JMV-1645
JMV-1645 is a potent and selective B1 bradykinin receptor antagonist with a Ki value of 0.023 nM on the human cloned B1 receptor. JMV-1645 can be utilized in trauma and infection research.
For research use only. We do not sell to patients.
- CAS No.: 284037-77-0
- Formula: C49H69N13O12S
- Molecular Weight:1064.22
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Bradykinin Receptor Isoforms
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Biological Activity
Description
IC50 & Target
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Bradykinin B1 Receptor (B1R) 0.023 nM (Ki) |
Chemical Information
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CAS No. 284037-77-0
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Molecular Weight 1064.22
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Formula C49H69N13O12S
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Sequence
H-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-D-BT-OH
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Sequence Shortening
H-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-D-BT-OH
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JMV-1645 Related Classifications
HY-P2109 Related Classifications
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