1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Tesmilifene fumarate

Tesmilifene fumarate (Synonyms: DPPE fumarate)

Cat. No.: HY-101179
Handling Instructions

Tesmilifene fumarate (DPPE fumarate), an H1C receptor antagonist, potentiates a wide range of cytotoxics and even to offer some protection of normal cells.

For research use only. We do not sell to patients.

Tesmilifene fumarate Chemical Structure

Tesmilifene fumarate Chemical Structure

CAS No. : 1185241-83-1

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Description

Tesmilifene fumarate (DPPE fumarate), an H1C receptor antagonist, potentiates a wide range of cytotoxics and even to offer some protection of normal cells[1][2].

In Vitro

Tesmilifene may modulate the effects of 12(S)HETE in cancer cells, and indirectly, influence the susceptibility of cellular DNA to chemotherapy[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tesmilifene (DPPE, 20 mg/kg (s.c.) and 20 μg (icv in 5 μL)) potentiated seizures induced by both convulsants[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BKTO mice (25-45 g)[2].
Dosage: 20 mg/kg (s.c.) and 20 μg (icv in 5 μL).
Administration: S.C. and icv.
Result: Potentiated seizures induced by both convulsants.
Clinical Trial
Molecular Weight

399.48

Formula

C₂₃H₂₉NO₅

CAS No.

1185241-83-1

SMILES

CCN(CC)CCOC1=CC=C(CC2=CC=CC=C2)C=C1.O=C(O)/C=C/C(O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TesmilifeneDPPEHistamine Receptorseizureanti-histaminicchemotherapyInhibitorinhibitorinhibit

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Tesmilifene fumarate
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