4 Results for "

promyelocytic leukaemia

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "promyelocytic leukaemia" in MCE Product Catalog:

Antiproliferative agent-3
Antiproliferative agent-3
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Cat. No.: HY-145866
Target:  

Drug Intermediate

Research Areas:  

Cancer

Antiproliferative agent-3 is an antiproliferative agent. Antiproliferative agent-3 exhibits anticancer activity against a variety of cancers, including estrogen receptor-positive breast cancer. Antiproliferative agent-3 shows no toxicity to wild-type zebrafish embryos. Antiproliferative agent-3 can be used in the research of chronic myeloid leukemia, promyelocytic leukemia, Burkitt's lymphoma, estrogen receptor-positive mammary adenocarcinoma, cervical cancer, and lung cancer .
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Monbarbatain C
Monbarbatain C
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Cat. No.: HY-N17880
CAS No.: 1334310-62-1
Category:  

Orchidaceae Lignans Monomeria barbata Lindl. Phenylpropanoids Plants

Target:  

Free Radical Scavengers Drug Derivative

Monbarbatain C is a biphenanthrene compound found in the tubers of Monomeria barbata Lindl. Monbarbatain C induces cytotoxic activity against liver carcinoma and promyelocytic leukaemia cells in vitro. Monbarbatain C mediates DPPH radical scavenging activity in vitro. Monbarbatain C can be used for the research of liver carcinoma, promyelocytic leukaemia, ovarian carcinoma, and epidermoid carcinoma .
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Acanthoic acid
Acanthoic acid
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Cat. No.: HY-116136
CAS No.: 119290-87-8
Synonyms: NP1302
Category:  

Triterpenes Terpenoids Plants Araliaceae Acanthopanax koreanum

Target:  

LXR FXR AMPK Sirtuin p38 MAPK Acetyl-CoA Carboxylase Cytochrome P450 HIF/HIF Prolyl-Hydroxylase PPAR Caspase PARP Bcl-2 Family Apoptosis

Acanthoic acid (NP1302) is an orally active pimarane-type diterpenoid. Acanthoic acid is isolated from the root bark of Araliaceae family plant Eleutherococcus senticosus (Siberian ginseng). Acanthoic acid activates LXR and FXR. Acanthoic acid activates the AMPK-LKB1, SIRT1, and p38 MAPK signaling pathways and increases the phosphorylation level of ACC. Acanthoic acid downregulates the expression of SREBP-1, CYP2E1, HIF-1α, and PPARγ, and upregulates the expression of PPARα. Acanthoic acid induces Apoptosis by activating Caspase-3, promoting PARP cleavage, and downregulating Bcl-xL. Acanthoic acid exhibits antioxidant, anti-fibrotic, and hepatoprotective effects. It reduces lipid accumulation and lipogenesis. Acanthoic acid is used in studies on non-alcoholic fatty liver disease, alcoholic liver disease, acute promyelocytic leukemia, and Acetaminophen-induced hepatotoxicity .
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Hericerin A
Hericerin A
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Cat. No.: HY-N21648
CAS No.: 1629208-29-2
Category:  

Other Monoterpenes Terpenoids Hericiaceae Plants Hericium erinaceum

Target:  

Akt c-Myc Apoptosis Endogenous Metabolite

Hericerin A is an isoindolinone derivative and a selective cytotoxic agent. Hericerin A is isolated from Hericium erinaceus cultured on brown rice. Hericerin A downregulates the phosphorylation of AKT and downregulates c-Myc oncoprotein levels downstream of p-AKT inactivation. Hericerin A induces Apoptosis. Hericerin A exhibits anticancer activity against leukemia. Hericerin A is used in research on acute promyelocytic leukemia, breast cancer, and Helicobacter pylori infection .
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