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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
transcytosis
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "transcytosis" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-172705
Research Areas:
DSPE-PEG2000-RVG29 is a PEG conjugate composed of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 specifically binds to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB), crosses the BBB, and mediates receptor-dependent transcytosis. DSPE-PEG2000-RVG29 can be used for brain-targeted drug delivery, surface modification of nanocarriers, as well as gene and nucleic acid delivery. DSPE-PEG2000-RVG29 is applicable to research related to hypoxic-ischemic brain injury, Parkinson's disease, and other conditions .
Cat. No.: HY-171306
MK16 is a lipid material that can be used to construct blood-brain barrier penetrable lipid nanoparticles for mRNA delivery. MK16 facilitates blood-brain barrier crossing via γ-secretase-mediated and caveolae-mediated transcytosis. MK16 can be used for drug delivery research .
Cat. No.: HY-P5423
CAS No.: 107658-43-5
Cat. No.: HY-P10502
CAS No.: 2378836-93-0
Cat. No.: HY-170704
CAS No.: 1480940-53-1
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DSPE-PEG2000-TCO is a click chemistry coupling partner. DSPE-PEG2000-TCO undergoes a reverse electron-demand Diels-Alder click reaction to form a covalent linkage with tetrazine-modified Cetuximab (HY-P9905). DSPE-PEG2000-TCO maintains the stability of lipid nanoparticles (LNPs) and has high mRNA encapsulation efficiency, which supports cellular uptake and mRNA transfection. DSPE-PEG2000-TCO is used to prepare EGFR-targeted and APN-targeted mRNA-loaded LNPs, mediating receptor-dependent endocytosis, mRNA delivery, and intestinal epithelial transcytosis .
Cat. No.: HY-P10502A
Cat. No.: HY-P1754A
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Cat. No.: HY-P1754
CAS No.: 119260-99-0
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Cat. No.: HY-174787
Human ACKR3 mRNA encodes the human atypical chemokine receptor 3 (ACKR3) protein, a member of the G-protein coupled receptor family. ACKR3 is a typical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis.
Cat. No.: HY-172705A
DSPE-PEG3400-RVG29 is a PEG conjugate composed of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 specifically binds to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB), crosses the BBB, and mediates receptor-dependent transcytosis. DSPE-PEG3400-RVG29 can be used for brain-targeted drug delivery, surface modification of nanocarriers, as well as gene and nucleic acid delivery. DSPE-PEG3400-RVG29 is applicable to research related to hypoxic-ischemic brain injury, Parkinson's disease, and other conditions
Cat. No.: HY-P12128
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SYN1753 is a selective inhibitor of human neonatal Fc receptor (hFcRn) with a Kd value of 0.5 μM. SYN1753 binds to the albumin-binding site of hFcRn, inhibits the hFcRn-albumin interaction, and thereby suppresses FcRn-mediated transcytosis of human albumin. SYN1753 can be used in studies related to acetaminophen-induced liver injury .
Cat. No.: HY-165650
CAS No.: 165615-97-4
Synonyms: C16-GM1; N-Hexadecaoyl (13,13,14,14,15,15,16,16,16)-moosialogaglioside GM1
C16 Ganglioside GM1 (d18:1/16:0) (C16-GM1) is a member of the ganglioside family containing saturated C16:0 acyl chains. C16 Ganglioside GM1 (d18:1/16:0) serves as a functional receptor for Cholera toxin (HY-P1446) B subunit, while showing reduced efficiency in both transcytosis and retrograde pathways. C16 Ganglioside GM1 (d18:1/16:0) can be used for diarrheal diseases research .
Cat. No.: HY-165650A
Synonyms: C16-GM1 ammonium; N-Hexadecaoyl (13,13,14,14,15,15,16,16,16)-moosialogaglioside GM1 ammonium
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C16 Ganglioside GM1 (d18:1/16:0) (C16-GM1) ammonium is a member of the ganglioside family containing saturated C16:0 acyl chains. C16 Ganglioside GM1 (d18:1/16:0) ammonium serves as a functional receptor for Cholera toxin (HY-P1446) B subunit, while showing reduced efficiency in both transcytosis and retrograde pathways. C16 Ganglioside GM1 (d18:1/16:0) ammonium can be used for diarrheal diseases research .
Cat. No.: HY-P11771
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KS-487 is a cyclic peptide targeting LRP1 that binds to cluster IV (CL4) domain of LRP1 and facilitates molecular delivery to brain tissue via receptor-mediated transcytosis (RMT). The EC50 of KS-487 binding to human LRP1 (CL4) is 10.5 nM. Compared with Angiopep-2, KS-487 exhibits enhanced brain selectivity and can be used in studies related to brain-targeted delivery systems .
Cat. No.: HY-182098
DSPE-PEG1000-GALA is a PEG compound which composed of DSPE and a lung endothelium-targeting peptide GALA (HY-P5423). GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. DSPE-PEG1000-GALA can be used for drug delivery .
Cat. No.: HY-182098A
DSPE-PEG2000-GALA is a PEG compound which composed of DSPE and a lung endothelium-targeting peptide GALA (HY-P5423). GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. DSPE-PEG2000-GALA can be used for drug delivery .
Cat. No.: HY-182098B
DSPE-PEG3400-GALA is a PEG compound which composed of DSPE and a lung endothelium-targeting peptide GALA (HY-P5423). GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. DSPE-PEG3400-GALA can be used for drug delivery .
Cat. No.: HY-182098C
DSPE-PEG5000-GALA is a PEG compound which composed of DSPE and a lung endothelium-targeting peptide GALA (HY-P5423). GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. DSPE-PEG5000-GALA can be used for drug delivery .
Cat. No.: HY-P992048
Synonyms: HIRMab; SHP-631; TAK-531
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
