1. Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
  2. Reactive Oxygen Species
  3. Tin-protoporphyrin IX

Tin-protoporphyrin IX (Synonyms: SnPPIX)

Cat. No.: HY-101194
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Tin-protoporphyrin IX (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin-protoporphyrin IX (SnPPIX) sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model.

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Tin-protoporphyrin IX Chemical Structure

Tin-protoporphyrin IX Chemical Structure

CAS No. : 14325-05-4

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Description

Tin-protoporphyrin IX (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin-protoporphyrin IX (SnPPIX) sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model[1].

IC50 & Target

IC50: Heme oxygenase-1 (HO-1)[1]

In Vitro

Tin-protoporphyrin IX (SnPPIX)(20 μM, 50 μM; 24 hours) significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells. In contrast, SnPPIX has no significant effect on PDAC cells proliferation at all exposures except at 50 μM[1].

Cell Viability Assay[1]

Cell Line: Capan-1, CD18/HPAF, PDAC cells
Concentration: 20 μM, 50 μM
Incubation Time: 24 or 72 hours
Result: Inhibited Capan-1 and CD18/HPAF cells proliferation and inhibits PDAC cells growth at 50μM.
In Vivo

Tin-protoporphyrin IX (SnPPIX)(intraperitoneal injection; 5 mg/kg; at 0, 7, 15, and 20 days) alone or combines with Gemcitabine significantly reduced the weight of pancreatic tumors (P < 0.05), decreases metastasis and improved the efficacy of Gemcitabine treatment[1].

Animal Model: Male and female athymic nude mice with PDAC cell-derived xenograft tumors[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; at days 1, 4, 6, 8, 11, 13, 15, 18, and 20
Result: Inhibited tumor growth and sensitized tumors to chemotherapy (Gemcitabine).
Molecular Weight

750.26

Formula

C₃₄H₃₂Cl₂N₄O₄Sn

CAS No.

14325-05-4

SMILES

[Cl-][Sn+4]123([N-]4C5=C(CCC([O-])=O)C(C)=C4C=C(C(C=C)=C6C)[N]1=C6C=C(C(C=C)=C7C)[N-]2C7=CC(C(C)=C8CCC([O-])=O)=[N]3C8=C5)[Cl-].[H+].[H+]

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Keywords:

Tin-protoporphyrin IXSnPPIXReactive Oxygen SpeciesPancreatic ductal adenocarcinoma (PDAC)Heme oxygenase-1HO-1PDAD,snppChemotherapyInhibitorinhibitorinhibit

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