferation and growth of NSCLC cells by IKKβ inhibition.Additionally, Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice. Abietic acid is promising for research in non-small-cell lung cancer (NSCLC), liver injury-related deseases and psoriasis .

HY-119917

Gossypetin 4 Publications Verification	p38 MAPK MEK Bacterial	Infection Cancer
Gossypetin is a hexahydroxylated flavonoid and is a potent *mitogen-activated protein kinase* kinase (MKK)3 and MKK6 inhibitor with strongly attenuates the MKK3/6-p38** signaling pathway, has various pharmacological activities, including antioxidant, antibacterial and anticancer activities .

HY-10456

TAK-715 10+ Cited Publications	p38 MAPK Casein Kinase Wnt	Inflammation/Immunology
TAK-715 is an orally active and potent p38 MAPK inhibitor with IC₅₀s of 7.1 nM, 200 nM for p38α and p38β, respectively. TAK-715 inhibits *casein kinase* I (CK1δ/ε)** to regulate activation of Wnt/β-catenin signaling. TAK-715 shows good significant efficacy in a rat arthritis model .

HY-16558

Butein Maximum Cited Publications 6 Publications Verification 2’,3,4,4’-tetrahydroxy Chalcone	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)	Cancer
Butein is a cAMP-specific PDE inhibitor with an IC₅₀ of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR and p60 ^c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).

HY-128326

ZAK-IN-1	MAP3K	Cardiovascular Disease
ZAK-IN-1 is an orally active and selective selective leucine-zipper and sterile‑α motif kinase (ZAK) inhibitor with IC₅₀ of 4 nM and K_D of 8 nM. ZAK-IN-1 exhibits excellent selectivity against a panel of 403 wild-type kinases. ZAK-IN-1 blocks *p38/GATA-4* and JNK/c-Jun signaling and shows promising anti antihypertrophic cardiomyopathy (HCM) efficacy. ZAK-IN-1 can be used for the study of HCM .

HY-N7255

Cycloartenol 2 Publications Verification	p38 MAPK Apoptosis	Cancer
Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development .

HY-15300

Skepinone-L 2 Publications Verification CBS3830	p38 MAPK Autophagy	Inflammation/Immunology
Skepinone-L (CBS3830), a chemical probe, is a selective p38 mitogen-activated protein kinase inhibitor.

HY-10520

CGP 57380 3 Publications Verification	MNK Apoptosis	Cancer
CGP 57380 is a cell-permeable pyrazolo-pyrimidine compound that acts as a selective inhibitor of Mnk1 with IC₅₀ of 2.2 μM, but has no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases.

HY-107427

PF-3644022 2 Publications Verification	MAPKAPK2 (MK2) p38 MAPK	Inflammation/Immunology
PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC₅₀ of 5.2 nM and a K_i of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) with IC₅₀s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNFα production and has anti-inflammatory effect .

HY-B1165

Cyproheptadine (hydrochloride sesquihydrate) 3 Publications Verification	p38 MAPK Checkpoint Kinase (Chk) Histamine Receptor 5-HT Receptor CDK PARP Apoptosis	Cancer
Cyproheptadine hydrochloride sesquihydrate acts as a p38 MAP kinase activator, CHK2 activator, histamine H1 receptor inhibitor and serotonin receptor inhibitor. Cyproheptadine hydrochloride sesquihydrate mediates cell cycle arrest via G1 phase arrest, G1/S transition arrest, G0/G1 phase arrest, reduced expression of cyclins D1/D2/D3, upregulated expression of HBP1, p16, p21, p27, and decreased phosphorylation of retinoblastoma protein. Cyproheptadine hydrochloride sesquihydrate induces Apoptosis by increasing PARP and cleaved PARP, as well as activating the mitochondrial caspase pathway. Cyproheptadine hydrochloride sesquihydrate inhibits tumor growth with extremely low toxicity to normal cells. Cyproheptadine hydrochloride sesquihydrate can be used in research related to hepatocellular carcinoma, multiple myeloma and acute myeloid leukemia .

HY-10295A

SB 202190 hydrochloride Maximum Cited Publications 134 Publications Verification	Organoid p38 MAPK Autophagy Apoptosis	Neurological Disease Cancer
SB 202190 hydrochloride is a selective **p38 MAP kinase inhibitor with IC₅₀*s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 hydrochloride binds to the ATP pocket of the active recombinant human p38* kinase with a K_d of 38 nM. SB 202190 hydrochloride has anti-cancer activity . SB202190 hydrochloride induces autophagy .

HY-112401

p38 MAP Kinase Inhibitor IV	p38 MAPK	Inflammation/Immunology
p38 MAP Kinase Inhibitor IV is a highly specific ATP-competitive p38α MAPK inhibitor with IC₅₀s of 0.13 and 0.55 μM for p38α and p38β MAPK, respectively .

HY-112389

p38 MAP Kinase Inhibitor III 2 Publications Verification	p38 MAPK	Inflammation/Immunology
p38 MAP Kinase Inhibitor III (compound 7h) is a p38 MAPK inhibitor with an ₅₀ of 0.9 μM. p38 MAP Kinase Inhibitor III also inhibits IL-1β and TNF-α release with ₅₀ values of 0.37 μM and 0.044 μM, respectively .

HY-16715

Acumapimod 1 Publications Verification BCT197	p38 MAPK Autophagy	Inflammation/Immunology
Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC₅₀ of less than 1 μM for p38α.

HY-18306

SB 242235 2 Publications Verification	p38 MAPK Autophagy	Cancer
SB-242235 is a potent and selective **p38 MAP kinase inhibitor, with an IC₅₀** of 1.0　μM in primary human chondrocytes .

HY-P6442

Chemerin15	Chemerin Receptor Syk ERK Src p38 MAPK P-selectin	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Chemerin15 is an anti-inflammatory peptide derived from Chemerin. Chemerin15 binds to ChemR23. Chemerin15 inhibits TNFα-induced activation of Syk, ERK and Src kinases. Chemerin15 increases the expression of *p-p38* mRNA and protein. Chemerin15 mediates phagocytosis, resolution of inflammation, CD62L shedding and downregulation of PSGL-1 expression in macrophages and microglia. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury via ChemR23. Chemerin15 enhances microglial phagocytosis, thereby alleviating cerebral ischemia-reperfusion injury .

HY-N2902

Artocarpin	Reactive Oxygen Species (ROS)	Cancer
Artocarpin is an orally active apoptosis inducer. Artocarpin targets NF-κB, Erk1/2, p38 MAPK, AktS473, p53, Akt 1 kinase and Akt 2 kinase. Artocarpin induces reactive oxygen species (ROS) production, mediates p53-dependent and p53-independent apoptotic signaling pathways, induces G1-phase cell cycle arrest, and triggers autophagic cell death. Artocarpin exerts cytotoxic and bactericidal effects on cancer cells, reduces bacterial load, and exhibits anti-inflammatory, analgesic and anti-angiogenic activities .

HY-N4119

Neoeriocitrin	Phosphatase Cholinesterase (ChE) p38 MAPK Apoptosis Autophagy	Neurological Disease Metabolic Disease
Neoeriocitrin is a Naringin (HY-N0153) analogue found in Drynaria Rhizome. Neoeriocitrin induces cells proliferation, differentiation, up-regulates type I collagen, osteocalcin, and key osteogenic markers, and increases ALP activity. Neoeriocitrin increases expression of Runx2, COL I, OCN and Beclin1. Neoeriocitrin inhibits phosphorylation of *P38* mitogen-activated protein kinase, reduces acetylcholinesterase (AChE) activity, and increases choline acetyltransferase (ChAT) activity. Neoeriocitrin reduces apoptosis and induces autophagy. Neoeriocitrin can be used for the researches of osteoporosis and Alzheimer's disease .

HY-P10954

Link N peptide	p38 MAPK	Others
Link N peptide is a proteoglycan aggregates activator in the extracellular matrix. Link N peptide can selectively activate the p38 mitogen-activated protein kinase (MAPK) pathway to promote the expression of type I and II collagens in human intervertebral disc cells. Link N peptide is promising for research of intervertebral disc degeneration-related diseases .

HY-139534

ARI-1 1 Publications Verification	ROR Apoptosis Akt mTOR PARP	Cancer
ARI-1 is a receptor tyrosine kinase-like orphan receptor 1 (ROR1) inhibitor. ARI-1 blocks the PI3K/AKT/mTOR signaling pathway in a ROR1-dependent manner. ARI-1 upregulates cleaved-PARP and *p-P38. ARI-1 induces Apoptosis*. ARI-1 has anticancer activity against non-small cell lung cancer .

HY-N1745A

3-Deoxysappanchalcone 2 Publications Verification	Influenza Virus	Infection Inflammation/Immunology Cancer
3-Deoxysappanchalcone is a kinase inhibitor and antiviral agent. 3-Deoxysappanchalcone directly targets MET, EGFR, AKT, mTOR, p38 MAPK, JNK, thrombin, FXa, and influenza virus neuraminidase, thereby regulating related signaling pathways. 3-Deoxysappanchalcone induces cell cycle arrest, ROS production, and apoptosis. 3-Deoxysappanchalcone exhibits anti-inflammatory, anti-allergic, anticoagulant, and antithrombotic activities. 3-Deoxysappanchalcone is applicable to research related to gefitinib-resistant lung cancer, esophageal squamous cell carcinoma, thrombosis, and influenza virus infection .

HY-117273

AZ304	Raf Autophagy	Cancer
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC₅₀s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 (IC₅₀, 6 nM), CSF1R (IC₅₀, 35 nM). Anti-tumor activity .

HY-18302

c-Kit-IN-5-1 1 Publications Verification	c-Kit	Inflammation/Immunology
c-Kit-IN-5 is potent inhibitor of c-Kit, with IC₅₀s of 22 nM and 16 nM in kinase assay and cell assay, respectively. c-Kit-IN-5 shows more than 200-fold selectivity for c-Kit over KDR, p38, Lck, and Src. c-Kit-IN-5 also exhibits desirable pharmacokinetic properties .

HY-112349

SB 203580 sulfone	Drug Derivative Interleukin Related Lipoxygenase	Inflammation/Immunology
SB 203580 sulfone is an analog of p38 MAP kinase inhibitor SB 203580. SB 203580 sulfone inhibits the IL-1 production (IC₅₀ of 0.2 μM in monocytes) and binds competitively with CSAID binding proteins (CSBP), inhibits it mediated stress response signaling with an IC₅₀ of 0.03 μM. SB 203580 sulfone inhibits 5-LO with an IC₅₀ value of 24 µM. SB 203580 sulfone can be used in the research of inflammatory diseases .

HY-119715

AG-012986	CDK Apoptosis	Inflammation/Immunology Cancer
AG-012986 is a pan-CDK inhibitor with K_i values of 44 nM (CDK1), 9.2 nM (CDK4), 94 nM (CDK2), and IC50 values of 22 nM (CDK5), 4 nM (CDK9). AG-012986 causes apoptosis of T-cells by targeting upstream kinases in the **p38 Mitogen-activated protein kinase (MAPK**) pathway and impairing cellular survival. AG-012986 induces cell cycle arrest, retinoblastoma protein hypophosphorylation, and reduces K_i-67 expression. AG-012986 exerts antiproliferative activity in tumor cells, demonstrates antitumor efficacy in human xenograft models, and causes retinal and peripheral neurotoxicity, plus immune cell toxicity. AG-012986 can be used for the research of colon carcinoma, non-small cell lung carcinoma, lung carcinoma, breast carcinoma, ovarian tumor, pancreatic carcinoma, osteosarcoma, lymphoma, leukemia, retinotoxicity .

HY-120595

JNJ-49095397 RV568	p38 MAPK Src	Inflammation/Immunology
JNJ-49095397 (RV568) is an inhaled narrow-spectrum kinase inhibitor (NSKI) against both the α and γ isoforms of p38 MAPK. JNJ-49095397 also inhibits SRC kinase family, specifically haematopoietic kinase (HCK) JNJ-49095397 shows potent anti-inflammatory effects and can be used for the research of chronic obstructive pulmonary disease (COPD) and asthma .

HY-114221

Org 48762-0 UR13870	p38 MAPK	Inflammation/Immunology
Org 48762-0 (UR13870) is a potent, orally active and selective *p38* inhibitor with an EC₅₀ of 0.1 μM for p38α kinase. Org 48762-0 shows a high degree of kinase selectivity for p38α and p38β over other kinases. Org 48762-0 reduces Lipopolysaccharides (HY-D1056) (LPS)-induced TNFα release. Org 48762-0 can be used for the study of rheumatoid arthritis (RA) and Werner syndrome .

HY-N12188

Stigmasta-3,5-dien-7-one	NF-κB TNF Receptor Interleukin Related p38 MAPK	Inflammation/Immunology
Stigmasta-3,5-dien-7-one is a steroid compound that can be isolated from Harrisonia abyssinica. Stigmasta-3,5-dien-7-one blocks the NF-κB signaling pathway via down-regulation of phospho-p38 mitogen-activated protein kinase and phosphorylation and degradation of inhibitor of NF-κB α. Stigmasta-3,5-dien-7-one reduces LPS (HY-D1056)-induced nitric oxide, PGE₂, and pro-inflammatory cytokine levels in macrophages. Stigmasta-3,5-dien-7-one can be used for inflammation diseases .

HY-177320

p38 Kinase-IN-9	p38 MAPK	Inflammation/Immunology
p38 Kinase-IN-9 (example 4) is a **p38 kinase inhibitor with an IC₅₀** of <1 μM. p38 Kinase-IN-9 can be used for the study of p38 kinase mediated diseases, including inflammatory diseases .

HY-149850

p38 Kinase inhibitor 5	p38 MAPK	Inflammation/Immunology
p38 Kinase inhibitor 5 (AA6) is a potent *p38* kinase inhibitor with an IC₅₀ of 403.57 nM. p38 Kinase inhibitor 5 has anti-inflammatory activity .

HY-153348

p38 Kinase inhibitor 4	p38 MAPK	Cancer
p38 Kinase inhibitor 4 (compound 135) is a potent *p38* inhibitor .

HY-49073

p38 MAP Kinase Inhibitor Ⅵ	p38 MAPK	Cancer
p38 MAP Kinase Inhibitor VI (compound c32) is a p38 MAPK inhibitor with an inhibition rate of 24% .

HY-171275

p38 MAP Kinase-IN-1	p38 MAPK	Inflammation/Immunology
p38 MAP Kinase-IN-1 (Compound 4) is the inhibitor for *p38*, and can be used for inflammation and auto-immune responses related research .

HY-171295

p38 Kinase inhibitor 7	p38 MAPK	Inflammation/Immunology
p38 Kinase inhibitor 7 (Comp:XXXIX) is the inhibitor for *p38α* with an IC₅₀ of 5.25 nM. p38 Kinase inhibitor 7 inhibits TNFα production in cell THP-1 with an IC₅₀ of 5.88 nM .

HY-10971A

Alisertib sodium MLN 8237 sodium	Aurora Kinase Autophagy Apoptosis	Cancer
Alisertib (MLN 8237) sodium is an orally active and selective Aurora A kinase inhibitor (IC₅₀=1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib sodium induces apoptosis and autophagy through targeting the *AKT/mTOR/AMPK/p38* pathway in leukemic cells. Antitumor activity .

HY-121605

RL71	Apoptosis	Cancer
RL71 is a curcuminoid anticancer agent that exhibits potent cytotoxicity against a variety of ER-negative breast cancer cells. RL71 (1 μM) induces cell cycle arrest in the G2/M phase and induces apoptosis in SKBr3 cells. RL7 also decreases HER2/neu phosphorylation and increases p27. RL71 also significantly reduced the phosphorylation of Akt and transiently increased the stress kinases JNK1/2 and p38 MAPK. Furthermore, RL71 exhibited anti-angiogenic potential in vitro, inhibiting the migration of HUVEC cells and the ability of these cells to form tubular networks .

HY-178267

p38 MAP Kinase-IN-2	p38 MAPK	Cancer
p38 MAP Kinase-IN-2 (Compound 5) is a p38 MAP Kinase inhibitor. p38 MAP Kinase-IN-2 can be used for the research of cancer .

HY-178209

p38 MAP Kinase-IN-3	p38 MAPK	Metabolic Disease
p38 MAP Kinase-IN-3 is a p38 MAP kinase inhibitor (IC₅₀ = 0.09 µM). p38 MAP Kinase-IN-3 can be used for research on metabolic conditions .

HY-174829

7,4'-Dimethoxy-3-hydroxyflavone	Protease Activated Receptor (PAR) NF-κB Reactive Oxygen Species (ROS) Calcium Channel Akt ERK p38 MAPK PKC	Cardiovascular Disease Metabolic Disease
7,4'-Dimethoxy-3-hydroxyflavone is an orally active PAR4 antagonist. 7,4'-Dimethoxy-3-hydroxyflavone inhibits PAR4-mediated human platelet aggregation with an IC₅₀ of 1.4 μM. 7,4'-Dimethoxy-3-hydroxyflavone inhibits PAR4-mediated human platelet aggregation and PAR4 signaling pathways, including NF-κB, *Ca ²⁺/protein kinase* C, Akt, ERK and p38**. 7,4'-Dimethoxy-3-hydroxyflavone prevents vascular PAR4 expression, endothelial dysfunction and ameliorates oxidative stress in Streptozotocin (STZ) (HY-13753)-induced diabetic mice. 7,4'-Dimethoxy-3-hydroxyflavone prevents thrombosis in mice without affecting bleeding time ^[1][2].

HY-183531

p38 MAP Kinase-IN-4	p38 MAPK	Inflammation/Immunology
p38 MAP Kinase-IN-4 is a p38α MAPK inhibitor with an IC₅₀ of 40.5 nM. p38 MAP Kinase-IN-4 is applicable to inflammation-related research .

HY-171296

p38 Kinase inhibitor 8	p38 MAPK JNK	Inflammation/Immunology
p38 Kinase inhibitor 8 (Compound CCLXXVIII) is the orally active inhibitor for *p38β* and JNK2α2 with IC₅₀s of 6.3 nM and 53.6 nM. p38 Kinase inhibitor 8 exhibits anti-inflammatory effect in rats collagen-induced arthritis models .

HY-119298

AW-814141	p38 MAPK	Inflammation/Immunology
AW-814141 is a selective and orally active p38 MAP kinase inhibitor. AW-814141 has an IC₅₀ values of 100 nM and 158 nM for *p38-α* and β isoforms, respectively. AW-814141 can inhibit the production of TNF-α induced by LPS (HY-D1056). AW-814141 can inhibit paw edema in rats in a dose-dependent manner. AW-814141 exhibits anti-inflammatory activity and can be used in the research of inflammatory diseases such as rheumatoid arthritis .

HY-10320G

Doramapimod (GMP) BIRB 796 (GMP)	p38 MAPK	Cancer
Doramapimod GMP (BIRB 796 GMP) is an orally active inhibitor for p38 MAPK, with IC₅₀s of 38, 65, 200 and 520 nM, for p38α, p38β, p38γ, p38δ. Doramapimod exhibits cytotoxicity and antitumor activity against multiple myeloma, synergizes with multidrug resistance protein 1 (ABCB1) and aurora kinase inhibitor VX680, promoting their antitumor efficacy against oral epidermoid carcinoma and cervical cancer. Doramapimod also exhibits anti-inflammatory activity .

HY-N1818

Deoxysappanone B 3-Deoxysappanone B	p38 MAPK	Neurological Disease Inflammation/Immunology
Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage .

HY-16558R

Butein (Standard) 2’,3,4,4’-tetrahydroxy Chalcone (Standard)	Reference Standards EGFR Autophagy Apoptosis Phosphodiesterase (PDE)	Cancer
Butein (Standard) is the analytical standard of Butein. This product is intended for research and analytical applications. Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).

HY-19399A

(±)-Iroxanadine BRX 005; BRX 235	p38 MAPK HSP	Cardiovascular Disease
(±)-Iroxanadine (BRX 005; BRX 235), a vasculoprotector, is a **p38 kinase and HSP** protein activator. (±)-Iroxanadine has the potential for atherosclerosis and vascular diseases research .

Cat. No.	Product Name

HY-L010

MAPK Compound Library

1,063 compounds

MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. In mammalian cells, four MAPK families have been clearly characterized: ERK1/2, C-Jun N-terminal kinse/stress-activated protein kinase (JNK/SAPK) , p38 kinase and ERK5. They respond to different signals. Each MAPK-related cascade consists of three enzymes that are activated in series: a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK) and a MAP kinase (MAPK). MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers.

MCE designs a unique collection of 1,063 MAPK signaling pathway inhibitors that act as a useful tool for MAPK-related drug screening and disease research.

Cat. No.	Product Name	Type

HY-W745090

Isomaltulose monohydrate

Biochemical Assay Reagents

Isomaltulose monohydrate is a fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Isomaltulose monohydrate can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Isomaltulose monohydrate inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM) , cathepsin G release (IC< sub>50: 2.76 μM) and chemotaxis. Isomaltulose monohydrate can improve excessive activation of neutrophils and reduce inflammation or tissue damage. A series of derivatives of Isomaltulose monohydrate are found to have inhibitory effects on FSGS-related TRPC6 functional mutants .

Cat. No.	Product Name	Target	Research Area

HY-P6442

Chemerin15	Chemerin Receptor Syk ERK Src p38 MAPK P-selectin	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Chemerin15 is an anti-inflammatory peptide derived from Chemerin. Chemerin15 binds to ChemR23. Chemerin15 inhibits TNFα-induced activation of Syk, ERK and Src kinases. Chemerin15 increases the expression of *p-p38* mRNA and protein. Chemerin15 mediates phagocytosis, resolution of inflammation, CD62L shedding and downregulation of PSGL-1 expression in macrophages and microglia. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury via ChemR23. Chemerin15 enhances microglial phagocytosis, thereby alleviating cerebral ischemia-reperfusion injury .

HY-P10954

Link N peptide	p38 MAPK	Others
Link N peptide is a proteoglycan aggregates activator in the extracellular matrix. Link N peptide can selectively activate the p38 mitogen-activated protein kinase (MAPK) pathway to promote the expression of type I and II collagens in human intervertebral disc cells. Link N peptide is promising for research of intervertebral disc degeneration-related diseases .

HY-P11650

HE4-1 leech peptide	p38 MAPK JNK	Cardiovascular Disease
HE4-1 leech peptide is a p38 MAPK inhibitor with an additional *c-Jun N-terminal kinase* (JNK)** inhibitory role. HE4-1 leech peptide suppresses macrophage migration, and does not significantly affect macrophage immunological activities including phagocytic ability, lysozyme activity, and expression levels of most inflammatory factors. HE4-1 leech peptide can be used for the research of atherosclerosis .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99524

Vatelizumab GBR500	Integrin	Neurological Disease Inflammation/Immunology
Vatelizumab (GBR500) is a monoclonal antibody that targets the α2 subunit (CD49b) of very late antigen 2 (VLA-2). Vatelizumab can be used for research on multiple sclerosis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6871

Abietic acid 3 Publications Verification	Infection Colophony Classification of Application Fields Pinaceae Ketones, Aldehydes, Acids Metabolic Disease Plants Inflammation/Immunology Disease Research Fields	Bacterial IKK Ferroptosis
Abietic acid, an orally active diterpene isolated from Colophony, displays significant anti-proliferative, anti-inflammatory, anti-obesity effect, bacteriostatic, cell cycle arresting and pro-apoptotic activities. Abietic acid inhibits lipoxygenase activity for allergy. Abietic acid enhances cell migration and tube formation in HUVECs. Abietic acid induces significant angiogenic potential, which is associated with upregulation of extracellular signal-regulated kinase (ERK) and p38 expression. Abietic acid attenuates sepsis-induced lung injury by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to inhibit M1 macrophage polarization. Abietic acid exhibits a positive effect against liver injury by attenuating inflammation and ferroptosis. Abietic acid shows accelerated wound closure in a mouse model of cutaneous wounds. Abietic acid significantly reduces the proliferation and growth of NSCLC cells by IKKβ inhibition.Additionally, Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice. Abietic acid is promising for research in non-small-cell lung cancer (NSCLC), liver injury-related deseases and psoriasis .

HY-119917

Gossypetin 4 Publications Verification	Infection Flavonols Flavonoids Classification of Application Fields Rhodiola rosea Linn. Crassulaceae Phenols Polyphenols Plants Disease Research Fields Source Classification	p38 MAPK MEK Bacterial
Gossypetin is a hexahydroxylated flavonoid and is a potent *mitogen-activated protein kinase* kinase (MKK)3 and MKK6 inhibitor with strongly attenuates the MKK3/6-p38** signaling pathway, has various pharmacological activities, including antioxidant, antibacterial and anticancer activities .

HY-16558

Butein Maximum Cited Publications 6 Publications Verification 2’,3,4,4’-tetrahydroxy Chalcone	Chalcones Flavonoids other families Classification of Application Fields Anti-aging Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)
Butein is a cAMP-specific PDE inhibitor with an IC₅₀ of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR and p60 ^c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).

HY-N7255

Cycloartenol 2 Publications Verification	Microorganisms other families Classification of Application Fields Plants Disease Research Fields Steroids Source Classification Cancer	p38 MAPK Apoptosis
Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development .

HY-106950

Fosfructose Diphosphofructose; Esafosfan; FDP	Cardiovascular Disease Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Toll-like Receptor (TLR) COX
Fosfructose is an orally active cyclooxygenase-2 inhibitor and Toll-like receptor 4 modulator. Fosfructose reduces the expression of cyclooxygenase-2, thereby decreasing prostaglandin production. By inhibiting the Toll-like receptor 4 signaling pathway, Fosfructose downregulates LPS-induced adhesion molecule expression. Fosfructose is applicable to research related to ischemic stroke, epilepsy, sepsis, myocardial injury, osteoporosis, and ultraviolet B-induced skin damage .

HY-N2902

Artocarpin	Structural Classification Flavonols Flavonoids Plants Moraceae Source Classification	Reactive Oxygen Species (ROS)
Artocarpin is an orally active apoptosis inducer. Artocarpin targets NF-κB, Erk1/2, p38 MAPK, AktS473, p53, Akt 1 kinase and Akt 2 kinase. Artocarpin induces reactive oxygen species (ROS) production, mediates p53-dependent and p53-independent apoptotic signaling pathways, induces G1-phase cell cycle arrest, and triggers autophagic cell death. Artocarpin exerts cytotoxic and bactericidal effects on cancer cells, reduces bacterial load, and exhibits anti-inflammatory, analgesic and anti-angiogenic activities .

HY-N4119

Neoeriocitrin	Structural Classification Flavonoids other families Flavonones Phenols Polyphenols Plants Source Classification	Phosphatase Cholinesterase (ChE) p38 MAPK Apoptosis Autophagy
Neoeriocitrin is a Naringin (HY-N0153) analogue found in Drynaria Rhizome. Neoeriocitrin induces cells proliferation, differentiation, up-regulates type I collagen, osteocalcin, and key osteogenic markers, and increases ALP activity. Neoeriocitrin increases expression of Runx2, COL I, OCN and Beclin1. Neoeriocitrin inhibits phosphorylation of *P38* mitogen-activated protein kinase, reduces acetylcholinesterase (AChE) activity, and increases choline acetyltransferase (ChAT) activity. Neoeriocitrin reduces apoptosis and induces autophagy. Neoeriocitrin can be used for the researches of osteoporosis and Alzheimer's disease .

HY-N1745A

3-Deoxysappanchalcone 2 Publications Verification	Structural Classification Chalcones Flavonoids Classification of Application Fields Leguminosae Caesalpinia sappan L. Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Influenza Virus
3-Deoxysappanchalcone is a kinase inhibitor and antiviral agent. 3-Deoxysappanchalcone directly targets MET, EGFR, AKT, mTOR, p38 MAPK, JNK, thrombin, FXa, and influenza virus neuraminidase, thereby regulating related signaling pathways. 3-Deoxysappanchalcone induces cell cycle arrest, ROS production, and apoptosis. 3-Deoxysappanchalcone exhibits anti-inflammatory, anti-allergic, anticoagulant, and antithrombotic activities. 3-Deoxysappanchalcone is applicable to research related to gefitinib-resistant lung cancer, esophageal squamous cell carcinoma, thrombosis, and influenza virus infection .

HY-N5073

Vitexin-4''-O-glucoside 4''-O-Glucosylvitexin	Cardiovascular Disease Structural Classification Flavonoids Classification of Application Fields Flavones Rosaceae Phenols Polyphenols Crataegus pinnatifida Bge. Plants Disease Research Fields Source Classification	JNK p38 MAPK Interleukin Related TNF Receptor Caspase Lactate Dehydrogenase Apoptosis
Vitexin-4''-O-glucoside (4''-O-Glucosylvitexin) is an orally active natural flavonoid component with multiple pharmacological effects including antioxidation, anti-inflammation, cytoprotection and anti-apoptosis. Vitexin-4''-O-glucoside regulates the MAPK signaling pathway by downregulating the phosphorylation levels of JNK and p38, thereby blocking endoplasmic reticulum stress responses. Vitexin-4''-O-glucoside alleviates oxidative stress by reducing MDA content and upregulating the activities of SOD and CAT, attenuates inflammation by downregulating the expressions of inflammatory factors TNF-α, IL-1β and IL-6, and also reduces LDH release and inhibits caspase-3 activation. Vitexin-4''-O-glucoside effectively improves drug-induced acute liver injury and exerts significant protective effects against myocardial hypoxia/reoxygenation injury. Vitexin-4''-O-glucoside can be used in studies on acute liver injury, cardiovascular diseases and myocardial hypoxia-reoxygenation injury .

HY-N12188

Stigmasta-3,5-dien-7-one	Structural Classification Harrisonia abyssinica Oliv. Cardiacglycosides Rutaceae Plants Steroids Source Classification	NF-κB TNF Receptor Interleukin Related p38 MAPK
Stigmasta-3,5-dien-7-one is a steroid compound that can be isolated from Harrisonia abyssinica. Stigmasta-3,5-dien-7-one blocks the NF-κB signaling pathway via down-regulation of phospho-p38 mitogen-activated protein kinase and phosphorylation and degradation of inhibitor of NF-κB α. Stigmasta-3,5-dien-7-one reduces LPS (HY-D1056)-induced nitric oxide, PGE₂, and pro-inflammatory cytokine levels in macrophages. Stigmasta-3,5-dien-7-one can be used for inflammation diseases .

HY-N1818

Deoxysappanone B 3-Deoxysappanone B	Leguminosae Caesalpinia sappan L. Phenols Polyphenols Plants Source Classification	p38 MAPK
Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage .

HY-16558R

Butein (Standard) 2’,3,4,4’-tetrahydroxy Chalcone (Standard)	Structural Classification Chalcones Flavonoids other families Phenols Polyphenols Plants Source Classification	Reference Standards EGFR Autophagy Apoptosis Phosphodiesterase (PDE)
Butein (Standard) is the analytical standard of Butein. This product is intended for research and analytical applications. Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).

HY-W744699

Larixol (+)-Larixol	Larix decidua Miller Natural Products Pinaceae Plants Source Classification	Src ERK Akt
Larixol is an fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Larixol can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Larixol inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM), cathepsin G release (IC₅₀: 2.76 μM), and chemotaxis. Larixol improves neutrophil hyperactivation and reduces inflammation or tissue damage. A series of Larixol derivatives were found to have inhibitory effects on FSGS-related TRPC6 functional mutants .

HY-N11723

Catenarin Katenarin	Quinones Microorganisms Anthraquinones Source Classification	CCR CXCR p38 MAPK JNK Calcium Channel
Catenarin, an anthraquinone compound, inhibits CCR5- and CXCR4-mediated chemotaxis. Catenarin reduces the phosphorylation of mitogen-activated protein kinases (p38 and JNK) and their upstream kinases (MKK6 and MKK7), and calcium mobilization. Catenarin shows anti-inflammatory effect and suppresses leukocyte migration in the diabetes. Catenarin exhibits significant inhibitory effects against Gram-positive bacteria. Catenarin prevents type 1 diabetes (T1D) in nonobese diabetic mice ^[1][2].

HY-N7255R

Cycloartenol (Standard)	Structural Classification Microorganisms other families Plants Steroids Source Classification	Reference Standards p38 MAPK Apoptosis
Cycloartenol (Standard) is the analytical standard of Cycloartenol. This product is intended for research and analytical applications. Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development .

HY-N4119R

Neoeriocitrin (Standard)	Structural Classification Flavonoids other families Flavonones Phenols Polyphenols Plants Source Classification	Reference Standards Phosphatase Cholinesterase (ChE) p38 MAPK Apoptosis Autophagy
Neoeriocitrin (Standard) is the analytical standard of Neoeriocitrin (HY-N4119). This product is intended for research and analytical applications. Neoeriocitrin is a Naringin (HY-N0153) analogue found in Drynaria Rhizome. Neoeriocitrin induces cells proliferation, differentiation, up-regulates type I collagen, osteocalcin, and key osteogenic markers, and increases ALP activity. Neoeriocitrin increases expression of Runx2, COL I, OCN and Beclin1. Neoeriocitrin inhibits phosphorylation of *P38* mitogen-activated protein kinase, reduces acetylcholinesterase (AChE) activity, and increases choline acetyltransferase (ChAT) activity. Neoeriocitrin reduces apoptosis and induces autophagy. Neoeriocitrin can be used for the researches of osteoporosis and Alzheimer's disease .

HY-118817

Evariquinone	Quinones Structural Classification Microorganisms Anthraquinones Source Classification	Reactive Oxygen Species (ROS) Calcium Channel JNK ERK p38 MAPK Apoptosis
Evariquinone is an anthraquinone compound isolated from the endophytic fungus Colletotrichum sp. JS-0367 of mulberry. Evariquinone possesses direct antioxidant activity. It inhibits excessive phosphorylation of the JNK, ERK1/2 and p38 MAPK signaling pathways by suppressing ROS and Ca ²⁺, thereby reducing neuronal apoptosis. Evariquinone can be used to study glutamate excitotoxicity-related neurological disorders (such as Alzheimer's disease, Parkinson's disease, cerebral ischemia, etc.) .

HY-N8529

Eupalestin	Structural Classification Flavonoids Flavones Lupinus perennis L. Plants Compositae Source Classification	NF-κB p38 MAPK Adenosine Deaminase Interleukin Related
Eupalestin is an anti-inflammatory agent. Eupalestin reduces the levels of p-p65 NF-κB and p-p38 MAPK. Eupalestin inhibits MPO and adenosine deaminase. Eupalestin decreases the levels of pro-inflammatory cytokines including IL-17A, IL-6, TNF and IFN-γ. Eupalestin exerts anti-inflammatory activity in a carrageenan (HY-125474)-induced mouse pleurisy model .

Species:	Human (11)
Tag:	His (3) Tag Free (2) GST (7) Flag (1)
Source:	Sf9 insect cells (2) Sf9 insect cells (7) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703924

	p38 gamma/MAPK12 Protein, Human (sf9, GST) Mitogen-activated protein kinase 12; MAP kinase 12; MAPK 12; Extracellular signal-regulated kinase 6 (ERK-6); Mitogen-activated protein kinase p38 gamma (MAP kinase p38 gamma); Stress-activated protein kinase 3	Human	Sf9 insect cells
	The p38 gamma/MAPK12 protein is an important serine/threonine kinase in the MAP kinase pathway and can respond to extracellular stimuli such as pro-inflammatory cytokines or stress. p38 MAPK activates transcription factors such as ELK1 and ATF2, each of which phosphorylates approximately 200 to 300 substrates. p38 gamma/MAPK12 Protein, Human (Active, sf9, GST) is the recombinant human-derived p38 gamma/MAPK12 protein, expressed by Sf9 insect cells, with N-GST labeled tag.

HY-P701730

	P38β Protein, Human (Inactive, sf9) MAPK11; Mitogen-activated protein kinase 11; MAP kinase 11; MAPK 11; Mitogen-activated protein kinase p38 beta; MAP kinase p38 beta; p38b; Stress-activated protein kinase 2b; SAPK2b; p38-2	Human	Sf9 insect cells
	The P38β protein is an important serine/threonine kinase in the MAP kinase pathway that responds to extracellular stimuli, including proinflammatory cytokines and physical stress. As part of the p38 MAPK family, P38β directly activates transcription factors that phosphorylate many proteins, including RPS6KA5/MSK1 and RPS6KA4/MSK2. P38β Protein, Human (sf9) is the recombinant human-derived P38β protein, expressed by sf9 insect cells , with tag free.

HY-P706079

	P38β Protein, Human (Active, sf9, His-GST) Mitogen-activated protein kinase 11; Mitogen-activated protein kinase p38 beta; MAP kinase p38 beta; p38b; Stress-activated protein kinase 2b; SAPK2b; p38-2; PRKM11; SAPK2; SAPK2B	Human	Sf9 insect cells

HY-P701731

	P38β Protein, Human (Inactive, sf9, GST) MAPK11; Mitogen-activated protein kinase 11; MAP kinase 11; MAPK 11; Mitogen-activated protein kinase p38 beta; MAP kinase p38 beta; p38b; Stress-activated protein kinase 2b; SAPK2b; p38-2	Human	Sf9 insect cells
	The P38β protein is an important serine/threonine kinase in the MAP kinase pathway that responds to extracellular stimuli, including proinflammatory cytokines and physical stress. As part of the p38 MAPK family, P38β directly activates transcription factors that phosphorylate many proteins, including RPS6KA5/MSK1 and RPS6KA4/MSK2. P38β Protein, Human (sf9, GST) is the recombinant human-derived P38β protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P705668

	P38β Protein, Human (Active, Phosphorylated, Sf9, GST) MAPK11; Mitogen-activated protein kinase 11; MAP kinase 11; MAPK 11; Mitogen-activated protein kinase p38 beta; MAP kinase p38 beta; p38b; Stress-activated protein kinase 2b; SAPK2b; p38-2	Human	Sf9 insect cells
	The P38β protein is an important serine/threonine kinase in the MAP kinase pathway that responds to extracellular stimuli, including proinflammatory cytokines and physical stress. As part of the p38 MAPK family, P38β directly activates transcription factors that phosphorylate many proteins, including RPS6KA5/MSK1 and RPS6KA4/MSK2. P38β Protein, Human (Active, Phosphorylated, Sf9, GST) is the recombinant human-derived P38β protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P76532

	p38 gamma/MAPK12 Protein, Human (sf9) Mitogen-activated protein kinase 12; Extracellular signal-regulated kinase 6; ERK-6; SAPK3	Human	Sf9 insect cells
	The p38 gamma/MAPK12 protein is an important serine/threonine kinase in the MAP kinase pathway and can respond to extracellular stimuli such as pro-inflammatory cytokines or stress. p38 MAPK activates transcription factors such as ELK1 and ATF2, each of which phosphorylates approximately 200 to 300 substrates. p38 gamma/MAPK12 Protein, Human (sf9) is the recombinant human-derived p38 gamma/MAPK12 protein, expressed by Sf9 insect cells, with tag free.

HY-P76533

	p38 gamma/MAPK12 Protein, Human (sf9, His-GST) Mitogen-activated protein kinase 12; Extracellular signal-regulated kinase 6; ERK-6; SAPK3	Human	Sf9 insect cells
	The p38 gamma/MAPK12 protein is an important serine/threonine kinase in the MAP kinase pathway and can respond to extracellular stimuli such as pro-inflammatory cytokines or stress. p38 MAPK activates transcription factors such as ELK1 and ATF2, each of which phosphorylates approximately 200 to 300 substrates. p38 gamma/MAPK12 Protein, Human (sf9, His-GST) is the recombinant human-derived p38 gamma/MAPK12 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P73334

	p38 delta/MAPK13 Protein, Human (Active, sf9, GST) Mitogen-activated protein kinase 13; MAPK 13; PRKM13; SAPK4	Human	Sf9 insect cells
	The p38 delta/MAPK13 protein is an important serine/threonine kinase in the MAP kinase pathway. It coordinates cellular responses to stimuli such as cytokines or stress and directly activates the transcription factors ELK1 and ATF2. In this cascade, p38 MAPK (including MAPK13) each phosphorylates approximately 200 to 300 substrates. p38 delta/MAPK13 Protein, Human (sf9, GST) is the recombinant human-derived p38 delta/MAPK13 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P73335

	p38 alpha/MAPK14 Protein, Human (Active, sf9, His) Mitogen-activated protein kinase 14; MAPK 14; CSBP; MXI2; SAPK2A	Human	Sf9 insect cells
	The p38 α/MAPK14 protein is an important serine/threonine kinase in the MAP kinase pathway. It can respond to stimuli such as cytokines or stress and directly activate transcription factors. In this cascade, p38 MAPK each phosphorylates approximately 200 to 300 substrates, including the downstream kinases RPS6KA5/MSK1 and RPS6KA4/MSK2, which are critical for immediate early gene induction. p38 alpha/MAPK14 Protein, Human (Activated, sf9, His) is the recombinant human-derived p38 alpha/MAPK14 protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P704008

	MAPK1/ERK2 Protein, Human (Inactive, GST) MAPK1; mitogen-activated protein kinase 1; PRKM1, PRKM2; ERK; ERK2; MAPK2; p41mapk; ERK-2; MAPK 2; p42-MAPK; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; protein tyrosine kinase ERK2; mitogen-activated protein kinase 2; extracellular signal-regulated kinase 2; p38; p40; p41; ERT1; PRKM1; PRKM2; P42MAPK	Human	E. coli
	ERK2 Protein, a key component of the MAPK/ERK cascade, regulates diverse cellular processes such as transcription, translation, mitosis, apoptosis, endosomal dynamics, and Golgi apparatus fragmentation. Through phosphorylation, it modulates substrates including transcription factors, cytoskeletal elements, apoptosis regulators, translation regulators, protein kinases, and phosphatases. MAPK1/ERK2 Protein, Human (Inactive, GST) is the recombinant human-derived MAPK1/ERK2 protein, expressed by E. coli, with N-GST labeled tag.

HY-P702735

	MAPK1/ERK2 Protein, Human (Active, Flag-His) MAPK1; mitogen-activated protein kinase 1; PRKM1, PRKM2; ERK; ERK2; MAPK2; p41mapk; ERK-2; MAPK 2; p42-MAPK; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; protein tyrosine kinase ERK2; mitogen-activated protein kinase 2; extracellular signal-regulated kinase 2; p38; p40; p41; ERT1; PRKM1; PRKM2; P42MAPK	Human	E. coli
	ERK2 Protein, a key component of the MAPK/ERK cascade, regulates diverse cellular processes such as transcription, translation, mitosis, apoptosis, endosomal dynamics, and Golgi apparatus fragmentation. Through phosphorylation, it modulates substrates including transcription factors, cytoskeletal elements, apoptosis regulators, translation regulators, protein kinases, and phosphatases. MAPK1 Protein, Human (Active, Flag, His) is the recombinant human-derived MAPK1, expressed by E. coli, with N-His, N-Flag labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-121605S

RL71-d6

RL71-d₆ is a deuterium labeled RL71 (HY-121605). RL71 is a curcuminoid anticancer agent that exhibits potent cytotoxicity against a variety of ER-negative breast cancer cells. RL71 (1 μM) induces cell cycle arrest in the G2/M phase and induces apoptosis in SKBr3 cells. RL7 also decreases HER2/neu phosphorylation and increases p27. RL71 also significantly reduced the phosphorylation of Akt and transiently increased the stress kinases JNK1/2 and p38 MAPK. Furthermore, RL71 exhibited anti-angiogenic potential in vitro, inhibiting the migration of HUVEC cells and the ability of these cells to form tubular networks .

Host:	Mouse (5) Rabbit (9)
Reactivity:	Human (14) Rat (8) Mouse (9) Monkey (2)
Application:	IHC-P (6) ICC/IF (6) IF-Tissue (1) IP (3) IHC-F (1) WB (12) FC (3) ELISA (6)
Isotype:	IgG (9) IgG1 (4)
Conjugation:	Non-conjugated (14)
Clonality:	Polyclonal (2) Monoclonal (9) Recombinant (3)
Modification:	Phosphorylated (2) Unmodified (9)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P87386

	p38 beta/MAPK11 + p38 gamma/MAPK12 + p38 delta/MAPK13 Antibody (YA7069) ERK 6 antibody; ERK-6 antibody; ERK6 antibody; Extracellular signal-regulated kinase 6 antibody; MAP kinase 12 antibody; MAP kinase p38 gamma antibody; MAPK 12 antibody; Mapk12 antibody; Mitogen Activated Protein kinase 12 antibody; Mitogen activated protein kinase p38 gamma antibody	WB	Human, Mouse, Rat, Monkey
	p38 beta/MAPK11 + p38 gamma/MAPK12 + p38 delta/MAPK13 Antibody (YA7069) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p38 beta/MAPK11 + p38 gamma/MAPK12 + p38 delta/MAPK13.

HY-P80776A

	Phospho-p38 alpha/MAPK14 (Thr180+Tyr182) Antibody 1 Publications Verification p38 (phospho T180 + Y182); p-p38 (phospho T180 + Y182); p38 (phospho T180/Y182); CSAID Binding Protein 1; CSAID binding protein; CSAID-binding protein; Csaids binding protein; CSBP 1; CSBP 2; CSBP; CSBP1; CSBP2; CSPB 1; CSPB1; Cytokine suppressive anti inflammatory drug binding protein; Cytokine suppressive anti-inflammatory drug-binding protein; EXIP; MAP kinase 14; MAP kinase MXI2; MAP kinase p38 alpha; MAPK 14; MAPK14; MAX interacting protein 2; MAX-interacting protein 2; Mitogen Activated Protein kinase 14; Mitogen activated protein kinase p38 alpha; Mitogen-activated protein kinase 14; Mitogen-activated protein kinase p38 alpha; MK14_HUMAN; Mxi 2; Mxi2; p38 ALPHA; p38; p38 MAP kinase; p38 MAPK; p38 mitogen activated protein kinase; p38ALPHA; p38alpha Exip; PRKM14; PRKM15; RK; SAPK 2A; SAPK2A; Stress Activated Protein kinase 2A.	WB, IHC-P, FC, ICC/IF, ELISA	Human, Mouse
	Phospho-p38 alpha/MAPK14 (Thr180+Tyr182) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-p38 alpha/MAPK14 (Thr180+Tyr182).

HY-P85311

	p38β Antibody (YA5003) MAPK11; PRKM11; SAPK2; SAPK2B; Mitogen-activated protein kinase 11; MAP kinase 11; MAPK 11; Mitogen-activated protein kinase p38 beta; MAP kinase p38 beta; p38b; Stress-activated protein kinase 2b; SAPK2b; p38-2	WB, ELISA	Human
	p38β Antibody (YA5003) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to p38β.

HY-P85712

	p38 alpha/MAPK14 Antibody (YA5404) Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein 2; Mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; Stress-activated protein kinase 2a; SAPK2a;	WB, ICC/IF, ELISA	Human, Mouse, Rat
	p38 alpha/MAPK14 Antibody (YA5404) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p38 alpha/MAPK14.

HY-P86460

	p38 alpha/MAPK14 Antibody (YA6152) Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein 2; Mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; Stress-activated protein kinase 2a; SAPK2a;	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	p38 alpha/MAPK14 Antibody (YA6152) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p38 alpha/MAPK14.

HY-P87165

	p38 gamma/MAPK12 Antibody (YA6858) ERK 6 antibody; ERK-6 antibody; ERK6 antibody; Extracellular signal-regulated kinase 6 antibody; MAP kinase 12 antibody; MAP kinase p38 gamma antibody; MAPK 12 antibody; Mapk12 antibody; Mitogen Activated Protein kinase 12 antibody; Mitogen activated protein kinase p38 gamma antibody; ERK 6 antibody; ERK-6 antibody; ERK6 antibody; Extracellular signal-regulated kinase 6 antibody; MAP kinase 12 antibody; MAP kinase p38 gamma antibody; MAPK 12 antibody; Mapk12 antibody; Mitogen Activated Protein kinase 12 antibody; Mitogen activated protein kinase p38 gamma antibody; Mitogen-activated protein kinase 12 antibody; Mitogen-activated protein kinase p38 gamma antibody; MK12_HUMAN antibody; p38 GAMMA antibody; p38GAMMA antibody; PRKM12 antibody; SAPK 3 antibody; SAPK-3 antibody; SAPK3 antibody; Stress Activated Protein kinase 3 antibody; Stress-activated protein kinase 3 antibody;	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	p38 gamma/MAPK12 Antibody (YA6858) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p38 gamma/MAPK12.

HY-P80776

	p38 alpha/MAPK14 Antibody (YA696) 2 Publications Verification MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein	WB	Human, Mouse, Rat, Monkey
	p38 alpha/MAPK14 Antibody (YA696) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p38 alpha/MAPK14.

HY-P80777

	p38 alpha/MAPK14 Antibody (YA252) 2 Publications Verification MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein	WB, IP	Human
	p38 alpha/MAPK14 Antibody (YA252) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p38 alpha/MAPK14.

HY-P80777A

	p38 alpha/MAPK14 Antibody (YA252)(PBS only) MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein	WB, IP	Human
	p38 alpha/MAPK14 Antibody (YA252) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p38 alpha/MAPK14.

HY-P86654

	ERK1/2 Antibody (YA6346) ERK1+ERK2; ERK 1; ERK 2; ERK-2; ERK1; ERK2; ERT1; ERT2; Extracellular signal regulated kinase 1; Extracellular signal regulated kinase 2; Extracellular signal-regulated kinase 2; HS44KDAP; HUMKER1A; Insulin stimulated MAP2 kinase; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAP kinase isoform p44; MAPK 1; MAPK 2; MAPK 3; MAPK1; MAPK2; MAPK3; MGC20180; Microtubule associated protein 2 kinase; Mitogen activated protein kinase 1; Mitogen activated protein kinase 2; Mitogen activated protein kinase 3; Mitogen-activated protein kinase 1; Mitogen-activated protein kinase 2; MK01_HUMAN; MK03_HUMAN; p38; p40; p41; p41mapk; p42 MAPK; p42-MAPK; p42MAPK; p44 ERK1; p44 MAPK; p44ERK1; p44MAPK; PRKM 1; PRKM 2; PRKM 3; PRKM1; PRKM2; PRKM3; Protein kinase mitogen activated 1; Protein kinase mitogen activated 2; Protein kinase mitogen activated 3; Protein tyrosine kinase ERK 2.	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, FC	Human, Mouse, Rat
	ERK1/2 Antibody (YA6346) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERK1/2.

HY-P85333

	MAPKAPK5 Antibody (YA5025) MAPKAPK5; PRAK; MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAP-K5; MAPKAPK-5; MK-5; MK5; p38-regulated/activated protein kinase; PRAK	IHC-P, ELISA	Human
	MAPKAPK5 Antibody (YA5025) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MAPKAPK5.

HY-P85333A

	MAPKAPK5 Antibody (YA5025)(PBS only) MAPKAPK5; PRAK; MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAP-K5; MAPKAPK-5; MK-5; MK5; p38-regulated/activated protein kinase; PRAK	IHC-P, ELISA	Human
	MAPKAPK5 Antibody (YA5025) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MAPKAPK5.

HY-P810544

	Phospho-p38 (Thr180) Antibody (YA9813) MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	Phospho-p38 (Thr180) Antibody (YA9813) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-p38 (Thr180).

HY-P80842

	Phospho-p38 alpha/MAPK14 (Thr180/Tyr182) Antibody 3 Publications Verification MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein	WB	Human, Mouse, Rat
	Phospho-p38 alpha/MAPK14 (Thr180/Tyr182) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-p38 alpha/MAPK14 (Thr180/Tyr182).

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Cat. No.	Product Name		Classification

HY-125387

TOP1210		Alkynes
TOP1210 is a narrow-spectrum tyrosine kinase inhibitor with potent inhibitory activity against P38α, Src, and Syk kinases. TOP1210 effectively reduced proinflammatory cytokines released by peripheral blood monocytes, primary macrophages, HT29 cells, inflammatory cells in ulcerative colitis (UC) biopsies, and myofibroblasts isolated from inflamed colonic UC mucosa. TOP1210 showed significant anti-inflammatory effects in cell experiments and UC biopsies, superior to some selective kinase inhibitors. The multi-kinase inhibition of TOP1210 provides the possibility of obtaining a wider range of therapeutic effects, especially in the regulation of autoimmune responses .

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p38 kinase

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