1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Tesmilifene fumarate

Tesmilifene fumarate (Synonyms: DPPE fumarate)

Cat. No.: HY-101179 Purity: 99.69%
Handling Instructions

Tesmilifene fumarate (DPPE fumarate), an H1C receptor antagonist, potentiates a wide range of cytotoxics and even to offer some protection of normal cells.

For research use only. We do not sell to patients.

Tesmilifene fumarate Chemical Structure

Tesmilifene fumarate Chemical Structure

CAS No. : 1185241-83-1

Size Price Stock Quantity
5 mg USD 85 In-stock
Estimated Time of Arrival: December 31
10 mg USD 130 In-stock
Estimated Time of Arrival: December 31
25 mg USD 240 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Tesmilifene fumarate (DPPE fumarate), an H1C receptor antagonist, potentiates a wide range of cytotoxics and even to offer some protection of normal cells[1][2].

In Vitro

Tesmilifene may modulate the effects of 12(S)HETE in cancer cells, and indirectly, influence the susceptibility of cellular DNA to chemotherapy[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tesmilifene (DPPE, 20 mg/kg (s.c.) and 20 μg (icv in 5 μL)) potentiated seizures induced by both convulsants[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BKTO mice (25-45 g)[2].
Dosage: 20 mg/kg (s.c.) and 20 μg (icv in 5 μL).
Administration: S.C. and icv.
Result: Potentiated seizures induced by both convulsants.
Clinical Trial
Molecular Weight

399.48

Formula

C23H29NO5

CAS No.
SMILES

CCN(CC)CCOC1=CC=C(CC2=CC=CC=C2)C=C1.O=C(O)/C=C/C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (625.81 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5033 mL 12.5163 mL 25.0325 mL
5 mM 0.5007 mL 2.5033 mL 5.0065 mL
10 mM 0.2503 mL 1.2516 mL 2.5033 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.21 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.21 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.21 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
Tesmilifene fumarate
Cat. No.:
HY-101179
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