1. PROTAC
  2. Ligands for E3 Ligase
  3. Thalidomide-O-amido-C8-NHBoc

Thalidomide-O-amido-C8-NHBoc contains a Thalidomide group, an amide, an alkylC8 chain, and a carbamate protecting group.

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Thalidomide-O-amido-C8-NHBoc

Thalidomide-O-amido-C8-NHBoc Chemical Structure

CAS No. : 1950635-34-3

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10 mM * 1 mL in DMSO
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Description

Thalidomide-O-amido-C8-NHBoc contains a Thalidomide group, an amide, an alkylC8 chain, and a carbamate protecting group.

Molecular Weight

558.62

Formula

C28H38N4O8

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(NCCCCCCCCNC(OC(C)(C)C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (179.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7901 mL 8.9506 mL 17.9013 mL
5 mM 0.3580 mL 1.7901 mL 3.5803 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7901 mL 8.9506 mL 17.9013 mL 44.7531 mL
5 mM 0.3580 mL 1.7901 mL 3.5803 mL 8.9506 mL
10 mM 0.1790 mL 0.8951 mL 1.7901 mL 4.4753 mL
15 mM 0.1193 mL 0.5967 mL 1.1934 mL 2.9835 mL
20 mM 0.0895 mL 0.4475 mL 0.8951 mL 2.2377 mL
25 mM 0.0716 mL 0.3580 mL 0.7161 mL 1.7901 mL
30 mM 0.0597 mL 0.2984 mL 0.5967 mL 1.4918 mL
40 mM 0.0448 mL 0.2238 mL 0.4475 mL 1.1188 mL
50 mM 0.0358 mL 0.1790 mL 0.3580 mL 0.8951 mL
60 mM 0.0298 mL 0.1492 mL 0.2984 mL 0.7459 mL
80 mM 0.0224 mL 0.1119 mL 0.2238 mL 0.5594 mL
100 mM 0.0179 mL 0.0895 mL 0.1790 mL 0.4475 mL
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Thalidomide-O-amido-C8-NHBoc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Thalidomide-O-amido-C8-NHBoc
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