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Cat. No.: HY-10977AR

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Tivozanib hydrochloride hydrate (Standard)

Name: Tivozanib hydrochloride hydrate (Standard)
Brand: MedChemExpress
SKU: HY-10977AR
Price: 175.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: AV-951 hydrochloride hydrate (Standard); KRN951 hydrochloride hydrate (Standard))

Tivozanib (hydrochloride hydrate) (Standard) is the analytical standard of Tivozanib (hydrochloride hydrate). This product is intended for research and analytical applications. Tivozanib hydrochloride hydrate is the hydrate hydrochloride form of Tivozanib (HY-10977). Tivozanib hydrochloride hydrate is a selective, orally active inhibitor for vascular endothelial growth factor receptor (VEGFR)-1, 2 3, with IC50s of 30, 6.5 and 15 nM, respectively. Tivozanib hydrochloride hydrate exhibits antitumor efficacy.

For research use only. We do not sell to patients.

Purity: 98%
CAS No.: 682745-41-1
Formula: C₂₂H₂₂Cl₂N₄O₆
Molecular Weight:509.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tivozanib hydrochloride hydrate (Standard) Chemical Structure

CAS No.: 682745-41-1

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Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 682745-41-1
Molecular Weight 509.34
Formula C₂₂H₂₂Cl₂N₄O₆
SMILES

O=C(NC1=CC=C(C=C1Cl)OC2=CC=NC3=CC(OC)=C(C=C23)OC)NC4=NOC(C)=C4.Cl.O
Synonyms

AV-951 hydrochloride hydrate (Standard); KRN951 hydrochloride hydrate (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Nakamura K, et al., KRN951, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, has antitumor activities and affects functional vascular properties. Cancer Res. 2006 Sep 15;66(18):9134-42. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Tivozanib hydrochloride hydrate (Standard)

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