1. Cell Cycle/DNA Damage
  2. Topoisomerase
  3. Topoisomerase I inhibitor 4

Topoisomerase I inhibitor 4 

Cat. No.: HY-143301
Handling Instructions

Topoisomerase I inhibitor 4 (compound 7a) is a topoisomerase I inhibitor. Topoisomerase I inhibitor 4 inhibits HepG2, A549, MCF-7 and HeLa cancer cells proliferation with IC50s of 1.20, 2.09, 1.56 and 1.92 μM, respectively. Topoisomerase I inhibitor 4 can be used for the research of cancer.

For research use only. We do not sell to patients.

Topoisomerase I inhibitor 4 Chemical Structure

Topoisomerase I inhibitor 4 Chemical Structure

CAS No. : 2485135-31-5

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Description

Topoisomerase I inhibitor 4 (compound 7a) is a topoisomerase I inhibitor. Topoisomerase I inhibitor 4 inhibits HepG2, A549, MCF-7 and HeLa cancer cells proliferation with IC50s of 1.20, 2.09, 1.56 and 1.92 μM, respectively. Topoisomerase I inhibitor 4 can be used for the research of cancer[1].

IC50 & Target

IC50: 1.20 μM (HepG2), 2.09 μM (A549), 1.56 μM (MCF-7), 1.92 μM (HeLa)[1]

In Vitro

Topoisomerase I inhibitor 4 (1-80 μM) shows Top1 inhibitory activity[1].
Topoisomerase I inhibitor 4 (0-40 μM; 48 h) inhibits proliferation of cancer cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: HepG2, A549, MCF-7 and HeLa cell lines
Concentration: 0-40 μM
Incubation Time: 48 hours
Result: Showed antiproliferative activities to HepG2, A549, MCF-7 and HeLa cells with IC50s of 1.20, 2.09, 1.56 and 1.92 μM, respectively.
Molecular Weight

386.42

Formula

C23H19FN4O

CAS No.
SMILES

O=C1C2=C(N=C3C4=CC5=CC=CC=C5C=C4CN13)C=C(C(F)=C2)N6CCNCC6

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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References
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Topoisomerase I inhibitor 4
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