Trypanothione synthetase-IN-3 

Trypanothione synthetase-IN-3 is a noncompetitive mixed hyperbolic Trypanothione synthetase (TryS) inhibitor (K_i: 0.8 μM). Trypanothione synthetase-IN-3 can be used in the study of parasites, such as L. infantum^[1].

Trypanothione synthetase (TryS)^[1]

Trypanothione synthetase-IN-3 (30 min) displays noncompetitive inhibitory behavior against Li TryS with IC₅₀ values of 2 μM -5.6 μM (determined by various substrates)^[1].
Trypanothione synthetase-IN-3 (24 h) inhibits proliferation of L. infantum axenic amastigotes with an EC₅₀ value of 43.7 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1559.13

C₆₈H₅₄O₄₃

1314875-96-1

O=C(C1=CC(O)=C(C(O)=C1)O)O[C@@H]2[C@H]([C@H](O[C@@H]([C@H]2OC(C3=CC(O)=C(C(O)=C3)O)=O)COC(C4=CC(O)=C(C(O)=C4)O)=O)O[C@@H]5[C@@H]([C@H]([C@@H]([C@H](O5)COC(C6=CC(O)=C(C(O)=C6)O)=O)OC(C7=CC(O)=C(C(O)=C7)O)=O)OC(C8=CC(O)=C(C(O)=C8)O)=O)OC(C9=CC(O)=C(C(O)=C9)O)=O)OC(C%10=CC(O)=C(C(O)=C%10)O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mercedes Alcón-Calderón, et al. Identification of L. infantum trypanothione synthetase inhibitors with leishmanicidal activity from a (non-biased) in-house chemical library. European Journal of Medicinal Chemistry, 2022, 114675.