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Cat. No.: HY-P11658

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Anticancer peptoid 1

(Synonyms: Peptoid 1)

Anticancer peptoid 1 (Peptoid 1) is a peptoid with antitumor activity. Anticancer peptoid 1 exerts cytotoxicity primarily via plasma membrane damage. Anticancer peptoid 1 exerts cytotoxicity against a broad range of cancer cell lines, including those with multidrug resistance. Anticancer peptoid 1 inhibits tumor growth in a human breast cancer xenotransplantation mouse model without noticeable acute adverse effects. Anticancer peptoid 1 can be used for the research of cancer, such as breast cancer, and prostate cancer.

For research use only. We do not sell to patients.

CAS No.: 620948-14-3
Formula: C₁₀₄H₁₃₉N₁₇O₁₂
Molecular Weight:1819.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer peptoid 1 Chemical Structure

CAS No.: 620948-14-3

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Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HaCaT	ED₅₀	20 μM Compound: 13	Cytotoxicity against human HaCaT cells assessed as reduction in cell viability pretreated for 1 hr followed by DMEM addition measured after 24 hrs by alamar blue assay Cytotoxicity against human HaCaT cells assessed as reduction in cell viability pretreated for 1 hr followed by DMEM addition measured after 24 hrs by alamar blue assay	[PMID: 30108804]

In Vitro

Anticancer peptoid 1 (72 h) potently induces cytotoxicity in MCF-7, LNCaP, OVCAR-3, MRC-5, and primary dermal fibroblast cells with LC₅₀ values of 5, 5, 6, 8, and 8 μM respectively after 72 h treatment^[1].
Anticancer peptoid 1 (0-50 μM; 72 h) potently induces cytotoxicity in both MCF-7 and multidrug-resistant MCF-7/TxT50 cells, overcoming multidrug resistance^[1].
Anticancer peptoid 1 (50 μM; 5-60 min) induces rapid plasma membrane damage in MCF-7 cells, with 50 μM causing ~50% LDH leakage^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

MCF-7 (human breast cancer) cells
Concentration:

50 μM (for 50% LDH leakage measurement)
Incubation Time:

5, 30, 60 min
Result:

Caused fast LDH release into media; 50 μM peptoid 1 induced ~50% LDH leakage.
Induced rapid plasma membrane damag.

In Vivo

Anticancer peptoid 1 (1 mg/kg; mammary fat pad injection; three times per week; 12 weeks) significantly inhibits tumor growth in a human breast cancer orthotopic xenograft mouse model with no observed acute toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NOD.Cg-Prkdcscid Il2rg^tmlWjl/SzJ (NSG) (4-8 week old female, immunocompromised, orthotopic xenograft model via mammary fat pad injection of human breast cancer cells)^[1]
Dosage:

1 mg/kg
Administration:

Mammary fat pad injection; three times per week; 12 weeks
Result:

Significantly inhibited tumor growth compared to the control peptoid, with a p-value of 0.0014.
Showed no noticeable acute adverse effects.

Chemical Information

CAS No. 620948-14-3
Molecular Weight 1819.32
Formula C₁₀₄H₁₃₉N₁₇O₁₂
Synonyms

Peptoid 1
Sequence

({NLys}-{Nspe}-{Nspe})4-NH2
Sequence Shortening

({NLys}-{Nspe}-{Nspe})4-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huang W, et al. Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity. PLoS One. 2014;9(2):e90397. Published 2014 Feb 28. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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