2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. VEGFR-2-IN-21

VEGFR-2-IN-21 (Compound 5d) is a potent VEGFR-2 inhibitor with an IC50 of 0.10 μM. VEGFR-2-IN-21 shows anticancer activity.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

VEGFR-2-IN-21

VEGFR-2-IN-21 Chemical Structure

CAS No. : 2531029-88-4

Size Stock
50 mg   Obtenir un devis  
100 mg   Obtenir un devis  
250 mg   Obtenir un devis  

* Veuillez sélectionner la quantité avant d'ajouter des articles.

This product is a controlled substance and not for sale in your territory.

VEGFR-2-IN-21 Related Antibodies

Top Publications Citing Use of Products

Voir tous les produits spécifiques à Isoform VEGFR:

Voir toutes les isoformes
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • Activité biologique

  • Pureté et documentation

  • Références

  • Avis client

Description

VEGFR-2-IN-21 (Compound 5d) is a potent VEGFR-2 inhibitor with an IC50 of 0.10 μM. VEGFR-2-IN-21 shows anticancer activity[1].

IC50 & Target

VEGFR-2

0.10 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
7.77 μM
Compound: 47
Cytotoxicity against human HCT-116 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
[PMID: 38728867]
HepG2 IC50
8.98 μM
Compound: 47
Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
[PMID: 38728867]
MCF7 IC50
6.99 μM
Compound: 47
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 38728867]
In Vitro

VEGFR-2-IN-21 (Compound 5d) shows inhibitory activities against the three HepG2, HCT116 and MCF-7 cancer cell lines with IC50 values of 8.98 ± 0.1, 7.77 ± 0.1 and 6.99 ± 0.1 µM respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VEGFR-2-IN-21 Related Antibodies
Masse moléculaire

574.05

Formule

C28H24ClN7O3S
CAS No.
SMILES

O=S(C1=CC=C(/N=N/C2=CC=C(C3=NCC(N(C)C4=CC=C(Cl)C=C34)=O)C=C2)C=C1)(NC5=NC(C)=CC(C)=N5)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

VEGFR-2-IN-21 Related Classifications

  • Calculateur de molarité

  • Calculateur de dilution

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2-IN-212531029-88-4VEGFRVascular endothelial growth factor receptorHepG2HCT116MCF-7anticancerInhibitorinhibitorinhibit

Vos produits récemment consultés:

Demande en ligne

Your information is safe with us. * Required Fields.

Nom du produit

  

Requested Quantity *

Nom du demandeur *

 

Civilité

Adresse e-mail *

 

Numéro de téléphone *

Department

 

Nom de l'organisation *

City

État

Country or Region *

      

Remarques

Bulk Inquiry

Inquiry Information

Nom du produit:
VEGFR-2-IN-21
Cat. No.:
HY-147800
Quantité:
MCE Japan Authorized Agent:

Avis client

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nom du produit

  

Lot #

Nom du demandeur *

 

Adresse e-mail *

Numéro de téléphone

 

Department *

Nom de l'organisation *

 

Country or Region *

Remarques

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.