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Cat. No.: HY-143301

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Topoisomerase I inhibitor 4

Topoisomerase I inhibitor 4 (compound 7a) is a topoisomerase I inhibitor. Topoisomerase I inhibitor 4 inhibits HepG2, A549, MCF-7 and HeLa cancer cells proliferation with IC₅₀s of 1.20, 2.09, 1.56 and 1.92 μM, respectively. Topoisomerase I inhibitor 4 can be used for the research of cancer.

For research use only. We do not sell to patients.

CAS No.: 2485135-31-5
Formula: C₂₃H₁₉FN₄O
Molecular Weight:386.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Topoisomerase I inhibitor 4 Chemical Structure

CAS No.: 2485135-31-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 1.20 μM (HepG2), 2.09 μM (A549), 1.56 μM (MCF-7), 1.92 μM (HeLa)^[1]

All Topoisomerase Isoforms :

In Vitro

Topoisomerase I inhibitor 4 (1-80 μM) shows Top1 inhibitory activity^[1].
Topoisomerase I inhibitor 4 (0-40 μM; 48 h) inhibits proliferation of cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

HepG2, A549, MCF-7 and HeLa cell lines
Concentration:

0-40 μM
Incubation Time:

48 hours
Result:

Showed antiproliferative activities to HepG2, A549, MCF-7 and HeLa cells with IC₅₀s of 1.20, 2.09, 1.56 and 1.92 μM, respectively.

Chemical Information

CAS No. 2485135-31-5
Molecular Weight 386.42
Formula C₂₃H₁₉FN₄O
SMILES

O=C1C2=C(N=C3C4=CC5=CC=CC=C5C=C4CN13)C=C(C(F)=C2)N6CCNCC6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xiang, Y, et al. Design, synthesis, and anticancer activities of 8,9-substituted Luotonin A analogs as novel topoisomerase I inhibitors. Med Chem Res 30, 1512–1522 (2021).

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Topoisomerase I inhibitor 4

All Topoisomerase Isoforms