522629-08-9
522629-08-9
Chemical Structure
CGP 57380
- CAS No.: 522629-08-9
- Formula:C11H9FN6
- Molecular Weight:244.23
IUPAC Name: N3-(4-fluorophenyl)-3H-pyrazolo[3,4-d]pyrimidine-3,4-diamine
InChIKey: SIIPGZWXUQVYMG-UHFFFAOYSA-N
SMILES: NC1=NC=NC2=C1C(NC3=CC=C(F)C=C3)N=N2
Biological Activity: CGP 57380 is a cell-permeable pyrazolo-pyrimidine compound that acts as a selective inhibitor of Mnk1 with IC50 of 2.2 μM, but has no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases.
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CGP 57380 | 98.71% | CGP 57380 is a cell-permeable pyrazolo-pyrimidine compound that acts as a selective inhibitor of Mnk1 with IC50 of 2.2 μM, but has no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. | ||||||||||||||||||||
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CGP 57380 (Standard) | ≥98% | CGP 57380 (Standard) is the analytical standard of CGP 57380 (HY-10520). This product is intended for research and analytical applications. CGP 57380 is a cell-permeable pyrazolo-pyrimidine compound that acts as a selective inhibitor of Mnk1 with IC50 of 2.2 μM, but has no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. | ||||||||||||||||||||
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Structural Analogs
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Similarity Score 0.56
HY-B1045Chlorazanil hydrochloride -
Similarity Score 0.54
HY-12990Spautin-1 -
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HY-169055SARS-CoV-2 Mpro-IN-25 -
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HY-115823ztz240 -
Similarity Score 0.54
HY-105752Loflucarban -
Similarity Score 0.53
HY-112468PNU112455A hydrochloride -
Similarity Score 0.53
HY-148321WAY-353591 -
Similarity Score 0.53
HY-160896Autophagy-IN-5 -
Similarity Score 0.53
HY-119672Oct4 inducer-1 -
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