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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
transforming growth factor-beta type I receptor
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "transforming growth factor-beta type I receptor" in MCE Product Catalog:
23
23 Publications Verification
Synonyms: E-616452; SJN 2511
Target:
Research Areas:
RepSox (E-616452) is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor. RepSox inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox can be used for the research of obesity and associated metabolic diseases such as type 2 diabetes .
2
2 Cited Publications
Cat. No.: HY-78349
CAS No.: 607737-87-1
Target:
Research Areas:
A 77-01 is a potent inhibitor of transforming growth factor (TGF)-β type I receptor superfamily activin-like kinase ALK5 with an IC50 of 25 nM .
2
2 Cited Publications
Cat. No.: HY-18758
CAS No.: 868612-83-3
Target:
Research Areas:
IN-1130 is a highly selective transforming growth factor-β type I receptor kinase (ALK5) inhibitor with an IC50 of 5.3 nM for ALK5-mediated Smad3 phosphorylation. IN-1130 inhibits ALK5 phosphorylation of casein (IC50=36 nM) and p38α mitogen-activated protein kinase (IC50=4.3 μM). IN-1130 suppresses renal fibrosis in obstructive nephropathy and blocks breast cancer lung metastasis .
2
2 Cited Publications
Cat. No.: HY-P72454
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR1; Serine/Threonine-Protein Kinase receptor R4; Prev. ESS1; Activin receptor-Like Kinase 5; Prev. MSSE; TbetaR-I; ALK-5; TGFR-1; ALK5; SKR4; transforming growth factor-beta receptor type I; Multiple Self-Healing Squamous Epithelioma; TGF-beta Recepto
Species:
Mouse
Source:
HEK293
1
1 Cited Publications
Target:
Research Areas:
TGFβ-IN-5 is a type I transforming growth factor-β receptor (TGF-β R1) kinase inhibitor with an IC50 value of 0.0485 μM. TGFβ-IN-5 reverses the effect of TGF-β-mediated cell activation on the expression of fibrosis-related genes. TGFβ-IN-5 can be used in the research of fibroproliferative diseases .
1
1 Cited Publications
Cat. No.: HY-P78525
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TGFBR1; Serine/Threonine-Protein Kinase receptor R4; Prev. ESS1; Activin receptor-Like Kinase 5; Prev. MSSE; TbetaR-I; ALK-5; TGFR-1; ALK5; SKR4; transforming growth factor-beta receptor type I; Multiple Self-Healing Squamous Epithelioma; TGF-beta Recepto
Species:
Human
Source:
HEK293
Target:
Research Areas:
BIBF0775 is a potent and selective transforming growth factor β (TGFβ) type I receptor (Alk5) inhibitor with an IC50 of 34 nM.
Cat. No.: HY-13012R
CAS No.: 446859-33-2
Synonyms: E-616452 (Standard); SJN 2511 (Standard)
Research Areas:
RepSox (Standard) is the analytical standard of RepSox. This product is intended for research and analytical applications. RepSox (E-616452) is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor. RepSox inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox can be used for the research of obesity and associated metabolic diseases such as type 2 diabetes .
Cat. No.: HY-W707119
CAS No.: 2319939-07-4
Synonyms: E-616452 hydrochloride; SJN 2511 hydrochloride
Research Areas:
RepSox hydrochloride is a potent and selective inhibitor of transforming growth factor-β receptor I/activin-like kinase 5 (TGF-β-RI/ALK5). RepSox hydrochloride inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox hydrochloride can be used in the study of obesity and related metabolic diseases such as type 2 diabetes.
Cat. No.: HY-18758R
CAS No.: 868612-83-3
Target:
Research Areas:
IN-1130 (Standard) is the analytical standard of IN-1130. This product is intended for research and analytical applications. IN-1130 is a highly selective transforming growth factor-β type I receptor kinase (ALK5) inhibitor with an IC50 of 5.3 nM for ALK5-mediated Smad3 phosphorylation. IN-1130 inhibits ALK5 phosphorylation of casein (IC50=36 nM) and p38α mitogen-activated protein kinase (IC50=4.3 μM). IN-1130 suppresses renal fibrosis in obstructive nephropathy and blocks breast cancer lung metastasis .
Cat. No.: HY-P72453
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR1; Serine/Threonine-Protein Kinase receptor R4; Prev. ESS1; Activin receptor-Like Kinase 5; Prev. MSSE; TbetaR-I; ALK-5; TGFR-1; ALK5; SKR4; transforming growth factor-beta receptor type I; Multiple Self-Healing Squamous Epithelioma; TGF-beta receptor type-1; TGF-beta type I receptor; ACVRLK4; TGF-beta receptor type I; TBR-I; LDS1A; TBRI; LDS2A; Activin A receptor type II-Like Protein Kinase Of 53kD; AAT5; Mutant transforming growth factor beta receptor I; LDS1; Activin A receptor type II-Like Kinase, 53kDa; transforming growth factor beta receptor 1; transforming growth factor beta receptor I
Species:
Human
Source:
HEK293
Cat. No.: HY-P706225
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR1; Serine/Threonine-Protein Kinase receptor R4; Prev. ESS1; Activin receptor-Like Kinase 5; Prev. MSSE; TbetaR-I; ALK-5; TGFR-1; ALK5; SKR4; transforming growth factor-beta receptor type I; Multiple Self-Healing Squamous Epithelioma; TGF-beta receptor type-1; TGF-beta type I receptor; ACVRLK4; TGF-beta receptor type I; TBR-I; LDS1A; TBRI; LDS2A; Activin A receptor type II-Like Protein Kinase Of 53kD; AAT5; Mutant transforming growth factor beta receptor I; LDS1; Activin A receptor type II-Like Kinase, 53kDa; transforming growth factor beta receptor 1; transforming growth factor beta receptor I
Species:
Human
Source:
E. coli
Cat. No.: HY-L018
458 compounds
The transforming growth factor beta (TGF-β) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. The TGF-β superfamily comprises TGF-βs, bone morphogenetic proteins (BMPs), activins and related proteins. Signaling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, which catalyzes the phosphorylation of the Type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD (e.g. SMAD4). R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. Deregulation of TGF-β signaling contributes to developmental defects and human diseases, including cancers, some bone diseases, chronic kidney disease, etc.
MCE designs a unique collection of 458 TGF-beta/Smad signaling pathway compounds. TGF-beta/Smad Compound Library acts as a useful tool for TGF-beta/Smad-related drug screening and disease research.
Cat. No.: HY-13012S
Synonyms: E-616452-d5; SJN 2511-d5
Cat. No.: HY-P74522
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR1; Serine/Threonine-Protein Kinase receptor R4; Prev. ESS1; Activin receptor-Like Kinase 5; Prev. MSSE; TbetaR-I; ALK-5; TGFR-1; ALK5; SKR4; transforming growth factor-beta receptor type I; Multiple Self-Healing Squamous Epithelioma; TGF-beta Recepto
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P74523
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR1; Serine/Threonine-Protein Kinase receptor R4; Prev. ESS1; Activin receptor-Like Kinase 5; Prev. MSSE; TbetaR-I; ALK-5; TGFR-1; ALK5; SKR4; transforming growth factor-beta receptor type I; Multiple Self-Healing Squamous Epithelioma; TGF-beta Recepto
Species:
Human
Source:
HEK293
Cat. No.: HY-P704918
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR1; Serine/Threonine-Protein Kinase receptor R4; Prev. ESS1; Activin receptor-Like Kinase 5; Prev. MSSE; TbetaR-I; ALK-5; TGFR-1; ALK5; SKR4; transforming growth factor-beta receptor type I; Multiple Self-Healing Squamous Epithelioma; TGF-beta Recepto
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
