von Willebrand factor

By Targets:	Antibiotic (2) Apoptosis (2) Bacterial (1) Biochemical Assay Reagents (1) Integrin (8) P-selectin (1) TNF Receptor (1) Transmembrane Glycoprotein (1)
By Research Areas:	Cardiovascular Disease (14) Infection (2) Inflammation/Immunology (4) Metabolic Disease (1)
Oligonucleotides:	Aptamers (6) Antisense Oligonucleotides (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99227

Caplacizumab (His Tag) 1 Publications Verification ALX-0681; ALX-0081	Integrin Transmembrane Glycoprotein	Cardiovascular Disease
Caplacizumab (His Tag) is a humanized anti-von Willebrand factor (vWF) nanobody. Caplacizumab (His Tag) inhibits the binding of vWF with platelet glycoprotein (GP) Ibα. Caplacizumab (His Tag) inhibits the vWF-mediated platelet adhesion and prevents further microthrombi formation. Caplacizumab (His Tag) can be used for the research of thrombotic thrombocytopenic purpura (TTP) .

HY-131150

Ristomycin sulfate	Antibiotic Bacterial	Cardiovascular Disease Infection
Ristomycin sulfate is an antibacterial antibiotic and platelet aggregation inducer. Ristomycin sulfate interacts with the D-alanyl-D-alanine terminus of bacterial cell wall precursors to regulate bacterial cell wall synthesis. Ristomycin sulfate induces platelet aggregation in vitro and inhibits the growth of Gram-positive bacteria. Ristomycin sulfate serves as an in vitro diagnostic compound for detecting von Willebrand factor activity. Ristomycin sulfate is applicable to research related to von Willebrand disease and Bernard-Soulier syndrome .

HY-153999A

Rondaptivon pegol sodium BT200 sodium	Integrin Apoptosis	Cardiovascular Disease Inflammation/Immunology
Rondaptivon pegol (BT200) sodium is an aptamer targeting von Willebrand factor (VWF), with an EC₅₀ of 33 nM in humans. Rondaptivon pegol sodium effectively alleviates acute myocardial ischemia-reperfusion injury in mice by inhibiting VWF activity, reducing microvascular obstruction, inflammatory responses and cardiomyocyte apoptosis (apoptosis). Rondaptivon pegol sodium inhibits the binding of VWF to platelet glycoprotein GPIb, thereby preventing arterial thrombosis in cynomolgus monkeys. Rondaptivon pegol sodium can be used in research related to arterial thrombosis, stroke, myocardial infarction and myocardial ischemia-reperfusion injury .

HY-138053

Ristocetin A sulfate Ristomycin III	Antibiotic	Cardiovascular Disease Infection
Ristocetin A sulfate (Ristomycin III) is a glycopeptide antibiotic that binds to **von Willebrand factor (VWF) and bacterial cell wall components. Ristocetin A sulfate interferes with the biosynthesis of bacterial peptidoglycan by inhibiting transpeptidation. As an inducer of platelet adhesion and aggregation**, Ristocetin A sulfate drives conformational changes by binding to the A1 domain of VWF, thereby activating downstream signaling pathways and promoting cytoskeletal rearrangement. Ristocetin A sulfate not only enhances platelet adhesion and spreading on immobilized VWF, but also induces the formation of asymmetric dimers with anticooperativity between platelets and plasma VWF. Ristocetin A sulfate is widely used in studies related to thromboembolic diseases and bacterial infections .

HY-145726

ISIS 104838	TNF Receptor	Cardiovascular Disease Inflammation/Immunology
ISIS 104838 is an antisense oligonucleotide targeting TNF-α. ISIS 104838 specifically binds to human TNF-α mRNA via Watson-Crick base pairing to form a DNA:RNA hybrid duplex, thereby recruiting the ubiquitously expressed intracellular enzyme RNase H to degrade the target mRNA and inhibit TNF-α protein synthesis at the transcriptional level. ISIS 104838 induces moderate, self-limiting thrombocytopenia in cynomolgus monkeys. ISIS 104838 can be used for the study of inflammatory diseases .

HY-P4812

*Prepro-von* Willebrand factor (641-650) (bovine)**	Biochemical Assay Reagents	Metabolic Disease
Prepro-von Willebrand factor (641-650) (bovine) is a fragment of Prepro-von Willebrand factor, which binds to type I collagen .

HY-153999

Rondaptivon pegol BT200	Integrin Apoptosis	Cardiovascular Disease Inflammation/Immunology
Rondaptivon pegol (BT200) is an aptamer targeting von Willebrand factor (VWF), with an EC₅₀ of 33 nM in humans. Rondaptivon pegol effectively alleviates acute myocardial ischemia-reperfusion injury in mice by inhibiting VWF activity, reducing microvascular obstruction, inflammatory responses and cardiomyocyte apoptosis (apoptosis). Rondaptivon pegol inhibits the binding of VWF to platelet glycoprotein GPIb, thereby preventing arterial thrombosis in cynomolgus monkeys. Rondaptivon pegol can be used in research related to arterial thrombosis, stroke, myocardial infarction and myocardial ischemia-reperfusion injury .

HY-147079A

Egaptivon pegol sodium ARC 1779 sodium	Integrin	Cardiovascular Disease
Egaptivon pegol sodium is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol sodium has anti-thrombotic efficacy.

HY-147079

Egaptivon pegol ARC 1779	Integrin	Cardiovascular Disease
Egaptivon pegol (ARC1779) is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol has anti-thrombotic efficacy.

HY-138019

SP-8008	Integrin	Cardiovascular Disease
SP-8008 is a selective shear stress-induced platelet aggregation (SIPA) inhibitor with an IC₅₀ of 1.44 μM. SP-8008 effectively interferes von Willebrand factor (vWF) and platelet glycoprotein (GP) Ib interaction. SP-8008 exerts its antithrombotic effect by selectively inhibiting shear stress-induced platelet aggregation .

HY-153998

BT100 sodium	Integrin	Cardiovascular Disease
BT100 (sodium), a aptamer, inhibits binding of von Willebrand factor (VWF) to platelet glycoprotein GPIb, preventing arterial thrombosis .

HY-N19251

Sulfobacin B	Integrin	Cardiovascular Disease
Sulfobacin B is a competitive von Willebrand factor receptor GPIb/IX inhibitor with an IC₅₀ of 2.2 μM. Sulfobacin B inhibits binding of von Willebrand factor to GPIb/IX in a competitive manner. Sulfobacin B can be used for the research of thrombosis .

HY-106428

Icrocaptide ITF1697	P-selectin	Cardiovascular Disease Inflammation/Immunology
Icrocaptide (ITF1697) is a stable Lys-Pro-containing peptide that inhibits the intracellular Ca ²⁺-dependent fusion of Weibel-Palade bodies with the plasma membrane. Icrocaptide exerts its activity at the early stages of endothelial activation and inhibits P-selectin and von Willebrand factor secretion. Icrocaptide can be used for the study of a variety of microvascular disorders .

Cat. No.	Product Name	Target	Research Area

HY-P4812

*Prepro-von* Willebrand factor (641-650) (bovine)**	Biochemical Assay Reagents	Metabolic Disease
Prepro-von Willebrand factor (641-650) (bovine) is a fragment of Prepro-von Willebrand factor, which binds to type I collagen .

HY-106428

Icrocaptide ITF1697	P-selectin	Cardiovascular Disease Inflammation/Immunology
Icrocaptide (ITF1697) is a stable Lys-Pro-containing peptide that inhibits the intracellular Ca ²⁺-dependent fusion of Weibel-Palade bodies with the plasma membrane. Icrocaptide exerts its activity at the early stages of endothelial activation and inhibits P-selectin and von Willebrand factor secretion. Icrocaptide can be used for the study of a variety of microvascular disorders .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99227

Caplacizumab (His Tag) 1 Publications Verification ALX-0681; ALX-0081	Integrin Transmembrane Glycoprotein	Cardiovascular Disease
Caplacizumab (His Tag) is a humanized anti-von Willebrand factor (vWF) nanobody. Caplacizumab (His Tag) inhibits the binding of vWF with platelet glycoprotein (GP) Ibα. Caplacizumab (His Tag) inhibits the vWF-mediated platelet adhesion and prevents further microthrombi formation. Caplacizumab (His Tag) can be used for the research of thrombotic thrombocytopenic purpura (TTP) .

HY-P99875

Efanesoctocog alfa BIVV-001; Altuvoct	Inhibitory Antibodies	Cardiovascular Disease
Efanesoctocog alfa is a B domain-deleted single-chain Factor VIII (FVIII) connected to D'D3 domain of von Willebrand Factor (vWF). Efanesoctocog alfa has an extended half-life. Efanesoctocog alfa can be used for the study of inherited hemophilia A .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-131150

Ristomycin sulfate	Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Inflammation/Immunology Disease Research Fields Other Antibiotics Source Classification	Antibiotic Bacterial
Ristomycin sulfate is an antibacterial antibiotic and platelet aggregation inducer. Ristomycin sulfate interacts with the D-alanyl-D-alanine terminus of bacterial cell wall precursors to regulate bacterial cell wall synthesis. Ristomycin sulfate induces platelet aggregation in vitro and inhibits the growth of Gram-positive bacteria. Ristomycin sulfate serves as an in vitro diagnostic compound for detecting von Willebrand factor activity. Ristomycin sulfate is applicable to research related to von Willebrand disease and Bernard-Soulier syndrome .

HY-N19251

Sulfobacin B	Structural Classification Natural Products Microorganisms Source Classification	Integrin
Sulfobacin B is a competitive von Willebrand factor receptor GPIb/IX inhibitor with an IC₅₀ of 2.2 μM. Sulfobacin B inhibits binding of von Willebrand factor to GPIb/IX in a competitive manner. Sulfobacin B can be used for the research of thrombosis .

Species:	Human (2)
Tag:	His (2)
Source:	CHO (1) CHO (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P73541

	Von Willebrand Factor/vWF Protein, Human (CHO, His) von Willebrand factor; vWF; von Willebrand antigen II; F8VWF	Human	CHO
	Von Willebrand Factor/vWF Protein, Human (CHO, His) is the recombinant human-derived Von Willebrand Factor/vWF protein, expressed by CHO, with C-His labeled tag.

HY-P79144

	ADAMTS13 Protein, Human (CHO, His) ADAM-TS 13; ADAM-TS13; ADAMTS-13von Willebrand factor-cleaving protease; vWF-CP; vWF-cleaving protease; A Disintegrin-like and Metalloproteinase Domain with Thrombospondin Motifs 13	Human	CHO
	The ADAMTS13 protein, a metalloproteinase, has a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 motif. It cleaves von Willebrand Factor and defects in this gene cause thrombotic thrombocytopenic purpura. Alternative splicing generates multiple transcript variants. ADAMTS13 is broadly expressed in various tissues, including the liver, testis, and 24 other tissues. ADAMTS13 Protein, Human (CHO, His) is the recombinant human-derived ADAMTS13, expressed by CHO, with C-10His labeled tag. The total length of ADAMTS13 Protein, Human (CHO, His) is 655 a.a.*.

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Host:	Rabbit (3)
Reactivity:	Human (1) Mouse (1) Rat (3)
Application:	IHC-P (3) ICC/IF (1) IP (1) WB (3) ELISA (1)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

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HY-P82661

	von Willebrand Factor Antibody (YA2406) VWF; von Willebrand factor; von Willebrand antigen II; F8VWF	WB, IHC-P	Rat
	von Willebrand Factor Antibody (YA2406) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to von Willebrand Factor.

HY-P82661A

	von Willebrand Factor Antibody (YA2406)(PBS only) VWF; von Willebrand factor; von Willebrand antigen II; F8VWF	WB, IHC-P	Rat
	von Willebrand Factor Antibody (YA2406) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to von Willebrand Factor.

HY-P86402

	von Willebrand Factor Antibody (YA6094)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	von Willebrand Factor Antibody (YA6094) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to von Willebrand Factor.

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Cat. No.	Product Name		Classification

HY-153999A

Rondaptivon pegol sodium BT200 sodium		Aptamers
Rondaptivon pegol (BT200) sodium is an aptamer targeting von Willebrand factor (VWF), with an EC₅₀ of 33 nM in humans. Rondaptivon pegol sodium effectively alleviates acute myocardial ischemia-reperfusion injury in mice by inhibiting VWF activity, reducing microvascular obstruction, inflammatory responses and cardiomyocyte apoptosis (apoptosis). Rondaptivon pegol sodium inhibits the binding of VWF to platelet glycoprotein GPIb, thereby preventing arterial thrombosis in cynomolgus monkeys. Rondaptivon pegol sodium can be used in research related to arterial thrombosis, stroke, myocardial infarction and myocardial ischemia-reperfusion injury .

HY-145726

ISIS 104838		Antisense Oligonucleotides
ISIS 104838 is an antisense oligonucleotide targeting TNF-α. ISIS 104838 specifically binds to human TNF-α mRNA via Watson-Crick base pairing to form a DNA:RNA hybrid duplex, thereby recruiting the ubiquitously expressed intracellular enzyme RNase H to degrade the target mRNA and inhibit TNF-α protein synthesis at the transcriptional level. ISIS 104838 induces moderate, self-limiting thrombocytopenia in cynomolgus monkeys. ISIS 104838 can be used for the study of inflammatory diseases .

HY-153999

Rondaptivon pegol BT200		Aptamers
Rondaptivon pegol (BT200) is an aptamer targeting von Willebrand factor (VWF), with an EC₅₀ of 33 nM in humans. Rondaptivon pegol effectively alleviates acute myocardial ischemia-reperfusion injury in mice by inhibiting VWF activity, reducing microvascular obstruction, inflammatory responses and cardiomyocyte apoptosis (apoptosis). Rondaptivon pegol inhibits the binding of VWF to platelet glycoprotein GPIb, thereby preventing arterial thrombosis in cynomolgus monkeys. Rondaptivon pegol can be used in research related to arterial thrombosis, stroke, myocardial infarction and myocardial ischemia-reperfusion injury .

HY-147079A

Egaptivon pegol sodium ARC 1779 sodium		Aptamers
Egaptivon pegol sodium is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol sodium has anti-thrombotic efficacy.

HY-147079

Egaptivon pegol ARC 1779		Aptamers
Egaptivon pegol (ARC1779) is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol has anti-thrombotic efficacy.

HY-156501

BT101 sodium		Aptamers
BT101 (sodium), a complementary aptamer, has been developed to specifically inhibit BT100 function. BT100, a aptamer, inhibits binding of von Willebrand factor (VWF) to platelet glycoprotein GPIb, preventing arterial thrombosis .

HY-153998

BT100 sodium		Aptamers
BT100 (sodium), a aptamer, inhibits binding of von Willebrand factor (VWF) to platelet glycoprotein GPIb, preventing arterial thrombosis .

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von Willebrand factor

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