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Cat. No.: HY-156462

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Topoisomerase I inhibitor 9

Topoisomerase I inhibitor 9 (compound 3d) is a leishmanial topoisomerase IB inhibitor. Topoisomerase I inhibitor 9 has antileishmanial activity against L. donovani promastigotes, with the IC₅₀ of 34.81μM.

For research use only. We do not sell to patients.

CAS No.: 1228150-86-4
Formula: C₂₃H₁₅Br₂FN₂
Molecular Weight:498.19

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Topoisomerase I inhibitor 9 Chemical Structure

CAS No.: 1228150-86-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

34.81 μM^[1]

All Topoisomerase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	4.5 μM Compound: 2m	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	10.1007/s00044-013-0764-4
A549	IC₅₀	4.5 μmol Compound: 2m	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	10.1007/s00044-013-0764-4
HeLa	IC₅₀	2.7 μM Compound: 2m	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	10.1007/s00044-013-0764-4
HeLa	IC₅₀	2.7 μmol Compound: 2m	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	10.1007/s00044-013-0764-4
J774.A1	CC₅₀	4.45 μM Compound: 3d	Cytotoxicity against mouse J774.A1 cells assessed as reduction in viability incubated for 20 hrs by MTT assay Cytotoxicity against mouse J774.A1 cells assessed as reduction in viability incubated for 20 hrs by MTT assay	[PMID: 37859718]
PC-3	IC₅₀	3.9 μM Compound: 2m	Cytotoxicity against human PC3 cells after 48 hrs by MTT assay Cytotoxicity against human PC3 cells after 48 hrs by MTT assay	10.1007/s00044-013-0764-4
PC-3	IC₅₀	3.9 μmol Compound: 2m	Cytotoxicity against human PC3 cells after 48 hrs by MTT assay Cytotoxicity against human PC3 cells after 48 hrs by MTT assay	10.1007/s00044-013-0764-4

Chemical Information

CAS No. 1228150-86-4
Molecular Weight 498.19
Formula C₂₃H₁₅Br₂FN₂
SMILES

FC1=CC=C(C(C2=CNC3=C2C=C(Br)C=C3)C4=CNC5=C4C=C(Br)C=C5)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kour P, et al. Design, synthesis, and biological evaluation of 3,3'-diindolylmethane N-linked glycoconjugate as a leishmanial topoisomerase IB inhibitor with reduced cytotoxicity. RSC Med Chem. 2023;14(10):2100-2114. Published 2023 Aug 30. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Topoisomerase I inhibitor 9

All Topoisomerase Isoforms