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Cat. No.: HY-189290

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Tyrosinase-IN-52

Tyrosinase-IN-52 is a synthetic heterocyclic derivative of 4-(4-fluorobenzyl) piperazine-acetanilide that possesses tyrosinase inhibitory activity (mushroom IC₅₀ = 85.24 μM). Tyrosinase-IN-52 modulates melanogenesis through a biphasic effect, thereby regulating melanin content, and weakly scavenges DPPH radicals. Tyrosinase-IN-52 exhibits low cytotoxicity against mouse fibroblast 3T3 cells. Tyrosinase-IN-52 can be used for pigmentation-related research.

For research use only. We do not sell to patients.

CAS No.: 890297-34-4
Formula: C₁₉H₂₁FN₄O₃
Molecular Weight:372.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tyrosinase-IN-52 Chemical Structure

CAS No.: 890297-34-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

Tyrosinase-IN-52 (Compound 2h) (1-200 μM; 10 min) is a potent tyrosinase inhibitor with an IC₅₀ of 85.24 μM, exhibiting superior activity to Kojic acid (HY-W050154)^[1].
Tyrosinase-IN-52 (1.56-200 μM; 24 h) exhibits low cytotoxicity against 3T3 cells, with cell viability remaining at approximately 80% at 200 μM^[1].
Tyrosinase-IN-52 (0-350 μM; 48 h) exhibits a biphasic effect on melanogenesis in HaCaT cells, inhibiting melanin content to 86.86% of the control at 200 μM^[1].
Tyrosinase-IN-52 (25-200 μM; 30 min) exhibits weak antioxidant activity, with DPPH radical scavenging rates below 10% at all tested concentrations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 890297-34-4
Molecular Weight 372.39
Formula C₁₉H₂₁FN₄O₃
SMILES

FC(C=C1)=CC=C1CN2CCN(CC(NC3=CC=C([N+]([O-])=O)C=C3)=O)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yılmaz EA, et al. Design, synthesis, and development of 4-(4-Fluorobenzyl)piperazine-acetanilide conjugates as novel tyrosinase inhibitors. Bioorganic chemistry. 2026 Oct 05;181:110284.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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