70035-83-5
70035-83-5
Chemical Structure
CDKi free base
- CAS No.: 70035-83-5
- Formula:C4H6N4O
- Molecular Weight:126.12
IUPAC Name: 2,4-diaminopyrimidin-5-ol
InChIKey: YQGHJCYLMLPCCB-UHFFFAOYSA-N
SMILES: OC1=CN=C(N=C1N)N
Biological Activity: CDKi free base is a CDK inhibitor. CDKi free base induces morphological changes, DNA fragmentation, and cell death in vestibular schwannoma cells. CDKi free base downregulates pRb, EGF-R, PI3K, NF-κB, and Shh levels, while upregulating JNK, ASK1, Caspase 3, and p21, and induces PARP-1 cleavage. CDKi free base can be used in research related to vestibular schwannoma[1].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
CDKi free base | CDKi free base is a CDK inhibitor. CDKi free base induces morphological changes, DNA fragmentation, and cell death in vestibular schwannoma cells. CDKi free base downregulates pRb, EGF-R, PI3K, NF-κB, and Shh levels, while upregulating JNK, ASK1, Caspase 3, and p21, and induces PARP-1 cleavage. CDKi free base can be used in research related to vestibular schwannoma. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
