1629208-29-2
Chemical Structure
Hericerin A
- CAS No.: 1629208-29-2
- Formula:C21H29NO4
- Molecular Weight:359.47
IUPAC Name: (E)-5-(3,7-dimethylocta-2,6-dien-1-yl)-4-hydroxy-2-(2-hydroxyethyl)-6-methoxyisoindolin-1-one
InChIKey: IBLGITSBTNDCAL-OVCLIPMQSA-N
SMILES: OC1=C2C(=CC(OC)=C1C/C=C(/CCC=C(C)C)\C)C(=O)N(CCO)C2
Biological Activity: Hericerin A is an isoindolinone derivative and a selective cytotoxic agent. Hericerin A is isolated from Hericium erinaceus cultured on brown rice. Hericerin A downregulates the phosphorylation of AKT and downregulates c-Myc oncoprotein levels downstream of p-AKT inactivation. Hericerin A induces Apoptosis. Hericerin A exhibits anticancer activity against leukemia. Hericerin A is used in research on acute promyelocytic leukemia, breast cancer, and Helicobacter pylori infection[1][2][3].
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Hericerin A | Hericerin A is an isoindolinone derivative and a selective cytotoxic agent. Hericerin A is isolated from Hericium erinaceus cultured on brown rice. Hericerin A downregulates the phosphorylation of AKT and downregulates c-Myc oncoprotein levels downstream of p-AKT inactivation. Hericerin A induces Apoptosis. Hericerin A exhibits anticancer activity against leukemia. Hericerin A is used in research on acute promyelocytic leukemia, breast cancer, and Helicobacter pylori infection. | |||||||||||||||||||||
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References
- [1]. Li W, et al. Isolation and identification of aromatic compounds in Lion's Mane Mushroom and their anticancer activities. Food chemistry. 2015 Mar 01;170:336-42. [Content Brief]
- [2]. Thongkongkaew T, et al. Anti-Xanthine Oxidase 5′-Hydroxyhericenes A–D from the Edible Mushroom Hericium erinaceus and Structure Revision of 3-[2, 3-Dihydroxy-4-(hydroxymethyl) tetrahydrofuran-1-yl]-pyridine-4, 5-diol. ACS omega. 2023 Nov 21;8(48):46284.
- [3]. Ryu SH, et al. Nutritional and functional enhancement of lion's mane mushroom (Hericium erinaceus) via sustainable brown rice cultivation. Future Foods. 2026 Jan 6:100903.
