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Cat. No.: HY-152488

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3’-β-C-Ethynyl-5-methyl uridine

3’-β-C-Ethynyl-5-methyl uridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis. 3’-β-C-Ethynyl-5-methyl uridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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CAS No.: 180300-52-1
Formule: C₁₂H₁₄N₂O₆
Masse moléculaire:282.25

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

3’-β-C-Ethynyl-5-methyl uridine Chemical Structure

CAS No.: 180300-52-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

3’-β-C-Ethynyl-5-methyl uridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis^[1]. 3’-β-C-Ethynyl-5-methyl uridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cellular Effect

Cell Line	Type	Value	Description	References
KB	IC₅₀	>300 μM Compound: EMUrd(14c)	In vitro tumor cell growth inhibitory activity against human nasopharyngeal KB cell lines In vitro tumor cell growth inhibitory activity against human nasopharyngeal KB cell lines	[PMID: 8960561]
L1210	IC₅₀	>300 μM Compound: EMUrd(14c)	In vitro tumor cell growth inhibitory activity against mouse leukemia L1210 cell lines. In vitro tumor cell growth inhibitory activity against mouse leukemia L1210 cell lines.	[PMID: 8960561]

Chemical Information

CAS No. 180300-52-1
Masse moléculaire 282.25
Formule C₁₂H₁₄N₂O₆
SMILES

OC[C@@H]1[C@](O)(C#C)[C@@H](O)[C@H](N(C(N2)=O)C=C(C)C2=O)O1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. [Content Brief]

[2]. Cavanagh BL, et al. Thymidine analogues for tracking DNA synthesis. Molecules. 2011 Sep 15;16(9):7980-93. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

3’-β-C-Ethynyl-5-methyl uridine

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3’-β-C-Ethynyl-5-methyl uridine

Activité biologique

Description

Cellular Effect

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

3’-β-C-Ethynyl-5-methyl uridine Related Classifications

HY-152488 Related Classifications

Bioz

Keywords

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