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Cat. No.: HY-184978

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Thalidomide-NH-CO-NH-C10-COOH

Thalidomide-NH-CO-NH-C10-COOH is a conjugate of an E3 ligase ligand and a linker, which can be used for the synthesis of PROTACs, such as PROTAC CDK9 degrader-6 (HY-149963).

For research use only. We do not sell to patients.

CAS No.: 2305936-79-0
Formula: C₂₆H₃₄N₄O₇
Molecular Weight:514.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Thalidomide-NH-CO-NH-C10-COOH Chemical Structure

CAS No.: 2305936-79-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Thalidomide-NH-CO-NH-C10-COOH is a conjugate of an E3 ligase ligand and a linker, which can be used for the synthesis of PROTACs, such as PROTAC CDK9 degrader-6 (HY-149963)^[1].

All E3 Ligase Ligand-Linker Conjugates Isoforms :

Chemical Information

CAS No. 2305936-79-0
Molecular Weight 514.57
Formula C₂₆H₃₄N₄O₇
SMILES

O=C(NCCCCCCCCCCC(O)=O)CNC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tokarski RJ, et al. Bifunctional degraders of cyclin dependent kinase 9 (CDK9): Probing the relationship between linker length, properties, and selective protein degradation. European journal of medicinal chemistry. 2023 Jun 05;254:115342. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Thalidomide-NH-CO-NH-C10-COOH

All E3 Ligase Ligand-Linker Conjugates Isoforms