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Results for "

schwannoma

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

1

Screening Libraries

1

Recombinant Proteins

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-400902
    VT3989

    		YAP VEGFR Hippo (MST) Cancer
    VT3989 is an orally active pan-TEAD autopalmitoylation inhibitor that modulates the Hippo signaling pathway. VT3989 directly binds to TEAD transcription factors to block their palmitoylation modification, thereby disrupting the formation of YAP/TAZ-TEAD complexes and inhibiting downstream oncogenic transcriptional activity. VT3989 effectively inhibits the growth of NF2-deficient schwannoma and meningioma cells and reverses the Schwann cell phenotype. In addition, VT3989 exerts a synergistic effect when combined with Osimtinib (HY-15772) in EGFR-mutant non-small cell lung cancer models, significantly delaying tumor recurrence and prolonging survival. VT3989 can be used for the research of epithelioid hemangioendothelioma, malignant pleural mesothelioma, type 2 neurofibromatosis and related advanced solid tumors .
    VT3989
  • HY-15827
    NSC 405020
    3 Publications Verification

    		 MMP Cardiovascular Disease Cancer
    NSC 405020 is a specific MMP14 inhibitor. NSC 405020 can directly interact with the hemopexin domain of MMP14. NSC 405020 reduces the expression of full length and active cleaved Notch3 (NICD3). NSC 405020 can be used to research vestibular schwannoma, hemostasis and thrombosis .
    NSC 405020
  • HY-110085
    2,2′-Dihydroxy-6,6′-dinaphthyl disulfide

    DDD; Bis(6-hydroxy-2-naphthyl)disulfide; PIR-3.5

    		 PAK Cancer
    2,2′-Dihydroxy-6,6′-dinaphthyl disulfide (PIR-3.5) is a PAK1 inhibitor .
    2,2′-Dihydroxy-6,6′-dinaphthyl disulfide
  • HY-107662
    TCS PrP Inhibitor 13

    		Apoptosis Infection Cancer
    TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrP C) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC50 value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis .
    TCS PrP Inhibitor 13
  • HY-120614
    BMS-186511

    		Farnesyl Transferase Cancer
    BMS-186511 is a farnesyltransferase (FT) inhibitor and shows anticancer activity .
    BMS-186511
  • HY-107662R
    TCS PrP Inhibitor 13 (Standard)

    		Reference Standards Apoptosis Infection Cancer
    TCS PrP Inhibitor 13 (Standard) is the analytical standard of TCS PrP Inhibitor 13 (HY-107662). This product is intended for research and analytical applications. TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrPC) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC50 value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis .
    TCS PrP Inhibitor 13 (Standard)

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