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Art. -Nr.: HY-N21648

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Hericerin A

Hericerin A is an isoindolinone derivative and a selective cytotoxic agent. Hericerin A is isolated from Hericium erinaceus cultured on brown rice. Hericerin A downregulates the phosphorylation of AKT and downregulates c-Myc oncoprotein levels downstream of p-AKT inactivation. Hericerin A induces Apoptosis. Hericerin A exhibits anticancer activity against leukemia. Hericerin A is used in research on acute promyelocytic leukemia, breast cancer, and Helicobacter pylori infection.

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CAS. Nr.: 1629208-29-2
Formel: C₂₁H₂₉NO₄
Molecular Weight:359.47

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Hericerin A Chemical Structure

CAS. Nr.: 1629208-29-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
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Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

Fungal Metabolite

Alle Akt Isoform-spezifische Produkte anzeigen :

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vitro

Anti-cancerApoptosisCell Cycle Regulation

Anti-cancer

Hericerin A (0.01-100 μM; 72 h) reduces HL-60 cell viability with an IC₅₀ of 3.06 μM^[1].
Hericerin A (0.01-100 μM; 72 h) exhibits weak cytotoxicity against HEL-299 cells, inhibiting growth by less than 30% at concentrations up to 50 μM, with an IC₅₀ of 64.61 μM^[1].
Hericerin A inhibits proliferation and induces apoptosis in HL-60 leukemia cells with an IC₅₀ of 3.06 μmol/L and in HEL-299 cells with an IC₅₀ of 64.61 μmol/L^[4].

Apoptosis

Cell Cycle Regulation

Hericerin A (3.06 μM; 24-48 h) induces apoptosis in HL-60 cells, increasing the sub-G₁ population in a time-dependent manner^[1].

Apoptosis

Hericerin A (3.06 μM; 24-48 h) induces apoptotic morphological changes in HL-60 cells^[1].

Apoptosis

Anti-cancer

Hericerin A (3.06 μM; 24-48 h) induces apoptosis in HL-60 cells through the modulation of apoptosis-related proteins and down-regulation of p-AKT and c-myc^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HL-60 human acute promyelocytic leukaemia cells
Concentration:

0.01-100 μM
Incubation Time:

72 h
Result:

Reduced the percentage of viable HL-60 cells with an IC50 value of 3.06 μM.

Cell Viability Assay^[1]

Cell Line:

HEL-299 human lung fibroblast cells
Concentration:

0.01-100 μM
Incubation Time:

72 h
Result:

Inhibited the growth of HEL-299 cells by less than 30% at concentrations up to 50 μM with an IC50 value of 64.61 μM.

Apoptosis Analysis^[1]

Cell Line:

HL-60 cells
Concentration:

3.06 μM
Incubation Time:

24 h; 48 h
Result:

Increased the proportion of sub-G1 fraction (M1) cells to 10.30% at 24 h and 13.49% at 48 h.\nIncreased the number of apoptotic bodies after 24 and 48 h incubation periods.

Western Blot Analysis^[1]

Cell Line:

HL-60 cells
Concentration:

3.06 μM
Incubation Time:

24 h; 48 h
Result:

Increased Bax expression and decreased Bcl-2 expression in a time-dependent manner.
Increased active forms of caspase-3 and caused proteolytic cleavage of PARP.
Decreased p-AKT levels and down-regulated c-myc.

Related Protocols :

Chemical Information

CAS. Nr. 1629208-29-2
Molecular Weight 359.47
Formel C₂₁H₂₉NO₄
SMILES

OC1=C2C(=CC(OC)=C1C/C=C(/CCC=C(C)C)\C)C(=O)N(CCO)C2
Structure Classification
- Terpenoids
- Other Monoterpenes
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Li W, et al. Isolation and identification of aromatic compounds in Lion's Mane Mushroom and their anticancer activities. Food chemistry. 2015 Mar 01;170:336-42. [Content Brief]

[2]. Thongkongkaew T, et al. Anti-Xanthine Oxidase 5′-Hydroxyhericenes A–D from the Edible Mushroom Hericium erinaceus and Structure Revision of 3-[2, 3-Dihydroxy-4-(hydroxymethyl) tetrahydrofuran-1-yl]-pyridine-4, 5-diol. ACS omega. 2023 Nov 21;8(48):46284.

[3]. Ryu SH, et al. Nutritional and functional enhancement of lion's mane mushroom (Hericium erinaceus) via sustainable brown rice cultivation. Future Foods. 2026 Jan 6:100903.

[4]. Winder M, et al. The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology. Acta pharmaceutica (Zagreb, Croatia). 2021 Mar 01;71(1):1-16.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
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Hericerin A

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Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

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IC50 & Target

In Vitro

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Hericerin A Related Classifications

HY-N21648 Related Classifications

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