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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
thymidylate synthetase
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "thymidylate synthetase" in MCE Product Catalog:
352
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Category:
Cat. No.: HY-90006S
CAS No.: 90344-84-6
Synonyms: 5-FU-d1
Cat. No.: HY-90006S1
CAS No.: 1189423-58-2
Synonyms: 5-FU-13C,15N2
Cat. No.: HY-90006S2
CAS No.: 68941-95-7
Gradient elution with sodium acetate buffer-ACN eluent on two ZIC-HILIC homemade columns separates 2-deoxyuridine in under 9 min .
In Vivo:2'-Deoxyuridine (34.42 ng/mL, gavage, 15 min) passes the blood-brain barrier (BBB) to enter the hippocampus of mice brain . 2'-Deoxyuridine (20 mg/kg, gavage, daily for 4 weeks) improves cognition and memory loss and attenuates the damage to the hippocampus in Aβ25-35-induced mice model .
Cat. No.: HY-D0186S4
CAS No.: 478511-30-7
Cat. No.: HY-16638
CAS No.: 76849-19-9
Synonyms: PDDF
Target:
Research Areas:
CB 3717 is a potent inhibitor of human thymidylate synthetase, competitively binding with 5,10-methylenetetrahydrofolate (Ki = 4.9 X 10(-9) M). It also competitively inhibits human dihydrofolate reductase with dihydrofolate (Ki = 2.3 X 10(-8) M). In WI-L2 human lymphoblastoid cells, CB 3717 treatment led to a significant decrease in cellular dTTP levels and a notable increase in dUMP levels, indicating a disruption in nucleotide metabolism. The growth-inhibitory effect of CB 3717 was reversed by thymidine supplementation, demonstrating that thymidylate synthetase became rate-limiting in the presence of this compound. Delayed thymidine supplementation beyond 8 hours resulted in severe cytotoxicity, underscoring the critical timing of nucleotide rescue strategies in CB 3717-treated cells .
Cat. No.: HY-D0186S7
CAS No.: 369656-76-8
Cat. No.: HY-W778990
CAS No.: 478510-94-0
Cat. No.: HY-121256
CAS No.: 18921-73-8
Research Areas:
Chlorasquin inhibits thymidylate synthetase with an approximate Ki value of 4.9 μM. Chlorasquin is also a folate antagonist, testing the Methotrexate (HY-14519) effect. Chlorasquin binds tighter to dihydrofolate reductase at alkaline pH than does Methotrexate, which is promising for research of antipsoriatic agents .
Cat. No.: HY-10823
CAS No.: 139987-54-5
Synonyms: GW1843; 1843U89; OSI-7904
Research Areas:
OSI-7904L (GW1843; 1843U89; OSI-7904) is a thymidylate synthase (TS) inhibitor with a Ki of 90 pM. OSI-7904L blocks de novo synthesis of thymidine nucleotides, DNA synthesis and induces cell death. OSI-7904L inhibits the growth of human cells, induces tumor regression, and achieves durable antitumor effects in mouse xenograft models. OSI-7904L can be used in research related to colon adenocarcinoma .
Cat. No.: HY-D0186S5
Cat. No.: HY-D0186S
CAS No.: 478510-85-9
Cat. No.: HY-D0186S1
CAS No.: 478510-87-1
Cat. No.: HY-D0186S2
CAS No.: 478510-89-3
Cat. No.: HY-D0186S3
CAS No.: 478510-91-7
Research Areas:
CB 3705 is a dihydrofolate reductase (DHFR) and thymidylate synthetase (TS) inhibitor. CB 3705 inhibits L1210 cells and mutant L1210 cell line (L1210:C15) with ID50s of 4.77 μM and 408 μM, respectively .
Cat. No.: HY-90006S3
CAS No.: 202407-03-2
Synonyms: 5-FU-13C4,15N2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
