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pantothenate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PANK (7) Apoptosis (4) Drug Derivative (2) Drug Intermediate (1) Endogenous Metabolite (9) Environmental Pollutants (2) Fluorescent Dye (1) Isotope-Labeled Compounds (2) Reference Standards (3) SARS-CoV (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Endocrinology (4) Inflammation/Immunology (4) Metabolic Disease (13) Neurological Disease (9)

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Products

Isotope-Labeled Compounds

Targets Recommended: PANK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0430

D-Pantothenic acid Maximum Cited Publications 6 Publications Verification pantothenate; Vitamin B5	Environmental Pollutants Endogenous Metabolite	Others
D-Pantothenic acid (Pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism .

HY-N0681

D-Pantothenic acid hemicalcium salt Maximum Cited Publications 6 Publications Verification Calcium pantothenate; Calcium D-pantothenate; Vitamin B5 calcium salt	Environmental Pollutants Apoptosis Endogenous Metabolite	Metabolic Disease Inflammation/Immunology Endocrinology
D-Pantothenic acid hemicalcium salt is an orally active vitamin that reduces patulin in apple juice. D-Pantothenic acid hemicalcium salt removes ROS. D-Pantothenic acid hemicalcium salt has antibacterial and immunomodulatory activities. D-Pantothenic acid hemicalcium salt also has the effect of improving osteoporosis and obesity .

HY-B1028

Pantethine 5 Publications Verification D-Pantethine; LBF disulfide	Endogenous Metabolite SARS-CoV	Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology Cancer
Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration .

HY-44170

Pantothenate kinase-IN-2 2 Publications Verification	PANK	Neurological Disease Metabolic Disease
Pantothenate kinase-IN-2 is a pantothenate kinase inhibitor with IC₅₀ values of 92 nM for PanK2, 70 nM for PanK1β, and 25 nM for PanK3. Pantothenate kinase-IN-2 can bind specifically to the ATP-PanK3 complex and block CoA biosynthesis. Pantothenate kinase-IN-2 can be used for the research of pank-associated neurodegeneration and type 2 diabetes .

HY-B0430A

D-Pantothenic acid sodium Maximum Cited Publications 6 Publications Verification Sodium pantothenate; Vitamin B5 sodium	Apoptosis Endogenous Metabolite	Metabolic Disease
D-Pantothenic acid sodium (Sodium pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid sodium plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism .

HY-124634

PZ-2891 4 Publications Verification	PANK	Neurological Disease
PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC₅₀s of 40.2 nM, 0.7 nM and 1.3 nM, respectively .

HY-139729

HOPan 2 Publications Verification	PANK Drug Derivative	Metabolic Disease
HOPan is a PanK substrate and Pantothenate (HY-B0430) analog. HOPan inhibits CoA levels .

HY-144734

Pantothenate kinase-IN-1	PANK	Neurological Disease Metabolic Disease
Pantothenate kinase-IN-1 is a PANK3 inhibitor with an IC₅₀ of 0.51 μM. Pantothenate kinase-IN-1 acts as a pantothenate-competitive inhibitor, which occupies the pantothenate-binding site of PANK3 and binds to both protomers in the PANK3 dimer. Pantothenate kinase-IN-1 exhibits metabolic stability in mouse and rat plasma. Pantothenate kinase-IN-1 can be used in the research of pantothenate kinase-associated neurodegenerative diseases and metabolic diseases .

HY-159509

Claziprotamidum Claziprotamide; BBP-671	PANK	Neurological Disease Metabolic Disease
Claziprotamidum (Claziprotamide; BBP-671) is a panthothenate kinase (PANK) activator with oral activity and blood-brain barrier permeability. Claziprotamidum binds to and activates all PANK isoforms, with the highest affinity for PANK3 (K_D = 97 pM; IC₅₀ = 1.39 nM). Claziprotamidum increases the intracellular biosynthesis of Coenzyme A (HY-128851) and restores mitochondrial function. Claziprotamidum can be used in the research of pantothenate kinase-associated neurodegeneration and propionic acidemia .

HY-109033

Fosmetpantotenate RE-024	Drug Intermediate	Neurological Disease
Fosmetpantotenate is a phosphopantothenic acid (PPA) precursor designed to release PPA intracellularly, leading to restoration of CoA levels. Fosmetpantotenate is used to research pantothenate kinase-associated neurodegeneration.

HY-169491

Pantothenate-AMC	Fluorescent Dye	Metabolic Disease
Pantothenate-AMC is a fluorogenic substrate used for detecting the enzymatic activity of vanin-1, an enzyme involved in the recycling of L-pantothenic acid. Upon enzymatic cleavage by vanin-1, 7-amino-7-methylcoumarin (AMC) is released, and its fluorescence can be used to quantify vanin-1 activity. The excitation/emission maxima of AMC are 340-360 nm and 440-460 nm, respectively .

HY-144432S

D-Pantothenic acid-13C3,15N hemicalcium hemihydrate pantothenate-13C3,15N; Vitamin B5-13C3,15N hemicalcium hemihydrate	Isotope-Labeled Compounds	Others
Vitamin B5- ¹³C₃, ¹⁵N hemicalcium hemihydrate is the ¹³C and ¹⁵N labeled Vitamin B5 hemicalcium hemihydrate .

HY-B0430B

(±)-Pantothenic acid (±)-pantothenate; (±)-Vitamin B5	Endogenous Metabolite	Neurological Disease Metabolic Disease
(±)-Pantothenic acid ((±)-Pantothenate), a B-vitamin, is an essential vitamin required for the biosynthesis of coenzyme A (CoA) in mammalian cells. Pantothenic acid has protective activity against valproic acid (VPA)-induced neural tube defects (NTD) in CD-1 mice .

HY-164909

PZ-3022	PANK	Metabolic Disease
PZ-3022 is an orally active allosteric agonist of pantothenate kinase (PanK) with an EC₅₀ of 5.3 nM against PanK3. PZ-3022 antagonizes the inhibitory effect of C3-CoA. PZ-3022 increases CoA levels in cells and the liver, upregulates CoASH and C2-CoA, downregulates C3-CoA, and restores impaired TCA cycle and mitochondrial function. PZ-3022 can be used for the research of propionic acidemia and metabolic CoA deficiency .

HY-N0681R

D-Pantothenic acid hemicalcium salt (Standard) Calcium pantothenate (Standard); Calcium D-pantothenate (Standard); Vitamin B5 calcium salt (Standard)	Reference Standards Endogenous Metabolite Apoptosis	Others
D-Pantothenic acid (hemicalcium salt) (Standard) is the analytical standard of D-Pantothenic acid (hemicalcium salt). This product is intended for research and analytical applications. D-Pantothenic acid hemicalcium salt is a vitamin that reduces patulin in apple juice.

HY-B1028R

Pantethine (Standard) D-Pantethine (Standard); LBF disulfide (Standard)	Reference Standards Endogenous Metabolite SARS-CoV	Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology Cancer
Pantethine (Standard) is the analytical standard of Pantethine. This product is intended for research and analytical applications. Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration .

HY-B0430AR

D-Pantothenic acid sodium (Standard) Sodium pantothenate (Standard); Vitamin B5 sodium (Standard)	Reference Standards Apoptosis Endogenous Metabolite	Metabolic Disease
D-Pantothenic acid (sodium) (Standard) is the analytical standard of D-Pantothenic acid (sodium). This product is intended for research and analytical applications. D-Pantothenic acid sodium (Sodium pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid sodium plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism[1].

HY-177153

Allantoin calcium pantothenate	Drug Derivative	Others
Allantoin calcium pantothenate is a complex formed by Allantoin (HY-N0543) and Calcium pantothenate (HY-N0681). Allantoin calcium pantothenate has protective, anti-irritant, soothing and moisturizing properties. Allantoin calcium pantothenate can be safely used as an anti-irritant, wound healing agent and conditioning agent. Allantoin calcium pantothenate can be incorporated at 0.2-2% in most formulations. Allantoin calcium pantothenate can be used in cosmetics-related research .

HY-B1028S

Pantethine-15N2 D-Pantethine-¹⁵N₂; LBF disulfide-¹⁵N₂	Isotope-Labeled Compounds	Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Pantethine- ¹⁵N₂ is the ¹⁵N₂ labeled Pantethine. Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration .

HY-181917

Pantothenate kinase-IN-3	PANK	Metabolic Disease
Pantothenate kinase-IN-3 is an orally active PANK3-selective binder and CoA biosynthesis activator with a human PANK3 K_i of 9.1 nM, human PANK3 K_a of 1.8 nM, human PANK1β K_i of 113 nM, human PANK1β K_a of 23.4 nM, and oral effectiveness.Pantothenate kinase-IN-3 binds PANK3 via a water-mediated interaction between its sulfonamide NH and Gly193, elevates cellular, hepatic, and forebrain CoA levels, and shows improved metabolic stability in mouse and human microsomes.Pantothenate kinase-IN-3 has solubility properties favorable at pH 7.Pantothenate kinase-IN-3 can be used for the research of hepatic metabolic CoA deficiencies (acidemias) .

HY-W654307

(RS)-Pantoic acid sodium monohydrate	Endogenous Metabolite	Metabolic Disease
(RS) -Pantoic acid sodium monohydrate is an intermediate in the phosphopantothenate biosynthesis pathway for the de novo synthesis of R-pantothenate (vitamin B5) from valine in plants and microorganisms.

MEM Vitamine Solution (100×)
MCE MEM Vitamin Solution (100×) contains eight vitamins, including choline chloride, D-calcium pantothenate, folic acid, nicotinamide, pyridoxal hydrochloride, riboflavin, thiamine hydrochloride, and inositol. It can be used as a serum-free supplement for cell culture media to enhance cell viability and promote cell growth.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0430

D-Pantothenic acid Maximum Cited Publications 6 Publications Verification pantothenate; Vitamin B5	Structural Classification Human Gut Microbiota Metabolites Microorganisms other families Animals Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Plants Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite
D-Pantothenic acid (Pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism .

HY-N0681

D-Pantothenic acid hemicalcium salt Maximum Cited Publications 6 Publications Verification Calcium pantothenate; Calcium D-pantothenate; Vitamin B5 calcium salt	Structural Classification Natural Products other families Classification of Application Fields Other Diseases Plants Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Apoptosis Endogenous Metabolite
D-Pantothenic acid hemicalcium salt is an orally active vitamin that reduces patulin in apple juice. D-Pantothenic acid hemicalcium salt removes ROS. D-Pantothenic acid hemicalcium salt has antibacterial and immunomodulatory activities. D-Pantothenic acid hemicalcium salt also has the effect of improving osteoporosis and obesity .

HY-B1028

Pantethine 5 Publications Verification D-Pantethine; LBF disulfide	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite SARS-CoV
Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration .

HY-B0430A

D-Pantothenic acid sodium Maximum Cited Publications 6 Publications Verification Sodium pantothenate; Vitamin B5 sodium	Alkaloids Classification of Application Fields Ketones, Aldehydes, Acids Other Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Apoptosis Endogenous Metabolite
D-Pantothenic acid sodium (Sodium pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid sodium plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism .

HY-B0430B

(±)-Pantothenic acid (±)-pantothenate; (±)-Vitamin B5	Other disease Disease markers Endogenous metabolite	Endogenous Metabolite
(±)-Pantothenic acid ((±)-Pantothenate), a B-vitamin, is an essential vitamin required for the biosynthesis of coenzyme A (CoA) in mammalian cells. Pantothenic acid has protective activity against valproic acid (VPA)-induced neural tube defects (NTD) in CD-1 mice .

HY-N0681R

D-Pantothenic acid hemicalcium salt (Standard) Calcium pantothenate (Standard); Calcium D-pantothenate (Standard); Vitamin B5 calcium salt (Standard)	Structural Classification Natural Products other families Plants Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Apoptosis
D-Pantothenic acid (hemicalcium salt) (Standard) is the analytical standard of D-Pantothenic acid (hemicalcium salt). This product is intended for research and analytical applications. D-Pantothenic acid hemicalcium salt is a vitamin that reduces patulin in apple juice.

HY-B1028R

Pantethine (Standard) D-Pantethine (Standard); LBF disulfide (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite SARS-CoV
Pantethine (Standard) is the analytical standard of Pantethine. This product is intended for research and analytical applications. Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration .

HY-B0430AR

D-Pantothenic acid sodium (Standard) Sodium pantothenate (Standard); Vitamin B5 sodium (Standard)	Structural Classification Alkaloids Ketones, Aldehydes, Acids Other Alkaloids Endogenous metabolite Source Classification	Reference Standards Apoptosis Endogenous Metabolite
D-Pantothenic acid (sodium) (Standard) is the analytical standard of D-Pantothenic acid (sodium). This product is intended for research and analytical applications. D-Pantothenic acid sodium (Sodium pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid sodium plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism[1].

Cat. No.	Product Name	Chemical Structure

HY-144432S

D-Pantothenic acid-13C3,15N hemicalcium hemihydrate
Vitamin B5- ¹³C₃, ¹⁵N hemicalcium hemihydrate is the ¹³C and ¹⁵N labeled Vitamin B5 hemicalcium hemihydrate .

HY-B1028S

Pantethine-15N2
Pantethine- ¹⁵N₂ is the ¹⁵N₂ labeled Pantethine. Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration .

Pantethine-15N2

Pantethine- ¹⁵N₂ is the ¹⁵N₂ labeled Pantethine. Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration .

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