WLSEAGPVVTVRALRGTGSW TFA

Cat. No.: HY-P3436A: Fiche technique Instruction de manipulation
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WLSEAGPVVTVRALRGTGSW TFA is a cardiomyocyte-targeting peptide that specifically recognizes tenascin X on the surface of cardiomyocytes. WLSEAGPVVTVRALRGTGSW TFA can serve as a targeting ligand to conjugate with various therapeutic carriers (drugs, genes, exosomes, nanoparticles, etc.) for research on cardiovascular diseases (such as myocardial infarction, heart failure).

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WLSEAGPVVTVRALRGTGSW TFA Chemical Structure

Size		Stock
MOQ		Minimum order quantity
50 mg		Obtenir un devis
100 mg		Obtenir un devis
250 mg		Obtenir un devis
Other size		Obtenir un devis

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This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of WLSEAGPVVTVRALRGTGSW TFA:

WLSEAGPVVTVRALRGTGSW

Other Forms of WLSEAGPVVTVRALRGTGSW TFA:

WLSEAGPVVTVRALRGTGSW In-stock

Recommandations en vedette

•Related Small Molecules:

•Related Proteins:

Activité biologique
Pureté et documentation
Références
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Description

In Vitro

WLSEAGPVVTVRALRGTGSW TFA enhances the internalization of exosomes by cardiomyocytes and promotes the targeted delivery of miR302 after conjugation with bone marrow mesenchymal stem cell-derived exosomes^[1].
WLSEAGPVVTVRALRGTGSW TFA mediates the preferential localization of phages displaying this peptide in mouse heart tissues, including uptake by cardiomyocytes in vivo, and blocks the uptake of phages displaying its own sequence by primary cardiomyocytes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Masse moléculaire

2256.44

Formule

C₉₉H₁₅₃F₃N₂₈O₂₉

Sequence Shortening

WLSEAGPVVTVRALRGTGSW

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvant et solubilité

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Gu J, et al. Engineered bone marrow mesenchymal stem cell-derived exosomes loaded with miR302 through the cardiomyocyte specific peptide can reduce myocardial ischemia and reperfusion (I/R) injury. Journal of translational medicine. 2024 Feb 17;22(1):168.

[2]. McGuire MJ, et al. In vitro selection of a peptide with high selectivity for cardiomyocytes in vivo. J Mol Biol. 2004;342(1):171-182. [Content Brief]