1. Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
  2. Reactive Oxygen Species
  3. Tin-protoporphyrin IX

Tin-protoporphyrin IX (Synonyms: SnPPIX)

Cat. No.: HY-101194 Purity: ≥95.0%
Handling Instructions

Tin-protoporphyrin IX (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin-protoporphyrin IX (SnPPIX) sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model.

For research use only. We do not sell to patients.

Tin-protoporphyrin IX Chemical Structure

Tin-protoporphyrin IX Chemical Structure

CAS No. : 14325-05-4

Size Price Stock Quantity
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 400 In-stock
Estimated Time of Arrival: December 31
50 mg USD 950 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tin-protoporphyrin IX (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin-protoporphyrin IX (SnPPIX) sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model[1].

IC50 & Target

IC50: Heme oxygenase-1 (HO-1)[1]

In Vitro

Tin-protoporphyrin IX (SnPPIX)(20 μM, 50 μM; 24 hours) significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells. In contrast, SnPPIX has no significant effect on PDAC cells proliferation at all exposures except at 50 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Capan-1, CD18/HPAF, PDAC cells
Concentration: 20 μM, 50 μM
Incubation Time: 24 or 72 hours
Result: Inhibited Capan-1 and CD18/HPAF cells proliferation and inhibits PDAC cells growth at 50μM.
In Vivo

Tin-protoporphyrin IX (SnPPIX)(intraperitoneal injection; 5 mg/kg; at 0, 7, 15, and 20 days) alone or combines with Gemcitabine significantly reduced the weight of pancreatic tumors (P < 0.05), decreases metastasis and improved the efficacy of Gemcitabine treatment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female athymic nude mice with PDAC cell-derived xenograft tumors[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; at days 1, 4, 6, 8, 11, 13, 15, 18, and 20
Result: Inhibited tumor growth and sensitized tumors to chemotherapy (Gemcitabine).
Molecular Weight

750.26

Formula

C₃₄H₃₂Cl₂N₄O₄Sn

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

0.1 M NaOH : 14.29 mg/mL (19.05 mM; ultrasonic and adjust pH to 12 with NaOH)

DMF : 1 mg/mL (1.33 mM; Need ultrasonic and warming)

DMSO : 0.5 mg/mL (0.67 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3329 mL 6.6644 mL 13.3287 mL
5 mM 0.2666 mL 1.3329 mL 2.6657 mL
10 mM 0.1333 mL 0.6664 mL 1.3329 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: ≥95.0%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Tin-protoporphyrin IX
Cat. No.:
HY-101194
Quantity:
MCE Japan Authorized Agent: