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preventive

" in MedChemExpress (MCE) Product Catalog:

45

Inhibitors & Agonists

1

Peptides

2

Inhibitory Antibodies

18

Natural
Products

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0256
    Hederagenin
    Maximum Cited Publications
    7 Publications Verification

    		 COX NF-κB E1/E2/E3 Enzyme Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin can also bind to SKP2, with KD = 67.9 μM. Hederagenin also has preventive potential against alcoholic liver injury .
    Hederagenin
  • HY-N0679
    Retinyl acetate
    4 Publications Verification

    Retinol acetate; Vitamin A acetate

    		 Environmental Pollutants Cancer
    Retinyl acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities .
    Retinyl acetate
  • HY-N0522
    (-)-Gallocatechin gallate
    3 Publications Verification

    (-)-Gallocatechol gallate

    		 COMT Cancer
    (-)-Gallocatechin gallate is the polyphenol isolated from tea, with cancer-preventive activities.
    (-)-Gallocatechin gallate
  • HY-116807
    Dihydrolipoic Acid
    2 Publications Verification

    DHLA

    		 Reactive Oxygen Species (ROS) Neurological Disease Inflammation/Immunology
    Dihydrolipoic Acid (DHLA) is an excellent antioxidant capable of scavenging almost any oxygen-centered radical . Dihydrolipoic acid exhibits anti-inflammatory properties in various diseases. Dihydrolipoic Acid exerts a preventive effect via ERK/Nrf2/HO-1/ROS/NLRP3 pathway in LPS-induced sickness behavior rats. Dihydrolipoic Acid can be used for the reaserch of depression .
    Dihydrolipoic Acid
  • HY-N2419
    Erythrodiol
    1 Publications Verification

    		 Endogenous Metabolite Metabolic Disease
    Erythrodiol is an olive oil component. Erythrodiol promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein. Erythrodiol is a good candidate to be further explored for therapeutic or preventive application in the context of atherosclerosis .
    Erythrodiol
  • HY-N6660
    Trisdecanoin

    Tricaprin; Glyceryl tridecanoate

    		 Endogenous Metabolite Androgen Receptor Cardiovascular Disease Metabolic Disease
    Trisdecanoin (Tricaprin; Glyceryl tridecanoate) is an orally available precursor of decanoic acid (DA precursor) that can be hydrolyzed to decanoic acid. Trisdecanoin and its metabolite capric acid not only provide the body with a quick source of energy, but can also affect lipid metabolism. Trisdecanoin is a major component of medium chain triglycerides (MCT), which has preventive or inhibitory properties for abdominal aortic aneurysms (AAA), inhibition of cardiovascular disease, and anti-androgen (NSAA) and anti-hyperglycemic properties. Trisdecanoin can be used as an additive in food, medicine and cosmetics .
    Trisdecanoin
  • HY-N6057
    Obtusin

    		Monoamine Oxidase Neurological Disease
    Obtusin, isolated from Cassia obtusifolia Linn seed, is a highly selective and competitive human monoamine oxidase-A (hMAO-A) inhibitor with an IC50 of 11.12 μM and a Ki of 6.15 μM. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression .
    Obtusin
  • HY-B1787
    Sulindac sulfone

    		mTOR Drug Metabolite CDK PPAR Apoptosis Cancer
    Sulindac sulfone is an orally active metabolite of Sulindac (HY-B0008). Sulindac sulfone activates PPARγ and drives transcriptional induction of SSAT by binding to the PPRE-2 element. Sulindac sulfone induces Apoptosis. Sulindac sulfone negatively regulates the function of VDAC1/2 to inhibit the mTORC1 pathway, reduces Cyclin D1 levels, and induces G1 cell cycle arrest in colon cancer cells. Sulindac sulfone exerts colon cancer preventive effects through a COX-independent mechanism. Sulindac sulfone can be used in research related to colon cancer .
    Sulindac sulfone
  • HY-130479
    AdipoR agonist 1

    		Adiponectin Receptor PPAR PGC-1α Sirtuin AMPK Metabolic Disease
    AdipoR agonist 1 (Compound 112254) is an agonist for adiponectin receptor (AdipoR), which activates the transcriptional regulators like peroxisome proliferator-activated receptors (PPARs), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and adenylate-activated protein kinase (AMPK). AdipoR agonist 1 is utilized in preventive doping research .
    AdipoR agonist 1
  • HY-B2008
    Famoxadone

    DPX-JE874

    		 Environmental Pollutants Fungal Infection
    Famoxadone is a fungicide active against various oomycetes. Famoxadone induces rapid lysis of zoospores of P. viticola and P. infestans, and inhibits sporangial differentiation, zoospore release, sporangial germination and mycelial growth. Famoxadone exerts a preventive control effect on plant diseases. Famoxadone can be used in research related to grape downy mildew, potato late blight, tomato late blight and plant oomycete diseases .
    Famoxadone
  • HY-N0679R
    Retinyl acetate (Standard)

    Retinol acetate (Standard); Vitamin A acetate (Standard)

    		 Reference Standards Others Cancer
    Retinyl acetate (Standard) is the analytical standard of Retinyl acetate. This product is intended for research and analytical applications. Retinyl acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities .
    Retinyl acetate (Standard)
  • HY-106328
    Fluasterone
    1 Publications Verification

    		 Mitochondrial Metabolism Metabolic Disease Inflammation/Immunology Cancer
    Fluasterone is a potent G6PD inhibitor with a Ki of 0.51 μM. Fluasterone has anti-inflammatory, cancer preventive, and anti-diabetic effects. Fluasterone is orally active .
    Fluasterone
  • HY-165027
    DL-1′-Acetoxychavicol acetate

    		NO Synthase COX Others
    DL-1′-Acetoxychavicol acetate is a compound with anti-inflammatory and anticancer preventive potential that inhibits the activities of NOX, iNOS, and COX-2 in inflammatory cells and exhibits preventive activity in multiple inflammation-related cancer models.
    DL-1′-Acetoxychavicol acetate
  • HY-N0522R
    (-)-Gallocatechin gallate (Standard)

    (-)-Gallocatechol gallate (Standard)

    		 Reference Standards Others Cancer
    (-)-Gallocatechin gallate (Standard) is the analytical standard of (-)-Gallocatechin gallate. This product is intended for research and analytical applications. (-)-Gallocatechin gallate is the polyphenol isolated from tea, with cancer-preventive activities.
    (-)-Gallocatechin gallate (Standard)
  • HY-101698
    Alniditan

    Alnitidan

    		 5-HT Receptor Neurological Disease Inflammation/Immunology
    Alniditan (Alnitidan) is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK293 cells, respectively. Alniditan has migraine-preventive effects .
    Alniditan
  • HY-116266
    RS 67333

    		5-HT Receptor Others
    RS 67333 is a 5-HT4R agonist with stress-preventive activity. RS 67333 attenuates stress-induced body weight changes and prevents depression- and anxiety-like behaviors in two mouse strains tested in different stress models.
    RS 67333
  • HY-N0256R
    Hederagenin (Standard)

    		Reference Standards COX NF-κB Cancer
    Hederagenin (Standard) is the analytical standard of Hederagenin. This product is intended for research and analytical applications. Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin also has preventive potential against alcoholic liver injury .
    Hederagenin (Standard)
  • HY-101698B
    Alniditan dihydrochloride

    Alnitidan dihydrochloride

    		 5-HT Receptor Neurological Disease Inflammation/Immunology
    Alniditan (Alnitidan) dihydrochloride is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK293 cells, respectively. Alniditan dihydrochloride has migraine-preventive effects .
    Alniditan dihydrochloride
  • HY-N0679S4
    Retinyl acetate-d4

    Retinol acetate-d4; Vitamin A acetate-d4

    		 Isotope-Labeled Compounds Cancer
    Retinyl acetate-d4 is the deuterium labeled Retinyl acetate . Retinyl acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities .
    Retinyl acetate-d4
  • HY-116726
    Crambene

    		Glutathione S-transferase Cancer
    Crambene is an orally active cyanide compound isolated from cruciferous vegetables. Crambene has a cancer-preventive effect and induces significant upregulation of quinone reductase and glutathione S-transferase in vitro and in vivo .
    Crambene
  • HY-W742324
    Pyriofenone

    IKF-309

    		 Fungal Others
    Pyriofenone (IKF-309) is an arylphenyl ketone fungicide used primarily to control powdery mildew on crops such as cereals, rice, fruit trees, and vegetables. Pyriofenone has moderate efficacy against rice blast. Pyriofenone acts through preventive, residual, curative, rainfast, cross-stratum, and fumigant activities .
    Pyriofenone
  • HY-19106
    MCI-727 free base

    		Secretin Receptor Inflammation/Immunology Endocrinology
    MCI-727 free base is an orally active anti-ulcer agent. MCI-727 free base can increase the plasma secretin concentration in rats and dogs. MCI-727 free base can also stimulate the exocrine function of the pancreas in rats by promoting the release of endogenous secretin, and exert preventive and therapeutic effects on mild acute pancreatitis. MCI-727 free base can be used in the research of ulcer-related diseases .
    MCI-727 free base
  • HY-120050
    GK470

    		Phospholipase Inflammation/Immunology
    GK470 (compound 28) is an inhibitor of group IVA cytosolic phospholipase A2 (GIVA cPLA2) with an IC50 of 300 nM in vesicle assays. GK470 has anti-inflammatory activity, inhibiting the release of arachidonic acid in SW982 fibroblast-like synoviocytes with an IC50 value of 0.6 μM. GK470 exhibits comparable anti-inflammatory effects to Methotrexate (HY-14519) in a preventive collagen-induced arthritis model and significantly reduces plasma PGE2 levels .
    GK470
  • HY-163332
    MPO-IN-6

    		Glycosidase Dipeptidyl Peptidase Glutathione Peroxidase Cardiovascular Disease
    MPO-IN-6 (compound ADC) is an electrophile with good antioxidant and anti-inflammatory properties. MPO-IN-6 is a myeloperoxidase (MPO), dipeptidyl peptidase-4 (DPP-4), and α-glucosidase (α-GD) inhibitor with IC50s of 10 μM, 31.02 μM, and 46.05 μM, respectively. MPO-IN-6 is a potential cardiovascular preventive agent .
    MPO-IN-6
  • HY-N8690
    4,2'-Dihydroxy-4'-methoxychalcone

    		Others Inflammation/Immunology
    4,2'-Dihydroxy-4'-methoxychalcone, a chalcone, shows allergy-preventive effects .
    4,2'-Dihydroxy-4'-methoxychalcone
  • HY-119657
    Cellocidin

    		Bacterial Others
    Cellocidin is an agricultural antibiotic with preventive effects against rice bacterial leaf blight and is thought to work by inhibiting the α-ketoglutarate-succinate system in Xanthomonas sp.
    Cellocidin
  • HY-N3009R
    Secoxyloganin (Standard)

    		Reference Standards Others Cardiovascular Disease
    Secoxyloganin (Standard) is the analytical standard of Secoxyloganin. This product is intended for research and analytical applications. Secoxyloganin, isolated from Lonicera japonica Thunb, inhibits the blood flow (BF) decrease. Secoxyloganin has allergy-preventive activity .
    Secoxyloganin (Standard)
  • HY-106328R
    Fluasterone (Standard)

    		Mitochondrial Metabolism Reference Standards Metabolic Disease Inflammation/Immunology Cancer
    Fluasterone (Standard) is the analytical standard of Fluasterone. This product is intended for research and analytical applications. Fluasterone is a potent G6PD inhibitor with a Ki of 0.51 μM. Fluasterone has anti-inflammatory, cancer preventive, and anti-diabetic effects. Fluasterone is orally active .
    Fluasterone (Standard)
  • HY-N2419R
    Erythrodiol (Standard)

    		Reference Standards Endogenous Metabolite Metabolic Disease
    Erythrodiol (Standard) is the analytical standard of Erythrodiol. This product is intended for research and analytical applications. Erythrodiol is an olive oil component. Erythrodiol promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein. Erythrodiol is a good candidate to be further explored for therapeutic or preventive application in the context of atherosclerosis .
    Erythrodiol (Standard)
  • HY-114766
    Pumafentrine

    		Phosphodiesterase (PDE) Inflammation/Immunology
    Pumafentrine is an orally active, potent dual PDE3/PDE4 inhibitor. Pumafentrine dose-dependently ameliorates the clinical score and colonic TNFα production in murine Dextran sulphate sodium (DSS; HY-116282C)-induced colitis in a preventive setting .
    Pumafentrine
  • HY-159910
    LH1513

    		Mitochondrial Metabolism Cancer
    LH1513 is a dioxalate derivative of l-lysine (HY-N0469) that inhibits CaOx crystallization with better activity than citrate and pyruvate. LH1513 has potential preventive activity in hyperoxaluria models and effectively prevents urinary CaOx crystal formation in Agxt knockout mice. AGXT-1 is a mitochondrial protein involved in metabolism .
    LH1513
  • HY-146435
    Anti-inflammatory agent 22

    		TNF Receptor Inflammation/Immunology
    Anti-inflammatory agent 22 (compound 14a) is an orally active anti-inflammatory agent. Anti-inflammatory agent 22 inhibits LPS-induced TNF-α production with an IC50 value of 14.6 μM. Anti-inflammatory agent 22 has preventive effects on lymphedematous tissue via suppression of adipogenesis. Anti-inflammatory agent 22 suppresses limb lymphedema volume in mice .
    Anti-inflammatory agent 22
  • HY-N12708
    23-O-β-D-Glucopyranosyl-20-isoveratramine

    		Others Others
    23-O-β-D-Glucopyranosyl-20-isoveratramine is a potential anti-allergic agent extracted from nettles. A variety of COX-1, COX-2, 5-lipoxygenase and trypsin-like inhibitors and H1 antagonists are found in nettle extract, which can inhibit seasonal allergies, allergic rhinitis and other inflammatory diseases. and preventive effects .
    23-O-β-D-Glucopyranosyl-20-isoveratramine
  • HY-W040235
    Fluazuron

    		Endogenous Metabolite Others
    Fluazuron is an insect growth regulator with activity against larvae of Amblyomma sculptum. Fluazuron exhibits 100% efficacy by interfering with the molting process. Fluazuron has shown rapid absorption and slow metabolism in experiments. The use of Fluazuron offers a potential preventive measure for the control of Brazilian spotted fever. The results of Fluazuron offer good prospects for the development of feed products containing FLU to control ticks in free-living capybaras .
    Fluazuron
  • HY-145644
    Ogalvibart

    C-135-LS; BMS-986414

    		 SARS-CoV Infection Cancer
    Ogalvibart (C-135-LS) is a human anti-SARS-CoV-2 monoclonal antibody (IgG1 type). Ogalvibart binds to the spike (S) glycoprotein receptor-binding domain (RBD) of SARS-CoV-2. Ogalvibart in combination with C144LS (1:1 ratio) shows good preventive activity and can effectively block the development of COVID19 in a rhesus monkey disease model .
    Ogalvibart
  • HY-B0019
    Azasetron

    (Rac)-SENS-401 free base

    		 5-HT Receptor Neurological Disease
    Azasetron ((Rac)-SENS-401 free base) is an antiemetic drug with 5-HT3 receptor antagonist activity. Azasetron is often used as a preventive measure for postoperative nausea and vomiting or chemotherapy-induced nausea and vomiting. Azasetron does not impair neutrophil chemotaxis or phagocytosis and does not scavenge O(-)(2) or H(2)O(2) generated by cell-free systems .
    Azasetron
  • HY-119805
    YM 13650

    		Others Inflammation/Immunology
    YM 13650 is an orally active anti-nephritic agent. YM 13650 exhibits dose-dependent preventive and therapeutic effects in both the rat immune complex nephritis model and the mouse spontaneous lupus nephritis model. YM 13650 can inhibit the increase in urinary protein, improve serum cholesterol and urea nitrogen levels, alleviate renal pathological damage, and prolong the survival time of mice. YM 13650 can be used in the research of nephritic diseases .
    YM 13650
  • HY-116807R
    Dihydrolipoic Acid (Standard)

    DHLA (Standard)

    		 Reference Standards Reactive Oxygen Species (ROS) Neurological Disease Inflammation/Immunology
    Dihydrolipoic Acid (Standard) is the analytical standard of Dihydrolipoic Acid. This product is intended for research and analytical applications. Dihydrolipoic Acid (DHLA) is an excellent antioxidant capable of scavenging almost any oxygen-centered radical . Dihydrolipoic acid exhibits anti-inflammatory properties in various diseases. Dihydrolipoic Acid exerts a preventive effect via ERK/Nrf2/HO-1/ROS/NLRP3 pathway in LPS-induced sickness behavior rats. Dihydrolipoic Acid can be used for the reaserch of depression .
    Dihydrolipoic Acid (Standard)
  • HY-B2008R
    Famoxadone (Standard)

    DPX-JE874 (Standard)

    		 Reference Standards Fungal Infection
    Famoxadone (Standard) is the analytical standard of Famoxadone. This product is intended for research and analytical applications. Famoxadone is a fungicide active against various oomycetes. Famoxadone induces rapid lysis of zoospores of P. viticola and P. infestans, and inhibits sporangial differentiation, zoospore release, sporangial germination and mycelial growth. Famoxadone exerts a preventive control effect on plant diseases. Famoxadone can be used in research related to grape downy mildew, potato late blight, tomato late blight and plant oomycete diseases .
    Famoxadone (Standard)
  • HY-W777959
    Azasetron Hydrochloride-13C,d3

    		Isotope-Labeled Compounds 5-HT Receptor Neurological Disease
    Azasetron Hydrochloride- 13C,d3 is the deuterium and 13C-labeled Azasetron (HY-B0019). Azasetron ((Rac)-SENS-401 free base) is an antiemetic drug with 5-HT3 receptor antagonist activity. Azasetron is often used as a preventive measure for postoperative nausea and vomiting or chemotherapy-induced nausea and vomiting. Azasetron does not impair neutrophil chemotaxis or phagocytosis and does not scavenge O(-)(2) or H(2)O(2) generated by cell-free systems .
    Azasetron Hydrochloride-13C,d3
  • HY-N6660R
    Trisdecanoin (Standard)

    Tricaprin (Standard); Glyceryl tridecanoate (Standard)

    		 Reference Standards Endogenous Metabolite Androgen Receptor Metabolic Disease
    Trisdecanoin (Standard) is the analytical standard of Trisdecanoin. This product is intended for research and analytical applications. Trisdecanoin (Tricaprin; Glyceryl tridecanoate) is an orally available precursor of decanoic acid (DA precursor) that can be hydrolyzed to decanoic acid. Trisdecanoin and its metabolite capric acid not only provide the body with a quick source of energy, but can also affect lipid metabolism. Trisdecanoin is a major component of medium chain triglycerides (MCT), which has preventive or inhibitory properties for abdominal aortic aneurysms (AAA), inhibition of cardiovascular disease, and anti-androgen (NSAA) and anti-hyperglycemic properties. Trisdecanoin can be used as an additive in food, medicine and cosmetics .
    Trisdecanoin (Standard)
  • HY-113327R
    1,3,7-Trimethyluric acid (Standard)

    		Drug Metabolite Reference Standards Endogenous Metabolite Cancer
    Hederagenin (Standard) is the analytical standard of Hederagenin. This product is intended for research and analytical applications. Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin also has preventive potential against alcoholic liver injury .
    1,3,7-Trimethyluric acid (Standard)
  • HY-118243
    KMS88009

    		Amyloid-β Others
    KMS88009 is a potent small molecule that directly interferes with the formation of amyloid-β oligomers, thereby preserving cognitive behavior when used preventively and reversing cognitive behavior decline when used therapeutically. Oral administration of KMS88009 around the onset of Alzheimer's disease symptoms significantly reduced the assembly of amyloid-β oligomers and improved cognitive behavior in the APP/PS1 double transgenic mouse model. This unique dual mode of action suggests that KMS88009 may be a powerful therapeutic candidate for the treatment of Alzheimer's disease. In an evaluation, the physicochemical properties, pharmacokinetics and toxicity of this anti-amyloidogenic small molecule KMS88009 were studied, as well as post-mortem analysis of APP/PS1 TG mice after behavioral testing.
    KMS88009
  • HY-P992345
    DS002

    		Trk Receptor Neurological Disease
    DS002 is a human monoclonal antibody targeting NGF/bNGF, with an IC50 of 6.60 nM against human NGF, 1.98 nM against rat NGF, and 8.46 nM against mouse NGF. DS002 blocks NGF-TrkA binding, interrupts pain signal transduction, inhibits TrkA-mediated downstream signaling pathways, and alters aromatic amino acid metabolic pathways. DS002 inhibits cancer cell proliferation. DS002 exerts a preventive effect on Paclitaxel-, Cisplatin- and Vincristine-induced peripheral neuropathy in rats. DS002 can be used in studies related to chronic pain and chemotherapy-induced peripheral neuropathy .
    DS002
  • HY-P11467
    Gy-CATH

    		Bacterial p38 MAPK NF-κB PERK JNK Cardiovascular Disease Infection
    Gy-CATH is an anionic antimicrobial peptide. Gy-CATH activates MAPK and NF-κB signaling pathways (elevated levels of phospho-ERK, -p38, -JNK, -p65, and -IκBα). Gy-CATH upregulates the expression levels of three physiological anticoagulant pathways. Gy-CATH inhibits ADP-, Collagen-, and PMA-induced platelet aggregation. Gy-CATH has no direct antimicrobial activity, but shows significant preventive abilities against mice infected with Staphylococcus aureus, Escherichia coli, and Methicillin (HY-121544)-resistant Staphylococcus aureus. Gy-CATH exhibits potent immunomodulatory activity, enhancing macrophage-and neutrophil-mediated bactericidal functions. Gy-CATH significantly reduces the extent of pulmonary fibrin deposition and prevents thrombosis in mice .
    Gy-CATH

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