1-Thio-beta-D-glucose tetraacetate
Based on 1 publication(s) in Google Scholar
1-Thio-beta-D-glucose tetraacetate exhibits cytotoxicity in cells HeLa and human ocular lens epithelium CECH with IC50s of >250 and >200 μM. 1-Thio-beta-D-glucose tetraacetate reveals moderate anticancer property.
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 19879-84-6
- Formula: C14H20O9S
- Molecular Weight:364.37
-
Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 1-Thio-beta-D-glucose tetraacetate
More
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
>500 μM
Compound: 6
|
Antiproliferative activity against p53 deficient human HCT116 cells after 96 hrs by MTS assay
Antiproliferative activity against p53 deficient human HCT116 cells after 96 hrs by MTS assay
|
[PMID: 26890119] |
| HCT-116 | IC50 |
>750 μM
Compound: 6
|
Antiproliferative activity against p53 expressing human HCT116 cells after 96 hrs by MTS assay
Antiproliferative activity against p53 expressing human HCT116 cells after 96 hrs by MTS assay
|
[PMID: 26890119] |
Chemical Information
-
CAS No. 19879-84-6
-
Appearance Solid
-
Molecular Weight 364.37
-
Formula C14H20O9S
-
Color White to off-white
-
SMILES
CC(O[C@H]1[C@@H]([C@H](O[C@H]([C@@H]1OC(C)=O)S)COC(C)=O)OC(C)=O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (1)
-
Journal Impact Factor
-
Most Recent
Solvent & Solubility
DMSO : 100 mg/mL (274.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (13.72 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
-
Data Sheet (276 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7445 mL | 13.7223 mL | 27.4446 mL | 68.6116 mL |
| 5 mM | 0.5489 mL | 2.7445 mL | 5.4889 mL | 13.7223 mL | |
| 10 mM | 0.2744 mL | 1.3722 mL | 2.7445 mL | 6.8612 mL | |
| 15 mM | 0.1830 mL | 0.9148 mL | 1.8296 mL | 4.5741 mL | |
| 20 mM | 0.1372 mL | 0.6861 mL | 1.3722 mL | 3.4306 mL | |
| 25 mM | 0.1098 mL | 0.5489 mL | 1.0978 mL | 2.7445 mL | |
| 30 mM | 0.0915 mL | 0.4574 mL | 0.9148 mL | 2.2871 mL | |
| 40 mM | 0.0686 mL | 0.3431 mL | 0.6861 mL | 1.7153 mL | |
| 50 mM | 0.0549 mL | 0.2744 mL | 0.5489 mL | 1.3722 mL | |
| 60 mM | 0.0457 mL | 0.2287 mL | 0.4574 mL | 1.1435 mL | |
| 80 mM | 0.0343 mL | 0.1715 mL | 0.3431 mL | 0.8576 mL | |
| 100 mM | 0.0274 mL | 0.1372 mL | 0.2744 mL | 0.6861 mL |
1-Thio-beta-D-glucose tetraacetate Related Classifications
HY-W039865 Related Classifications
Powered by Bioz