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SPA70 is a potent and selective antagonist of human pregnane X receptor (hPXR), with an IC50 of 540 nM (Ki=390 nM). SPA70 can enhance the chemosensitivity of cancer cells.

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SPA70 Chemical Structure

SPA70 Chemical Structure

CAS No. : 931314-31-7

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5 mg USD 485 In-stock
10 mg USD 780 In-stock
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Description

SPA70 is a potent and selective antagonist of human pregnane X receptor (hPXR), with an IC50 of 540 nM (Ki=390 nM). SPA70 can enhance the chemosensitivity of cancer cells[1].

IC50 & Target

IC50: 540 nM (hPXR)[1]
Molecular Weight

415.51

Formula

C21H25N3O4S
CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

CC1=C(S(=O)(C2=CC=C(C(C)(C)C)C=C2)=O)N=NN1C3=CC(OC)=CC=C3OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 40 mg/mL (96.27 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4067 mL 12.0334 mL 24.0668 mL
5 mM 0.4813 mL 2.4067 mL 4.8134 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4067 mL 12.0334 mL 24.0668 mL 60.1670 mL
5 mM 0.4813 mL 2.4067 mL 4.8134 mL 12.0334 mL
10 mM 0.2407 mL 1.2033 mL 2.4067 mL 6.0167 mL
15 mM 0.1604 mL 0.8022 mL 1.6045 mL 4.0111 mL
20 mM 0.1203 mL 0.6017 mL 1.2033 mL 3.0084 mL
25 mM 0.0963 mL 0.4813 mL 0.9627 mL 2.4067 mL
30 mM 0.0802 mL 0.4011 mL 0.8022 mL 2.0056 mL
40 mM 0.0602 mL 0.3008 mL 0.6017 mL 1.5042 mL
50 mM 0.0481 mL 0.2407 mL 0.4813 mL 1.2033 mL
60 mM 0.0401 mL 0.2006 mL 0.4011 mL 1.0028 mL
80 mM 0.0301 mL 0.1504 mL 0.3008 mL 0.7521 mL
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SPA70 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SPA70931314-31-7SPA 70SPA-70Otherspregnane X receptorhPXRcancerInhibitorinhibitorinhibit

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