70588-05-5
Chemical Structure
Obtusin
- CAS No.: 70588-05-5
- Formula:C18H16O7
- Molecular Weight:344.32
IUPAC Name: 1,7-dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione
InChIKey: CFLNHFUPWNRWJA-UHFFFAOYSA-N
SMILES: O=C1C2=C(C=C(C)C(O)=C2OC)C(C3=CC(OC)=C(OC)C(O)=C13)=O
Biological Activity: Obtusin is an orally active human monoamine oxidase A (hMAO-A) inhibitor discovered from the seeds of Cassia obtusifolia, with a Ki value of 6.15 μM. Obtusin inhibits high glucose-induced activation of the MAPKs/NF-κB/VEGF pathway and downregulates the expression of Poldip2, Nox4, VCAM-1, and HIF-1α, thereby alleviating oxidative stress, endothelial activation, and angiogenesis-related functions. Obtusin ameliorates diabetic retinopathy in vivo. Obtusin is used in research related to diabetes and neurodegenerative diseases (anxiety and depression)[1][2].
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Obtusin | 99.10% | Obtusin is an orally active human monoamine oxidase A (hMAO-A) inhibitor discovered from the seeds of Cassia obtusifolia, with a Ki value of 6.15 μM. Obtusin inhibits high glucose-induced activation of the MAPKs/NF-κB/VEGF pathway and downregulates the expression of Poldip2, Nox4, VCAM-1, and HIF-1α, thereby alleviating oxidative stress, endothelial activation, and angiogenesis-related functions. Obtusin ameliorates diabetic retinopathy in vivo. Obtusin is used in research related to diabetes and neurodegenerative diseases (anxiety and depression). | ||||||||||||||||||||
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Similarity Score 0.87
HY-133860Chrysoobtusin -
Similarity Score 0.87
HY-N0261Aurantio-obtusin -
Similarity Score 0.85
HY-N120091-Desmethylobtusin -
Similarity Score 0.84
HY-N120066,8-Dihydroxy-1,2,7-trimethoxy-3-methylanthraquinone -
Similarity Score 0.83
HY-N12008OAT1/3-IN-2 -
Similarity Score 0.82
HY-N115217-Methoxy obtusifolin -
Similarity Score 0.79
HY-N103691,2,3,7-Tetrahydroxy-8-methoxy-6-methyl-9,10-anthraquinone -
Similarity Score 0.79
HY-N165291,6,8-Trihydroxy-2,7-dimethoxy-3-methylanthraquinone -
Similarity Score 0.76
HY-N99612-Hydroxyl emodin-1-methyl ether -
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References
- [1]. Xu J, et al. Obtusin ameliorates diabetic retinopathy by inhibiting oxidative stress and inflammation. Psychopharmacology. 2024 Dec;241(12):2471-2484.
- [2]. Paudel P, et al. In Vitro and in Silico Human Monoamine Oxidase Inhibitory Potential of Anthraquinones, Naphthopyrones, and Naphthalenic Lactones from Cassia obtusifolia Linn Seeds. ACS Omega. 2019 Sep 18;4(14):16139-16152. [Content Brief]
